Clinical trials: Adult Depression
Surgery
Green Light for Post-Operative Wellness
This is an unblinded, parallel group randomized controlled trial to evaluate bright green light as an adjunct therapy after surgery at UPMC Shadyside.
- Trial name
- GLOW (NCT07218289)
- Testing
- Bright Green Light Therapy, Dim White Light Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rebecca E Kotcher, MD
Depression
Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults With Depression
This study will determine whether there are age-related differences in the body systems controlling sleep and stress hormone patterns.
- Trial name
- NCT00106197
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Uma Rao
Anxiety Disorder, Chronic Myeloproliferative Disorders
Music Therapy to Ease Pain and Emotional Distress in Patients With Hematologic Cancer Who Are Undergoing High-Dose Therapy and Stem Cell Transplantation
RATIONALE: Music therapy may be effective in relieving pain and emotional distress in patients who are undergoing cancer therapy.
- Conditions
- Anxiety Disorder, Chronic Myeloproliferative Disorders, Depression, Lymphoma
- Trial name
- NCT00014482
- Testing
- pain therapy, psychosocial assessment and care
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Intervention, Waitlist Control
Qigong and Executive Attention in Older Adults with Depressive Symptoms
The goal of this randomized controlled trial is to test whether executive attention unpacks the antidepressant effect of Baduanjin (a form of health qigong) in older adults.
- Trial name
- NCT06852417
- Testing
- Health qigong training
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Caregiver Burden, Depression
Support for Caregivers of Older Adults With Cognitive Decline
This randomized control study is to test effectiveness of occupational therapy support for informal caregivers of older adults with cognitive decline.
- Conditions
- Caregiver Burden, Depression, Confidence, Self, Cognition
- Trial name
- NCT04787068
- Testing
- Occupational Therapy support
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Depression
DNA-based Dietary Advice for Adults With Depressive Disorders
To evaluate the feasibility of nutrigenomics as an intervention for mental health conditions, a phase I randomized controlled trial of 42 adults (19 to 50 years) with depressive disorders using a 2:1 ratio of group selection (28…
- Trial name
- NCT03310827
- Testing
- Personalized Nutrition
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Karen Davison
Depressive Disorder, Depression
Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)
To assess the long-term safety and tolerability of oral OPC-34712 (brexpiprazole), given in addition to an FDA approved antidepressant (ADT) for the treatment of adults with Major Depressive Disorder (MDD)
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders
- Trial name
- Orion (NCT01360866)
- Testing
- OPC-34712, Escitalopram, Fluoxetine
- Where
- 142 sites in United States, Canada and 9 more
- Volunteers
- 2,944 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Depression, Unipolar, Fall
Integrated Tele-Behavioral Activation and Fall Prevention for Low-income Homebound Seniors With Depression
This study will test clinical and cost effectiveness of an integrated tele- and bachelor's-level counselor/coach delivered behavioral activation (BA) and fall prevention (FP) for low-income homebound older adults.
- Trial name
- TBF (NCT05011864)
- Testing
- Behavioral Activation, Fall Prevention, Telephone support
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- University of Texas at Austin
Delirium
Effectiveness and Safety of a Flexible Family Visitation Model for Delirium Prevention in Adult Intensive Care Units: a Cluster-randomized, Crossover Trial (The ICU Visits Study)
A cluster-randomized crossover trial involving adult ICU patients, family members, and ICU professionals will be conducted. Forty medical-surgical Brazilian ICUs with visiting hours <4.5 h/day will be randomly assigned to either…
- Trial name
- NCT02932358
- Testing
- Flexible Family Visitation Model (FFVM), Restrictive Family Visitation Model (RFVM)
- Where
- 33 sites in Brazil
- Volunteers
- 1,650 people
- Sponsor
- Hospital Moinhos de Vento
Heart Rate Variability, Stress
Effectiveness of Information Technology-Assisted Horticultural Therapy Program on Heart Rate Variability, Stress, Depression and Happiness Among Older Adults Resident in Long-Term Care Facilities
This study aims to address existing research gaps by investigating the effects of technology-assisted horticultural therapy on stress, depression, and happiness among older adults residing in long-term care facilities.
- Conditions
- Heart Rate Variability, Stress, Depression, Happiness
- Trial name
- NCT06797804
- Testing
- Information Technology-Assisted Horticultural Therapy Program
- Where
- Taiwan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder
The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.
The goal of this clinical trial is to test whether a personalized approach to treatment selection improves symptoms in older adults with treatment-resistant depression.
- Conditions
- Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- BAARD (NCT07810738)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation
- Where
- 3 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Post-traumatic Stress Disorder, Depression
Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSD
Post-Traumatic Stress Disorder (PTSD) is a mental disorder that may develop in people who have been exposed to a traumatic event, including actual or threatened death, serious injury, or sexual violence.
- Trial name
- SUMMIT-90 (NCT06141876)
- Testing
- APEX-002-A02
- Volunteers
- 160 people
- Sponsor
- Apex Labs Ltd.
Suicidal Ideation, Social Behavior
Massive Mental Health Screening Using Smartphones in 24 Pre-graduate Education Centers in Mexico City: TEDUCA Survey Protocol
The objective of this study is to make a massive suicide risk and social behavior assessment in 24 pre-graduate education centers in Mexico City (approximately 30,000 students aged between 15 and 22 years), taking also into…
- Conditions
- Suicidal Ideation, Social Behavior, Depression, Depressive Disorder
- Trial name
- TEDUCA (NCT04067076)
- Testing
- Self-administered evaluation questionnaire
- Where
- Mexico
- Volunteers
- 30,000 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Treatment Resistant Depression (TRD), Late Life Depression (LLD)
Lumateperone for Late-Life Depression
The purpose of this research study is to examine how well a medication called lumateperone (Caplyta) works to relieve depression in older adults with treatment-resistant depression. Lumateperone (Caplyta) is approved by the U.S.
- Conditions
- Treatment Resistant Depression (TRD), Late Life Depression (LLD), Depression / Major Depressive Disorder
- Trial name
- IRL Grey-C (NCT07623135)
- Testing
- Lumateperone
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Eric Lenze
Depressive Disorder, Major
A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy
The purpose of this study is to assess the efficacy of flexibly dosed JNJ-42847922 (20 milligram [mg] or 40 mg) compared to flexibly dosed quetiapine extended-release (XR) (150 mg or 300 mg) as adjunctive therapy to an…
- Trial name
- NCT03321526
- Testing
- JNJ-42847922, Quetiapine XR, Selective Serotonin Reuptake Inhibitor (SSRI)
- Where
- 50 sites in United States
- Volunteers
- 107 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder (MDD), Major Depressive Disorder With Anxious Distress
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
This is a randomized, parallel-group, double-blind, placebo-controlled, monotherapy study to evaluate the efficacy, safety, and tolerability of SPT-300 (GlyphAllo) in adults with major depressive disorder (MDD), with or without…
- Trial name
- NCT07065240
- Testing
- SPT-300
- Where
- 61 sites in United States, Bulgaria and 5 more
- Volunteers
- 360 people
- Sponsor
- Seaport Therapeutics
Type 1 Diabetes, Hashimoto Disease
Telehealth Music Therapy for Adults With Endocrine Disorder and Depression
The goal of this clinical trial is to explore if a telehealth music therapy intervention helps with quality of life, depression symptoms, anxiety symptoms. It will also explore the participants' relationship to music.
- Conditions
- Type 1 Diabetes, Hashimoto Disease, Graves Disease, Addison Disease
- Trial name
- NCT07413874
- Testing
- Telehealth Resource Oriented Music Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Appalachian State University
Major Depressive Disorder
Randomised Placebo-controlled Venlafaxine-referenced Study of Efficacy and Safety of 5 and 10 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder in Adults
The purpose of this Venlafaxine-referenced study is to evaluate the efficacy, safety and tolerability of two fixed doses of Vortioxetine in the acute treatment of Major Depressive Disorder (MDD).
- Trial name
- NCT00839423
- Testing
- Vortioxetine (Lu AA21004), Venlafaxine XL
- Volunteers
- 426 people
- Sponsor
- H. Lundbeck A/S
Schizophrenia, Bipolar Disorder
Medication Adherence in Older Adults With Serious Mental Illness
The goal of this pilot study is to learn about how well older people with serious mental illness (including schizophrenia, schizoaffective disorder, bipolar disorder, major depression) follow prescribed medication regimens, and…
- Conditions
- Schizophrenia, Bipolar Disorder, Depression
- Trial name
- NCT00224380
- Testing
- Using Medications Effectively
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Depression
To Demonstrate the Relative Bioavailability of Geneva and Dista (Prozac) 20 mg Fluoxetine Hydrochloride Capsules (Pulvules) In Healthy Adult Males Under Fed and Fasted Conditions
To demonstrate the relative bioavailability of Geneva and Dista (Prozac) 20 mg Fluoxetine Hydrochloride capsules (Pulvules) in healthy adult males under fed and fasted conditions.
- Trial name
- NCT00913588
- Testing
- Fluoxetine HCl 20 mg Capsules Under Fasting Conditions (Geneva Pharmaceutical, Inc.), Fluoxetine HCl 20 mg Capsules Under Fed Conditions (Geneva Pharmaceutical, Inc.), Prozac Fluoxetine HCl 20 mg Capsules Under Fed Conditions (Dista)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sandoz
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