Clinical trials: Adult Depression
Depression, Epilepsy
PEARL Intervention to Reduce Depression Among Adults With Epilepsy
The purpose of this study is to test the effectiveness of a home-based depression treatment intervention called "Program to Encourage Active, Rewarding Lives (PEARL)".
- Trial name
- PEARL (NCT00459329)
- Testing
- Program to Encourage Active, Rewarding Lives (PEARL)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Major Depressive Disorder, Alzheimer Disease
Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
In this study, the investigators will be examining the effects of the deep repetitive transcranial magnetic stimulation (rTMS) using the H1 coil in patients over the age of 60 diagnosed with mild to early-moderate Alzheimer's…
- Conditions
- Major Depressive Disorder, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT03665831
- Testing
- Brainsway H1-Coil Deep TMS System
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Rotman Research Institute at Baycrest
Depression
Collaborative Stepped-care Intervention for Adults With Subthreshold Depressive Symptoms in the Primary Care Setting
To ensure accessibility and availability of mental health services in the community and to reduce the burden associated with depression and related conditions, the study aim to evaluate the effectiveness of a collaborative…
- Trial name
- NCT06658041
- Testing
- Cognitive behavioural therapy (CBT)-based intervention with stepped-care, Care-as-usual
- Where
- Hong Kong
- Volunteers
- 352 people
- Sponsor
- The University of Hong Kong
Dementia, Alzheimer Disease
Effectiveness of a 3-month Individual Reminiscence Therapy Program in Older Adults With Alzheimer's Disease
This research aims to evaluate the effectiveness of individual Reminiscence Therapy (RT) program, using a simple reminiscence format, to improve the overall cognitive function, mood, and quality of life (QoL) of older adults with…
- Conditions
- Dementia, Alzheimer Disease, Cognitive Impairment
- Trial name
- NCT06812442
- Testing
- Reminiscence therapy
- Where
- 4 sites in Portugal
- Volunteers
- 40 people
- Sponsor
- Rsocialform - Geriatria, Lda
Bipolar Disorder I or II With a Major Depressive Episode
ALTO-100 in Bipolar Disorder With Depression (BD-D)
The purpose of this study is to assess antidepressant efficacy differences between ALTO-100 and placebo during the Double-Blind period in patients with bipolar disorder I or II with current major depressive episode, when used…
- Trial name
- NCT06656416
- Testing
- ALTO-100
- Where
- 68 sites in United States, United Kingdom
- Volunteers
- 200 people
- Sponsor
- Alto Neuroscience
Major Depressive Disorder, Insomnia
A Study to Evaluate the Safety, Tolerability, and Efficacy of SAGE-217 Compared to Placebo in Adult Participants With Comorbid Major Depressive Disorder (MDD) and Insomnia
This study is a randomized, double-blind, placebo-controlled study of the safety, tolerability, and efficacy of SAGE-217 compared to placebo in adult participants with comorbid major depressive disorder (MDD) and insomnia.
- Trial name
- NCT03771664
- Testing
- SAGE-217
- Where
- 28 sites in United States
- Volunteers
- 87 people
- Sponsor
- Biogen
Depressive Disorder, Major
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
The purpose of this study is to know how well seltorexant works, and also to evaluate safety and maintenance effect of seltorexant compared with placebo as an adjunctive therapy to an antidepressant in improving depressive…
- Trial name
- NCT06559306
- Testing
- Seltorexant, Selective Serotonin Reuptake Inhibitor (SSRI)/Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
- Where
- 205 sites in United States, Argentina and 14 more
- Volunteers
- 752 people
- Sponsor
- Janssen Research & Development, LLC
Depression in Old Age, Depression
Enhancing Processing Speed and Executive Functioning in Depressed Older Adults With Computerized Cognitive Training
The purpose of this research study is to determine how treatment response may change depending on how studies are designed, and if mobile cognitive training can be used to improve treatment response in depressed older adults.
- Trial name
- NCT04836533
- Testing
- Experimental: Computerized Cognitive Training, Experimental: Open-label antidepressant treatment, Active Comparator: Solitaire Training
- Where
- United States
- Sponsor
- Queens College, The City University of New York
HIV Infections, Fatigue
Effectiveness of Modafinil for Treating Fatigue in Adults With HIV/AIDS
This study will determine whether modafinil (Provigil®), a medication approved for the treatment of narcolepsy, is effective in reducing fatigue in adults with HIV/AIDS.
- Trial name
- NCT00118378
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder Patients
Study to Evaluate Safety and Tolerability of FK949E in Elderly Patients With Major Depressive Disorder
The objective of the study was to evaluate the safety and plasma concentration changes of quetiapine after multiple oral administration of FK949E (extended-release formulation of quetiapine) in elderly patients with major…
- Trial name
- NCT01903200
- Testing
- FK949E
- Where
- 2 sites in Japan
- Volunteers
- 16 people
- Sponsor
- Astellas Pharma Inc
Depression
Developing E-health Services (DES): The Feasibility and Acceptability of Video-conferencing for Adults With Depression
Depression impacts 1 in 5 people in the United Kingdom and is a significant risk factor for self-harming behaviours and suicide.
- Trial name
- DES (NCT03288506)
- Testing
- Google Hangout (VC) group
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Major Depressive Disorder
Pentoxifylline as an Adjunct to Citalopram in Adult Patients With Major Depressive Disorder
The aim of this study is to test if combining the antidepressant Citalopram with Pentoxifylline (PTX), a medicine with anti-inflammatory and phosphodiesterase inhibitory properties, enhanced antidepressant efficacy in adult…
- Trial name
- NCT05271084
- Testing
- Citalopram (tablet) 20 mg + Pentoxifylline (tablet) 400Mg
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- Hawler Medical University
Major Depressive Disorder
Adjunctive Mixed Salts Amphetamine for Depressed Adults With Incomplete Response to Current Antidepressant Therapy
In this Phase 4 trial we will study the safety, tolerability and efficacy of mixed salts amphetamine (MSA), trade name Adderall, augmentation of antidepressant therapy for Major Depressive Disorder (MDD) in depressed outpatient…
- Trial name
- NCT02058693
- Testing
- mixed salts amphetamine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Rush University Medical Center
Older Adults (50-90 Years), Mental Health
Project HOPEFUL: A PN-RCT With Implementation Science
This PN-RCT replicates and evaluates an 8-week warm calling treatment (i.e. caring contacts) delivered to older adults receiving home and community-based services (HCBS; classified as "homebound") in 20-30 minute call "dosages"…
- Conditions
- Older Adults (50-90 Years), Mental Health, Depression and Suicide Ideation, Social Functioning
- Trial name
- NCT07475039
- Testing
- Standardized and manualized warm calls from providers trained in the BE training, Standardized and manualized warm calls from providers trained in the BE training + ASIST training
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Florida
Taste Disorders
Gustatory Dysfunction Among a Sample of Depressed Egyptian Adults Under Anti-depressants Therapy
Assess gustatory thresholds among a sample of depressed Egyptian adults (age from 20 to 50 years old) under anti-depressants therapy ( for at least 3 months) using filter paper disc(FPD) method through a scoring system.
- Trial name
- NCT03599011
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Hearing Loss, Depression
Treating Hearing Loss to Improve Mood and Cognition in Older Adults
Age-related hearing loss (ARHL) is the third most common health condition affecting older adults after heart disease and arthritis and is the fifth leading cause of years lived with disability worldwide.
- Trial name
- NCT03321006
- Testing
- Phonak Audeo B-R 90 hearing aid device (Active), Duloxetine or escitalopram
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York State Psychiatric Institute
Functional Disability, Dementia
Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
ASPREE-XT is a post-treatment, longitudinal observational follow-up study of ASPREE participants. Although the ASPREE trial medication was ceased, the study activity was not stopped and ASPREE participants are continuing with…
- Conditions
- Functional Disability, Dementia, Heart Disease, Stroke
- Trial name
- NCT07224347
- Where
- 36 sites in United States, Australia
- Volunteers
- 19,114 people, healthy volunteers welcome
- Sponsor
- Anne Murray
Anxiety, Depression
Effects of a 10-Week Zumba Program on Anxiety and Depression in Adults
This randomized controlled trial aimed to examine the effects of a 10-week Zumba exercise program on anxiety and depression levels in healthy adults.
- Conditions
- Anxiety, Depression, Psychological Well-being
- Trial name
- ZUMBA-AN-DE (NCT07317908)
- Testing
- Zumba-based Exercise Program
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Manuel Jesús Rodríguez Chavarría
Major Depressive Disorder, Generalized Anxiety Disorder
Cognitive Behavioral Therapy Group for Older Adults Delivered by Telethealth
The present aim of the study is to to adapt an established, manualized enhanced Group CBT (CBT-E) for seniors to a telehealth format, which will allow us to offer the group virtually during the COVID-19 pandemic.
- Conditions
- Major Depressive Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT04714164
- Testing
- Group Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
Treatment Satisfaction, Knowledge Acquisition Disability Nos
Psychoeducation for Adults With Autism and Their Significant Others/Family Members
Prisma is a four-session psychoeducational intervention administered in groups for individuals with ASD together with their family members and significant others.
- Conditions
- Treatment Satisfaction, Knowledge Acquisition Disability Nos, Anxiety, Depression
- Trial name
- Prisma (NCT04460976)
- Testing
- Psychoeducation for Adults With Autism and Their Significant Others/Family members (Prisma), Treatment as usual/standard care
- Where
- Sweden
- Volunteers
- 718 people
- Sponsor
- Karolinska Institutet
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