Clinical trials: Adipose Tissue-derived Stem Cell
Critical Limb Ischemia
Tolerance Study of Allogeneic of Adipose Tissue Derived Mesenchymal Stroma/Stem Cells (AdMSC) Transplantation in Patients With Critical Limb Ischemia.
Critical limb ischemia (CLI) is the most severe stage of peripheral arterial disease (PAD). Cell therapy delivered to the ischemic muscle constitutes a promising approach to treat CLI patients with no or poor options of…
- Trial name
- AlloDREAM (NCT06795620)
- Testing
- Adipose tissue derived mesenchymal Stroma/stem Cells transplantation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Knee Osteoarthritis
Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells (GXCPC1) for Knee Osteoarthritis
The aim of the investigators study was to investigate the safety and efficacy of allogeneic ADSCs for the clinical treatment of knee osteoarthritis.
- Trial name
- NCT03943576
- Testing
- GXCPC1, HA
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Gwo Xi Stem Cell Applied Technology Co., Ltd.
Peripheral Arterial Disease
Safety and Preliminary Efficacy of Adipose Derived Stem Cells and Low Frequency Ultrasound in PAD
This is a single center, open label, prospective, randomized, controlled study in patients with non- revascularizable moderate or severe lower extremity Peripheral Arterial Disease (PAD) receiving autologous stem cells therapy…
- Trial name
- NCT02756884
- Testing
- LoFU and aADSC, adipose derived stem cells
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Arkansas Heart Hospital
Complex Perianal Fistula
Clinical Trials of Autologous Cultured Adipose-derived Stem Cells (ANTG-ASC) on Complex Fistula
Mesenchymal stem cells derived from adipose tissue are pluripotent to differentiate into myocytes, adipocytes or others. They have an immunosuppressive activity. Complex perianal fistula is difficult to cure and easy to relapse.
- Trial name
- ANTG-ASC-210 (NCT01314092)
- Testing
- Autologous cultured adipose derived stem cells(low dose group), Autologous cultured adipose derived stem cells(high dose group)
- Where
- 6 sites in South Korea
- Volunteers
- 15 people
- Sponsor
- Anterogen Co., Ltd.
D017202
ADR-002K for Patients With Ischemic Cardiomyopathy Who Undergo Coronary Artery Bypass Surgery
Ischemic cardiomyopathy undergoing coronary artery bypass surgery
- Trial name
- NCT04695522
- Testing
- ADR-002K administration
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Osaka University
Urinary Incontinence
Stem Cells Tratment for the Local Feminine Stress Urinary Incontinence Treatment (HULPURO)
Evaluate the feasability and security of the autologous ASC for the femenine stress urinary incontinence
- Trial name
- HULPURO (NCT01804153)
- Testing
- Adipose-derived expanded stem cells
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Peripheral Vascular Diseases, Cardiovascular Diseases
Adipose CELL Derived Regenerative Endothelial Angiogenic Medicine
The main purpose of this study is to evaluate the safety and feasibility of regenerative therapy with expanded adipose derived stroma/stem cells sue, administered intramuscularly in patients with critical leg ischemia.
- Trial name
- ACELLDREAM (NCT01211028)
- Testing
- Expanded autologous ASCs
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Toulouse
Corneal Ulcer, Corneal Disease
Treatment of Patients With Inflammatory-dystrophic Diseases of the Cornea Using Autologous Stem Cells
Treatment of patients with inflammatory-dystrophic diseases of the cornea using autologous limbal stem cells (corneal epithelial stem cells) or adipose-derived mesenchymal stem cells
- Conditions
- Corneal Ulcer, Corneal Disease, Corneal Dystrophy
- Trial name
- NCT04484402
- Testing
- mesenchymal stem cells, limbal stem cells, standard treatment
- Where
- Belarus
- Volunteers
- 25 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Knee Osteoarthritis, Hip Osteoarthritis
Adipose-derived Mesenchymal Stem Cells in Osteoarthritis
This phase I/II study will enroll 100 subjects with mild to moderate osteoarthritis of the hip/knee/glenohumeral joints will be enrolled according to strict inclusion and exclusion criteria.
- Conditions
- Knee Osteoarthritis, Hip Osteoarthritis, Glenohumeral Osteoarthritis, Osteoarthritis
- Trial name
- NCT03869229
- Testing
- Intra-articular injection of ADMSC
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Alzheimer Disease
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy (HB-adMSCs) for the Treatment of Alzheimer's Disease
Hope Biosciences is conducting a research study of an investigational product called autologous adipose-derived mesenchymal stem cells (abbreviated as HB-adMSCs) as a possible treatment for Alzheimer's disease (AD).
- Trial name
- NCT04228666
- Testing
- HB-adMSCs
- Where
- United States
- Sponsor
- Hope Biosciences LLC
Crohn's Fistula
Darvadstrocel for Crohn's Fistula in the Realworld
Background Perianal fistula may affect 15-50% of patients with Crohn's disease (CD). Treatment is complex, requiring a multidisciplinary approach.
- Trial name
- NCT05742100
- Testing
- Darvadstrocel
- Where
- Spain
- Volunteers
- 73 people
- Sponsor
- Dolores Herreros Marcos
Facial Aging
Evaluating Facial Skin Quality Changes Post-Lipofilling
The goal of this prospective observational study is to evaluate changes in facial skin quality and identify predictive biological markers in donor adipose tissue in healthy women undergoing autologous facial fat transfer.
- Trial name
- NCT07737639
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Diabetes Mellitus Type 1
Use of Stem Cells in Diabetes Mellitus Type 1
Allogenic adipose derived mesenchymal stem cells will be injected into patients newly diagnosed with type 1 Diabetes Mellitus
- Trial name
- NCT02940418
- Testing
- Adipose mesenchymal cells with bone marrow mononuclear cells
- Where
- Jordan
- Volunteers
- 20 people
- Sponsor
- Sophia Al-Adwan
Acute Respiratory Distress Syndrome, Ards
Study of Allogeneic Adipose-Derived Mesenchymal Stem Cells for Non-COVID-19 Acute Respiratory Distress Syndrome
This is a Phase 2 randomized study to assess the safety and efficacy of COVI-MSC in the setting of current standard of care treatments for subjects hospitalized subjects with acute respiratory distress syndrome not related to…
- Trial name
- NCT04909879
- Testing
- COVI-MSC
- Sponsor
- Sorrento Therapeutics, Inc.
Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma
MV-NIS Infected Mesenchymal Stem Cells in Treating Recurrent Ovarian, Primary Peritoneal or Fallopian Tube Cancer
This phase I/II trial studies the side effects and best dose of oncolytic measles virus encoding thyroidal sodium iodide symporter (MV-NIS) infected mesenchymal stem cells and to see how well it works in treating patients with…
- Conditions
- Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma
- Trial name
- NCT02068794
- Testing
- Laboratory Biomarker Analysis, Mesenchymal Stem Cell Transplantation, Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
Wound of Skin
Adipose-derived Stem Cells to Treat Chronic Wounds.
The goal of this study is to determine whether autologous, adipose-derived regenerative cells improve the healing of chronic wounds.
- Trial name
- NCT05797688
- Testing
- The Celution System
- Where
- United States
- Sponsor
- Winthrop University Hospital
Autism
Adipose Derived Stem Cell Therapy for Autism
The intent of this clinical study is to answer the questions: 1. Is the proposed treatment safe 2. Is treatment effective in improving the disease pathology of patients with Autism.
- Trial name
- NCT01502488
- Testing
- Fat Harvesting and Stem Cell Injection
- Where
- United States
- Sponsor
- Ageless Regenerative Institute
Myocardial Ischemia
Safety & Efficacy of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia (ATHENA II)
This is a prospective, randomized, placebo-controlled, double blind safety and efficacy clinical trial.
- Trial name
- ATHENA II (NCT02052427)
- Testing
- Celution System
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Cytori Therapeutics
Critical Limb Ischemia, Arteriosclerosis Obliterans
Effectiveness and Safety of Adipose-Derived Regenerative Cells for the Treatment of Critical Lower Limb Ischemia
Adipose-derived regenerative cells (ADRC) will be extracted from lipoaspirate by enzymatic digestion. 10 mL of autologous ADRC suspension injected intramuscularly, close to the site of muscle injury.
- Conditions
- Critical Limb Ischemia, Arteriosclerosis Obliterans, Peripheral Arterial Disease, Thromboangiitis Obliterans
- Trial name
- NCT02864654
- Testing
- ADRC injection, ADRC isolation, Liposuction
- Where
- Russia
- Volunteers
- 9 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Ultra Filtration Failure
Evaluation of Autologous Adipose Derived Mesenchymal Stromal Cells (AD-MSC) Transplantation in Ultra Filtration Failure (UFF)
Peritoneal fibrosis may be occurred as a serious complication of peritoneal dialysis. It's the main factor of UFF that could lead to the Encapsulating Peritoneal Sclerosis (EPS).
- Trial name
- NCT02801890
- Testing
- Intravenous injection
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Royan Institute