Clinical trials: Adrenal Incidentaloma
Pheochromocytoma, Non-Secretory Adrenal Adenoma
Intraoperative Hemodynamic Instability During Unilateral Adrenalectomy for Pheochromocytoma
Pheochromocytomas are tumors of the adrenal gland that develop from cells producing adrenaline and noradrenaline. Consequently, intraoperative blood pressure variations (hypertensive and hypotensive episodes) are characteristic…
- Trial name
- HEMODADRE (NCT06062082)
- Testing
- adrenalectomy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Adrenal Incidentaloma
Natural History of NFAI: 10 Year Follow-up Results
The data on long term natural history of benign nonfunctioning adrenal tumors (NFATs) are lacking. The aim is to identify clinical characteristics associated with tumor growth and progression to mild autonomous cortisol excess…
- Trial name
- NCT04616703
- Testing
- CT imaging
- Where
- Slovenia
- Volunteers
- 65 people
- Sponsor
- University Medical Centre Ljubljana
Primary Hyperaldosteronism, Primary Hyperaldosteronism Due to Adrenal Adenoma
Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas
High blood pressure (hypertension) causes strokes and heart attacks. While most patients need long-term treatment with pills, some have a cause which can be removed, curing the hypertension.
- Trial name
- FABULAS (NCT03405025)
- Testing
- Endoscopic ultrasound guided radiofrequency ablation, ultrasound
- Where
- 3 sites in United Kingdom
- Volunteers
- 28 people
- Sponsor
- University College, London
Hyperaldosteronism
Adrenal Vein Sampling International Study (AVIS Study)
The AVIS Study is a retrospective multicenter international study that aims to answer a series of questions on the use and performance of adrenal venous catheterization (AVS) for the diagnosis of primary hyperaldosteronism…
- Trial name
- AVIS (NCT01234220)
- Where
- 20 sites in United States, Australia and 8 more
- Volunteers
- 2,604 people
- Sponsor
- University Hospital Padova
Urologic Diseases, Adrenal Tumor
Rare Cystic Benign Adrenal Incidentalomas
Benign complex cystic and vascular adrenal tumors comprise a group of lesions characterized by significant rarity. But, their detection is increasing due to improved radiologic imaging techniques.
- Trial name
- NCT03739918
- Where
- Egypt
- Volunteers
- 291 people
- Sponsor
- Mansoura University
Adrenal Adenoma, Cushing Syndrome
A Prospective Cohort Study for Patients With Adrenal Diseases
The purpose of this study is to investigate the pathologic features, complications, and prognostic factors of functioning adrenal adenoma and suggest follow-up algorithms for adrenal incidentaloma.
- Conditions
- Adrenal Adenoma, Cushing Syndrome, Pheochromocytoma, Adrenal Incidentaloma
- Trial name
- NCT03474237
- Testing
- Hormone study and Imaging study
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Seoul National University Hospital
Subclinical Hypercortisolism, Cushing Syndrome
Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism
Background: Adrenal tumors are a common kind of tumor. Some of these secrete extra cortisol into the body, which can lead to diabetes, obesity, and other diseases.
- Conditions
- Subclinical Hypercortisolism, Cushing Syndrome, Adrenal Neoplasm
- Trial name
- NCT02001051
- Testing
- Adrenalectomy, Observation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Cancer Institute (NCI)
Adrenal Tumor, Adrenal Disease
Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy
The goal of this multicenter, observational, analytic, randomized clinical trial is to analyze the laparoscopic and robot-assisted method in the surgical treatment of patients with adrenal diseases.
- Conditions
- Adrenal Tumor, Adrenal Disease, Adrenal Mass, Adrenalectomy; Status
- Trial name
- NCT06050057
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Olomouc
Primary Aldosteronism, Aldosterone-Producing Adenoma
Endoscopic Ultrasound-Guided Ethanol Ablation for Aldosterone-Producing Adenoma
This is a prospective, single-center, single-arm study evaluating endoscopic ultrasound-guided ethanol ablation for left-sided aldosterone-producing adenoma.
- Trial name
- CREATE (NCT07700472)
- Testing
- Endoscopic Ultrasound-Guided Ethanol Ablation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chongqing Medical University
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism
Predicting Reduction of Hypertension After Adrenalectomy for Primary Aldosteronism: a Multicenter Analysis
Primary aldosteronism (PA) is the excessive endogenous production of the mineralocorticoid aldosterone. Although various rare forms of PA exist, the vast majority of cases are accounted by either an aldosterone-producing adenoma…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism, Primary Aldosteronism Due to Conn Adenoma
- Trial name
- NCT04761354
- Testing
- Unilateral adrenalectomy
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 514 people
- Sponsor
- UMC Utrecht
Primary Aldosteronism, Aldosterone-Producing Adenoma
Effect of Adrenocorticotropic Hormone Stimulation During Adrenal Vein Sampling in Primary Aldosteronism
The purpose of our research is to evaluate the value of ACTH stimulation in AVS especially in lateralization is still controversial.
- Conditions
- Primary Aldosteronism, Aldosterone-Producing Adenoma, Idiopathic Hyperaldosteronism
- Trial name
- NCT05826080
- Where
- China
- Volunteers
- 59 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Primary Hyperaldosteronism, Aldosterone-Producing Adenoma
[18F]AlF-NOTA-pentixather PET/CT in Patients With Suspected Primary Hyperaldosteronism
The study was proposed to include 20 patients with clinical suspicion of primary aldosteronism for [18F]AlF-NOTA-pentixather PET/CT imaging and to analyze the specificity and sensitivity of [18F]AlF-NOTA-pentixather PET/CT for…
- Trial name
- NCT05815069
- Testing
- [18F]AlF-NOTA-pentixather PET/CT
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Adrenal Incidentalomas, Cushing Syndrome
Effect of Metyrapone on Cardiovascular Risk Factors in Patients With Adrenal Incidentalomas and Cushing's Syndrome
Drug interventional, controlled, randomized open-label, parallel-group, multicenter study in patients with bilateral adrenal incidentalomas associated with subclinical Cushing's syndrome
- Trial name
- NCT06801249
- Testing
- Metarapone, Standardized antihypertensive therapy
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Adrenal Mass, Adrenal Adenoma
A Randomized Clinical Trial About Use of 3D Laparoscopy Versus 2D Laparoscopy in Adrenal Surgery
Comparison between 2D traditional laparoscopic surgery and 3D laparoscopy for adrenal surgery.
- Conditions
- Adrenal Mass, Adrenal Adenoma, Adrenal Gland Neoplasms
- Trial name
- 3DAdrenal (NCT06576336)
- Testing
- laparoscopic adrenalectomy
- Where
- 2 sites in Italy
- Volunteers
- 350 people
- Sponsor
- University of Palermo
Hyperaldosteronism, Conn Syndrome
Laparoscopic Adrenalectomy Versus Radiofrequency Ablation
This is a prospective randomized controlled study comparing laparoscopic adrenalectomy (LA) versus image-guided percutaneous radiofrequency ablation (RFA) in treating aldosterone-producing adenoma.
- Conditions
- Hyperaldosteronism, Conn Syndrome, Adrenocortical Adenoma
- Trial name
- LARFA (NCT02030587)
- Testing
- Radiofrequency Ablation, Laparoscopic Adrenalectomy
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- Chinese University of Hong Kong
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia
First-in-human Evaluation of [18F]CETO
Purpose of this clinical phase 1 trial was to determine if para-chloro-2-[18F]fluoroethyletomidate positron emission computed tomography ([18F]CETO-positron emission computed tomography(PET)/computed tomography(CT)) can be used…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia, Adrenal Cushing Syndrome, Non-Secretory Adrenal Adenoma
- Trial name
- NCT05361083
- Testing
- F18CETO
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Cushing's Syndrome
Study to Evaluate CORT125134 in Participants With Cushing's Syndrome
Cushing's syndrome is a relatively rare disorder caused by prolonged exposure to high levels of the glucocorticoid hormone cortisol. Cushing's syndrome may result from elevated endogenous or exogenous sources of cortisol.
- Trial name
- NCT02804750
- Testing
- CORT125134
- Where
- 25 sites in United States, Hungary and 3 more
- Volunteers
- 35 people
- Sponsor
- Corcept Therapeutics
Adrenal Cortex Neoplasms
Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma
Between September 2006 and September 2008, 35 patients (32 women and 3 men; mean age 49years with adrenal incidentaloma (AI) were prospectively evaluated at the Department of Endocrinology and General Surgery of Istanbul…
- Trial name
- adrenal (NCT00768365)
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Adrenal Incidentaloma, Hypercortisolism
Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations
The investigators hypothesize that cardiovascular and metabolic alterations can occur in patients with adrenal adenomas and possible Autonomous Cortisol Secretion (pACS).
- Conditions
- Adrenal Incidentaloma, Hypercortisolism, Adrenal Tumor
- Trial name
- ITACA (NCT04127552)
- Testing
- Adrenalectomy
- Where
- Italy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Cushing Syndrome, Aldosteronism
China Adrenal Disease Registry
Epidemiologic studies have revealed a tremendous increase in the prevalence of adrenal associated disease and related mortality worldwide.
- Conditions
- Cushing Syndrome, Aldosteronism, Hypoadrenalism, Congenital Adrenal Hyperplasia
- Trial name
- CASE (NCT04890444)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine