Clinical trials: Adult Depression
Postoperative Pain, Adults
Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in adults in perioperative settings.
- Conditions
- Postoperative Pain, Adults, Anesthesia
- Trial name
- NCT04837170
- Testing
- Conventional therapy + S (+)-Ketamine, Conventional therapy
- Volunteers
- 12,000 people
- Sponsor
- Chinese PLA General Hospital
Mental Health (Depression), Mental Health and General Well-being
Thrive at Home: A Virtual Reality Social Intervention for Older Adults
The goal of this clinical trial is to evaluate whether a virtual reality (VR) based social platform can improve mental health and social connection for older adults who receive in-home care.
- Conditions
- Mental Health (Depression), Mental Health and General Well-being, Loneliness, Well Being
- Trial name
- Thrive at Home (NCT07835568)
- Testing
- Full Virtual Reality Social Intervention, Abbreviated Virtual Reality Social Intervention
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Chronic Pain, Mental Health Disorder
Therapeutic Writing for Adults Suffering From Chronic Pain and Comorbid Mental Health Disorders
The goal of this observational study is to understand the effects and experiences of therapeutic writing interventions in adult women with chronic pain and co-occurring mental health conditions.
- Conditions
- Chronic Pain, Mental Health Disorder, Psychiatric &Amp;Amp;or Mood Disorder, Psychiatric Comorbidities
- Trial name
- TWfCP&MH (NCT07058532)
- Testing
- Therapeutic Writing Intervention in Pain Rehabilitation
- Where
- Finland
- Sponsor
- Toni Salikka
Depression
Folic Acid and Omega -3 Fatty Acid Supplementation in Depressed Older Adults
Our specific aim is to determine the impact of folic acid and omega-3 supplementation on the severity of depressive symptoms among depressed adults aged 65 and above.
- Trial name
- NCT00480207
- Testing
- folic acid, omega-3, vit B12
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Prof. RH Belmaker
Bipolar Disorder
Clinical Trial of a Nutritional Supplement in Adults With Bipolar Disorder
The purpose of the trial was to determine whether a 36-ingredient micronutrient supplement (primarily vitamins and minerals) is beneficial for the treatment of bipolar disorder, when studied under randomized and fully blinded…
- Trial name
- NCT00109577
- Testing
- MCN36 (nutritional supplement)
- Where
- 2 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Depressive Disorder, Major
OnabotulinumtoxinA as Treatment for Major Depressive Disorder in Adult Females
This study will evaluate the safety and efficacy of onabotulinumtoxinA (BOTOX®) compared with placebo as treatment for major depressive disorder (MDD) in adult females.
- Trial name
- NCT02116361
- Testing
- onabotulinumtoxinA, Normal Saline
- Where
- 35 sites in United States
- Volunteers
- 258 people
- Sponsor
- Allergan
HIV/AIDS, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Youth to Text or Telehealth for Engagement in HIV Care
Youth To Text or Telehealth for Engagement in HIV Care (Y2TEC) is a randomized control pilot to assess the feasibility and acceptability of delivering a targeted problem-solving intervention to youth ages 18-29 living with HIV…
- Conditions
- HIV/AIDS, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Depression, Substance Use
- Trial name
- Y2TEC (NCT03681145)
- Testing
- Counselor delivered telehealth intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Major Depressive Disorder, Cardiovascular Diseases
Emotion Regulation Training to Reduce Cardiovascular Disease Risk Among Depressed Young Adults in Southern Mississippi
The proposed study will investigate the utility of a single-session emotion regulation training to reduce CVD risk among young adults diagnosed with MDD living in Southern MS.
- Conditions
- Major Depressive Disorder, Cardiovascular Diseases, Inflammation, Blood Pressure
- Trial name
- NCT05425290
- Testing
- Single-session emotion regulation training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern Mississippi
Depression
Using Peer Mentors to Deliver Depression Care
Can peer mentors be integrated into depression care to older adults with mental health professional supervision? We will assess whether peer mentors who are lay persons who are in recovery from depression can provide depression…
- Trial name
- NCT02261818
- Testing
- Meetings with peer mentors
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Frailty at Older Adults, Post-Traumatic Stress Disorder in Old Age
Multimodal Intervention for Older Adults After an Earthquake
This randomized controlled study was conducted among older adults (≥65 years) living in temporary container housing in Kahramanmaraş after the February 2023 earthquakes.
- Conditions
- Frailty at Older Adults, Post-Traumatic Stress Disorder in Old Age, Depression in Adults, Malnutrition Elderly
- Trial name
- NCT07273253
- Testing
- Multimodal intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications
RATIONALE: A personalized Internet-based program may help improve fatigue, depression, and quality of life in long-term survivors of stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00799461
- Testing
- internet-based intervention, questionnaire administration, psychosocial assessment and care
- Where
- United States
- Volunteers
- 1,337 people
- Sponsor
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Major Depressive Disorder
Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disorder
The purpose of this study is to evaluate the safety and efficacy of an 8-week double-masked treatment of tasimelteon or placebo in male and female subjects with Major Depressive Disorder.
- Trial name
- MAGELLAN (NCT01428661)
- Testing
- tasimelteon
- Where
- 40 sites in United States
- Volunteers
- 507 people
- Sponsor
- Vanda Pharmaceuticals
Major Depressive Disorder
An Open Label Study of the Genecept™ Assay in Treatment Resistant Depression
The purpose of this study is to examine the potential impact of the assay in terms of depression severity as measured by change in Clinical Global Impressions (CGI) scale at 3 months.
- Trial name
- NCT01438242
- Testing
- Genecept Assay
- Where
- United States
- Sponsor
- Genomind, LLC
Anhedonia, Depression in Adults
Positive Affect Treatment for Spanish-Speaking Individuals
The purpose of this study is to evaluate the feasibility and acceptability of Positive Affect Treatment (PAT) in a Spanish-speaking population.
- Conditions
- Anhedonia, Depression in Adults, Anxiety
- Trial name
- NCT07493369
- Testing
- Positive Affect Treatment
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Southern Methodist University
Depression
Addressing Mental Health in African American Job Training Adolescents and Young Adults
This project's focus is twofold-to change the culture of an employment training program for adolescents and young adults (Youth Opportunities, or "YO") to more fully address the many mental health issues faced by its participants…
- Trial name
- NCT00979524
- Testing
- Comprehensive Mental Health Services and Supports
- Where
- United States
- Volunteers
- 782 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Major Depressive Disorder
Yoga for Young Women With Depression
The investigators examine whether adding yoga-based therapy (YBT) to treatment as usual (TAU) for young adult women (age 18-34 years) with a primary diagnosis of MDD leads to (1) greater reductions in symptoms and (2) greater…
- Trial name
- NCT03388177
- Testing
- Yoga-based therapy, Treatment as usual
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- University of Groningen
HIV, Depression
Progress Adult Study
The purpose of this study is to study the HIV disease progression in HIV-infected Thai Adult.
- Trial name
- NCT01328275
- Testing
- standard regimens according to the Thai Ministry of Public Health national guidelines
- Where
- 3 sites in Thailand
- Volunteers
- 5,600 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Depressive Disorder, Major
A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder
The purpose of this study is to evaluate how well JNJ-89495120 works (anti-depressant effects) and how well it is tolerated as compared to placebo on reducing the symptoms of depression in participants with major depressive…
- Trial name
- Moonlight-1 (NCT06785012)
- Testing
- JNJ-89495120
- Where
- 44 sites in United States
- Volunteers
- 105 people
- Sponsor
- Janssen Research & Development, LLC
Depression, Pain
Telemedicine or Standard Care in Treating Patients With Depression and/or Pain Caused By Cancer
RATIONALE: Telemedicine may help in the treatment of depression and/or pain caused by cancer. It is not yet known whether telemedicine is more effective than standard care in treating depression and/or pain caused by cancer.
- Conditions
- Depression, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00313573
- Testing
- management of therapy complications, pain therapy, psychosocial assessment and care
- Where
- 17 sites in United States
- Volunteers
- 480 people
- Sponsor
- Indiana University
Depression Anxiety Disorder
Effect of Probiotics "Psychobiotics" on Depression and Metabolic Syndrome in Saudi Arabia
The goal of this clinical trial is to assess the effect of commercial multi-strains psychobiotics supplementation as an ad-on therapy on depressive symptoms and metabolic syndrome components (HDL-C, FPG, TGs, WC, BP) in adult…
- Trial name
- NCT06765057
- Testing
- Winclove's Ecologic® Barrier Probiotics
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Roaa Ahmed Alkreadees
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