Clinical trials: Adult
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
Fish Oil Affects Cognition and ADHD Symptoms in Adults With Autism Spectrum Disorder
The prevalence of autism spectrum disorder (ASD) is rising and was estimated to have a prevalence of around 1.5% in developed countries in 2016.
- Trial name
- NCT04779632
- Testing
- Experimental: Fish Oil, Comparator: Safflower Oil
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- University of Copenhagen
Moderate to Severe Plaque Psoriasis, Psoriatic Arthritis
2 Years Prospective Study to Collect Real-life Data on the Retention, Quality of Life, Effectiveness and Treatment Pattern of Secukinumab in Adult Patients With Moderate to Severe Plaque Psoriasis, Psoriatic Arthritis, Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis
This was an observational, prospective primary data collection study. The duration of observation was 2 years after study enrolment date.
- Conditions
- Moderate to Severe Plaque Psoriasis, Psoriatic Arthritis, Ankylosing Spondylitis, Non-radiographic Axial Spondyloarthritis
- Trial name
- PROMPT (NCT05155098)
- Testing
- secukinumab
- Where
- 10 sites in Thailand
- Volunteers
- 127 people
- Sponsor
- Novartis Pharmaceuticals
Dengue Fever
Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) at the End of Shelf Life in Healthy Adults
The purpose of this study is to evaluate the safety and immune response of a naturally aged lot of tetravalent dengue vaccine (TDV) in healthy participants, aged 18 to 60 years, in non-endemic country(ies) for dengue.
- Trial name
- NCT03771963
- Testing
- Tetravalent Dengue Vaccine (TDV)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Takeda
Appendicitis
Ultrasound-guided Abdominal Wall Nerve Blockade in Laparoscopic Surgery for Acute Appendicitis.
Acute appendicitis is a common disease and usually occurs within the ages of 10-30 years old." Ten percent of the population will get this disease during a lifetime." At Bispebjerg hospital it is one of the most common acute…
- Trial name
- BD-TAP APP (NCT01825863)
- Testing
- Ropivacaine, Saline 9%
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Bispebjerg Hospital
Postural Balance, Core Strength
Core Strength and Coordinative Skills
Evaluation of healthy young adults regarding balance, core strength/core stability and physical fitness. Correlation of primary outcome parameters and selected secondary parameters.
- Conditions
- Postural Balance, Core Strength, Core Stability, Physical Fitness
- Trial name
- NCT05719532
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Johannes Kepler University of Linz
Multiple Myeloma
A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma
Multiple Myeloma (MM) is a cancer of the blood's plasma cells ( blood cell). The cancer is typically found in the bones and bone marrow (the spongy tissue inside of the bones) and can cause bone pain, fractures, infections…
- Trial name
- NCT05650632
- Testing
- Etentamig (ABBV-383)
- Where
- 46 sites in United States, Canada and 5 more
- Volunteers
- 210 people
- Sponsor
- AbbVie
Pneumococcal Immunization
Safety and Immunogenicity of a Pneumococcal Conjugate Vaccine Candidate in Healthy Adults (19-49 Years)
This was a Phase I, randomized, active-controlled, observer-blinded, multi-center study to assess the safety and the immunogenicity of 4 Pneumococcal Conjugate Vaccines (PCV) candidates in parallel with Prevnar 13, in Healthy…
- Trial name
- NCT06698198
- Testing
- Pneumococcal Conjugate Vaccine, Prevnar 13®
- Where
- 2 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Asthma
The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma
The objective of this study was to investigate the relationship between single nucleotide polymorphism of chitinase 3-like 1 and human asthma.
- Trial name
- CHI3L1 (NCT01348932)
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Chronic Neck Pain
The Comparison of Pilates with Cognitive Functional Therapy in Adults with Chronic Neck Pain
The aim of this study is to compare the effectiveness of Pilates compared with Cognitive Functional Therapy in adults with chronic neck pain.
- Trial name
- NCT06225063
- Testing
- Pilates, Cognitive Functional Therapy
- Where
- Cyprus
- Volunteers
- 60 people
- Sponsor
- European University Cyprus
Chronic Pain, Emotional Distress
ReActivate: Physiotherapist Led Intervention for A Adolescents and Young Adults With Musculoskelatal Pain
Recurrent or persistent musculoskeletal pain is an alarmingly common problem among adolescents, in Sweden as well as globally. Pain often co-occur with and psychological distress and have both been shown to be predictors of…
- Trial name
- NCT06410963
- Testing
- Reactivate
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Örebro University, Sweden
Anorexia Nervosa
Study of Psilocybin for Anorexia in Young Adults
This is a single site trial of psilocybin therapy for the treatment of refractory Anorexia Nervosa in young adults. The psilocybin therapy will include three preparatory sessions, psilocybin dosing session one (20mg), two…
- Trial name
- SPANYA (NCT06399263)
- Testing
- Psilocybin, Preparation and Integration Sessions
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Marissa Raymond-Flesch, MD, MPH
Knee Osteoarthristis
Gender Based Comparison of the Effects of Sensory Modulated Graded Weight Bearing Physiotherapy In Adults With Knee Osteoarthritis
This comparative experimental study aims to evaluate the effectiveness of Sensory-Modulated Graded Weight-Bearing Physiotherapy (SMGWBP) in patients with knee osteoarthritis and compare treatment outcomes between male and female…
- Trial name
- GSMGWBP (NCT07784998)
- Testing
- Sensory-Modulated Graded Weight-Bearing Physiotherapy
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Shifa Tameer-e-Millat University
Charcot-Marie-Tooth Disease
A Study to Assess the Safety and Effectiveness of FLX-787 in Subjects With Charcot-Marie-Tooth Disease Experiencing Muscle Cramps.
The COMMIT Study will assess the safety and effectiveness of FLX-787 in men and women with Charcot-Marie-Tooth disease (CMT) experiencing muscle cramps.
- Trial name
- COMMIT (NCT03254199)
- Testing
- FLX-787-ODT (orally disintegrating tablet)
- Where
- 20 sites in United States
- Volunteers
- 27 people
- Sponsor
- Flex Pharma, Inc.
Human Immunodeficiency Virus, Metabolic Syndrome
2-5 Intermittent Caloric Restriction in HIV
Background: Weight gain can lead to obesity and diabetes even in people living with human immunodeficiency virus (HIV). Researchers want to see if the technique intermittent calorie restriction can help overweight people with HIV…
- Trial name
- 2-5toWIN (NCT03489109)
- Testing
- Intermittent fasting, Standard of Care
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Oral Hygiene, Pneumonia, Bacterial
Effectiveness of Oral Management Strategies on Improving Oral Frailty and Oral Bacteria
The aim of this study is to examine the effectiveness of nurse-driven oral management for improvements of oral frailty, and oral bacteria pneumonia patients with oral frailty using a randomized controlled trial (RCT) design.
- Trial name
- NCT05407532
- Testing
- Group with oral management, Group with oral care
- Where
- Taiwan
- Volunteers
- 55 people
- Sponsor
- National Cheng-Kung University Hospital
Acute Lymphoblastic Leukemia, B-precursor, Non-Hodgkin Lymphoma, B-cell
T-cells Expressing Anti-CD19 CAR in Pediatric and Young Adults With B-cell Malignancies
This phase 1 / 2 study will evaluate the response of B-cell malignancies expressing CD19 to autologous T cells transduced with a second generation anti-CD19 chimeric antigen receptor in children and young adults.
- Trial name
- NCT02772198
- Testing
- CD19 CAR T cells
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
RECOMBINANT BOTULINUM VACCINE A/B
Study to Evaluate the Safety, Tolerability and Immunogenicity of Recombinant Botulinum Vaccine A/B in Healthy Adults
The purpose of this trial is to evaluate the safety and tolerability of a two-dose regimen (Day 0 and Day 28) of recombinant Botulinum Vaccine (rBV) A/B in healthy volunteers when given intramuscularly at three ascending dosage…
- Trial name
- NCT00098098
- Testing
- rBV A/B
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- DynPort Vaccine Company LLC, A GDIT Company
Flexible Flatfoot
Effectiveness of Core Stability Exercises on Foot Posture, Function and Limb Alignment in Flexible Flat Feet Patients
Flexible flat foot is a very common musculoskeletal disorder of lower limbs in general population. Studies have reported that a flexible flat foot causes an alteration in the human body structures and lower limb kinetics due to a…
- Trial name
- NCT06567509
- Testing
- Core stability exercises and Short foot exercises, Conventional foot exercises and short foot exercises
- Where
- Malaysia
- Volunteers
- 85 people
- Sponsor
- International Islamic University Malaysia
Allergy, Asthma
Sublingual Cockroach Safety in Adults With Cockroach Allergy & Perennial Allergic Rhinitis With or Without Asthma
Immunotherapy may help reduce symptoms of allergy and asthma. Problems concerning compliance and adverse events with subcutaneous allergen immunotherapy have generated interest in delivering immunotherapy sublingually (under the…
- Trial name
- SCSS (NCT00434421)
- Testing
- Glycerinated German cockroach allergenic extract
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory CS1 Positive Multiple Myeloma
This phase I trial studies the side effects and best dose of CS1-chimeric antigen receptor (CAR) T therapy after chemotherapy in treating patients who have CS1 positive multiple myeloma that has come back (relapsed) or does not…
- Trial name
- NCT03710421
- Testing
- CS1-CAR T Therapy, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- City of Hope Medical Center
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