Clinical trials: Adult Depression
Post COVID-19 Syndrome, Stress Disorders
A Study of Activity Leader to Forest Therapy Campaign in Different Environments Targets on the Participants Which Had Been Infected by SARS-COV-2
The goal of this clinical trial is to investigate the impact of self-guided forest healing activities and guided forest healing activities on the reduction of psychological stress inindividuals diagnosed with the new coronavirus.
- Conditions
- Post COVID-19 Syndrome, Stress Disorders, Life Quality, Depression Anxiety Disorder
- Trial name
- NCT06601920
- Testing
- Forest healing activities
- Where
- Taiwan
- Volunteers
- 161 people
- Sponsor
- Taipei City Hospital
Autism Spectrum Disorder, Major Depressive Disorder
rTMS for Depression in Young Adults With Autism
The current clinical trial is focused on evaluating the efficacy of rTMS for treatment of depression in youth and young adults (hereafter called transition aged youth, TAY) with autism spectrum disorder (ASD).
- Trial name
- rTMS-MDD (NCT04972136)
- Testing
- Active Bilateral Theta Burst Stimulation
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre for Addiction and Mental Health
Depression
Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder
The primary objective of the study is to determine whether armodafinil treatment, at a dosage of 150 mg/day, is more effective than placebo treatment as adjunctive therapy to mood stabilizers for treatment of adults with major…
- Trial name
- NCT01072630
- Testing
- Armodafinil
- Where
- 92 sites in United States, Argentina and 8 more
- Volunteers
- 492 people
- Sponsor
- Cephalon
Diabetes Complications, Depression Anxiety Disorder
Joint Effects of Physical Activity and Diet Quality on Depression and Mortality in Diabetes
This observational study aims to investigate whether physical activity (PA) and diet quality (DQ) can reduce depression and mortality risk in individuals with diabetes.
- Conditions
- Diabetes Complications, Depression Anxiety Disorder, Diabetes
- Trial name
- NCT07122271
- Where
- China
- Volunteers
- 3,621 people
- Sponsor
- Minghui Wang
Healthy Volunteers
Induction of Dreaming With EEG and Anesthesia in Healthy Adults
This open-label, randomized crossover study in healthy adults tests two propofol protocols to produce distinct experiential states.
- Trial name
- IDEA (NCT07198711)
- Testing
- Propofol - Emergence-from-LOR Protocol, Propofol - Light Sedation Protocol
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type 2 Diabetes Mellitus
Emotional Disorders and Outcomes in Adults With Type 2 Diabetes Mellitus at Primary Care
This study aims to determine which factors are related to change in diabetes-related distress and change in depressive symptoms after three years of follow-up in Asian adults with type 2 diabetes mellitus in primary care.
- Trial name
- EDDMQoL-Pro (NCT02730754)
- Volunteers
- 336 people
- Sponsor
- Universiti Putra Malaysia
Exercise
Effects of HIIT and MICT Training on Cardiorespiratory Fitness, Testosterone/Cortisol Ratio, and Mental Health in Young Adults
This study will use a randomized, double-blind clinical trial to evaluate the effects of eight-week HIIT and MICT exercise programs on cardiorespiratory fitness, the testosterone/cortisol ratio, and mental health in 68 healthy…
- Trial name
- NCT07397702
- Testing
- High-intensity interval training, Moderate-intensity continuous training
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Bipolar Depression
A Preliminary Study of the Effectiveness and Tolerability of Aripiprazole in Bipolar Depression
The specific aim of this study is to obtain preliminary evidence of the acute effectiveness and tolerability of aripiprazole in the treatment of bipolar depression.
- Trial name
- NCT00363337
- Testing
- aripiprazole
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Lindner Center of HOPE
Suicidal Ideation, Mental Health
Gamified Virtual Reality Exercise for Suicidal Ideation in Older Adults
This is a two-arm, parallel-group randomized controlled trial designed to evaluate the effectiveness of a gamified virtual reality (VR)-based exercise program in reducing suicidal ideation among community-dwelling older adults…
- Conditions
- Suicidal Ideation, Mental Health, Depression, Geriatric Psychiatry
- Trial name
- VR-GAME-SI (NCT07862803)
- Testing
- Gamified VR-Based Exercise Program, Conventional Exercise Program
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Islamic Azad University, Sanandaj
Severe Mental Illness, Bipolar Disorder
A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness
The goal of this clinical trial is to learn whether MoodSync, a mobile application for patients and their family caregivers, improves mood stability, medication adherence, daily functioning and early detection of relapse warning…
- Conditions
- Severe Mental Illness, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder
- Trial name
- MoodSync (NCT07879131)
- Testing
- MoodSync, Standard care
- Where
- Bahrain
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Major Depressive Disorder
Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder
This is a Double-blind study wherein patients with Major Depressive Disorder (MDD) will receive either from 1 to 3 mg a day of study medication (OPC-34712)or placebo (an inactive substance) in addition to an FDA approved…
- Trial name
- STEP-D222 (NCT01052077)
- Testing
- OPC-34712, ADT
- Where
- 43 sites in United States
- Volunteers
- 773 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Sleep Disorder, Depressive Symptoms
Different Exercising Intensities and Frequencies of Exercise on Depressive Mood and Insomnia
Aerobic exercise intervention for depression was conventionally recommended three times weekly with moderate intensity in previous studies, but little is known about the training effect of aerobic exercise at low frequency and…
- Trial name
- NCT04354922
- Testing
- Exercise intervention
- Where
- Hong Kong
- Volunteers
- 75 people
- Sponsor
- The University of Hong Kong
Major Depressive Disorder, Dysthymia
A Study of L-DOPA for Depression and Slowing in Older Adults
Individuals with Late Life Depression (LLD) often have cognitive problems, particularly problems with memory, attention, and problem solving, all of which contribute to antidepressant non-response.
- Conditions
- Major Depressive Disorder, Dysthymia, Depression Not Otherwise Specified, Decreased Processing Speed
- Trial name
- NCT02744391
- Testing
- Levodopa
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder (MDD)
A Study of HS-10353 in Adult Participants With Major Depressive Disorder
This is a randomized, double-blind, placebo-controlled Phase II clinical study to evaluate the efficacy and safety of continuous oral administration of HS-10353 in Chinese adults with depression.HS-10353 is a new generation of…
- Trial name
- NCT05938179
- Testing
- HS-10353 30mg oral capsules, HS-10353 50mg oral capsules
- Volunteers
- 144 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Grief, Bereavement
Pragmatic RCT to Assess the Effectiveness of an Online Self-help Programme for Older Adults After Spousal Bereavement
Introduction: The death of a partner is a frequent and very stressful critical life event in later life. Grief and psychological distress after the loss of a partner are normative reactions.
- Trial name
- LEAVES-PT (NCT05156346)
- Testing
- LEAVES
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Type 2 Diabetes Mellitus (T2DM), Health-related Quality of Life
Psychological Well-Being, Depression, and Health-Related Quality of Life in Adults With Type 2 Diabetes: A Cross-Sectional Study
This prospective cross-sectional observational study aims to explore the relationships among psychological well-being, depression, and quality of life in patients with type 2 diabetes attending the outpatient metabolic clinic at…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Health-related Quality of Life, Depressive Symptoms, Psychological Well-being
- Trial name
- PWDQ-T2D (NCT07241325)
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Depression in Adults
Brief Culturally Adapted Behavioral Activation Therapy for Adults With Depression in Indonesian Primary Care: A Type-2 Hybrid Effectiveness-Implementation Trial
This is a type-2 hybrid effectiveness-implementation study of brief culturally adapted behavioral activation for adults with depression in primary care setting.
- Trial name
- NCT07373080
- Testing
- Training and supervision on BAT
- Where
- Indonesia
- Volunteers
- 96 people
- Sponsor
- Gadjah Mada University
Depressive Symptoms, Anxiety
Mental Health Mobile Apps for Adults
In Hong Kong, the shortage of mental health professionals has been a public health concern for many decades. The World Health Organization (WHO) recommends self-care intervention as one of the most promising and exciting new…
- Conditions
- Depressive Symptoms, Anxiety, Well-Being, Psychological
- Trial name
- NCT06099301
- Testing
- Brief advice of a list of mobile apps
- Where
- Hong Kong
- Volunteers
- 234 people
- Sponsor
- Hong Kong Metropolitan University
Anxiety Disorders and Symptoms, Depressive Symptoms
Mobile CBT for Middle Aged and Older Adults
This study aims to assess a mobile app called MAYA for use in middle-aged and older adults with anxiety or mood disorders. The MAYA app is designed to teach coping skills for anxiety and depression that are drawn from cognitive…
- Conditions
- Anxiety Disorders and Symptoms, Depressive Symptoms, Depression
- Trial name
- NCT05754151
- Testing
- MAYA Mobile Application
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Weill Medical College of Cornell University
Depression
A Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder
The primary objective of the study is to determine whether armodafinil treatment, at a dosage of 150 mg/day, is more effective than placebo treatment as adjunctive therapy to mood stabilizers for treatment of adults with major…
- Trial name
- NCT01072929
- Testing
- Armodafinil
- Where
- 40 sites in United States
- Volunteers
- 433 people
- Sponsor
- Cephalon
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