Clinical trials: Adjuvant Treatment
Colo-rectal Cancer, RAS Wild-type
Optimization of Individualized Therapy for CRCs With Secondary RESISTance Towards Anti-EGFR Targeted Therapy Using an Avatar Model
In this exploratory phase II trial, the possibility of a personalized treatment after resistance to cetuximab will be evaluated.
- Conditions
- Colo-rectal Cancer, RAS Wild-type, UICC III, UICC II + RF
- Trial name
- 2016-003295-46 (NCT03263663)
- Testing
- targeted substance according to the avatar model
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- PD Dr. med. Volker Heinemann
Breast Cancer
Reducing Underuse of Early-Stage Breast Cancer Treatment in Minority Communities
The purpose of this study is to determine if a physician-centered intervention will help women with early stage breast cancer receive appropriate treatment.
- Trial name
- NCT00145197
- Testing
- Improving the Delivery of Effective Care to Minorities
- Where
- United States
- Volunteers
- 1,164 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Nausea, Vomiting
Use of Hypnosis in Hyperemesis Gravidarum
Aim: It has been aimed in this study to investigate the effects of hypnosis used to augment the conventional therapy on nausea, vomiting, rescue drug consumption and hospital stay in cases of Hyperemesis Gravidarum (HG).
- Conditions
- Nausea, Vomiting, Hyperemesis Gravidarum
- Trial name
- NCT04828967
- Testing
- Hypnosis
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Turkiye Yuksek Ihtisas Education and Research Hospital
Breast Cancer
Assessment of Endometrial Changes in Postmenopausal Women With Breast Cancer in Adjuvant Treatment With Anastrozole
To investigate the global incidence of the endometrial changes in postmenopausal women receiving Anastrozole for the adjuvant treatment of hormone receptors positive breast cancer.
- Trial name
- NCT00623519
- Where
- 12 sites in Spain
- Volunteers
- 165 people
- Sponsor
- AstraZeneca
Breast Cancer, Cardiac Toxicity
SWOG-9342 Chemotherapy in Treating Women Enrolled in the SWOG-8897 Clinical Trial
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This clinical trial is studying the effect of chemotherapy on heart function in treating women who…
- Trial name
- NCT00002900
- Testing
- management of therapy complications
- Where
- 105 sites in United States
- Volunteers
- 180 people
- Sponsor
- SWOG Cancer Research Network
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)
Patients with human papillomavirus (HPV)-related oropharyngeal cancer generally have favorable outcomes and how well they do depends on the specific details about the patient and their cancer.
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Oropharynx Cancer, Oropharynx Squamous Cell Carcinoma
- Trial name
- SAVAL (NCT06088381)
- Testing
- Experimental Observation, Observation per Standard of Care, Adjuvant Treatment per Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 61 people
- Sponsor
- University of Maryland, Baltimore
Sarcoma,Soft Tissue
A Study to Compare Adjuvant Concurrent Chemoradiation (CCRT) to Adjuvant Radiation Therapy (RT) in Grade 2 and 3 Extremity Soft Tissue Sarcomas
The aim of the study is to retrospectively evaluate the outcome of adjuvant concurrent chemoradiation delivered to patients with high grade non-metastatic soft tissue sarcomas of the extremities at the investigators institution…
- Trial name
- NCT02994264
- Testing
- adjuvant concurrent chemoradiation
- Volunteers
- 80 people
- Sponsor
- Institut de Cancérologie de Lorraine
Knee Osteoarthritis
Metformin as Adjuvant Therapy in Obese Knee Osteoarthritis Patients
This study aims to evaluate the possible efficacy and safety of addition of metformin to celecoxib in patients with knee osteoarthritis.
- Trial name
- NCT05638893
- Testing
- Metformin Hcl 500Mg Tab
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Cardiovascular Diseases
Mediterranean Diet and Physical Activity in Breast Cancer Patients Under Hormone Therapy
This study aims to evaluate body weight status, lifestyle patterns, and cardiometabolic risk in women in remission from breast cancer undergoing adjuvant hormone therapy, and to assess the effects of a structured nutritional…
- Trial name
- NCT07443787
- Testing
- Mediterranean diet, Physical activity promotion
- Where
- Algeria
- Volunteers
- 150 people
- Sponsor
- MOHAMEDI Ilhem Sarra Manel
Glioblastoma Multiforme
Tumor Treating Fields for Newly Diagnosed Glioblastoma: Two Emulated Trials With Chinese Multi-Hospital Based Real-World Data
The goal of this observational study is to learn about the effectiveness of Optune® (Tumor Treating Fields) in newly diagnosed glioblastoma (GBM) in China.
- Trial name
- NCT06346821
- Testing
- Optune® (Tumor Treating Fields)
- Where
- China
- Volunteers
- 181 people
- Sponsor
- Sichuan University
Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer, Hot Flashes
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
Researchers are looking for a better way to treat women with, or at high risk for developing hormone-receptor positive breast cancer, who have vasomotor symptoms (VMS), a condition of having hot flashes caused by anti-cancer…
- Trial name
- OASIS-4 (NCT05587296)
- Testing
- Elinzanetant (BAY3427080)
- Where
- 102 sites in Austria, Belgium and 14 more
- Volunteers
- 474 people
- Sponsor
- Bayer
Cough, ILD
A Non-pharmacological Cough Control Therapy
Coughing affects almost all individuals with ILD leading to physical, psychological and social distress and prevents individuals from performing their activities of daily living, working or socialising in public places.
- Conditions
- Cough, ILD, Pulmonary Disease, Pulmonary Fibrosis
- Trial name
- NCT04767074
- Testing
- Non-pharmacological Cough control Therapy
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- West Park Healthcare Centre
Bronchopulmonary Dysplasia, Premature
THE EFFECT OF NEBULIZED AZITHROMYCIN AS THERAPY FOR BRONCHOPULMONARY DYSPLASIA
The aim of the study is to determine the effectiveness of nebulized azithromycin therapy in prevention of BPD in very low birth weight preterm infants when compared with placebo.
- Conditions
- Bronchopulmonary Dysplasia, Premature, Ventilation, Mechanical
- Trial name
- NCT06584474
- Testing
- Azithromycin neubilization, Lung ultrasound
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Glioblastoma, Malignant Glioma
Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults
This phase I trial studies the side effects of nivolumab before and after surgery in treating children and young adults with high grade glioma that has come back (recurrent) or is increasing in scope or severity (progressive).
- Conditions
- Glioblastoma, Malignant Glioma, Recurrent Glioblastoma, Recurrent Malignant Glioma
- Trial name
- NCT04323046
- Testing
- Nivolumab, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 20 sites in United States, Australia
- Volunteers
- 9 people
- Sponsor
- Sabine Mueller, MD, PhD
Heart Failure, Reduced Ejection Fraction, Vitamin B12 Deficiency
Heart Failure With Reduced Ejection Fraction: Adjuvant Therapy With Neurostimulation and Chlorella Pyrenoidosa (HD-tDCS)
Reduced ejection fraction heart failure (HFrEF) is a complex and multifactorial condition. It is characterized by a decrease in the ability of the left ventricle to eject blood effectively during systole, resulting in an ejection…
- Trial name
- HD-tDCS (NCT06528366)
- Testing
- Chlorella pyrenoidosa, High Definition Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Federal University of Paraíba
Breast Cancer
Impact of Art Therapy on Fatigue and Quality of Life of Patients Treated With Adjuvant Radiotherapy for Breast Cancer
The purpose of this study is to compare intervention by Art-therapy to standard care in patients treated with adjuvant radiotherapy for breast cancer and evaluate the fatigue.
- Trial name
- ART-THERAPIE (NCT01331629)
- Testing
- ART-THERAPIE
- Where
- 6 sites in France
- Volunteers
- 322 people
- Sponsor
- Centre Francois Baclesse
Chronic Pain, Musculoskeletal Pain
Lessons in Affect Regulation to Keep Stress and Pain UndeR Control (LARKSPUR R34)
Chronic pain affects millions of Americans but integrative as well as conventional treatments fall short in terms of alleviating this pain.
- Trial name
- LARKSPUR (NCT03699553)
- Testing
- LARKSPUR; Online Positive Emotions Skills for Individuals with Chronic Musculoskeletal Pain, Emotion Reporting Control Group
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Bladder Cancer, Drug/Agent Toxicity by Tissue/Organ
Gemcitabine, Cisplatin, and Amifostine Following Surgery in Treating Patients With Locally Advanced Bladder Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy.
- Trial name
- NCT00006105
- Testing
- amifostine trihydrate, cisplatin, gemcitabine hydrochloride
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Chicago
Intestinal Insufficiency, Short Bowel Syndrome
Prescription Pattern of Adjuvant Drugs and Vitamins in Patients Undergoing Long-term Home Nutritional Support for Intestinal Insufficiency
Intestinal insufficiency due to short bowel syndrome is a chronic, disabling condition with significant morbidity and mortality.Standard care includes home parenteral/enteral nutrition as well as intestinal transplantation…
- Trial name
- NCT01696656
- Testing
- Drug prescription pattern
- Where
- Brazil
- Volunteers
- 37 people
- Sponsor
- University of Sao Paulo
Stages III Skin Melanoma, Stages II Skin Melanoma
Efficacy of Propranolol Treatment to Prevent Melanoma Progression
Melanoma's incidence is increasing worldwide. The efforts made in melanoma screening led to an earlier detection of the primary tumour and a better prognosis, but melanoma remains an aggressive cancer when it comes to its…
- Conditions
- Stages III Skin Melanoma, Stages II Skin Melanoma, Stage IB Skin Melanoma
- Trial name
- NCT01988831
- Testing
- Propranolol hydrochloride
- Where
- Switzerland
- Volunteers
- 450 people
- Sponsor
- University Hospital, Geneva
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