Clinical trials: Adult ICU Patients
Delirium in the Intensive Care Unit
EEG Abnormalities in Adult ICU Patients With High Risk of Delirium
The purpose of this study is to assess the prevalence of EEG abnormalities on Ceribell POC EEG in adult medical, surgical, and cardiovascular ICU patients with high risk of delirium
- Trial name
- NCT07485244
- Testing
- Ceribell EEG System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ceribell Inc.
Adult Patients at High Risk of Sepsis
Serial Measurement of Pancreatic Stone Protein (PSP) for Sepsis Early Detection in ICU Patients
In this study, 250 patients with high-risk of sepsis will be enrolled, including ≥ 50 subjects with confirmed sepsis. Diagnostic criteria for sepsis should meet the Third International Consensus Definitions for Sepsis and Septic…
- Trial name
- NCT07232784
- Testing
- blood sampling
- Where
- 3 sites in China
- Volunteers
- 250 people
- Sponsor
- Fapon Biotech Inc.
Sedation
Expanded Access for Inhaled Isoflurane Delivered Via the Sedaconda ACD-S for Sedation of Difficult-to-Sedate Adult Mechanically Ventilated Intensive Care Unit Patients
The purpose of this Expanded Access Protocol is to provide access to inhaled isoflurane delivered via the Sedaconda ACD-S device for sedation of adult patients in the ICU that are mechanically ventilated and are difficult to…
- Trial name
- NCT07457593
- Testing
- Isoflurane, Sedaconda ACD-S
- Sponsor
- Sedana Medical
Adult Intensive Care Patients
GlySure Acute Care Settings Study
The company who have developed the GlySure product have previously carried out a study to be able to show that the GlySure system is accurate in measuring blood sugar (glucose) levels.
- Trial name
- NCT02421107
- Testing
- Glysure CGM, iStat intermittent testing
- Volunteers
- 40 people
- Sponsor
- GlySure
Bacterial Pneumonia
Cx611-0204 SEPCELL Study
The purpose of this randomised, multicentre, double-blind, placebo-controlled, phase Ib/IIa study is to assess the safety, tolerability and efficacy of eASCs (Cx611) administered intravenously as adjunctive therapy, therefore in…
- Trial name
- SEPCELL (NCT03158727)
- Testing
- Cx611
- Where
- 33 sites in Belgium, France and 4 more
- Volunteers
- 84 people
- Sponsor
- Tigenix S.A.U.
Pneumonia
Study to Demonstrate the Clinical Efficacy of Levofloxacin in the Treatment of Pneumonia
Primary Objective: The primary objective of the study is to demonstrate the non-inferiority in clinical efficacy at the test of cure (TOC) visit planned 5-7 days after treatment completion of levofloxacin 750 mg once daily (od)…
- Trial name
- NCT00253955
- Testing
- Levofloxacin, Piperacillin/Tazobactam
- Where
- 17 sites in Austria, Belgium and 15 more
- Volunteers
- 460 people
- Sponsor
- Sanofi
Blood Glucose
Clinical Study of the Intravenous Blood Glucose System in Hospitalized Adult Elective or Non-Emergent Surgery and Medical/Surgical Intensive Care Unit Patients
The primary objective of this study is to evaluate the performance and safety of the intravenous blood glucose (IVBG) System relative to point of care (POC) meter performance when each method is compared to the Yellow Springs…
- Trial name
- NCT00906490
- Testing
- Intravenous Blood Glucose monitoring system
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Edwards Lifesciences
Blood Glucose Monitoring in Medical ICU
Comparative Study of GlySure Continuous Intra-vascular Glucose Monitoring and Intermittent Monitoring in Medical ICU
It has been shown that close control of blood glucose levels in the intensive care unit patient has benefits for patient morbidity and mortality rates as well as an impact upon discharge times.
- Trial name
- MICU (NCT02142088)
- Testing
- GlySure Intravascular Continuous glucose monitoring sensor
- Volunteers
- 60 people
- Sponsor
- GlySure
Anesthesia
Study of the Efficacy and Safety of Remimazolam in General Anesthesia in Adults Undergoing Cardiac Surgery
This study investigates the use of remimazolam as a sedative/hypnotic in general anesthesia. Remimazolam or propofol will be administered together with fentanyl/sufentanil/remifentanil as opioid analgesics and a neuromuscular…
- Trial name
- NCT02523859
- Testing
- Propofol, Remimazolam
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Paion UK Ltd.
Hyperglycemia
Feasibility Study to Evaluate Safety and Device Performance of the Hospital Glucose Management System (HGMS)
The purpose of this study is to assess safety and device performance of the Medtronic Hospital Glucose Management System (HGMS) for up to 72-hours.
- Trial name
- MAHI (NCT01763567)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Medtronic MiniMed, Inc.
Sedation
Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)
This is a study to compare safety and efficacy of inhaled isoflurane administered via the Sedaconda ACD-S device system versus intravenous propofol for sedation of mechanically ventilated patients in the Intensive Care Unit (ICU)…
- Trial name
- INSPiRE-ICU2 (NCT05327296)
- Testing
- Isoflurane, Propofol
- Where
- 16 sites in United States
- Volunteers
- 282 people
- Sponsor
- Sedana Medical
Post-Intensive Care Syndrome, Sedation
A Pooled Analysis of Long-Term Outcomes After Inhaled Isoflurane Via the Sedaconda ACD-S Compared to Intravenous Propofol
This pooled analysis will assess Cognitive, Mental Health, Functioning, and Quality of Life Assessments data from the Phase 3 registration studies INSPiRE-ICU 1 (NCT05312385) and INSPiRE-ICU 2 (NCT05327296) to explore potential…
- Trial name
- NCT06809218
- Testing
- Inhaled isoflurane administered by Sedaconda ACD-S, Intravenous infusion of propofol
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- Sedana Medical
Acute Respiratory Failure, Coma
EASiVENT Study Comparing INTELLiVENT-ASV vs Non Automated Ventilation in Adult ICU Patients
The purpose of the study is to assess the safety and efficacy of INTELLiVENT-ASV (Adaptive Support Ventilation) in adult ICU patients comparing to non automated ventilation.
- Conditions
- Acute Respiratory Failure, Coma, Acute Respiratory Distress Syndrome (ARDS), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT04400643
- Testing
- INTELLiVENT-ASV, Non-automated ventilation
- Where
- Portugal
- Volunteers
- 62 people
- Sponsor
- Hamilton Medical AG
Critical Illness
Observational Cohort Study on the Use of Parenteral Nutrition and Clinical Outcomes in Adult Critically Ill Patients
The aim of this study is to characterise the use of clinical nutrition support, especially of parenteral nutrition that is administered directly into a vein, in adult patients with critical illness.
- Trial name
- NCT04143503
- Where
- 76 sites in Austria, Belgium and 9 more
- Volunteers
- 1,208 people
- Sponsor
- Fresenius Kabi
Sedation
Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)
This is a study to compare safety and efficacy of inhaled isoflurane administered via the Sedaconda ACD-S device system versus intravenous propofol for sedation of mechanically ventilated patients in the Intensive Care Unit (ICU)…
- Trial name
- INSPiRE-ICU1 (NCT05312385)
- Testing
- Isoflurane, Propofol, Isoflurane (run-ins)
- Where
- 14 sites in United States
- Volunteers
- 277 people
- Sponsor
- Sedana Medical
Continuous Sedation in Initially Sedated Adults in ICU
Dexmedetomidine Versus Propofol for Continuous Sedation in the Intensive Care Unit (ICU)
Patients in the ICU who need help with their breathing are put onto a machine called a ventilator and are also given a medicine, called a sedative, which helps them to sleep and makes them more comfortable.
- Trial name
- Prodex (NCT00479661)
- Testing
- Dexmedetomidine, Propofol
- Where
- 40 sites in Belgium, Finland and 5 more
- Volunteers
- 500 people
- Sponsor
- Orion Corporation, Orion Pharma
General Anesthesia
Remimazolam Phase II Cardiac Anesthesia Study
This phase II study in patients undergoing elective cardiac surgery will evaluate the efficacy, safety, and pharmacokinetics of remimazolam, compared with propofol and sevoflurane, during the induction and maintenance of general…
- Trial name
- NCT01937767
- Testing
- Remimazolam, Propofol, Sevoflurane
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Paion UK Ltd.
Acute Kidney Injury
ProNephro NGAL Test for Early Detection of Acute Kidney Injury in Adult ICU Patients (ALPACA)
The purpose of this study is to evaluate the performance of the ProNephro AKI™ (NGAL) test for identifying critically ill adults at risk of developing moderate to severe acute kidney injury (KDIGO Stage 2/3) within 48 to 72 hours…
- Trial name
- ALPACA (NCT07751913)
- Testing
- ProNephro AKI™ (NGAL)
- Where
- 4 sites in United States
- Volunteers
- 800 people
- Sponsor
- BioPorto Diagnostics
COVID-19, SARS-CoV 2
Efficacy of Intravenous Melatonin on Mortality in Adult Patients Admitted to the Intensive Care Unit With COVID-19
There is an urgent need to evaluate effective treatments for COVID-19 patients. Melatonin has significant anti-inflammatory and antioxidant properties and it lacks of side-effects.
- Conditions
- COVID-19, SARS-CoV 2, Coronavirus Infection
- Trial name
- MELCOVID (NCT04568863)
- Testing
- Melatonin intravenous
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Pharmamel S.L.
Continuous Sedation in Initially Sedated Adults in ICU
Dexmedetomidine Versus Midazolam for Continuous Sedation in the Intensive Care Unit (ICU)
Patients in ICU who need help with their breathing are put onto a machine called a ventilator and are also given a medicine, called a sedative, which helps them to sleep and makes them more comfortable.
- Trial name
- MIDEX (NCT00481312)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 43 sites in Belgium, Estonia and 7 more
- Volunteers
- 501 people
- Sponsor
- Orion Corporation, Orion Pharma