Clinical trials: Adult Depression
Major Depressive Disorder
A Long-Term Safety Study of ALKS 5461
This is a 52-week open-label study to evaluate the safety and tolerability of ALKS 5461.
- Trial name
- NCT02141399
- Testing
- ALKS 5461
- Where
- 158 sites in United States, Australia and 6 more
- Volunteers
- 1,485 people
- Sponsor
- Alkermes, Inc.
Unipolar Depression
Transcranial Direct Current Stimulation for Depression
This study will test the efficacy of transcranial direct current stimulation (tDCS) combined with mindfulness, remotely-delivered using a telemedicine protocol in 25 adults with unipolar depression.
- Trial name
- NCT07042217
- Testing
- transcranial direct current stimulation (tDCS) and mindfulness instruction
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Soterix Medical
Depression, Depression Disorder
GynMDD Add-On to Supportive Psychotherapy in Mild to Moderate Depression
The goal of this clinical trial is to learn whether the dietary supplement GynMDD, when taken as an add-on to supportive psychotherapy, can improve symptoms of mild to moderate depression in adults aged 18 to 65.
- Conditions
- Depression, Depression Disorder, Depression in Adults
- Trial name
- SWING (NCT07416747)
- Testing
- GynMDD
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Fondation FondaMental
Depression - Major Depressive Disorder, Older Adults (65 Years and Older)
Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression
The primary aims of this study are to assess the feasibility, acceptability, and tolerability of using an immersive virtual reality (VR) headset to engage in behavioral activation (BA) for older adults diagnosed with major…
- Conditions
- Depression - Major Depressive Disorder, Older Adults (65 Years and Older), Behavioral Activation Treatment, Virtual Reality Therapy
- Trial name
- NCT07188623
- Testing
- VR-Enhanced BA
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Stress, Physiological, Stress, Psychological
Wise Interventions and Responses to Stress
This study compares the effects of two wise interventions (implicit theory of personality intervention and implicit theory of personality intervention plus self-affirmation) with a control condition in the stress responses of…
- Conditions
- Stress, Physiological, Stress, Psychological, Social Stress, Depression
- Trial name
- ITP-RSA (NCT04786496)
- Testing
- ITP+SA Wise intervention, ITP Wise intervention, Control condition
- Where
- Spain
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Deusto
Alcoholism, Depression
Treating Alcohol Use In Older Adults With Depression
The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.
- Trial name
- NCT00018824
- Testing
- NALTREXONE
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- US Department of Veterans Affairs
Major Depressive Disorder
Relapse Prevention Study Of Desvenlafaxine Succinate Sustained Release In Outpatients With Major Depressive Disorder
The primary purpose of this study is to compare the long-term efficacy and safety of desvenlafaxine succinate sustained release versus placebo in adults with Major Depressive Disorder, using a randomized withdrawal design.
- Trial name
- NCT00887224
- Testing
- Desvenlafaxine succinate sustained release 50 mg, Desvenlafaxine succinate sustained release 25 mg
- Where
- 90 sites in United States, Canada and 12 more
- Volunteers
- 874 people
- Sponsor
- Pfizer
Bipolar Disorder
Efficacy and Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder
The purpose of this study is to determine whether quetiapine when used as adjunct to lithium or divalproex is safe and effective in the maintenance treatment of adult patients with Bipolar I Disorder.
- Trial name
- NCT00081380
- Testing
- Seroquel®, quetiapine fumarate (atypical antipsychotic), lithium (mood stabilizer), divalproex (mood stabilizer)
- Where
- 94 sites in United States, Canada
- Volunteers
- 710 people
- Sponsor
- AstraZeneca
Psoriasis (PsO), Psychological Distress
Online Therapist-guided Receptive Music Therapy in Adults With Psoriasis
This single-center, three-arm randomized controlled trial evaluated a four-week online therapist-guided receptive music therapy program as an adjunct to treatment as usual in adults with moderate-to-severe psoriasis and…
- Conditions
- Psoriasis (PsO), Psychological Distress, Depressive Symptom, Anxiety
- Trial name
- RePSO (NCT05894759)
- Testing
- Therapist-guided receptive music therapy, Audio-based active relaxation control
- Where
- Romania
- Volunteers
- 75 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Depression - Major Depressive Disorder
Single-case Intervention Study for Visual Screening Assessment for Proof of Concept and Prediction of Clinical Response to Brexiprazole as Adjunctive Treatment in Adults With Major Depressive Disorder.
Major Depressive Disorder (MDD) is the most prevalent mental disorder in the world, with high rates of recurrence and dysfunction.
- Trial name
- ETBREX (NCT07723079)
- Testing
- Eyetracking (Tobii Pro Fusion 250 hz)
- Where
- Brazil
- Volunteers
- 1 people
- Sponsor
- University of Sao Paulo
Adult Attention Deficit Hyperactivity Disorder (ADHD) With Co-occuring Anxiety and Depressive Disorders
Lisdexamfetamine Dimesylate in the Treatment of Adult ADHD With Anxiety Disorder Comorbidity
1. To evaluate the safety, and efficacy of Lisdexamfetamine dimesylate in the treatment of outpatients with DSM-IV ADHD with anxiety and depressive disorder comorbidity, as well as to evaluate the effects on quality of life . 2.
- Trial name
- NCT01863459
- Testing
- Lisdexamfetamine Dimesylate
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Centre for Anxiety, Attention Deficit and Trauma, Ontario, Canada
Anxiety and Depression
Assessing the Efficacy of Micro-dosed Psilocybin on Reducing Anxiety & Depression Levels in Adults
To investigate the efficacy of a 16 week treatment with PSIL428 patient reported anxiety levels in otherwise healthy individuals suffering from depression and or anxiety symptoms.
- Trial name
- NCT04989972
- Testing
- PSIL428, Oyster mushroom
- Where
- Jamaica
- Sponsor
- Wake Network, Inc.
Depression, Interpersonal Relations
IPT-based Group Intervention by Non-specialist for Improvement of Depressive Symptoms in Community Young Adults in Brazil
Major depressive disorder is a highly prevalent, recurrent, and debilitating disease, the third cause of years of lost life in the world, and it may be the most common disease in 2030, according to the World Health Organization…
- Trial name
- NCT06480019
- Testing
- Interpersonal psychotherapy
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Autism Spectrum Disorder
Insecure Attachment and Psychosocial Functioning in Autistic Adults Are Mediated by Depression and Paranoid Ideation
The present study examines if depressive symptoms, paranoid ideation, and emotion regulation strategies mediate the relationship between attachment and psychosocial functioning in autistic adults.
- Trial name
- NCT06030167
- Testing
- Insecure attachment and psychosocial functioning in autistic adults
- Where
- Netherlands
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Parnassia Groep
Major Depression
Spirituality Teaching Program for Depressed Adults
Major depression is a widely spread health problem in Canada. Recent research suggests a potential role for religion/spirituality in the prevention of and recovery from depression in adults.
- Trial name
- NCT00322777
- Testing
- Spirituality Teaching Program
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Canadian Institute of Natural and Integrative Medicine
Disabling Medical Events, Disabled
Enhanced Medical Rehabilitation in Older Adults
The purpose of this study is to provide evidence that Enhanced Medical Rehabilitation is an effective treatment for older adults after disabling medical events.
- Conditions
- Disabling Medical Events, Disabled, Depression
- Trial name
- EMR (NCT02114879)
- Testing
- Enhanced Medical Rehabilitation, Standard of Care Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 229 people
- Sponsor
- Washington University School of Medicine
Depressive Symptoms, Well-Being, Psychological
Metacognitive Training-Silver BeWell in Older Adults
The present study seeks to examine the feasibility, acceptance and efficacy of Metacognitive Training-Silver (MCT-Silver) BeWell among older adults (ages 60 years and older) delivered in a community setting (e.g.…
- Trial name
- NCT06312241
- Testing
- Metacognitive Training-Silver BeWell
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Major Depressive Disorder, Depression
A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression
The main goal of this clinical trial is to learn if the active study drug (code name: SP-624) has any effect on the electrical activity of the brain in adult healthy volunteers and in adults with major depression.
- Conditions
- Major Depressive Disorder, Depression, Healthy
- Trial name
- NCT06570369
- Testing
- SP-624
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Sirtsei Pharmaceuticals, Inc.
Major Depressive Disorder
Escitalopram Combination Comparison Study for Adult Patients With Major Depressive Disorder
The purpose of this study is to evaluate the effectiveness, safety and tolerability of an escitalopram combination treatment compared to single treatments, and to placebo in patients with major depressive disorder.
- Trial name
- NCT00239954
- Testing
- Escitalopram
- Where
- 4 sites in United States
- Sponsor
- Pharmacology Research Institute
Depressive Symptoms, Mood Disorders
Emoji-based Attention Bias Modification Training for Depressive Young Adults
Globally, the rates of young adults and college students reporting symptoms of depression have been rising over the past decade.
- Trial name
- NCT05415306
- Testing
- Attention Bias Modification, Deep-breathing training
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
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