Clinical trials: Adult ALL
Childhood Cancers
Cardiovascular Function in Adult Survivors of Childhood Malignancies
Anthracyclines have been used commonly to treat children with solid tumours and haematological malignancies and have led to their increased survival. Nonetheless, anthracycline has the side effect of cardiotoxicity.
- Trial name
- NCT01415999
- Where
- China
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Obesity & Overweight, Energy Expenditure
Metabolic and Nutritional Responses to Acute High-intensity Interval Exercise Performed Under Hypoxic vs. Normoxic Conditions at Matched External Workload in Adults With Overweight and Obesity.
Obesity management involves lifestyle and dietary measures that include appropriate nutrition and increased physical activity (PA).
- Conditions
- Obesity & Overweight, Energy Expenditure, Substrate Oxidation
- Trial name
- HYPOXHIIT (NCT07814599)
- Testing
- HIIE - Normoxia, HIIE - Hypoxia
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Adrenal Insufficiency
A Study of Infacort® Versus Cortef® in Healthy Adult Male and Female Subjects
This was a two-part, single centre, open-label, randomised, single dose, two-period, crossover study to evaluate the bioavailability of Infacort® versus Cortef® immediate release hydrocortisone tablets in dexamethasone-suppressed…
- Trial name
- NCT03311932
- Testing
- Infacort®, Cortef®
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Healthy Adults
Effects of Breathing Exercises on Fear of COVID-19, Anxiety, Sleep and Quality of Life During the COVID-19 Pandemic
It has been reported that in the first stages of the pandemic, a significant portion of the general population experienced psychological problems such as anxiety, depression and post-traumatic disorders.
- Trial name
- NCT04910932
- Testing
- Breathing Exercises, Information on COVID-19
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
Diabetes, Hypoglycemia
A Study to Improve Diabetes Management Among Adults Experiencing Severe Hypoglycemia
This pilot study will assess the feasibility, preliminary efficacy, and acceptability of the Diabetes-REM (Rescue, Engagement, and Management), a comprehensive patient-centered intervention delivered by community paramedics in…
- Conditions
- Diabetes, Hypoglycemia, Diabetes Type 1, Diabetes Type 2
- Trial name
- NCT04874532
- Testing
- Community Paramedic Program, Education Material
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Emotionality, Anxiety
Impact of Snoezelen Intervention and Reminiscence Therapy on Seniors' Emotionality and Anxiety
The aim of the study is to verify and compare the short-term and long-term effectiveness (retention) of Snoezelen intervention and reminiscence therapy and to analyze the dynamics of changes in the level of emotionality and…
- Trial name
- NCT07374887
- Testing
- Reminiscence therapy, Snoezelen intervention
- Where
- Slovakia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Matej Bel University
Idiopathic Pulmonary Fibrosis
A Phase II Study to Evaluate the Efficacy and Safety of SYH2059 Tablets in Adult Patients With Idiopathic Pulmonary Fibrosis
This is a multicenter, randomized, double-blind, placebo-controlled Phase II study. It Aims aims to evaluate the efficacy and safety of different doses of SYH2059 tablets compared with placebo in adult patients with IPF, observe…
- Trial name
- NCT07600021
- Testing
- SYH2059 Tablets
- Volunteers
- 156 people
- Sponsor
- InnovStone Therapeutics Limited
Type 2 Diabetes Mellitus
A Clinical Efficacy and Safety Study of Insulin Glargine U300 in Chinese Adult Patients With Uncontrolled Type 2 Diabetes Mellitus With a 3-month Extension Period
This is a prospective, interventional, single arm, multicenter, phase 4 study to evaluate the clinical efficacy and safety of initiating Insulin glargine U300 in insulin-naive patients or switching from any other basal insulin to…
- Trial name
- INITIATION (NCT05002933)
- Testing
- Insulin glargine 300 U/ml
- Where
- China
- Volunteers
- 570 people
- Sponsor
- Sanofi
HIV Infections
A Phase I, Multicenter, Randomized, Double-Blind, Placebo-Controlled HIV-1 Vaccine Trial to Evaluate the Safety and Immunogenicity of MN Recombinant Soluble gp120/HIV-1 (rsgp120/HIV-1) (Genentech) in Combination With QS21 Adjuvant and/or Alum in Healthy Adults
To extend the evaluation of safety and immunogenicity of MN recombinant soluble gp120/HIV-1 (MN rsgp120/HIV-1) in combination with QS21 with or without alum and on two different vaccination schedules.
- Trial name
- NCT00001052
- Testing
- Aluminum hydroxide, QS-21, rgp120/HIV-1MN
- Where
- 5 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 2 Diabetes
A Randomized Controlled Trial of Patient-Centered Self-Management Intervention in Adults With Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus (DM) is a serious health problem for Pakistan and around the world due to its increasing prevalence and the risk of adverse health outcomes including kidney failure, heart attack, stroke, leg amputation…
- Trial name
- NCT05491252
- Testing
- PAtient CEntered Self-Management Intervention (PACE-SMI)
- Where
- 4 sites in Pakistan
- Volunteers
- 612 people
- Sponsor
- Shifa Tameer-e-Millat University
Sarcoma
Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Hyperthermia therapy kills tumor cells by heating them to several degrees above body temperature.
- Trial name
- NCT00003052
- Testing
- doxorubicin hydrochloride, etoposide, ifosfamide
- Where
- 4 sites in Germany
- Volunteers
- 340 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
PTSD, Trauma, Psychological
Narrative Exposure Therapy for Adults With Intellectual Disability
The purpose of the study is to identify how Narrative Exposure Therapy (NET) can be adapted for delivery with adults with mild Intellectual Disability (ID) and to explore whether NET can reduce symptoms of traumatic stress in…
- Trial name
- NCT04418752
- Testing
- Psychological therapy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nottingham
COVID-19
Study of Monovalent and Bivalent Recombinant Protein Vaccines Against COVID-19 in Adults 18 Years of Age and Older
The purpose of this Phase III study is to assess the efficacy, safety, and immunogenicity of two CoV2 preS dTM-AS03 vaccines (monovalent and bivalent) as part of primary series vaccinations in a multi-stage approach, as well as a…
- Trial name
- VAT00008 (NCT04904549)
- Testing
- SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent D614) (primary series), SARS-CoV-2 adjuvanted recombinant protein vaccine (bivalent D614 + B.1.351) (primary series), SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent B.1.351) (booster dose) >= 4 months after last vaccination
- Where
- 86 sites in United States, Colombia and 9 more
- Volunteers
- 23,670 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Anorexia Nervosa
Outcomes of a Skill-Based Program for Eating Disorders
This study aims to measure the effect of a neurobiologically-guided intensive family based treatment for adults with anorexia nervosa.
- Trial name
- NEW FED TR (NCT02852538)
- Testing
- NEW FED TR
- Where
- 2 sites in United States
- Volunteers
- 93 people
- Sponsor
- University of California, San Diego
Acute Appendicitis
Comparative Study on the Diagnostic Validity of the Alvarado Score, Appendicitis Inflammatory Response (AIR), and Adult Appendicitis Score (AAS) in Acute Appendicitis at East Lancashire Hospitals NHS Trust (ELHT)
This retrospective observational study aims to compare the diagnostic accuracy of Alvarado Score, Appendicitis Inflammatory Response (AIR) Score, and Adult Appendicitis Score (AAS) in predicting histologically confirmed acute…
- Trial name
- DV-AAA ELHT (NCT07804238)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Neurologic Manifestations, Neurobehavioral Manifestations
Training Cognitive Control Processes in Older Adults
Control processes are classes of brain activity that initiate, coordinate, synchronize, and regulate elemental cognitive functions for the conduct of goal-directed behavior.
- Trial name
- NCT00586638
- Testing
- Video game based training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University
Anesthesia
Dose-Finding Pediatric and Adult Trial With Sugammadex (Org 25969, MK-8616, SCH 900616) (19.4.306) (MK-8616-034) (P05961)
The purpose of this study is: to explore the dose-response relation of sugammadex (Org 25969, MK-8616, SCH 900616) given as a reversal agent at reappearance of T2 after 0.6 mg.kg-1 rocuronium in pediatric and adult participants…
- Trial name
- NCT00421148
- Testing
- Sugammadex 0.5 mg/kg, Sugammadex 1 mg/kg, Sugammadex 2 mg/kg
- Volunteers
- 94 people
- Sponsor
- Merck Sharp & Dohme LLC
Sickle Cell Disease
Music Therapy in Sickle Cell Transition Study
The purpose of this study is to investigate the effects of the BEATS Music Therapy Program on the self-efficacy, trust, knowledge, and adherence of young adult patients with sickle cell disease during transition.
- Trial name
- NCT02466555
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Leukemia, Acute Lymphoblastic, Acute Myeloid Leukemia
Bridging Study to Eliminate Presence of MRD for Acute Leukemia Before HCT
This is a Phase 2 study designed for the purpose of estimating various parameters surrounding the efficacy of Clofarabine, Cyclophosphamide and Etoposide in eliminating minimal residual disease (MRD) in acute leukemia patients…
- Trial name
- NCT02349178
- Testing
- Clofarabine, Cyclophosphamide, Etoposide
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- Medical College of Wisconsin
Safety Issues, Tolerance
Study to Assess the Safety, Tolerability and Pharmacokinetics of ZX-7101A and the Food Effect in Healthy Volunteers
Randomized, double-blind and placebo-controled study to assess the safety, tolerability and pharmacokinetics of single ascending doses of ZX-7101A and its food effect in China healthy adult volunteers.
- Conditions
- Safety Issues, Tolerance, Pharmacokinetics, Food Effect
- Trial name
- NCT05217732
- Testing
- ZX-7101A
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Nanjing Zenshine Pharmaceuticals