Clinical trials: Adolescent Bipolar Disorder
Bipolar Disorder, Psychotic Disorders
Determining the Safety and Effectiveness of Olanzapine in Children and Adolescents
This study will examine the safety and effectiveness of the antipsychotic drug olanzapine in children and adolescents with bipolar disorder or psychosis.
- Trial name
- NCT00183612
- Testing
- Olanzapine
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Early Intervention
Early Assessment and Intervention for Adolescents at Risk for Bipolar Disorder
Bipolar disorder is a severe and chronic illness associated with significant occupational and social impairment, enormous public health costs, and high rates of suicide.
- Trial name
- NCT03203707
- Testing
- Interpersonal and Social Rhythm Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Schizophrenia, Bipolar Disorder
A Study of the Safety and Tolerability of Oral Ziprasidone in Children and Teens With Psychotic Disorders
The purpose of this study is to evaluate the safety and tolerability of oral ziprasidone in children and teens with psychotic disorders
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT00650611
- Testing
- Ziprasidone
- Where
- 17 sites in United States
- Volunteers
- 63 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Depression, Stress Disorders, Post-traumatic
Cornerstone Program for Transition-Age Youth Study Protocol for a Randomized Controlled Trial
The purpose of this study is exploring a theoretically guided intervention, Cornerstone, which provides system 'boundary-spanning' services, including therapeutic services and mentorship, to transition-age youth with mental…
- Conditions
- Depression, Stress Disorders, Post-traumatic, Bipolar Disorder
- Trial name
- NCT02696109
- Testing
- Treatment As Usual, Cornerstone
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- New York University
Adolescent, Bipolar Depression
HD-tDCS for Adolescent Bipolar Depression Targeting S1
This randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy and underlying biological mechanisms of HD-tDCS targeting the primary somatosensory cortex in adolescents with bipolar depression.
- Conditions
- Adolescent, Bipolar Depression, tDCS, Primary Somatosensory Cortex
- Trial name
- NCT07246044
- Testing
- Active HD-tDCS, Antipsychotics, mood stabilizers, etc.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Schizophrenia, Schizoaffective Disorder
Efficacy and Tolerability Study of Betahistine to Ameliorate Antipsychotic Associated Weight Gain
The study attempts to evaluate a histamine analog long used for the treatment of Meniere's disease, betahistine, that shows promise in reversing the antihistaminergic effects thought to be involved in antipsychotic induced weight…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Bipolar I Disorder
- Trial name
- NCT00709202
- Testing
- Betahistine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Bipolar Disorder
Taurine in Adolescents With Bipolar Disorder
Recently, McLean hospital conducted a 4 month taurine study which showed a reduction in mania ratings. As a follow-up to the preliminary taurine study, and complementary to the currently ongoing double-blind, placebo-controlled…
- Trial name
- NCT00391001
- Testing
- Taurine
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Cambridge Health Alliance
Bipolar Disorder
Early Intervention for Youth at High Risk for Bipolar Disorder
Investigators will conduct a confirmatory efficacy trial of Interpersonal and Social Rhythm Therapy (IPSRT) delivered via telehealth for offspring of bipolar parents (OBP; age 12-18, n=120) at elevated risk for BP onset via risk…
- Trial name
- KEY (NCT04815239)
- Testing
- Interpersonal and Social Rhythm Therapy (IPSRT), The Healthy Lifestyle Behavior Intervention (HL)
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
First Episode Psychosis, Schizophrenia, Childhood
Early Psychosis Intervention - Spreading Evidence-based Treatment
Implementation of 'NAVIGATE' in Ontario aims to help youth and emerging adults suffering from a first episode of psychosis. Although Ontario already has early psychosis intervention programs, the team's recent work has identified…
- Conditions
- First Episode Psychosis, Schizophrenia, Childhood, Psychosis, Schizophrenia
- Trial name
- EPI-SET (NCT03919760)
- Testing
- NAVIGATE, Treatment as Usual
- Where
- 6 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Centre for Addiction and Mental Health
Bipolar Disorder
Neuronavigation rTMS to Improve Depressive Episodes of Bipolar Disorder in Adolescent
The purpose of this study is to explore a new stimulation target and protocol for the treatment of depressive episode in adolescents with bipolar disorder through the repetitive transcranial magnetic stimulation(rTMS) under…
- Trial name
- NCT05929183
- Testing
- Repetitive Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Depressive Disorder, Major, Bipolar Depression
Triple Chronotherapy in Adolescents
Study Purpose This study is a randomized controlled trial examining the effectiveness of TCT in the acute treatment of depression and suicidality in adolescents compared to usual treatment care, which includes individual and…
- Conditions
- Depressive Disorder, Major, Bipolar Depression, Suicidal Ideation
- Trial name
- TCT-RCT (NCT03679962)
- Testing
- Triple Chronotherapy, Treatment as Usual
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Billings Clinic
Bipolar Disorder
Lamictal as Add-on Treatment for Bipolar I Disorder in Pediatric Patients
The study will be a multi-center, parallel, group, placebo control, double-blind, randomized controlled trial of lamictal as add-on maintenance treatment in pediatric outpatients (aged 10 to 17 years) diagnosed with Bipolar I…
- Trial name
- NCT00723450
- Testing
- lamictal
- Where
- 46 sites in United States
- Volunteers
- 301 people
- Sponsor
- GlaxoSmithKline
Bipolar Disorder
Study to Determine the Effectiveness of Risperidone in Bipolar Disorder in Children and Adolescents
A clinical study to determine the safety and effectiveness of risperidone compared with placebo in the treatment of bipolar disorder (manic or mixed type) in children and adolescents aged 10 to 17 years.
- Trial name
- NCT00076115
- Testing
- Risperidone
- Volunteers
- 13 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Bipolar Disorder, Major Depressive Disorder
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
The purpose of this study is to advance a non-pharmacologic suicide preventive intervention with wide dissemination potential as an innovative high-yield solution to reduce suicide rates.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Mood Disorders, Suicide
- Trial name
- NCT05317481
- Testing
- BE-SMART-DR, psychoeducational control comparator condition (CC)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Mood Disorders, Prodromal Symptoms
MBCT and CBT for Youth at High Risk for Mood and Psychotic Disorders: a Randomized Controlled Trial
The present study is a randomized controlled trial comparing the efficacy and acceptability of CBT and MBCT group-based interventions adapted for young people at elevated risk for mood or psychotic disorder onset or relapse.
- Conditions
- Mood Disorders, Prodromal Symptoms, Bipolar Disorder, Parents
- Trial name
- NCT05070052
- Testing
- cognitive behavioral therapy, mindfulness-based cognitive therapy
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, Los Angeles
Bipolar Depression
Pediatric Bipolar Depression
The purpose of this study is to determine if quetiapine fumarate extended-release (quetiapine XR or SEROQUEL® XR) 150 to 300 mg/day taken by itself is effective and safe in treating children or adolescents aged 10 to 17 with…
- Trial name
- NCT00811473
- Testing
- Quetiapine XR
- Where
- 48 sites in United States, Colombia and 5 more
- Volunteers
- 193 people
- Sponsor
- AstraZeneca
Mania, Bipolar I
Open-Label Study of Latuda for the Treatment of Mania in Children and Adolescents 6-17 Years Old
This study is an 8-week open-label trial testing Lurasidone (Latuda®) as a treatment for mania in children and adolescents with Bipolar I, Bipolar II, and Bipolar Spectrum disorders.
- Conditions
- Mania, Bipolar I, Bipolar II, Bipolar Spectrum Disorder
- Trial name
- NCT01932541
- Testing
- Latuda (Lurasidone)
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Affective Disorders, Psychotic
A Study to Evaluate the Safety and Effectiveness of Topiramate Compared to Placebo in the Treatment of Patients With Bipolar I Disorder
The purpose of this study is to determine the safety and efficacy of topiramate in adolescents with manic or mixed episodes of Bipolar I Disorder.
- Conditions
- Bipolar Disorder, Affective Disorders, Psychotic, Mood Disorders, Mental Disorders
- Trial name
- NCT00035802
- Testing
- Topiramate
- Volunteers
- 13 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Mood Disorders, Psychotic Disorders
Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic Disorders
The present study aims to : 1. compare different approaches (high intensity vs. low intensity) to training community providers (those who routinely treat young patients with bipolar disorder, psychosis, or sub-threshold high-risk…
- Trial name
- FFT (NCT02097563)
- Testing
- High Intensity Training, Low Intensity Training
- Where
- 3 sites in United States
- Volunteers
- 133 people
- Sponsor
- University of California, Los Angeles
Bipolar Disorder, Depression
Treatment of Depression in Youth With Bipolar Disorders
THIS STUDY HAS BEEN DISCONTINUED. The study is designed to evaluate the safety and efficacy of fluoxetine for treating children and adolescents with Bipolar Disorder who are experiencing an episode of major depression while being…
- Trial name
- NCT00005015
- Testing
- Fluoxetine
- Sponsor
- National Institute of Mental Health (NIMH)