Clinical trials: Adjuvant Treatment
Periodontitis, Adult
To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics As an Adjuvant to NSPT
Background: Periodontitis is defined as "an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the…
- Trial name
- NCT06570863
- Testing
- Antibiotics(doxycycline), Probiotics, Metronidazole gel 25%
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dr fizza khalid
Infertility
Long Protocol and Growth Hormone in Poor Responders
The long down regulation protocol is widely used in the in vitro fertilization cycles, now it will be assessed regarding its efficacy, in poor responder females undergoing in vitro fertilization cycles, alone and after the…
- Trial name
- NCT02338206
- Testing
- Growth hormone
- Where
- Egypt
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Influenza
Safety, Tolerability, and Immunogenicity of Different Combinations of Trivalent Influenza Vaccine Varying Influenza Antigen Dose, Adjuvant Dose, and Route of Administration in Healthy Elderly Individuals Ages 65 Years and Older
The study will evaluate the safety, tolerability and immunogenicity of different doses and types of Influenza Vaccine in healthy elderly subjects.
- Trial name
- NCT00848848
- Testing
- Trivalent Influenza Vaccine, Trivalent Influenza Vaccine + high A, Trivalent Influenza Vaccine + ¼ dose adjuvant
- Where
- Belgium
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Seqirus
Pain
Music Therapy for Pain Management for Minor Procedures in Neonates.
The aim of this study is to assess the effectiveness and safety of music therapy as adjuvant therapy for pain management in newborns undergoing minor painful procedures.
- Trial name
- NCT04313179
- Testing
- Music therapy, Sucrose
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Breast Cancer, Hot Flashes
Effect of Non-estrogenic Pollen Extract PCC-100 on Hot Flushes
Many postmenopausal women have vasomotor symptoms during adjuvant hormonal treatment for breast cancer. PCC-100 is a pollen extract used for alleviation of postmenopausal symptoms.
- Conditions
- Breast Cancer, Hot Flashes, Postmenopausal Symptoms
- Trial name
- NCT03684096
- Testing
- non-estrogenic pollen extract PCC-100
- Where
- Belgium
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Cancer
Prognostic Factors for All Types of Cancer Combined
The purpose of this study is to investigate every possible applicability of flow cytometrical analysis in the intracellular detection of tumor-related material in activated macrophages in the broadest range of cancer types.
- Trial name
- ProFaCo (NCT00704587)
- Where
- 2 sites in Netherlands
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Atrium Medical Center
Bacteremia Due to Staphylococcus Aureus
Adjuvant Clopidogrel in Staphylococcus Aureus Bacteremia
The CLOPI-SNAP study is a randomized, multicenter, open-label clinical trial embedded within the SNAP (NCT 05137119) research platform.
- Trial name
- CLOPI-SNAP (NCT07384702)
- Testing
- Clopidogrel, No antiplatelet treatment
- Where
- 20 sites in Spain
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Poor Ovarian Reserve
Growth Hormone For Poor Ovarian Reserve Patients in ICSI Trials
Effect of Growth Hormone Adjuvant Therapy on ICSI Trials For Poor ovarian Reserve Patients
- Trial name
- NCT05602090
- Testing
- 4 IU of recombinant GH (Somatotropin )
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Squamous Cell Carcinoma, RP1
Neo-adjuvant Treatment for Squamous Cell Carcinoma Using Direct Tumor Injection With RP1.
This is a Phase 1b, single-center, open-label study, evaluating efficacy and safety of RP1 for the treatment of resectable cutaneous Squamous Cell Carcinoma in up to 12 evaluable patients.
- Trial name
- NCT05858229
- Testing
- RP1
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sherrif Ibrahim
Breast Cancer, Radiation Dermatitis
Randomized Phase III Trial With Mepitel Film for the Prophylaxis of Radiation Dermatitis in Breast Cancer Patients
Breast cancer patients undergoing adjuvant radiotherapy commonly experience radiation-induced skin reactions which adversely impact quality of life.
- Trial name
- NCT04166799
- Testing
- Mepitel Film
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Human Immunodeficiency Virus
Improving Prognosis in HIV Infection
The primary objective of this study is to assess the safety of probiotics in cART-treated immunologic non-responder (INR) patients with chronic HIV infection.
- Trial name
- NCT02640625
- Testing
- Probiotic compound
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Leukemia, Hematopoetic Stem Cell Transplantation
Exercise as an Immune Adjuvant for Allogeneic Cell Therapies
This study aims to improve the treatment of blood cancer by using exercise to collect healthier immune cells from donors. Allogeneic adoptive cell therapy is a treatment where immune cells from a healthy donor are given to a…
- Conditions
- Leukemia, Hematopoetic Stem Cell Transplantation, Donor Lymphocyte Infusion, CAR T-Cell Therapy
- Trial name
- Allo-X (NCT06643221)
- Testing
- Exercise, Isoproterenol, Bisoprolol Fumarate Tablet 10 mg
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Arizona
COVID-19
A Randomized Controlled Trial Assessing the Efficacy of Lianhua Qingwen as an Adjuvant Treatment in Patients With Mild Symptoms of COVID-19
COVID-19 virus remains in infected patients for extended periods of time. A great resource burden is placed on the healthcare system and society at large to isolate COVID-19 patients for prolonged periods.
- Trial name
- NCT04433013
- Testing
- Lianhua Qingwen
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nanyang Technological University
HIV Infections
Evaluating the Safety and Immune Response to an HIV Vaccine Boost Following the Administration of Two HIV Vaccines, in HIV-Uninfected, Healthy Adults (Study Extension to HVTN 073/SAAVI 102)
This is an extension of the HVTN 073/SAAVI 102 study. This study will evaluate the safety and immune response to an HIV envelope protein vaccine boost in people who have previously received the SAAVI DNA-C2 and SAAVI MVA-C…
- Trial name
- NCT01423825
- Testing
- Sub C gp140 Vaccine, MF59C.1 Adjuvant, Sodium chloride
- Where
- 4 sites in United States, South Africa
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Physiological Neonatal Jaundice, Physiological Hyperbilirubinaemia
Comparison of Effects of Fenofibrate Adjuvant Therapy Versus Conventional Phototherapy in Neonatal Jaundice.
Neonatal jaundice has significant importance in neonatal morbidity and mortality world-wide. Though phototherapy has a relentless use in neonatal jaundice, its cumbersome side effects and the physical separation of baby from the…
- Trial name
- NCT06346743
- Testing
- Fenofibrate, Phototherapy
- Where
- Pakistan
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Muhammad Zark
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
FLASH-Breast: Evaluating the Efficacy of Fezolinetant in Reducing Vasomotor Symptoms in Women With Breast Cancer on Endocrine Therapy
This is a phase II, randomized, double-blinded, placebo-controlled trial designed to evaluate the efficacy of fezolinetant (45 mg a day) vs.
- Trial name
- NCT06917313
- Testing
- Fezolinetant
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Yale University
Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8
A Tool for Improving the Shared Decision-making Process in Patients With Non-small Cell Lung Cancer
This clinical trial compares the use of a shared decision-making communication tool during a clinical encounter to standard care for improving the quality of the shared decision-making process among patients with non-small cell…
- Conditions
- Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT06122064
- Testing
- Best Practice, Communication Intervention, Electronic Health Record Review
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Non-small Cell Lung Cancer, Non-small Cell Lung Cancer Stage I
Adjuvant ctDNA-Adapted Personalized Treatment in Early Stage NSCLC (ADAPT-E)
In this study circulating tumor DNA (ctDNA) blood testing is used to detect the residual blood cancer. If residual cancer using this blood test is detected there may be at higher risk of having the cancer return.
- Conditions
- Non-small Cell Lung Cancer, Non-small Cell Lung Cancer Stage I, Non-small Cell Lung Cancer Stage II, Non-small Cell Lung Cancer Stage III
- Trial name
- NCT04585477
- Testing
- AVENIO ctDNA Surveillance Kit, Durvalumab, Durvalumab (Imfinzi) alone or in combination with platinum-based chemotherapy
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cancer
Does Prehabilitation Improve Exercise Performance and Insulin Resistance After Surgery for Oesophago-gastric Cancer?
The purpose of this study is to evaluate the effect of a multimodal pre-operative prehabilitation programme during neo-adjuvant therapy on cardiopulmonary exercise performance and insulin resistance prior to resection for…
- Trial name
- NCT02950324
- Testing
- Prehabilitation, Standard care
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Peri-implant Mucositis
Limosilactobacillus Reuteri as an Adjuvant in the Treatment of Peri-implant Mucositis
Mechanical debridement is the traditional method for the treatment of peri-implant mucositis and its success depends on the patient's correct oral hygiene.
- Trial name
- LRRCT (NCT05758103)
- Testing
- Limosilactobacillus reuteri Prodentis® (combining L. reuteri DSM 17938 and L. reuteri ATCC PTA 5289 strains)
- Where
- Portugal
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Malo Clinic