Clinical trials: Adipose Tissue Inflammation
Cholesterol
Dietary Cholesterol and Adipose Tissue Inflammation
Hypothesis: increasing dietary cholesterol in humans will increase visceral, but not subcutaneous adipocyte size, free cholesterol content, and inflammatory gene expression.
- Trial name
- NCT03729141
- Testing
- Added Cholesterol, No Added Cholesterol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Obesity
Human Intestinal Microbiota in Obesity and Nutritional Transition
The objectives of this study are: 1-To qualify the relationship between the gut microbiota and the host nutritional and metabolic status during dietary transition.2-To define the impact of nutritional transition on the intestinal…
- Trial name
- Micro-Obes (NCT01314690)
- Testing
- Caloric transition
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ceprodi S.A. Kot
Inflammation, Obesity
Systemic and White Adipose Tissue Inflammatory Profile in Lean Versus Obese Individuals
This study will compare the systemic and white adipose tissue inflammatory profile of individuals who are classified as lean and obese.
- Conditions
- Inflammation, Obesity, Inflammatory Response, Cardiovascular Risk Factor
- Trial name
- NCT04078776
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Obesity
Mechanisms Underlying Postoperative Insulin Resistance and Inflammation
Having an operation places an enormous burden on the body, leading to the development of inflammation and so called 'insulin resistance'.
- Trial name
- NCT01470534
- Testing
- carbohydrate drink, Muscle biopsy, Blood sampling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
Aging Problems, Aging
Evaluating the Safety and Efficacy of Autologous Adipose Tissue-derived Mesenchymal Stem Cell Transplantation on Proinflammatory Cytokines and Anti-inflammatory Cytokines on Ageing-related Low-grade Inflammation Patients.
Single-group, open-label, phase I / II clinical trial: Evaluation of the safety of autologous adipose tissue-derived mesenchymal stem cell transplantation in inflammaging (Ageing-related low-grade inflammation) patients.
- Conditions
- Aging Problems, Aging, Chronic Inflammation
- Trial name
- NCT05827757
- Testing
- autologous adipose-derived mesenchymal stem cell transplantation
- Where
- Vietnam
- Volunteers
- 72 people
- Sponsor
- DNA International Hospital
Atrial Fibrillation, Atrial Inflammation
Inflammation, Fibrosis and Risk of Recurrence After Atrial Fibrillation Ablation
FIBRO-RISK study aims to investigate the impact of inflammatory-mediated myocardial fibrosis on the risk of recurrence after successful ablation of atrial fibrillation.
- Trial name
- FIBRO-RISK (NCT03757741)
- Testing
- Cardiac imaging tests, Venous blood samle collection
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Obesity, Metabolic Diseases
Adaptation of Human Gut Microbiota to Energetic Restriction
Gut microbiota ecology is altered in obesity and could link obesity and its complications. Bariatric surgery enables a major and sustained weight loss therefore improving obesity related disease.
- Conditions
- Obesity, Metabolic Diseases, Nutrition Disorders, Body Weight
- Trial name
- microbaria (NCT01454232)
- Testing
- stools sampling, adipose tissue biopsy
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lipedema, Overweight and Obesity
Ketogenic Diet in Women With Lipedema
Lipedema is a chronic fat tissue disorder that usually affects the lower limbs, excluding the feet. Clinical symptoms of lipedema include a noticeable disproportion between the upper and lower body, a tendency to easy bruising…
- Trial name
- NCT07530341
- Testing
- Low carbohydrate high fat (ketogenic) diet with anti-inflammatory properties
- Where
- Poland
- Volunteers
- 121 people
- Sponsor
- Wroclaw Medical University
Asthma, Allergies and Obesity
The Relation Between Obesity, Adipose Tissue Content of Fatty Acids and Systemic and Airway Inflammation
Obesity has been recognized as a risk factors for developing asthma. In a cohort of 5384 children aged 15-17, we aim to: 1. To investigate the association of asthma prevalence at age 15-17 with body mass index (BMI) at age 15-17…
- Trial name
- NCT01229787
- Where
- Cyprus
- Volunteers
- 5,384 people, healthy volunteers welcome
- Sponsor
- Cyprus International Institute for Environment and Public Health
Obesity and Type 2 Diabetes, Bariatric Patients Undergoing Bariatric Surgery
Regional Adipose Tissue Characteristics in Type II Diabetes
Fat tissue in different parts of the body has different characteristics. Several studies have associated abdominal fat to an increased risk for multiple metabolic diseases, such as type 2 diabetes and cardiovascular disease…
- Conditions
- Obesity and Type 2 Diabetes, Bariatric Patients Undergoing Bariatric Surgery, Adipose Tissue Dysfunction Type 2 Diabetes Mellitus Bariatric Surgery, Adipose Tissue Inflammation
- Trial name
- NCT06599047
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal
Obesity
Diet Induced Weight Loss to Reduce Inflammation in Obese Women
Breast cancer is one of the most frequently seen cancers in the United States. It occurs at all ages but is particularly common in post menopausal women.
- Trial name
- NCT01699906
- Testing
- Diet regimen to induce weight loss
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Non-Alcoholic Fatty Liver Disease
Macrophage-mediated Inflammation in White Adipose Tissue and Non-alcoholic Fatty Liver Disease.
Non-alcoholic fatty liver disease (NAFLD) is present in one third of the population and due to its potential to cause irreversible liver damage and liver cancer, it is a significant health burden.
- Trial name
- NCT04059068
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Imperial College London
Heart Failure With Preserved Ejection Fraction, Obesity
Adipose Tissue Inflammation in HFpEF
To evaluate the role of adipose tissue inflammation in patients with heart failure with preserved ejection fraction (HFpEF). Patients undergoing coronary artery bypass grafting with HFpEF and without heart failure will be…
- Trial name
- SLIM-HFpEF (NCT04886713)
- Testing
- Adipose and myocardial tissue sampling, Cardiac magnetic resonance imaging, Cardiopulmonary exercise testing
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heart Center Leipzig - University Hospital
Diabetes Risk
Using Salsalate to Target Adipocyte Macrophage Infiltration
Background: The prevalence of obesity has increased throughout the last three decades due to genetic, metabolic, behavioral, and environmental factors.
- Trial name
- TAMI (NCT02130804)
- Testing
- Salsalate (4 g/day)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Southern California
NAFLD
Effects of Overfeeding Followed by Weight Loss on Liver Fat Content and Adipose Tissue Inflammation
A. BACKGROUND Accumulation of fat in the liver due to non-alcoholic causes (NAFLD) is associated with hepatic insulin resistance, which impairs the ability of insulin to inhibit the production of glucose and VLDL .
- Trial name
- NCT02133144
- Testing
- overeating fat, overeating carbohydrate
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Hypogonadism, Metabolic Syndrome
Testosterone Replacement in Metabolic Syndrome and Inflammation
Hypogonadism (HG) frequently complicates the Metabolic Syndrome (MetS), whether testosterone replacement (TRT) is beneficial has not been clearly ascertained.
- Conditions
- Hypogonadism, Metabolic Syndrome, Obesity, Erectile Dysfunction
- Trial name
- TERMSINFAT (NCT01123278)
- Testing
- Testosterone
- Where
- 2 sites in Italy
- Volunteers
- 82 people
- Sponsor
- University of Roma La Sapienza
Obesity
Beta-glucan and Insulin Sensitivity in Obese Humans
Obesity is an important health problem of modern civilization. In Western societies, almost half of the adult population has problems with an increased body weight.
- Trial name
- NCT01393210
- Testing
- low calorie diet plus beta-glucan, low-calorie diet
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Marek Straczkowski
Coronary Artery Disease, Atheroscleroses, Coronary
Vascular Inflammation ReDuction and Perivascular Fat Imaging by Computed Tomography
The goal of this clinical trial is to compare the effect of standard of care management vs. CaRi-Heart based management on vascular inflammation in patients with increased Fat Attenuation Index-Score.
- Conditions
- Coronary Artery Disease, Atheroscleroses, Coronary, Vascular Inflammation
- Trial name
- VIRDICT (NCT06083337)
- Testing
- CaRi-Heart device
- Where
- Greece
- Volunteers
- 140 people
- Sponsor
- Hippocration General Hospital
Adipose Tissue Inflammation, Morbid Obesity
n-3 Polyunsaturated Fatty Acids in Obesity
Inflammation in the adipose (fat) tissue is an important condition leading to metabolic derangements and cardiovascular disease in obese patients.
- Trial name
- PUFA-ATI (NCT00760760)
- Testing
- reesterified long-chain n-3 polyunsaturated fatty acids (EPA, DHA), control
- Where
- Austria
- Volunteers
- 55 people
- Sponsor
- Medical University of Vienna
Obesity
Fish Oils and Adipose Inflammation Reduction
This study is a clinical trial designed to assess whether fish oil treatments are effective in the prevention of obesity-related fat tissue (adipose) inflammation.
- Trial name
- FAIR (NCT02010359)
- Testing
- Lovaza
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania