Clinical trials: Adult
Ebola Virus Disease, Hemorrhagic Fever
Ebola CVD-Mali #2000 (Bivalent) VRC-EBOAdc069-00-vp (cAd3-EBO)
Ebola virus causes an infection known as Ebola virus disease (EVD). This it is generally a severe disease which can also lead to death. The 2014 outbreak of EVD in West Africa is the largest ever.
- Trial name
- NCT02368119
- Testing
- VRC-EBOADC069-00-vp, MVA-EbolaZ
- Where
- Mali
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
COVID-19 Patients
Efficacy and Safety of Ivermectin and Doxycycline in Combination or IVE Alone in Patients With COVID-19 Infection.
Burden: Initial outbreak of corona virus disease 2019 (COVID-19) was reported from Wuhan, China in early December 2019.Presently known to be caused by a novel beta-corona virus, named as Severe acute respiratory syndrome corona…
- Trial name
- NCT04407130
- Where
- Bangladesh
- Volunteers
- 72 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Gait, Unsteady, Health Behavior
The Effect of a Wearable Hip Assist Robot on Cardiopulmonary Metabolic Efficiency During Stair Ascent in Elderly Adults
The aim of this study was to identify the assistance effect of the new wearable hip assist robot, gait enhancing mechatronic system (GEMS) developed by Samsung Advanced Institute of Technology (Samsung Electronics Co, Ltd.…
- Trial name
- NCT03389165
- Testing
- Wearable hip assist robot
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Samsung Medical Center
KCNT1-Related Epilepsy
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of ABS-1230 in Pediatric and Young Adult Participants With KCNT1-related Epilepsy
This trial will evaluate the safety, tolerability, pharmacokinetics, and clinical activity of ABS-1230 compared with placebo in participants with KCNT1-related epilepsy
- Trial name
- KYRON (NCT07600736)
- Testing
- ABS-1230
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- Actio Biosciences, Inc.
Written Information, Written Info and Hearing Aid Reminder
A Self-management Intervention for Adult Patients With Hearing Difficulties to Promote Hearing Aid Use and Benefit
The aim of the present study is to test I-PLAN as a self-management tool to promote hearing aid use and benefit (measured by self-reported questionnaires and hearing aid data-logging) among new adult hearing aid patients via a…
- Conditions
- Written Information, Written Info and Hearing Aid Reminder, Written Info and Planning on Hearing Aid Use, All Materials
- Trial name
- NCT03742609
- Testing
- ii) the reminder, ii) written behavioural plan, iv) all materials
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Respiratory Distress Syndrome, Adult
A Randomized Trial of GM-CSF in Patients With ALI/ARDS
This study will test the hypothesis that administration of granulocyte-macrophage colony stimulating factor (GM-CSF) to patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) will improve the clinical…
- Trial name
- NCT00201409
- Testing
- GM-CSF
- Where
- 3 sites in United States
- Volunteers
- 132 people
- Sponsor
- University of Michigan
Leukemia
Resistance to Methotrexate in Patients With Acute Lymphoblastic Leukemia in Relapse or Remission
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about cancer and the development of drug resistance in patients.
- Trial name
- NCT00899899
- Testing
- microarray analysis, reverse transcriptase-polymerase chain reaction, laboratory biomarker analysis
- Volunteers
- 135 people
- Sponsor
- Children's Oncology Group
Muscle Strength
Effects of Vibrations on the Biceps Brachii Muscle and Grip Strength
It has been suggested that applying acute vibration exercises enhances muscle force, like several weeks of resistance training. The present study investigated the effects of local vibration with two different frequencies on…
- Trial name
- NCT05523232
- Testing
- Vibration training with 42 Hz, Vibration training with 63 Hz
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Saud University
Heart Failure
TEXT4HF: A Randomized Controlled Trial of a Tailored Text Messaging Intervention to Improve Self-Care in Older Adult Patients With Heart Failure
The goal of this study is to determine whether an individually tailored text messaging intervention can improve self-care in older adult patients with heart failure.
- Trial name
- TEXT4HF (NCT06473532)
- Testing
- TEXT4HF
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Illinois Chicago
Invasive Mold Infections
A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.
The purpose of this study is to evaluate the efficacy and safety of fosmanogepix (administered IV or oral) for the treatment of adult patients with invasive mold infections.
- Trial name
- NCT06925321
- Testing
- Fosmanogepix IV infusion, Standard of care antifungal therapy, Fosmanogepix oral tablet
- Where
- 90 sites in United States, Australia and 13 more
- Volunteers
- 234 people
- Sponsor
- Basilea Pharmaceutica
Healthy
A Study to Evaluate the Effects of Single and Multiple Doses of Hemay005 Tablets in Health Caucasian Adult Volunteers
The purpose of the study is to assess the safety and tolerability of single and multiple oral doses of Hemay005 tablets in healthy Caucasian adult volunteers.
- Trial name
- NCT05941247
- Testing
- Hemay005 60 mg
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Ganzhou Hemay Pharmaceutical Co., Ltd
Hypertension
To Demonstrate the Relative Bioequivalence of Lisinopril 1 x 40 mg Tablets Under Fasting Conditions
To Demonstrate the Relative Bioequivalence of Lisinopril 1 x 40 mg Tablets Under Fasting Conditions.
- Trial name
- NCT00883064
- Testing
- Lisinopril 40 mg Tablet (EON Labs Manufacturing Inc, USA), Lisinopril 40 mg Tablet (Zestril) (Zeneca, USA)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sandoz
Tinnitus
An Open-Label Study Evaluating Brexanolone in Adults With Tinnitus
The primary objective of this study is to evaluate the safety and tolerability of brexanolone in participants with tinnitus following a single 6-hour continuous intravenous (IV) infusion.
- Trial name
- NCT05645432
- Testing
- Brexanolone
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Adult Patients, Immune Primary Thrombocytopenia
TPO-mimetics Before Splenectomy in Adult Primary Immune Thrombocytopenia Patients.
This study aims at analyzing the therapeutic activity of TPO-mimetics Eltrombopag and Romiplostim as bridge therapy for splenectomy in adult patients with primary immune thrombocytopenia.
- Conditions
- Adult Patients, Immune Primary Thrombocytopenia, Splenectomy, TPO-mimetics
- Trial name
- ITP0614 (NCT02063763)
- Where
- 14 sites in Italy
- Volunteers
- 31 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Metastatic Osteosarcoma
Sorafenib in Treating Patients With Soft Tissue Sarcomas (Extremity Sarcoma Closed to Entry as of 5/30/07)
This phase II trial is studying how well sorafenib works in treating patients with soft tissue sarcoma. Sorafenib may stop the growth of soft tissue sarcoma by blocking blood flow to the tumor and blocking some of the enzymes…
- Conditions
- Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Metastatic Osteosarcoma, Recurrent Adult Soft Tissue Sarcoma, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
- Trial name
- NCT00330421
- Testing
- sorafenib tosylate, therapeutic conventional surgery, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Community-dwelling Older Adults, Fall Risk
Steady Feet: Proof of Value
It is well established that poorer functional performance is associated with falls in older adults. Exercise is shown to be an effective evidence-based intervention in improving functional performance.
- Trial name
- NCT04801316
- Testing
- Steady Feet exercise programme, Steady Feet Video
- Where
- Singapore
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Hepatic Impairment (HI)
A Study to Evaluate EDG-7500 in Adults With Hepatic Impairment
The purpose of this Phase 1 study is to understand and compare the amount of EDG-7500 in the blood after a single dose in participants with different levels of liver function impairment versus participants with normal liver…
- Trial name
- NCT07324616
- Testing
- EDG-7500
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Edgewise Therapeutics, Inc.
Influenza
H5N1 Vaccine Intramuscular Versus Intradermal in Healthy Adults
The purpose of this research study is to compare how the body reacts to different strengths of an H5N1 flu vaccine when given by different routes of injection (injection into the skin or into the muscle).
- Trial name
- NCT00310206
- Testing
- Inactivated Influenza A Vaccine A/H5N1
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Unspecified Adult Solid Tumor, Protocol Specific
Interleukin-12 Plus Interleukin-2 in Treating Patients With Advanced Solid Tumors
Phase I trial to study the effectiveness of interleukin-12 plus interleukin-2 in treating patients who have advanced solid tumors.
- Trial name
- NCT00005604
- Testing
- recombinant interleukin-12, aldesleukin, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Stress, Constipation
The Effects Of Probiotics On Stress Among Healthy Adults From Umm Al-Qura University At Makkah
The goal of this clinical trial is to study the effects of probiotic supplementation on stress levels and bowel habits in healthy Saudi adults for both males and females.
- Conditions
- Stress, Constipation, Anthropometry, Bowel Disease
- Trial name
- NCT06464484
- Testing
- Probiotics (Lactobacillus rhamnosus GG (ATCC 53103)
- Where
- Saudi Arabia
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Umm Al-Qura University
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