Clinical trials: Adipose Tissue Inflammation
Insulin Resistance, Obesity
Adipose Tissue Response to Overfeeding in Insulin Resistance-Prone vs. Insulin Sensitive Humans
Obesity has become an epidemic worldwide. Data from our laboratory and others demonstrate that most of the excess morbidity from obesity is related to insulin resistance (IR).
- Trial name
- NCT02084641
- Testing
- Over feeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Stanford University
Breast Cancer, Prostate Cancer
Body Composition and White Adipose Tissue Inflammation
The investigators want to find a better way to predict the risk of having fatty tissue inflammation by using a different approach to finding out body fat composition.
- Conditions
- Breast Cancer, Prostate Cancer, Body Composition, White Adipose Tissue Inflammation
- Trial name
- NCT02713022
- Testing
- DEXA Scan, Godin Leisure Time Exercise Questionnaire (GLTEQ)
- Where
- 9 sites in United States
- Volunteers
- 202 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obesity, Type 2 Diabetes Mellitus
The Influence of Fatty-Acids on Systemic and Subcutaneous Cytokines
This is a mono-center randomized controlled trial to be performed in the Center of Medical Research (ZMF) at Medical University Graz and is composed by one screening visit (V1) and two study visits (V2 and V3).
- Trial name
- TNF4 (NCT00708266)
- Testing
- Openflow microperfusion catheter, Intralipid 20%, 0.9% Saline Solution
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Decrease of Inflammation of Adipose Tissue, Sleep Apnea Syndrome
Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome
The main objective of this study is to evaluate the decrease of inflammation of adipose tissue in obese and non-obese patients having a sleep apnea syndrome and treated or not by continuous positive airway pressure (cPAP).
- Trial name
- ADISAS (NCT01196845)
- Testing
- cPAP
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Obesity, Metabolic Syndrome
The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function
Obesity is associated with increased cardiometabolic disease risk due, in part, to heightened chronic inflammation arising from adipose tissue.
- Trial name
- SADIE2 (NCT05972564)
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Vanderbilt University Medical Center
Metabolism Disorder, Adiposity
Effect of Exercise and Omega-3 on Metabolic Health in Elderly
The aim of this project is to investigate in elderly women, the effect of combined aerobic and resistive training and concomitant supplementation with omega-3 fatty acids on adipogenesis, metabolic functions and pro-inflammatory…
- Conditions
- Metabolism Disorder, Adiposity, Inflammatory Response
- Trial name
- EXODYA (NCT03386461)
- Testing
- Exercise training, omega 3 supplementation
- Where
- Czechia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Obesity, Inflammation
Gene Expression and Inflammation in Overweight Subjects
This study will look at gene expression (whether particular sets of genes are activated ["turned on"] or deactivated ["turned off"]) in overweight people as compared to non-overweight individuals.
- Conditions
- Obesity, Inflammation, Nutrition Therapy
- Trial name
- NCT00344266
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Obstructive Sleep Apnea
Obstructive Sleep Apnea-induced Changes in Adipose and Liver Tissue and Effects of Massive Weight Loss on Inflammation
UPDATED May 2016: Originally the study design included investigation of the effects of the bioactive compound resveratrol compared to placebo tablets and to CPAP treatment.
- Trial name
- NCT02419092
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Obese
Adipose Inflammation and Diabetes (FAB)
The study investigates whether the addition of resolution molecules can inhibit inflammation and insulin resistance in human tissue taken from obese individuals, and whether the results of these studies correlate with…
- Trial name
- FAB (NCT04255264)
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Göteborg University
Cancer of Colon, Nutrition Related Cancer
Preoperative Immunonutrition in Patients Undergoing Elective Colorectal Surgery for Neoplasm
Enhanced Recovery After Surgery (ERAS) protocols were developed to standardize perioperative practice in colon surgery to reduce morbidity, improve recovery, and shorten length of stay (LOS).
- Trial name
- NCT05916001
- Testing
- Oral Impact Nestle, Colorectal surgery
- Volunteers
- 216 people
- Sponsor
- University of Roma La Sapienza
Type 2 Diabetes
GLP-1 and Microvascular Function in Type 2 Diabetes
Some gut hormones, called incretins, stimulate insulin production in order to control sugar levels but also activate brain centres and signal to stop eating.
- Trial name
- GLP-1ADDS (NCT01740921)
- Testing
- Liraglutide, diet, Aspirin
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Acute Respiratory Distress Syndrome
Clinical Study to Assess the Safety and Preliminary Efficacy of HCR040 in Acute Respiratory Distress Syndrome
The main objective of the study is to assess the feasibility, safety, and tolerability of the administration of HCR040, a drug whose active substance is HC016, allogeneic adipose-derived adult mesenchymal stem cells expanded and…
- Trial name
- NCT04289194
- Testing
- HCR040 (Phase 1), HCR040 (Phase 2)
- Where
- 2 sites in Spain
- Volunteers
- 26 people
- Sponsor
- Histocell, S.L.
Overweight and Obesity, Insulin Sensitivity
Does Hyperbaric Oxygen Therapy Lead to a Sustained Increase in Insulin Sensitivity?
In a recent series of studies performed by our group, we have shown that exposure to hyperbaric oxygen (HBOT) leads to an increase in insulin sensitivity in male subjects and that this improvement can be measured in all men, not…
- Trial name
- HOTAIR3 (NCT02136615)
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Type 2 Diabetes, Inflammation
Effect of Alcohol on Cephalic Phase Reflex and Gene Expression
Moderate alcohol consumption has consistently been associated with lowered risk of developing type two diabetes mellitus compared to abstainers and heavy drinkers.
- Conditions
- Type 2 Diabetes, Inflammation, Carbohydrate&Lipid Metabolism, Oral Processing
- Trial name
- AR22 (NCT00652405)
- Testing
- alcohol
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Inflammation, Aging
Impact of Ageing on Adipose, Muscle and Systemic Inflammation
The accumulation and dysfunction of excess adipose (fat) tissue that occurs with ageing is associated with a number of chronic inflammatory disorders such as type 2 diabetes and cardiovascular disease but the underlying…
- Trial name
- NCT02777138
- Testing
- Maintaining a normal daily living lifestyle
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Bath
Growth Hormone Deficiency
Adipose Tissue and Serum Inflammation in GH Deficiency
This study will examine adipose tissue inflammation and adipokine expression and serum markers of inflammation and adipokine levels in patients with growth hormone (GH) deficiency before and after treatment.
- Trial name
- NCT03500913
- Testing
- Growth Hormone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Columbia University
Inflammation
Metabolic and Immune System Responses to a Mixed Meal
Overweight and obesity are major problems and their complications such as cardiovascular disease and type 2 diabetes mellitus pose great burdens on healthcare systems.
- Trial name
- NCT02416843
- Testing
- Consumption of a mixed meal
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Growth Hormone Deficiency
Adipose Tissue and Circulating Markers of Inflammation in GH Deficiency and Changes With GH Therapy
In order to examine the effect of GH on adipose tissue inflammation, this study will examine adipose tissue and serum inflammation in patients with GH deficiency before and after GH therapy.
- Trial name
- NCT03225755
- Testing
- Growth hormone
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
HIV Infections, Type 2 Diabetes
Exercise and Pioglitazone for HIV-Metabolic Syndromes
The purpose is to examine the safety and efficacy of 16wks of pioglitazone (Actos; 30mg/d) with and without aerobic and strength exercise training for reducing glucose intolerance and central adiposity in HIV-infected people.
- Conditions
- HIV Infections, Type 2 Diabetes, Obesity, HIV
- Trial name
- NCT00639457
- Testing
- Pioglitazone, Exercise training
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Breast Cancer, Obesity
A Pilot Study of Docosahexaenoic Acid (DHA) in Obese Menopausal Women
This study aims to determine if a supplement of an omega-3-fatty acid (docosahexaenoic - DHA) lowers inflammation in human fat tissue thereby lowering estrogen production and the potential risk for breast cancer.
- Trial name
- NCT01127867
- Testing
- dietary intervention
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rockefeller University