Clinical trials: Adrenal Insufficiency
Healthy, Adrenal Insufficiency
Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test
Objectives: To establish valid serum total cortisol and salivary cut-offs for use with the short Synacthen test in patients with normal CBG concentrations.
- Conditions
- Healthy, Adrenal Insufficiency, Hypopituitarism
- Trial name
- NCT00851942
- Testing
- Synacthen (Tetracosactrin)
- Where
- United Kingdom
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Adrenal Insufficiency
Objective Markers and New Indicators in AI Disease (OMNI-AID Study)
This pilot study is designed to compare healthy volunteers with three groups of patients with adrenal insufficiency and a final group of patients receiving high dose steroids for anti-inflammatory purposes.
- Trial name
- OMNI-AID (NCT03615859)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Adrenal Insufficiency
Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers
Cosyntropin (synthetic ACTH) stimulation test is considered the optimal test for diagnosis of primary and long-standing secondary adrenal insufficiency.
- Trial name
- NCT03752190
- Testing
- Cosyntropin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Primary Adrenal Insufficiency, Secondary Adrenal Insufficiency
Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM)
This is a randomized, controlled, open, three-armed, multi-centre study designed to compare the effects of dual-release hydrocortisone preparations versus conventional glucocorticoid therapy on anthropometric parameters…
- Trial name
- DREAM (NCT02277587)
- Testing
- Plenadren, Conventional glucocorticoid therapy
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Adrenal Insufficiency, Osteopenia, Osteoporosis
Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study
Bone disease and adrenal suppression are two of the many side effects of steroid use in pediatrics. Evidence has shown that adrenocorticotropic hormone (ACTH) protects against the adverse bone effects of steroids in animals and…
- Conditions
- Adrenal Insufficiency, Osteopenia, Osteoporosis, Steroid Suppression of ACTH Secretion
- Trial name
- NCT03709381
- Testing
- Low Dose Cosyntropin (ACTH) stimulation test, High Dose Cosyntropin (ACTH) stimulation test
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Adrenal Insufficiency
Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late Afternoon
Previous study showed that afternoon cosyntropin testing was associated with a sevenfold increased likelihood of failing the 1μg test.
- Trial name
- NCT03074123
- Testing
- low-dose cosyntropin stimulation test
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Adrenal Insufficiency, Adrenal Cancer
Salivary Free Cortisol Response to Cosyntropin Stimulation Test in Mitotane Treated Patients
In mitotane treated patients, serum cortisol cannot be used to diagnose hypoadrenalism, since mitotane increases cortisol binding globulin levels (CBG), artificially raising total cortisol.
- Trial name
- NCT03083834
- Testing
- Cosyntropin stimulation test
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Adrenal Insufficiency
Evaluation of the Muscular and Cutaneous Sodium Storage by 23Na MRI in Patients With Chronic Adrenal Insufficiency
This study investigates the sodium content in the calf muscle and the skin obtained via 23Na-magnetic resonance imaging in patients with chronic adrenal insufficiency compared to healthy controls.
- Trial name
- NCT03505775
- Testing
- 23Na magnetic resonance imaging
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Prader Willi Syndrome, Adrenal Insufficiency
Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome
The purpose of this study is to determine presence of central adrenal insufficiency in children with Prader Willi Syndrome using low dose (1 mcg) ACTH stimulation test compared to results of overnight metyrapone test.
- Trial name
- NCT02368379
- Testing
- Low dose (1 mcg) ACTH stimulation test, Overnight metyrapone test
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Adrenal Insufficiency
Optimising Steroid Replacement in Patients With Adrenal Insufficiency
Adrenal insufficiency is a condition where the adrenal glands do not produce an adequate amount of steroid hormones. The aetiology of adrenal insufficiency can be primary or secondary.
- Trial name
- NCT03282487
- Testing
- Modified release hydrocortisone
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Adelaide and Meath Hospital, incorporating The National Children's Hospital
Adrenal Insufficiency
Value of 25 mcg Cortrosyn Stimulation Test
The diagnosis of secondary AI is vital to prevent catastrophic events in patients. An optimal test should have a very low margin of error with high sensitivity and specificity, be easy and safe to administer, and have distinct…
- Trial name
- 25CST (NCT01428336)
- Testing
- 1 ug ACTH stimulation test, 250 ug ACTH stimulation test, 25 ug Cortrosyn stimulation test
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Addison's Disease, Adrenal Insufficiency
Counterregulatory Hormone Production in Adrenal Insufficiency and Diabetes Type I
Patients with adrenal insufficiency also exhibit an adrenomedullary dysfunction. Furthermore, patients who suffer from both, adrenal insufficiency and type I diabetes more frequently report hypoglycemia, particularly after…
- Conditions
- Addison's Disease, Adrenal Insufficiency, Diabetes Mellitus Type I
- Trial name
- CANDI (NCT01452893)
- Testing
- Spiroergometry
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Wuerzburg
Disorders of Sex Development, Congenital Adrenal Hyperplasia
Gene Polymorphisms Influencing Steroid Synthesis and Action
The extend of steroid biosynthesis and action is mainly dependent on underlying genetic polymorphisms and gene mutations. These sequence variations in multiple genes involved in steroid biosynthesis and action cause different…
- Conditions
- Disorders of Sex Development, Congenital Adrenal Hyperplasia, Congenital Adrenal Hypoplasia, Adrenal Insufficiency
- Trial name
- NCT00485186
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Adrenal Insufficiency, Inflammatory Lung Diseases
The Significance of Defensin Alpha 4 in the Pathophysiology of the Adrenal Insufficiency in Inflammatory Lung Diseases
The pathophysiology of the adrenal insufficiency of patients with critical diseases remains unclear. In a prior exploratory study investigating patients with exacerbation of chronic obstructive pulmonary disease (COPD), the…
- Trial name
- NCT01703013
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Adrenal Insufficiency
Adrenal Suppression and Adrenal Recovery Induced by Megestrol Acetate
Megestrol Acetate (MA) is a progesterone-like hormone that has been utilized as a birth control agent, chemotherapeutic drug, and more recently, to induce appetite and weight gain in patients malnourished as a result of radiation…
- Trial name
- NCT00575029
- Testing
- megestrol acetate
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Adrenal Gland Hypofunction
Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment
Suppression of the adrenal function is a common, potentially dangerous and unpredictable consequence of short term high dose glucocorticoid treatment. Identification of patients at risk would be of high clinical importance.
- Trial name
- NCT00975078
- Testing
- adrenal insufficiency testing, prednisone
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Adrenal Gland Hyperfunction, Adrenal Gland Hypofunction
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency
Corticotropin Releasing Hormone (CRH) is a hypothalamic hormone made up of 41 amino acids. Amino acids are proteins that when combined make up different substances, like hormones.
- Conditions
- Adrenal Gland Hyperfunction, Adrenal Gland Hypofunction, Cushing's Syndrome, Healthy
- Trial name
- NCT00001180
- Testing
- Ovine Corticotropin-Releasing Hormone (oCRH)
- Where
- United States
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hashimoto Disease, Adrenal Insufficiency
Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis
The purpose of this study is to determine whether patients with Hashimoto thyroiditis and impaired well-being may have a partial secondary adrenocortical insufficiency.
- Trial name
- NCT00552487
- Testing
- synacthen
- Where
- Germany
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Wuerzburg