Clinical trials: Adult Intensive Care Patients
Pneumonia
Study to Demonstrate the Clinical Efficacy of Levofloxacin in the Treatment of Pneumonia
Primary Objective: The primary objective of the study is to demonstrate the non-inferiority in clinical efficacy at the test of cure (TOC) visit planned 5-7 days after treatment completion of levofloxacin 750 mg once daily (od)…
- Trial name
- NCT00253955
- Testing
- Levofloxacin, Piperacillin/Tazobactam
- Where
- 17 sites in Austria, Belgium and 15 more
- Volunteers
- 460 people
- Sponsor
- Sanofi
Critically Ill
Impact of SPN on Infection Rate, Duration of Mechanical Ventilation & Rehabilitation in ICU Patients
Rationale: Enteral nutrition (EN) in the intensive care (ICU) patients is recommended as a standard of care. However, EN alone is often associated with insufficient energy intakes and increased complication rates.
- Trial name
- NCT00802503
- Testing
- SPN
- Where
- 2 sites in Switzerland
- Volunteers
- 305 people
- Sponsor
- University Hospital, Geneva
Intensive Care Units, Arterial Lines
Clot Formation and Coagulation Factors Consumption in the Clearing Fluid After Arterial Catheter Blood Sampling.
After blood sampling from an arterial catheter, the reinjection of the clearing fluid (a mixture of saline solution and blood) is proposed to limit blood loss.
- Trial name
- SECU-BIO2 (NCT06349551)
- Testing
- Patients of intensive care unit
- Where
- 2 sites in France
- Volunteers
- 213 people
- Sponsor
- Nantes University Hospital
Patient Care, Quality of Health Care
Comparison of Two Chest Radiograph Prescription Strategies in Intensive Care Unit
Current guidelines recommend Routine daily chest radiographs (CXRs) for mechanically ventilated patients in intensive care units (ICUs).
- Conditions
- Patient Care, Quality of Health Care, Intensive Care Units, Ventilation, Mechanical
- Trial name
- RARE (NCT00893672)
- Where
- France
- Volunteers
- 849 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19, SARS-CoV Infection
Characterization Immunology, Biochemical and Lung Microbiome, Correlated With the Ventilation Associated Pneumonia (VAP)
SARS-CoV-2, the virus that causes COVID-19, is currently a global public health problem, declared a pandemic by the World Health Organization, which today has more than one million deaths in the world, of which , 30,000…
- Trial name
- MicroNAV-II (NCT04944823)
- Testing
- Clinical follow-up for 24 months
- Where
- Colombia
- Volunteers
- 50 people
- Sponsor
- Universidad de la Sabana
Dysphagia
Comparison of Traditional Dysphagia Therapy and Developed Protocol for Dysphagia Patients in Intensive Care Unit
Dysphagia (swallowing disorders) in intensive care unit (ICU) patients is associated with poor outcomes, including aspiration pneumonia, prolonged hospitalization, and increased mortality.
- Trial name
- NCT07005427
- Testing
- dysphagia therapy, Designed protocol for dysphagia
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Intensive Care, Airway Extubation
High-flow Nasal Oxygen Therapy to Prevent Extubation Failure in Adult Trauma Intensive Care Patients
A significant proportion of patients who are intubated for trauma-related injuries, will fail the extubation process. This means that, when the decision has been made to remove the endotracheal tube, a certain proportion of these…
- Conditions
- Intensive Care, Airway Extubation, Critical Care, Oxygen Therapy
- Trial name
- NCT06110390
- Testing
- High flow nasal oxygen
- Where
- Qatar
- Volunteers
- 450 people
- Sponsor
- Hamad Medical Corporation
Hypotension
Early Prediction of ICU Hypotension Using Machine Learning
This prospective observational study aims to develop and internally validate a machine learning model for the early prediction of hypotension in adult intensive care unit patients.
- Trial name
- ICU-HypoAI (NCT07627607)
- Testing
- Routine ICU Data Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Kutahya Health Sciences University
Nutritional and Metabolic Diseases
Smart Phone Application for Enteral Nutrition
Internal medicine resident physicians were provided an ipod with the EN application to assist them in choosing EN formulas for patients during their ICU rotation.
- Trial name
- NCT03419299
- Testing
- Tube Feeding Application
- Volunteers
- 376 people
- Sponsor
- University of Oklahoma
Continuous Sedation in Initially Sedated Adults in ICU
Dexmedetomidine Versus Midazolam for Continuous Sedation in the Intensive Care Unit (ICU)
Patients in ICU who need help with their breathing are put onto a machine called a ventilator and are also given a medicine, called a sedative, which helps them to sleep and makes them more comfortable.
- Trial name
- MIDEX (NCT00481312)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 43 sites in Belgium, Estonia and 7 more
- Volunteers
- 501 people
- Sponsor
- Orion Corporation, Orion Pharma
Seizures
Seizure Identification on the Intensive Care Unit (ICU)
The aim of this project is to assess the ability of different groups of National Heath Service (NHS) professionals to correctly identify clinical seizures, and distinguish them from other movements commonly seen in the ICU…
- Trial name
- NCT07136298
- Testing
- Clinical Opinion
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Age:18-70 Years, Acute Severe Disease
Metabolomics Dynamics Study for Severe Patient
Acute severe disease is a major public health challenge that often affects young adults.In past decade, there are lot of new techniques have been developed that aim to improve the outcome of acute severe disease, But few of these…
- Conditions
- Age:18-70 Years, Acute Severe Disease, Acute Physiology And Chronic Health Evaluation(APACHE)II>10
- Trial name
- NCT02164786
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sichuan Academy of Medical Sciences
Covid19, COVID-19 Pneumonia
The Long Term Effects of COVID on Pulmonary Function
An observational cohort study of patients discharged from the ICU following admission with COVID19 infection, looking at their medical wellbeing 6 months after discharge from the ICU.
- Conditions
- Covid19, COVID-19 Pneumonia, Critical Illness, Quality of Life
- Trial name
- NCT05077982
- Testing
- Spirometry, 6-minute walk
- Where
- 2 sites in Malta
- Volunteers
- 123 people
- Sponsor
- Sciberras, Stephen M.D.
Acute Kidney Injury
Renal Angina Index for Predicting Acute Kidney Injury in Adult ICU Patients
Acute kidney injury (AKI) is a frequent complication of critical illness and is associated with increased morbidity and mortality.
- Trial name
- NCT07863505
- Testing
- Renal Angina Index Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 324 people
- Sponsor
- Izmir Katip Celebi University
Critically Ill Patients
High Protein Intake and Early Exercise in Adult Intensive Care Patients
This study analyse the impact of high protein intake associated to early programed exercise on functional outcomes of adult intensive care patients.
- Trial name
- NCT03469882
- Testing
- High protein nutrition, Cycle ergometry exercise, Usual care group
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Hospital Sao Domingos
Pain, ICU Delirium
Validation of the Polish Version of CPOT
Pain experienced by critically ill patients is a major problem affecting nearly 50% of the patients. Assessing pain in critically ill patients is a challenge even in an intensive care unit (ICU) with a minimal opioid-based…
- Trial name
- POL-CPOT (NCT03024528)
- Testing
- CPOT assessment
- Where
- Poland
- Volunteers
- 71 people
- Sponsor
- Pomeranian Medical University Szczecin
Intracranial Pressure
Wideband Tympanometry for Monitoring Intracranial Pressure in Adult Patients in Intensive Care, Operated on for an Intracranial Lesion After Traumatic Brain Injury, or With Intracranial Hemorrhage
Intracranial pressure is usually measured by invasive methods requiring an intracranial sensor. There is no non-invasive monitoring method recognized as a gold standard.
- Trial name
- TYMPIC (NCT04849221)
- Testing
- Tympanometry measurement in both ears, Collection of clinical and paraclinical data, Intracranial pressure reading (ICP)
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Respiratory Distress Syndrome, Adult
STUDY OF ELECTRICAL STIMULATION IN PULMONARY FUNCTION IN INTENSIVE CARE UNIT
Introduction: The Mechanical Ventilation (MV), a support method used in Intensive Care Units (ICU), reaches approximately 90% of critical patients whose withdrawal process represents 40% of the total time of their use.
- Trial name
- NCT03712215
- Testing
- Rehabilitation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Metodista de Piracicaba
Critical Illness, Obesity & Overweight
Body Roundness Index and Mortality in ICU Patients
This study investigates whether Body Roundness Index (BRI), an anthropometric measure derived from waist circumference and height, can predict mortality in adult intensive care unit (ICU) patients.
- Conditions
- Critical Illness, Obesity & Overweight, Mortality in Intensive Care Units, Body Composition
- Trial name
- BRI-ICU (NCT07631429)
- Where
- Turkey (Türkiye)
- Volunteers
- 550 people
- Sponsor
- Ondokuz Mayıs University
Adult, Intensive Care Unit
Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients
Delirium is common in septic patients, especially those receiving mechanical ventilation in the intensive care unit (ICU). Dexmedetomidine is a highly selective α2 adrenoreceptor agonist with anxiolytic, sedative, analgesic, and…
- Conditions
- Adult, Intensive Care Unit, Sepsis, Mechanical Ventilation
- Trial name
- NCT04876937
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University First Hospital