Clinical trials: Adult Depression
MDD
Senior Peer Alliance for Rural Research On Wellness
Dr. Brooke Hollister, Ph.D. from the department of Social and Behavioral Sciences at the University of California, San Francisco is conducting a study comparing two types of interventions for treating depression in rural older…
- Trial name
- SPARROW (NCT01913366)
- Testing
- CM-PST, SG-PST
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Bipolar I Disorder
Efficacy & Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder
The purpose of this study is to determine whether quetiapine when used as adjunct to lithium or divalproex is safe and effective in the maintenance treatment of adult patients with Bipolar I Disorder.
- Trial name
- NCT00107731
- Testing
- quetiapine fumarate, lithium, divalproex
- Where
- 166 sites in United States, Australia and 16 more
- Volunteers
- 710 people
- Sponsor
- AstraZeneca
Sickle Cell Disease, Depression
Designing an Implementation Strategy for Delivering Routine Mental Health Screening and Treatment
African Americans living with chronic health conditions are more likely to experience depression and other mental health disorders than their healthy counterparts, and are more likely to experience severe depression than whites…
- Conditions
- Sickle Cell Disease, Depression, Anxiety
- Trial name
- NCT04587661
- Testing
- off-the-shelf digital CBT, adapted digital CBT
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Pittsburgh
Depression / Major Depressive Disorder, Anxiety
Digital Single-Session Cognitive Behavioural Therapy in Healthy Adults
The goal of this study is to learn if digital single-session cognitive behavioural therapy can treat mental health in adults. The main question it aims to answer is: Does digital single-session cognitive behavioural therapy…
- Conditions
- Depression / Major Depressive Disorder, Anxiety, Anxiety Disorder Generalized
- Trial name
- CBT (NCT07873905)
- Testing
- Digital single-session cognitive behavioural therapy, Digital memory task
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Brunel University
Cancer, Major Depressive Disorder
Two Doses of Psilocybin for the Treatment of MDD in Adults With Cancer
This is a Phase 2, single-center study to explore the efficacy, safety, and tolerability of up to two 25-mg doses of psilocybin administered at an interval of 9 to 10 weeks in patients with MDD and cancer.
- Trial name
- 2Dose (NCT05947383)
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Sunstone Medical
Type 2 Diabetes, Quality of Life
Feasibility of Kanasina Gulabi, a Pilot Peer Support Intervention for Young Adults With Type 2 Diabetes in Mysore District, South India
The purpose of this study is to evaluate a pilot peer support intervention, entitled "Kanasina Gulabi" (Translation "My Dream Rose" in Kannada), designed to improve quality of life and diabetes management among young adults…
- Conditions
- Type 2 Diabetes, Quality of Life, Depression, Stigma, Social
- Trial name
- NCT06259318
- Testing
- Kanasina Gulabi
- Where
- India
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Depressive Disorder, Major
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) In The Treatment Of Major Depressive Disorder
The primary purpose of this study is to evaluate the efficacy and safety of two doses of DVS SR (50 and 100 mg/day) in the treatment of adults with Major Depressive Disorder.
- Trial name
- NCT00384033
- Testing
- Desvenlafaxine Succinate Sustained-Release (DVS SR), Duloxetine 60 mg/day
- Where
- 22 sites in United States
- Volunteers
- 638 people
- Sponsor
- Pfizer
Anxiety, Depression
Telehealth Cognitive Behavioral Stress Management for Adults With Cystic Fibrosis
The purpose of this study to to assess the feasibility, acceptability, and satisfaction of a telehealth cognitive behavioral stress management (CBSM) intervention among adults with cystic fibrosis (CF) who exhibit elevated…
- Conditions
- Anxiety, Depression, Stress, Coping Skills
- Trial name
- NCT03560726
- Testing
- Cognitive Behavioral Stress Management
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Jewish Health
Mild Cognitive Impairment, Depressive Symptoms
Homebound Elderly People Psychotherapeutic Intervention
This study aims to develop, implement, and assess the feasibility, acceptability, and preliminary efficacy of a 10-week structured and individualized cognitive-emotional intervention program for homebound older adults with Mild…
- Conditions
- Mild Cognitive Impairment, Depressive Symptoms, Anxiety State
- Trial name
- HEPPI (NCT04967378)
- Testing
- HEPPI
- Where
- Portugal
- Volunteers
- 51 people
- Sponsor
- University of Coimbra
Major Depressive Disorder
Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
This study will examine SPD489 in subjects aged 18-65 with major depressive disorder (MDD) who are taking certain types of antidepressants but continue to have residual depression symptoms.
- Trial name
- NCT01436149
- Testing
- SPD489 (Lisdexamfetamine dimesylate )
- Where
- 85 sites in United States, Canada and 4 more
- Volunteers
- 1,262 people
- Sponsor
- Shire
BD
The Effect of Methylphenidate on Cognitive Abilities of Adults With Bipolar Disorder
The purpose of the study is to explore the effect of MPH on working memory, attention and decision making in adults with BD in remission or in depressed state.
- Trial name
- NCT02020200
- Testing
- MPH
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shalvata Mental Health Center
Chronic Insomnia
Brief Trial of ACT-i for Adults With Chronic Insomnia
This is a prospective, randomized-controlled trial that assesses the efficacy of a brief Acceptance and Commitment Therapy (ACT-i), compared to an attentional control group, in adults with chronic insomnia.
- Trial name
- NCT07048600
- Testing
- Acceptance and Commitment Therapy for Insomnia, Attentional Control Group
- Where
- Romania
- Volunteers
- 76 people
- Sponsor
- Babes-Bolyai University
Depressive Disorder, Depression
Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress
The purpose of this study is to assess the tolerability, safety, and efficacy of brexpiprazole (2.0 mg/day) as adjunctive therapy in adult subjects with a diagnosis of MDD with and without anxious distress
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders
- Trial name
- NCT02196506
- Testing
- Brexpiprazole +ADT
- Where
- 47 sites in United States, Germany and 3 more
- Volunteers
- 837 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Major Depressive Disorder
Open-label Safety Extension Study of 2.5, 5 and 10 mg of Vortioxetine (Lu AA21004) in Long-term Treatment of Major Depressive Disorder in Adults
The purpose of the study is to evaluate long-term safety and tolerability of Vortioxetine over a period of 52 weeks in patients with Major Depressive Disorder (MDD) having completed 8-week acute treatment.
- Trial name
- NCT00694304
- Testing
- Vortioxetine (Lu AA21004)
- Volunteers
- 535 people
- Sponsor
- H. Lundbeck A/S
Depression, Posttraumatic Stress Disorder
Effectiveness of Group Focused Psychosocial Support for Adults Affected by Humanitarian Crises
This is an effectiveness study of group problem management plus, a low-intensity psychological intervention, delivered in five sessions to adults affected by humanitarian crises.
- Conditions
- Depression, Posttraumatic Stress Disorder, Psychological Distress
- Trial name
- GroupPM+ (NCT03747055)
- Testing
- Group problem management plus, Enhanced treatment as usual
- Where
- Nepal
- Volunteers
- 611 people
- Sponsor
- George Washington University
Major Depressive Disorder (MDD)
A Phase 2 Study to Evaluate Efficacy and Safety of KH607 Tablets in Adult Participents With Major Depressive Disorder
This is a two-part (open-label followed by double-blind) study evaluating the safety, tolerability, pharmacokinetics, and efficacy of KH607 in 120 participants diagnosed with moderate or severe Major Depressive Disorder.
- Trial name
- NCT07101120
- Testing
- KH607 tablets
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Chengdu Kanghong Pharmaceutical Group Co., Ltd.
Subthreshold Depression
Effects of Virtual Reality-Based Horticultural Intervention for Older Adults With Subthreshold Depression in Nursing Homes
Subthreshold depression represents a state of psychological sub-health between normal individuals and clinical depression. It constitutes a high-risk stage for developing clinical depression and a critical phase for alleviating…
- Trial name
- NCT07275034
- Testing
- Virtual Reality-Based Horticultural Intervention System, routine health management
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Major Depressive Disorder
rTMS for Adolescents and Young Adults
rTMS is a promising, though largely untested, option for treating adolescent and young adult depression. This study hypothesizes that rTMS will safely and significantly alleviate depression and decrease suicidal ideation in…
- Trial name
- JHU (NCT00984087)
- Testing
- TMS with Neurostar TMS Therapy System
- Where
- United States
- Sponsor
- Johns Hopkins University
Depressed GCS
CaffeinICU Study - A Study on Oral Caffeine in ICU Patients With Coma
Background: Depressed Glasgow Coma Scale (GCS) is common among critically ill patient s in the intensive care unit (ICU). It is one of the main reasons that hampers liberation from mechanical ventilation among ICU patients.
- Trial name
- CaffeinICU (NCT05232734)
- Testing
- Caffeine Citrate 20 MG/ML Oral Solution
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- Singapore General Hospital
Obesity, Depression
Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older
The goal of this randomized clinical trial is to test the efficacy of a fully digital intervention, combining the Lumen problem-solving therapy virtual coach for depression management with the Diabetes Prevention Program…
- Trial name
- IGNITE (NCT06636058)
- Testing
- vCare Intervention (6-month active treatment followed by 6-month maintenance), vCare Intervention (active treatment after 6 months)
- Where
- 2 sites in United States
- Volunteers
- 440 people
- Sponsor
- University of Illinois Chicago
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