Clinical trials: Adult Depression
Treatment-resistant Depression (TRD)
MBCT and Escitalopram for Treatment-Resistant Depression in Older Adults
This study is a randomized controlled trial designed to investigate the synergistic effects of combining mindfulness-based cognitive therapy (MBCT) with escitalopram hydrobromide versus escitalopram alone on cognitive function…
- Trial name
- NCT07077291
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Escitalopram Hydrobromide
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Yun Zhang
Depression - Major Depressive Disorder
A Megastudy of Single-Session Interventions for Depression
This project aims to learn if new kinds of digital single-session interventions (SSIs) for depression could be effective for American adults. Many existing SSIs are delivered in a simple text-based format.
- Trial name
- NCT06856668
- Testing
- Behavioral Activation (Action Brings Change Project 10-Minute Version), Mindful Acceptance, Moral Elevation
- Where
- United States
- Volunteers
- 7,505 people
- Sponsor
- Northwestern University
Geriatric Assessment, Geriatric Oncology
Geriatric Oncology Care in Brazil: Remote Geriatric Assessment-Driven Interventions With Supportive Care
The goal of this clinical trial is to determine whether a telehealth-delivered, geriatric assessment-guided supportive care program (GAIN-S) can improve health outcomes in older adults (age 65 and above) with solid tumors who are…
- Conditions
- Geriatric Assessment, Geriatric Oncology, Quality of Life, Functional Decline
- Trial name
- GAIN-S (NCT07084454)
- Testing
- GAIN-S Multidisciplinary Telehealth Intervention, Standard Oncology Care
- Where
- Brazil
- Volunteers
- 350 people
- Sponsor
- Cristiane Decat Bergerot, PhD
Physical Inactivity, Cognitive Decline
Developing and Assessing an Innovative Exergaming Technology for Older Adults Living in Long-term Care Homes
Residents living in long-term care (LTC) homes spend up to 75% of their day in sedentary, socially withdrawn situations which increases their risk for depression, dementia, decreased functional status and increased care costs.
- Conditions
- Physical Inactivity, Cognitive Decline, Aging, Social Isolation
- Trial name
- MouvMat (NCT05130203)
- Testing
- MouvMat Exergaming, Standard Recreational Programming
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Needs for Rehabilitation, Adult Attachment Style
The Need for Rehabilitation and the Connection With Attachment Styles Among Patients With Gynaecological Cancer
The purpose of this study is to provide new knowledge about: Integration of rehabilitation in a highly specialized gynaecological department. Development and testing of an individually adapted rehabilitation process.
- Conditions
- Needs for Rehabilitation, Adult Attachment Style, Quality of Life., Depression
- Trial name
- NCT01638741
- Testing
- Rehabilitation goals of patients with gynaecological cancer.
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Kamila Adellund Holt
Autism Spectrum Disorder, Depression
Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults
Autistic adults are at a greater risk for mental health problems compared to the general population, with 50% meeting criteria for a co-occurring psychiatric condition.
- Conditions
- Autism Spectrum Disorder, Depression, Anxiety
- Trial name
- NCT06060860
- Testing
- Cognitive-Behavioral Therapy (CBT), Mindfulness-Based Cognitive Therapy (MBCT)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of North Carolina, Chapel Hill
Cognitive/Functional Effects, Depression
Study of Physical and Mental Health of Older Patients With Newly Diagnosed Cancer
RATIONALE: Gathering information from older patients with newly diagnosed cancer may help doctors learn more about the risks of functional decline.
- Conditions
- Cognitive/Functional Effects, Depression, Hematopoietic/Lymphoid Cancer, Malnutrition
- Trial name
- NCT00769951
- Testing
- medical chart review, questionnaire administration, cognitive assessment
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Case Comprehensive Cancer Center
Depression
Empower@Home: A Feasibility Pilot
This is an open pilot feasibility study of a novel internet-based cognitive behavioral therapy program for older adults with elevated depressive symptoms.
- Trial name
- NCT05243264
- Testing
- Empower@Home
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Depression, Depressive Disorder, Major
A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise
This pilot study aims to test a model that predicts that enhanced neurotransmitter gamma-aminobutyric acid (GABA) function in reward and affect-regulation central nervous system (CNS) circuits mediates the antidepressant effects…
- Conditions
- Depression, Depressive Disorder, Major, Depressive Disorder, Unipolar Depression
- Trial name
- MEDEX (NCT02407704)
- Testing
- Venlafaxine XR, Aerobic Exercise, Lorazepam
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Kirk Erickson, PhD
Suicide
A Community-based Depression Screening Intervention for Middle-aged Suicide
The purpose of this study is to examine the effectiveness of a community-based depression-screening program for suicide prevention among middle-aged adults, the investigators conducted a quasi-experimental intervention study…
- Trial name
- NCT02468466
- Testing
- Multi-level suicide prevention programs, Suicide prevention program as usual
- Where
- 11 sites in Japan
- Volunteers
- 89,700 people
- Sponsor
- Aomori University of Health and Welfare
Major Depressive Disorder, MDD
Efficacy of Statins Among Major Depressive Disorder
The goal of this clinical trial is to learn if drug Rosuvastatin 10 mg works to treat MDD in adults. It will also learn about the safety of Rosuvastatin 10 mg .The main questions it aims to answer are: Does Rusovastatin lower the…
- Trial name
- NCT06698666
- Testing
- Rosuvastatin 10 mg tablet., Sertraline Pill
- Where
- Egypt
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Depressive Disorder, Major, Anhedonia
A Study of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and Long-term Extension Treatment With Aticaprant
The purpose of this study is to evaluate how well aticaprant works as compared with placebo when given along with an antidepressant therapy in improving the depressive symptoms in adult participants with major depressive disorder…
- Trial name
- VENTURA-7 (NCT06514742)
- Testing
- Aticaprant
- Where
- 84 sites in United States, Belgium and 7 more
- Volunteers
- 101 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder, Dysthymia
L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults
Individuals with Late Life Depression (LLD) often have cognitive problems, particularly problems with memory, attention, and problem solving, all of which contribute to antidepressant non-response.
- Conditions
- Major Depressive Disorder, Dysthymia, Depression
- Trial name
- NCT03761030
- Testing
- L-DOPA
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Major Depressive Disorder (MDD)
A Study of SEP-380135 in Adults With Schizophrenia or Major Depressive Episode
The purpose of this study is to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of multiple dose oral administration of SEP-380135 in participants with schizophrenia or with a major depressive…
- Conditions
- Schizophrenia, Major Depressive Disorder (MDD), Bipolar Disorder
- Trial name
- NCT07549581
- Testing
- SEP-380135
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Urinary Incontinence,Stress, Urinary Incontinence, Urge
Association of Urinary Incontinence With Depression, Insomnia, Frailty and Falls in Older Adults
The aim of our study is to provide a holistic analysis of the geriatric syndromes associated with urinary incontinence, which can result in significant adverse outcomes in the elderly, and to explore the gender-specific…
- Conditions
- Urinary Incontinence,Stress, Urinary Incontinence, Urge, Depressive Disorder, Insomnia
- Trial name
- NCT06627400
- Where
- Turkey (Türkiye)
- Volunteers
- 635 people
- Sponsor
- Kastamonu University
Chronic Pain, Depression
Pain Self-management Program for Older Adults
It is well documented that severe pain is more common in older adults than it is younger persons. Of concern, older adults may not have access to traditional face-to-face self-management programs, which are recognized to be…
- Conditions
- Chronic Pain, Depression, Anxiety
- Trial name
- NCT03512522
- Testing
- Online Group, Workbook Group
- Where
- Canada
- Volunteers
- 121 people
- Sponsor
- University of Regina
Anxiety, Depression
Social Factors in the Mental Health of Young Adults: Bridging Psychological and Network Analysis
The central goal of this project is to produce a novel, precise, and comprehensive account of social factors in young adult mental health - using a novel combination of network nominations, ecological momentary assessment, and…
- Conditions
- Anxiety, Depression, Loneliness, Stress
- Trial name
- NCT04771195
- Testing
- Examination of students' naturally occurring social ties
- Where
- United States
- Volunteers
- 9,941 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depressive Symptoms, Ageism
Cultural Arts Programme for Older Chinese
This study examines the effectiveness of an innovative cultural arts program in reducing depressive symptoms and age-related self-stigma among older Chinese as compared to service as usual through a randomized waitlist controlled…
- Conditions
- Depressive Symptoms, Ageism, Older Adults, Psychosocial Intervention
- Trial name
- NCT06527625
- Testing
- Cultural Arts Program, Treatment as usual
- Where
- Hong Kong
- Volunteers
- 63 people
- Sponsor
- The Hong Kong Polytechnic University
Major Depressive Disorder
Study of Safety & Tolerability of OPC-34712 as Adjunctive Therapy in Treatment of Adult Patients With Major Depressive Disorder
The purpose of this study is to assess the long-term safety, tolerability and efficacy of oral OPC-34712 as adjunctive therapy in the treatment of adult patients with Major Depressive Disorder (MDD).
- Trial name
- NCT01447576
- Testing
- ADT, OPC-34712
- Where
- 32 sites in United States
- Volunteers
- 1,036 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Suicide, Suicidal Ideation
Preventing Suicide Among Sexual and Gender Diverse Young Adults in Primary Care
The overall aim of this study is to reduce suicide among sexual and gender diverse youth ages 18-24 years old. This study will compare the effectiveness of two brief suicide prevention interventions that have been adapted for use…
- Trial name
- NCT05869552
- Testing
- STAT-PC, YST-III
- Where
- 3 sites in United States
- Volunteers
- 1,485 people
- Sponsor
- Elizabeth Arnold
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