Clinical trials: Adrenergic Beta-Receptor Blockader
Atrial Fibrillation
Safety Study of Tecadenoson to Treat Atrial Fibrillation
Assess the tolerability and safety of a rapid bolus of tecadenoson at different dose levels when given alone and in combination with a beta-blocker (esmolol) in patients with atrial fibrillation to control rapid heart rate.
- Trial name
- NCT00713401
- Testing
- Tecadenoson, Esmolol
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Gilead Sciences
Cardiovascular Disease
Beta-Blocker Influences on Inflammatory and Neural Responses to Stress
The purpose of this study is to map the neural and molecular mechanisms underlying psychological stress-induced changes in inflammation which could reveal new targets for intervention to reduce the risk of cardiovascular disease.
- Trial name
- NCT06263452
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Esophageal Varices in Cirrhosis of the Liver
HVPG-Guided Therapy Versus EVL Plus NSBB in Second Prophylaxis of Esophageal Variceal Bleeding
A single-center randomized controlled study comparing endoscopic or interventional therapy guided by the hepatic venous pressure gradient (HVPG) , to standard endosopic variceal ligation plus nonselective beta-blocker therapy…
- Trial name
- NCT03687216
- Testing
- HVPG-guided therapy, Routing Therapy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- West China Hospital
Esophageal and Gastric Varices, Liver Cirrhosis
Prevention of Esophageal Varices by Beta-Adrenergic Blockers
The purpose of this study is to learn whether timolol is useful in preventing or delaying the appearance of gastroesophageal varices, a complication that may develop in the future as a consequence of liver disease.
- Conditions
- Esophageal and Gastric Varices, Liver Cirrhosis, Portal Hypertension
- Trial name
- NCT00006398
- Testing
- Timolol Maleate
- Where
- 5 sites in United States, Spain and 1 more
- Volunteers
- 213 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hepatic Cirrhosis
Effect of Beta-adrenergic Blockers on Cardiac Function, Systemic and Splanchnic Haemodynamic and Kidney Function in Cirrhotic Patiets With Refractory Ascites
Multicentric, observational and prospective study with two groups of treatment: Refractory ascites and non-refractory ascites. All patients should be prescribed beta-adrenergic blockers as primary or secondary profilaxis for…
- Trial name
- ALB-BET (NCT02163512)
- Where
- 2 sites in Spain
- Volunteers
- 46 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Portal Hypertension Gastropathy, Esophageal Varices
Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal
This is a multicenter, randomized, double-blind, placebo-controlled study on the effectiveness of treatment with beta-blockers to prevent decompensation of cirrhosis with portal hypertension.
- Conditions
- Portal Hypertension Gastropathy, Esophageal Varices, Spontaneous Bacterial Peritonitis, Hepatic Encephalopathy
- Trial name
- PREDESCI (NCT01059396)
- Testing
- propranolol, carvedilol
- Where
- 8 sites in Spain
- Volunteers
- 201 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Actue Coronary Syndrome
Association of Beta-Blocker Therapy at Discharge With Clinical Outcomes in Patients With Actue Coronary Syndrome
Limited data are available on the efficacy of beta-blocker therapy for secondary prevention in Actue Coronary Syndrome(ACS) patients.
- Trial name
- NCT03658577
- Where
- China
- Volunteers
- 582 people
- Sponsor
- Shenzhen People's Hospital
Spinal Tumor, Spinal Hemangioma
The Efficacy and Safety of Beta-blockers Drugs in Adults With Spinal Hemangioma
Spinal hemangioma is one of the most common benign vertebral tumours. Being mostly asymptomatic, it is still associated with a pain syndrome especially if encroaches into the neural canal.
- Conditions
- Spinal Tumor, Spinal Hemangioma, Beta Blocker Toxicity
- Trial name
- NCT05106179
- Testing
- Atenolol Pill, Propranolol Pill
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Center for Vascular Pathology, Moscow
Community-Acquired Infections
Role of Beta-blockers in the Prevention on the Arisen of a Severe Sepsis (TESS)
The severe sepsis (SS) and toxic shock (TS) are both frequent and severe complications of infectious diseases. They are one of the top ten causes of death in industrialized countries.
- Trial name
- NCT01606631
- Where
- 9 sites in France
- Volunteers
- 2,444 people
- Sponsor
- Rennes University Hospital
Septic Shock, Tachycardia
Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility
Several data emphasize the relation between tachycardia (>90/min) and high mortality during septic shock. The investigators previously demonstrated the high mortality associated with hypercontractility, tachycardia and the…
- Conditions
- Septic Shock, Tachycardia, Mortality During Septic Shock, Beta-blocker
- Trial name
- HyperBetashock (NCT04748796)
- Testing
- echocardiography, Landiolol
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Heart Failure, Polygenic Score
UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent.
- Trial name
- UPBEAT (NCT07054489)
- Testing
- Beta blocker
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- David Lanfear
Acute Bleeding Esophageal Varices, Liver Cirrhosis
Hepatic Venous Pressure Gradient-guided Versus Standard Beta-blocker Therapy in Primary Prevention of Variceal Bleeding
Study hypothesis: Hepatic venous pressure gradient (HVPG)-directed primary prophylaxis with nonselective beta-blocker therapy (NSBB) leads to a reduction in first variceal bleeding episodes and is cost-effective in the long term.
- Trial name
- Porthos (NCT01618890)
- Testing
- Hepatic venous pressure gradient measurement
- Where
- 6 sites in Belgium, Netherlands
- Volunteers
- 78 people
- Sponsor
- Leiden University Medical Center
Hyperalgesia
Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids
This research study explores whether a beta-blocker (propranolol) can prevent a person from becoming more sensitive to pain after administration of an opioid (remifentanil).
- Trial name
- NCT01222091
- Testing
- Propranolol, Remifentanil
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acute Coronary Syndrome
Real World Assessment of Effects of Beta-blockers on Patients With Acute Coronary Syndrome
The study is aimed to optimized the dose-adjusted regimen of beta-blockers in patients with acute coronary syndrome by investigating therapeutic and curative results of target doses Beta-blockers using the dose-adjusted pathway…
- Trial name
- NCT03669991
- Where
- China
- Volunteers
- 2,200 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Atrial Fibrillation, Left Atrial Rhythm
Left Atrium Reservoir Function Modulation in Patients With Atrial Fibrillation: Digoxin Versus Beta Blocker
ß blocker and digoxin effect on left atrium reservoir function are unknown. This is a randomized open label study to compare the effect of theses two molecules on left atrium function
- Trial name
- NCT05540600
- Testing
- Digoxin 0.25 mg, Bisoprolol
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- University of Monastir
Aortic Stenosis
Impact of Beta-blocker on Outcome Among Patients Undergoing Transcatheter Aortic Valve Replacement (B-TAVR)
This is a multi-centric, open-label, randomized trial to evaluate the safety and efficacy of temporary discontinuation of beta-blocker treatment in patients undergoing transcatheter aortic valve replacement.
- Trial name
- NCT06472934
- Testing
- Transcatheter aortic valve replacement in the absence of B-blocker treatment, Transcatheter aortic valve replacement
- Where
- 11 sites in Austria, Germany and 1 more
- Volunteers
- 498 people
- Sponsor
- University Hospital, Basel, Switzerland
Heart Failure
Study to Assess the Safety of BAY1067197 in Stable Heart Failure Patients on Standard Therapy Including ß-blocker
This is a study to investigate the safety and tolerability of the partial A1 agonist BAY1067197 in patients with chronic heart failure.
- Trial name
- NCT01945606
- Testing
- BAY1067197 (treatment 2)
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Bayer
Aortic Blood Pressure
The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker
This study is divided into two parts: The first part evaluates the acute effect of non-pharmacological heart rate change on central hemodynamic parameters noninvasively in sick sinus syndrome patients with a permanent cardiac…
- Trial name
- NCT03245996
- Testing
- AAI 40 bpm, AAI 60 bpm, AAI 90 bpm
- Volunteers
- 27 people
- Sponsor
- Tartu University Hospital
Breast Cancer, Cardiotoxicity
Cardiotoxicity Prevention in Breast Cancer Patients Treated With Anthracyclines and/or Trastuzumab
The aim of the study is to analyze the protective impact on the cardiac damage of beta blockers and ACE inhibitors for breast cancer patients treated with anthracyclines-based chemotherapy with or without trastuzumab.
- Trial name
- SAFE (NCT02236806)
- Testing
- Bisoprolol, Ramipril
- Where
- Italy
- Volunteers
- 262 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Heart Rate Control in ICD Patients With Heart Failure
Effect of Ivabradine and Beta-blockers Combination Versus Beta-blockers Up-titration on Right Ventricular Pacing
The aim of this prospective, randomized and controlled trial is to evaluate the use of the ivabradine in combination to a low-dose of beta-blocker (bisoprolol) versus up-titration of beta-blocker (bisoprolol) to obtain heart rate…
- Trial name
- NCT01868880
- Testing
- Ivabradine plus beta-blocker (bisoprolol), betablocker titration
- Where
- Italy
- Sponsor
- Policlinico Casilino ASL RMB