Clinical trials: Adjuvant Drug Therapy
Lung Cancer
Neoadjuvant Pemetrexed, Carboplatin and Bevacizumab in Unresectable, Locally Advanced Lung Adenocarcinoma
The prognosis of patients with unresectable, locally advanced non-small cell lung cancer (NSCLC) is poor. Chemoradiotherapy is the main treatment modality for this disease.
- Trial name
- NCT01588704
- Testing
- Neoadjuvant Bevacizumab
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Si-Yu Wang
Gastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ]), Neoadjuvant Therapy
Neoadjuvant Cadonilimab Combined With Perioperative Oxaliplatin Plus S1 for Diffuse or Mixed Type of Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
This study aims to investigate the efficacy and safety of neoadjuvant cadonilimab in combination with perioperative SOX chemotherapy, compared to perioperative SOX chemotherapy alone, in patients with diffuse or mixed-type…
- Conditions
- Gastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ]), Neoadjuvant Therapy, Adjuvant Chemotherapy, pCR Rate
- Trial name
- NCT06949033
- Testing
- Neoadjuvant cadonilimab combined with perioperative SOX
- Where
- 4 sites in China
- Volunteers
- 668 people
- Sponsor
- Zuoyi Jiao
Prostate Cancer Metastatic, Castrate Resistant Prostate Cancer
Adjuvant High-intensity Interval Training During Chemotherapy in Metastatic Prostate Cancer Patients
This study aims to examine the use of high-intensity interval training (HIIT) and resistance training on docetaxel chemotherapy tolerability and toxicity in metastatic prostate cancer.
- Conditions
- Prostate Cancer Metastatic, Castrate Resistant Prostate Cancer, Metastatic Prostate Cancer, Metastatic Prostate Adenocarcinoma
- Trial name
- HIIT PCa (NCT05156372)
- Testing
- High Intensity Interval Training
- Where
- United States
- Sponsor
- The University of Texas Health Science Center at San Antonio
Breast Cancer
Capecitabine in Low Risk Triple Negative Breast Cancer
This study aims to evaluate the efficacy and safety of capecitabine as the only adjuvant chemotherapy drug in patients with low-risk early triple-negative breast cancer who have received adequate local treatment.
- Trial name
- Calorite (NCT06787339)
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Fudan University
Hepatocellular Carcinoma
Hepatic Arterial Infusion Chemotherapy(HAIC) for Hepatoma After Resection
To study if the addition of HAIC following complete removal of early stage liver cancer of HCC will prevent or delay the recurrence of the disease.
- Trial name
- HAICAT (NCT02767375)
- Testing
- Oxaliplatin(OXA), 5-fluorouracil (5-FU), Hepatic arterial catheter implantation
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Peking University Cancer Hospital & Institute
Pancreatic Cancer
Organoid-Guided Adjuvant Chemotherapy for Pancreatic Cancer
The purpose of this study is to explore whether adjuvant chemotherapy regimens guided by organoid drug sensitivity test can improve the outcomes of pancreatic cancer.
- Trial name
- NCT04931394
- Testing
- Adjuvant chemotherapy guided by organoid drug sensitivity test
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Changhai Hospital
HER2-negative Breast Cancer, Stage II Breast Cancer
Chemotherapy & Bevacizumab for Human Epidermal Growth Factor Receptor 2 (HER2)/Neu-Negative Stage II/III Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride, cyclophosphamide, paclitaxel, and gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by…
- Conditions
- HER2-negative Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer
- Trial name
- NCT00679029
- Testing
- doxorubicin hydrochloride, cyclophosphamide, bevacizumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Nebraska
Metastatic Colorectal Cancer, Liver Metastases
Optimal Control of Liver Metastases From Colorectal Cancer With Cetuximab and Hepatic Artery Infusion of Chemotherapy
The primary objective of the study is to increase by 15% the complete macroscopic resection rate of predominantly liver metastases from metastatic colorectal cancer through combining systemic cetuximab and hepatic artery infusion…
- Conditions
- Metastatic Colorectal Cancer, Liver Metastases, Hepatic Lesions
- Trial name
- OPTILIV (NCT00852228)
- Testing
- IV cetuximab, HAI chronomodulated chemotherapy, HAI conventional chemotherapy
- Where
- 14 sites in Belgium, France and 2 more
- Volunteers
- 60 people
- Sponsor
- Association pour la Recherche sur le Temps Biologique et la Chronothérapie
Stage III Colon Cancer
LEAn Body Mass Normalization of OXaliplatin Based Chemotherapy
Cytotoxic chemotherapy is usually scaled to the body surface area (BSA), and is currently not adjusted to the body proportions of lean and fat (i.e. body composition) of individual patients.
- Trial name
- LEANOX (NCT03255434)
- Testing
- Oxaliplatin, Oxaliplatin LBM
- Where
- 11 sites in France
- Volunteers
- 160 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Extranodal NK/T-cell Lymphoma, Nasal Type
Radiotherapy Followed by Adjuvant Chemotherapy in NK/T-cell Lymphoma
The purpose of this study is to evaluate the efficacy and tolerability of radiotherapy followed by adjuvant chemotherapy in stage I/II NK/T-cell lymphoma.
- Trial name
- NCT01667302
- Testing
- Radiotherapy followed by chemotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fudan University
Stomach Cancer
Nab-paclitaxel Combined With S-1 as Adjuvant Chemotherapy for Stage Ⅲ Gastric Cancer
This is a randomized, open-label phase III study. The treatment was compare the efficacy and safety of Albumin-bound Paclitaxel plus S-1 versus Oxaliplatin plus capecitabine (XELOX) treating stage Ⅲ gastric cancer as adjuvant…
- Trial name
- NCT04135781
- Testing
- nab paclitaxel, Tegafur, Oxaliplatin
- Where
- China
- Volunteers
- 616 people
- Sponsor
- Zhejiang Cancer Hospital
Stomach Neoplasms, Esophagogastric Junction Disorder
Perioperative Chemoimmunotherapy With/Without Preoperative Chemoradiation for Locally Advanced Gastric Cancer
NeoRacing is a randomized phase II trial carried out at Fudan University Shanghai Cancer Center (FUSCC) in China. The study can be divided into the screening stage, treatment stage and follow-up stage.
- Conditions
- Stomach Neoplasms, Esophagogastric Junction Disorder, Neoadjuvant Therapy, Chemoradiotherapy
- Trial name
- NeoRacing (NCT05161572)
- Testing
- Oxaliplatin, Tegafur-Gimeracil-Oteracil, Sintilimab
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Fudan University
Breast Cancer
Chemotherapy De-escalation in HR +, HER2-, Intermediate-risk Early Breast Cancer Treated With Adjuvant Ribociclib
The advent of CDK4/6 inhibitors (drugs designed to block the action of CDK4/6 proteins, which play a key role in cell proliferation) has improved treatment prospects for patients with metastatic breast cancer whose tumour cells…
- Trial name
- NoLEEta (NCT07237256)
- Testing
- Chemotherapy followed by endocrine therapy and ribociclib treatment, De-escalation
- Where
- 138 sites in France, Germany and 3 more
- Volunteers
- 3,902 people
- Sponsor
- UNICANCER
Breast Cancer
Chemotherapy Plus Monoclonal Antibody Therapy in Treating Women With Stage II or Stage IIIA Breast Cancer That Overexpresses HER2
Randomized phase II trial to study the effectiveness of chemotherapy with paclitaxel and the monoclonal antibody trastuzumab followed by chemotherapy in treating women who have stage II or stage IIIA breast cancer that…
- Trial name
- NCT00003992
- Testing
- trastuzumab, cyclophosphamide, doxorubicin hydrochloride
- Where
- 45 sites in United States, South Africa
- Volunteers
- 200 people
- Sponsor
- National Cancer Institute (NCI)
Epithelial Ovarian Cancer
Study on Neutropenia Induced by Adjuvant Paclitaxel/Carboplatin Chemotherapy in Patients With Epithelial Ovarian Cancer
To develop a robust prediction model to predict the occurrence of grade 3-4 neutropenia induced by adjuvant paclitaxel/carboplatin chemotherapy in patients with epithelial ovarian cancer and to validate this model.
- Trial name
- NCT01680575
- Where
- South Korea
- Volunteers
- 750 people
- Sponsor
- Asan Medical Center
Early Breast Cancer
The Prognostic Role of TILs and CD8+ T Cells in Operable Breast Cancer
T cells are a broad class of adaptive immune cells, while CD8⁺ T cells are a specific, specialized subset of T cells, defined by the presence of the CD8 surface receptor.
- Trial name
- Ν/Α (NCT07545434)
- Where
- Greece
- Volunteers
- 3,646 people
- Sponsor
- Hellenic Cooperative Oncology Group
Colorectal Cancer
Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles Versus 12 Cycles
The purpose of this study is to investigate which oxaliplatie based adjuvant method (8 cycles or 12 cycles) is better for patients receiving curative colorectal cancer resection.
- Trial name
- NCT00868816
- Testing
- 12 cycles of oxaliplatine based adjuvant chemotherapy, 8 cycles of oxaliplatine based adjuvant chemotherapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Fudan University
Stage III Colorectal Cancer, Neutropenia
A Trial of MB-6 for Reduction of Neutropenia Induced by Chemotherapy in Patients With Stage III Colorectal Cancer.
This is a randomized, double-blind, placebo-controlled multi-center phaseⅢstudy to evaluate efficacy and safety of oxaliplatin-based chemotherapy plus MB-6(320 mg/capsule, 6 capsules tid) in patients with stage 3 colorectal…
- Trial name
- MB-6 (NCT02135887)
- Testing
- MB-6
- Where
- Taiwan
- Volunteers
- 184 people
- Sponsor
- Microbio Co Ltd
Nasopharyngeal Carcinoma
TPF+CCRT vs.CCRT+PF in High Risk Nasopharyngeal Carcinoma
To see the effect of induction chemotherapy（TPF） followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy (PF) in treating patients with high risk nasopharyngeal carcinoma…
- Trial name
- NCT03306121
- Testing
- TPF+CCRT, CCRT+ PF
- Where
- China
- Volunteers
- 322 people
- Sponsor
- Sun Yat-sen University
Breast Cancer
Liposomal Doxorubicin Compared With Observation or Cyclophosphamide and Methotrexate in Treating Older Women Who Have Undergone Surgery for Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as methotrexate, cyclophosphamide, and liposomal doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- CASA (NCT00296010)
- Testing
- cyclophosphamide, methotrexate, pegylated liposomal doxorubicin hydrochloride
- Where
- 33 sites in Australia, Belgium and 7 more
- Volunteers
- 77 people
- Sponsor
- ETOP IBCSG Partners Foundation