Clinical trials: Adult Depression
Older Age; Depression
Online MBCT vs HEP for Depressive Symptoms in Older Adults: RCT
In Canada, depression affects more than 300,000 adults over the age of 60, which costs the healthcare system an estimated $5 billion each year.
- Trial name
- OMH-D RCT (NCT06189118)
- Testing
- Online Mindfulness Based Cognitive Therapy or Health Education Program
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Lady Davis Institute
Depression in Old Age
Leveraging Adult Protective Service Interaction to Offer Evidence-Based Treatment for Depression in Elder Neglect/Self Neglect
The purpose of this study is to test the feasibility and acceptability of an evidence-based treatment for depression delivered over an ipad, computer, or smartphone can help Adult Protective Services (APS) clients with their…
- Trial name
- NCT06910267
- Testing
- APS Treatment as Usual, Intervention-Behavioral Activation (BA)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiorespiratory Failure
Optimizing a Mobile Mindfulness Intervention for ICU Survivors
This is a factorial experimental trial involving adult survivors of cardiorespiratory failure treated in intensive care units (ICUs) that is conceptualized as the Optimization Phase of a multiphase optimization strategy (MOST)…
- Trial name
- LIFT2 (NCT04038567)
- Testing
- Mobile mindfulness-based training
- Where
- 3 sites in United States
- Volunteers
- 247 people
- Sponsor
- Duke University
Major Depressive Disorder (MDD), Depressive Disorder, Treatment-Resistant
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
The goal of this clinical trial is to learn if ACP-211 can help treat adults with major depressive disorder (MDD) who have not improved with antidepressant therapy (ADT), including those with treatment resistant depression (TRD).
- Trial name
- NORLIGHT (NCT07284667)
- Testing
- ACP-211
- Where
- 28 sites in United States
- Volunteers
- 153 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Insomnia
Online COgnitive Behavioural Therapy for Sleep and Mental Health for Older Adults With Insomnia and Subjective Cognitive Complaints
The goal of this randomized controlled clinical trial is to assess a novel cognitive-behavioral program for sleep and mental health using a multidomain web platform (eCBTi+) in participants with insomnia and subjective cognitive…
- Trial name
- e-COSMOS (NCT06032377)
- Testing
- cognitive behavioral therapy for sleep, anxiety, and depression, education about healthy nutrition habits and communication in older age
- Where
- 2 sites in Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Bipolar Depression
Quetiapine Efficacy in Bipolar Depression Study
To reassure the clinical study data on Seroquel antidepressant efficacy in patients who are diagnosed as bipolar depression
- Trial name
- QUEEN (NCT00523601)
- Where
- 3 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- AstraZeneca
Mental Health Care, Depression Anxiety Disorder
Effectiveness of Exercise, Walking, and Education on Mental Health, Mobility and Quality of Life in Elderly Residents of Nursing Homes
Clinical Trial This clinical trial aims to determine the impact of physiotherapy interventions on mental health, quality of life, and spinal mobility in older adults.
- Conditions
- Mental Health Care, Depression Anxiety Disorder, Quality of Life
- Trial name
- NCT07236424
- Testing
- Physiotherapy
- Where
- Bosnia and Herzegovina
- Volunteers
- 44 people
- Sponsor
- University of Mostar
Anxiety Depression
AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR ANXIETY AND DEPRESSION PRIMARY PREVENTION IN YOUTH
The goal of this clinical trial will be to evaluate the efficacy of an AI-informed peer-mentoring program to improve stress management and social skills and reduce the risk of depressive and anxiety symptoms in healthy…
- Trial name
- PeerMentorAnxD (NCT07472894)
- Testing
- Peer-mentoring behavioral intervention, Health Education
- Where
- 2 sites in Greece, Italy
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- University of Patras
Depression
Stress Reactivity of Physical Stressor on Depression
Depressive elderly individuals have showed higher basal level of cortisol and lower level of dehydroepiandrosterone (DHEA). Moreover, changes on these hormone levels have also observed in reactivity of an acute stress, such as…
- Trial name
- NCT01791023
- Testing
- Physical exercise
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Affective Psychosis, Bipolar, Manic Disorder
Phase 3 /Seroquel SR Acute Mania Monotherapy - US
The purpose of this study is to determine the safety and efficacy of sustained-release quetiapine fumarate (Seroquel®) in the treatment of patients with Acute Bipolar Mania for 3 weeks.
- Conditions
- Affective Psychosis, Bipolar, Manic Disorder, Manic-Depressive Psychosis, Mania
- Trial name
- NCT00422123
- Testing
- Quetiapine fumarate (Seroquel) SR
- Where
- 51 sites in United States
- Volunteers
- 447 people
- Sponsor
- AstraZeneca
Depression, Anxiety
A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health
Ketamine-Assisted Psychotherapy (KAP) is a relatively new approach for the treatment of mental health issues, which involves the combination of ketamine, a dissociative anaesthetic with psychedelic properties, and psychotherapy…
- Conditions
- Depression, Anxiety, Post Traumatic Stress Disorder
- Trial name
- NCT05604794
- Testing
- Ketamine-Assisted Psychotherapy (KAP)
- Where
- 11 sites in United States, Canada
- Volunteers
- 1,806 people
- Sponsor
- Field Trip Health
Depression Anxiety Disorder, Sleep Quality
Digital Silence and Mental Health
Social media use has been linked to negative mental health outcomes, including increased anxiety, depression, stress, poor sleep quality, and difficulties in emotion regulation.
- Trial name
- NCT07147829
- Testing
- digital detox
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Type 2 Diabetes Mellitus
Effects of Progressive Muscle Relaxation on Anxiety, Depression, and Quality of Life in Adults With Type 2 Diabetes
This randomized controlled study evaluated the effects of an eight-week progressive muscle relaxation program on anxiety, depression, and quality of life in 80 adults with type 2 diabetes mellitus.
- Trial name
- NCT07876401
- Testing
- Progressive Muscle Relaxation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gul Dural
Major Depressive Disorder
A Study to Evaluate SAGE-217 for Prevention of Relapse in Adult Participants With Major Depressive Disorder
This is a study with an Open-Label (OL) phase followed by a randomized, Double-Blind (DB), placebo-controlled phase to assess efficacy and safety of SAGE-217 on relapse prevention in adults with major depressive disorder (MDD).
- Trial name
- NCT04007367
- Testing
- SAGE-217
- Where
- 46 sites in United States
- Volunteers
- 53 people
- Sponsor
- Biogen
Myofascial Pain, Myalgia
BBTI vs PSR in Musculoskeletal Orofacial Pain Adults
This clinical study aims to compare the efficacy of two brief psychological interventions: Brief Behavioral Therapy for Insomnia (BBIT) and Physical Self-Regulation or (PSR) delivered over telehealth for the management of chronic…
- Trial name
- BBTI_PSR_21 (NCT04897581)
- Testing
- Brief Behavioral Therapy for Insomnia, BBTI, Physical Self-Regulation, PSR
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ian Boggero, PhD
Major Depressive Disorder (MDD)
Prescribing the Right Agent for Depression in Adults
Depression is a common mental health problem affecting almost 300 million people worldwide. Antidepressants are recommended as one of the first line treatments for people with moderate-to-severe symptoms of depression.
- Trial name
- PRADA (NCT07796295)
- Testing
- PRADA Tool, PETRUSHKA Tool
- Where
- 3 sites in Ethiopia, Pakistan and 1 more
- Volunteers
- 2,142 people
- Sponsor
- University of Oxford
Depression, Pain
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain…
- Conditions
- Depression, Pain, Cognitive Impairment
- Trial name
- PATH-Pain (NCT05081596)
- Testing
- PATH-Pain
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Weill Medical College of Cornell University
Depression
The PACE/PACENET Behavioral Health Laboratory Project
The purpose of the current project is to conduct a program evaluation that examines the impact of the The SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program - a telephone-based clinical service designed to…
- Trial name
- SUSTAINII (NCT02440594)
- Testing
- Enhanced BHL Program Services, Standard BHL Program Services
- Where
- United States
- Volunteers
- 2,432 people
- Sponsor
- University of Pennsylvania
Depression Disorders, Affective Disorders
Prevention of Mental Disorders Through Self-efficacy Interventions
Low self-efficacy is a transdiagnostic risk factor for several mental disorders. Self-efficacy refers to one's belief that one is capable of performing a behavior necessary to successfully complete a task or achieve a goal.
- Conditions
- Depression Disorders, Affective Disorders, Prevention, Substance Use Disorders
- Trial name
- SELFTIE (NCT06738953)
- Testing
- Cognitive-Behavioral Intervention to increase Self Efficacy
- Where
- Germany
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Health and Medical University Potsdam
Depression, Cancer
Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit
Our team has developed a digital intervention that aims to help adolescent and young adult cancer survivors (AYAs) manage symptoms of depression.
- Conditions
- Depression, Cancer, Adolescent, Young Adult
- Trial name
- ASCENT (NCT07173205)
- Testing
- AYA Survivors Coping and Emotional Needs Toolkit (ASCENT)
- Where
- 2 sites in United States
- Volunteers
- 208 people
- Sponsor
- East Carolina University
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