Clinical trials: Adult Depression
Major Depressive Disorder
Continuation Electroconvulsive Therapy Vs Medication to Prevent Relapses in Patients With Major Depressive Disorder
The purpose of this study is to compare the safety and effectiveness of two treatments to prevent relapses in seriously ill patients with major depressive disorder (MDD) who have responded to electroconvulsive therapy (ECT).
- Trial name
- NCT00000375
- Testing
- Nortriptyline-lithium (NOR-Li), Bilateral electroconvulsive therapy (ECT), Continuation therapy
- Where
- United States
- Sponsor
- National Institute of Mental Health (NIMH)
Psychological Distress, Anxiety
Acceptance and Commitment Therapy for Older Adults
Title: Acceptance and Commitment Therapy for older adults experiencing psychological distress: A hermeneutic single case efficacy design (HSCED) series.
- Conditions
- Psychological Distress, Anxiety, Depression
- Trial name
- NCT04280445
- Testing
- Psychological therapy
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Lincoln
Heart Rate Variability, Biofeedback, Nicotine Dependence, Nicotine Withdrawal, Anxiety, Depression, Insomnia
Effects of HRV Biofeedback on Autonomic Function and Nicotine Withdrawal Symptoms and Dependence in Smoking Cessation Adults
This study is a randomized controlled trial. It is estimated that 80 quitters will be recruited, and they will be randomly included in the experimental group and 40 in the control group.
- Trial name
- NCT04679636
- Testing
- heart rate variability biofeedback
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Defense Medical Center, Taiwan
Cognition, Affect (Mental Function)
BiomeBakery Project
This study aims to investigate the chronic effects of prebiotic fibre-fortified functional bakery product on cognitive, affective, inflammatory, metabolic, and anthropometric outcomes in healthy adults aged 60-75 years with mild…
- Conditions
- Cognition, Affect (Mental Function), C Reactive Protein
- Trial name
- NCT06796712
- Testing
- Prebiotic fibre fortified bread roll, Regular bread roll
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Reading
Depressive Symptoms
Efficacity of Psychological Intervention on Reducing the Suicidal Ideations, Depression Level and Improving Reinsertion
Suicide is the third leading cause of death in adolescents and young adults in the United States and the second leading cause in European countries.
- Trial name
- MLADO (NCT03655730)
- Testing
- weekly psychotherapeutic individual sessions, Usual care
- Where
- France
- Volunteers
- 159 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy, Major Depressive Disorder (MDD)
Lethargic Depression Study
This is a study of Major Depressive Disorder (MDD) in patients with decreased energy, pleasure and interests.
- Trial name
- NCT00064467
- Testing
- Extended-release bupropion (HCl)
- Where
- 24 sites in United States
- Volunteers
- 268 people
- Sponsor
- GlaxoSmithKline
Cancer, Depression, Anxiety
Identification of Anxiety and Depression in Adolescents/Young Adults (AYA) With Cancer
This is a prospective, multisite (but all within the UTSW IRB), observational study assessing the relationship of hope to anxiety and depression, QoL, and social support over time in the first year after cancer diagnosis or…
- Trial name
- NCT04589052
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Texas Southwestern Medical Center
Health Risk Behaviors
Association Between Sleep Disorders, Neck Pain, and Depression
This cross-sectional observational study investigates the association between sleep quality, neck pain-related disability, and depression symptoms in young adults aged 18-28.
- Trial name
- NCT07032480
- Testing
- Survey-Based Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 265 people
- Sponsor
- Saglik Bilimleri Universitesi
Depression, Anxiety
Post-COVID-19 Epidemic Depression Assessment in Adults in South Punjab Pakistan
To assess the depression in adults especially in post COVID-19 duration in the rural and urban settings.
- Trial name
- NCT04604080
- Testing
- service of questionnaire
- Where
- 5 sites in Pakistan
- Volunteers
- 390 people
- Sponsor
- Islamia University of Bahawalpur
Spina Bifida, Self Esteem
Psychosocial Teleassistance Programme for Adults With Spina Bifida
This clinical trial assesses the effect of a telecare psychosocial intervention designed for adults with spina bifida. The intervention consists of 10 weekly 1.5-hour group sessions, followed by two 3-month follow-up sessions.
- Conditions
- Spina Bifida, Self Esteem, Quality of Life (QOL), Self Concept
- Trial name
- NCT07178873
- Testing
- Psychosocial teleassistance intervention
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- University of Deusto
Major Depressive Disorder
Multi-domain Psychoeducation Self-management Program for Adults With MDD in Singapore
This is a single-centre, two-arm, unblinded pilot randomised controlled trial study on 60 participants (30 in each arm) from the community mental health service (CMHS) centre within a social service agency in Singapore based on…
- Trial name
- NCT05682183
- Testing
- Multi-domain Psychoeducation Self-management Programme, Treatment as usual
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- National University of Singapore
Major Depressive Disorder, Anxiety
Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms
The purpose of this study is to investigate the efficacy and safety of flexibly dosed adjunctive brexpiprazole treatment in subjects with major depressive disorder and anxiety symptoms, who are experiencing an inadequate…
- Trial name
- NCT02013531
- Testing
- Brexpiprazole
- Where
- 21 sites in United States
- Volunteers
- 37 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Generalized Anxiety Disorder
A Study To Assess Adverse Events and Change in Disease Activity With Oral Cariprazine When Added to Antidepressant Therapies (ADTs) Compared to Placebo in Adult Participants With Generalized Anxiety Disorder (GAD) Who Have Had an Inadequate Response to ADTs Alone
Generalized anxiety disorder (GAD) is usually treated with antidepressant therapy (ADT); however, sometimes ADTs alone are not enough to adequately treat GAD.
- Trial name
- CAR aGAD Ph 2 (NCT04965272)
- Testing
- Cariprazine 0.75 mg/day, Cariprazine 1.5 mg/day, Cariprazine 3.0 mg/day
- Where
- 36 sites in United States
- Sponsor
- AbbVie
Major Depressive Disorder (MDD)
Compare the Efficacy and Safety of KH607 Tablets Versus Vortioxetine Hydrobromide Tablets in Adult Patients With Major Depressive Disorder
This trial includes a short-term study and a long-term study. The short-term study is a multicenter, randomized, double-Blind, double-Dummy, Parallel-Controlled study with a 6-week duration.
- Trial name
- NCT07741331
- Testing
- KH607 tablets, Vortioxetine Hydrobromide Tablets, Part B: KH607
- Volunteers
- 326 people
- Sponsor
- Chengdu Kanghong Pharmaceutical Group Co., Ltd.
Emotional Disorder, Stress Related Disorder
Online Transdiagnostic Intervention for Emotional Disorders and Stress-related Disorders
The general objective of this study is to determine the indicators of suitability, clinical utility and satisfaction of the transdiagnostic online intervention for the treatment of emotional disorders and those derived from…
- Conditions
- Emotional Disorder, Stress Related Disorder, Anxiety Disorders, Depression
- Trial name
- NCT05081830
- Testing
- Transdiagnostic online intervention, TCC online intervention
- Where
- Mexico
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Vitamin D Deficiency, Depressive Symptoms
Supplementation and Depressive Symptomatology Incidence Among Saudi Arabian Adults
The goal of this randomized controlled trial is to explore the relationship between Vitamin D supplementation and depressive symptomatology in Saudi Arabian Population.
- Trial name
- NCT05916053
- Testing
- Vitamin D supplementation
- Where
- Saudi Arabia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Lebanese American University
Depression, Anxiety
Neurofeedback Training For Older Adults
Symptoms of depression and anxiety are common in older adults and are associated with poor outcomes and the risk of dementia. The prefrontal cortex (PFC) is crucial for emotion regulation.
- Trial name
- NCT05936697
- Testing
- fNIRS, EEG, Baseline Training
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The Hong Kong Polytechnic University
Major Depressive Disorder (MDD)
Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression
The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol can reduce depressive symptoms in older adults (ages 60-85) with Major Depressive Disorder (MDD) who have…
- Trial name
- NACC-D (NCT07212465)
- Testing
- Active Brainsway H7-Coil Deep TMS System
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Rotman Research Institute at Baycrest
Major Depressive Disorder
Efficacy and Safety of SR58611A co-Administered With Escitalopram in Adults With Major Depressive Disorder
The primary objective of the study is to compare, after 8 weeks, the efficacy of SR58611A vs. placebo in patients with Major Depressive Disorder who are on concomitant treatment with escitalopram.
- Trial name
- ALBERIO (NCT00432614)
- Testing
- SR58611A, escitalopram
- Where
- 13 sites in Belgium, Estonia and 11 more
- Volunteers
- 510 people
- Sponsor
- Sanofi
Major Depression
A Study to Evaluate SAGE-217 in Participants With Moderate to Severe Major Depressive Disorder
This is a two-part (open-label followed by double-blind) study evaluating the safety, tolerability, pharmacokinetics, and efficacy of SAGE-217 in 102 participants diagnosed with moderate to severe Major Depressive Disorder.
- Trial name
- NCT03000530
- Testing
- SAGE-217
- Where
- 8 sites in United States
- Volunteers
- 102 people
- Sponsor
- Biogen
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