Clinical trials: Adrenal Incidentaloma
Pheochromocytoma, Cardiovascular Complication
Cardiovascular Complications After Adrenalectomy for Pheochromocytoma and Non-secreting Tumors
Pheochromocytoma is an adrenomedullary chromaffin cell tumour that releases catecholamines. Adverse cardiovascular events are considered the main cause of morbidity and mortality in patients with pheochromocytoma.
- Conditions
- Pheochromocytoma, Cardiovascular Complication, Adrenal Incidentaloma
- Trial name
- HEMODYNAMICS (NCT07200245)
- Testing
- adrenalectomy
- Where
- France
- Volunteers
- 522 people
- Sponsor
- Central Hospital, Nancy, France
Mild Autonomous Cortisol Secretion Adenoma, Non Secreting Adenoma
Ultradian Steroid Rhythms in Adrenal Incidentalomas
Twenty to 40% of adrenal incidentalomas are responsible for MACS (mild autonomous cortisol producing secretion). The biological tools used in current practice to explore MACS do not provide precise information on cortisol…
- Trial name
- CHRONOMACS (NCT07387419)
- Testing
- U-RYTHM system
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS)
IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion
The goal of this study is to learn how two treatments-adrenalectomy (surgical removal of an adrenal gland) and semaglutide (a medication used for weight management)-affect insulin resistance and cortisol regulation in adults with…
- Conditions
- Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS), Subclinical Cushing's, Mild Autonomous Cortisol Excess
- Trial name
- IMPACT-MACS (NCT07361874)
- Testing
- Intervention 1: Adrenalectomy, Intervention 2: Semaglutide
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Adrenal Incidentaloma, Hypercortisolism
Serum and Salivary Cortisol Assessment in Patients With Adrenal Incidentalomas and Healthy Controls
The goal of this observational study is to evaluate the diagnostic accuracy of salivary cortisol compared with serum cortisol after a 1 mg overnight dexamethasone suppression test in participants (N = 100) with adrenal…
- Trial name
- SALICOR (NCT07350031)
- Testing
- 1 mg overnight dexamethasone suppression test
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Adrenal Incidentaloma, Adrenocortical Carcinoma
Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield
Standard diagnostic work-up for adrenal incidentalomas (AI) consists of periodical biochemical analysis and CT-scanning in case the initial work-up does not demonstrate the presence of hormonal hypersecretion or adrenocortical…
- Trial name
- SERENDIPITY (NCT02324647)
- Where
- Netherlands
- Volunteers
- 807 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Adrenal Incidentalomas, Thoracic CT-scan
Artificial Intelligence Used in Screening Adrenal Nodules
By collecting chest low-dose spiral CT plain scan images, extracting effective features from the adrenal gland regions, training and validating an artificial intelligence-based automatic diagnostic algorithm for adrenal nodules…
- Trial name
- NCT07198152
- Testing
- None intervention
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Adrenal Incidentaloma
Clinical Outcome of Autonomous Cortisol Secretion in Adrenal Incidentalomas
The primary aim of the study is to assess mortality and cardiovascular events potentially linked to cortisol excess in patients with adrenal incidentalomas stratified by cortisol values following the 1-mg overnight dexamethasone…
- Trial name
- NAPACA (NCT04917757)
- Testing
- 1mg Dexamethasone test
- Where
- 2 sites in Germany, Italy
- Volunteers
- 3,656 people
- Sponsor
- Wuerzburg University Hospital
Adrenal Incidentaloma, Hypercortisolism
Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations
The investigators hypothesize that cardiovascular and metabolic alterations can occur in patients with adrenal adenomas and possible Autonomous Cortisol Secretion (pACS).
- Conditions
- Adrenal Incidentaloma, Hypercortisolism, Adrenal Tumor
- Trial name
- ITACA (NCT04127552)
- Testing
- Adrenalectomy
- Where
- Italy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Adrenal Incidentalomas, Cushing Syndrome
Effect of Metyrapone on Cardiovascular Risk Factors in Patients With Adrenal Incidentalomas and Cushing's Syndrome
Drug interventional, controlled, randomized open-label, parallel-group, multicenter study in patients with bilateral adrenal incidentalomas associated with subclinical Cushing's syndrome
- Trial name
- NCT06801249
- Testing
- Metarapone, Standardized antihypertensive therapy
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Adrenal Tumor, Adrenal Incidentaloma
CRISAL Study:Cancer Risk In Secreting Adrenal Lesions
The aim of the present study is to report the cancer risk in secreting adrenal lesions. Secondary aims: to compare the incidence of cancer in secreting versus non-secreting adrenal lesions, in order to evaluate whether adrenal…
- Conditions
- Adrenal Tumor, Adrenal Incidentaloma, Surgery
- Trial name
- CRISAL (NCT06520111)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Roma La Sapienza
Diabetic Foot Ulcer, Coronary Artery Disease
Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT)
This pilot study wants to determine to which extent SPCCT allows obtaining images with improved quality and diagnostic confidence when compared to standard Dual Energy CT (DECT), both with and without contrast agent injection.
- Conditions
- Diabetic Foot Ulcer, Coronary Artery Disease, Parenchymatous; Pneumonia, Kidney Stone
- Trial name
- SPEQUA (NCT04328181)
- Testing
- Spectral Photon Counting Computed Tomography (SPCCT), DECT (Dual Energy CT)
- Where
- France
- Volunteers
- 339 people
- Sponsor
- Hospices Civils de Lyon
Adrenal Incidentalomas
Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas
The general objective is to evaluate the consequences of surgical removal of SCSI on hypertension and cardiovascular risk factors in order to determine on an evidence-based basis if surgical excision of SCSI is preferable to an…
- Trial name
- CHIRACIC (NCT02364089)
- Testing
- Laparoscopic surgical removal of the adrenal tumor, Standardized medical treatment of hypertension by SAHR
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 78 people
- Sponsor
- University Hospital, Bordeaux
Prevalence, Adrenal Incidentaloma
The Prevalence and Characteristics of Adrenal Incidentaloma
To investige the prevalence, characteristics and prognosis of adrenal incidentalomas in Chinese adults.
- Trial name
- NCT04682938
- Where
- China
- Volunteers
- 25,356 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Pheochromocytoma, Adrenal Incidentaloma
Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue
To investigate the effect of catecholamine excess on brown fat. To evaluate the effect of brown fat on energy expenditure and lipid and glucose metabolism
- Trial name
- NCT01949714
- Testing
- Removal of adrenal tumor
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Autonomous Cortisol Secretion, Adrenal Incidentaloma
Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study
This is a single center, prospective, observational study to explore and evaluate the differences on cognitive function and brain function by functional-MRI in autonomous cortisol secretion patients, and the different treatments…
- Conditions
- Autonomous Cortisol Secretion, Adrenal Incidentaloma, Non-functioning Adrenal Adenomas
- Trial name
- NCT05357456
- Testing
- Cognitive function assessment; functional magnetic resonance imaging, laparoscopic adrenal surgery
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Adrenal Incidentaloma, Subclinical Hypercortisolism
Evaluation of New Diagnostic Indicator of Subclinical Hypercortisolism
The purpose of this study is to evaluate the serum dehydroepiandrosterone sulfate in subclinical hypercortisolism
- Trial name
- NCT04833192
- Testing
- experimental group
- Where
- China
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cushing Syndrome, Aldosteronism
China Adrenal Disease Registry
Epidemiologic studies have revealed a tremendous increase in the prevalence of adrenal associated disease and related mortality worldwide.
- Conditions
- Cushing Syndrome, Aldosteronism, Hypoadrenalism, Congenital Adrenal Hyperplasia
- Trial name
- CASE (NCT04890444)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Stroke, Adrenal Incidentaloma
Association Between Stroke and Adrenal Incidentalomas
Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke.
- Trial name
- ABSAI (NCT05237817)
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Xuanwu Hospital, Beijing
Adrenal Incidentaloma, Subclinical Hypercortisolism
Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas
Subclinical hypercortisolism (SH) is a status of asymptomatic hypercortisolism, frequently found in patients with adrenal adenomas (estimated prevalence: 0.8-2% after 60 years of age).
- Trial name
- NCT04860180
- Testing
- adrenalectomy
- Volunteers
- 61 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Adrenal Incidentaloma, Cortisol Overproduction
Morbidity and Mortality in Autonomous Cortisol Secretion
Benign enlargements of the adrenal glands (adrenal adenomas) are frequent in adults. In the general population these adenomas are rare in subjects below 40 years of age but at the age of 60 and 80 years the prevalence is 6 and…
- Trial name
- NCT03919734
- Where
- Sweden
- Volunteers
- 4,596 people
- Sponsor
- Region Skane