Clinical trials: Adult Periodontitis
Chronic Periodontitis
Amoxicillin and Metronidazole During Periodontal Treatment
The aim of this multicenter randomized clinical trial is to compare the clinical, microbiological and immunological effects of the adjunctive use of systemic metronidazole plus amoxicillin administered in different phases of the…
- Trial name
- MOMENT (NCT02954393)
- Testing
- Scaling and root planing, Metronidazole active phase, Metronidazole healing phase
- Where
- 2 sites in Brazil
- Volunteers
- 180 people
- Sponsor
- Belén Retamal-Valdes
Periodontal Disease, Chronic Periodontitis (Disorder)
Salivary Mitofusin-1 Levels in Periodontitis: Associations With Disease Severity, Smoking, and Treatment Response
Periodontitis (gum inflammation) is a common disease worldwide. This study aims to investigate a novel biomarker, a protein called Mitofusin-1 (Mfn1), in saliva that may be associated with the severity of periodontitis and…
- Trial name
- NCT07262606
- Testing
- Non-surgical Periodontal Therapy (Scaling and Root Planing), Saliva Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Ömer Faruk Okumuş
Condition, Chronic Periodontitis
Metagenomic Analysis of the Link Between Periodontitis and Smoking: Case-control Study
Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and…
- Trial name
- NCT05995158
- Testing
- Metagenomic testing of the subgingival plaque samples
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Abdulaziz University
Chronic Periodontitis
STUDY ON THE EFFECTS OF PERIODONTAL TREATMENT ALONG WITH THE USE OF ANTIBIOTICS OVER HIGH SENSITIVE C-REACTIVE PROTEIN. RANDOMIZED CONTROLLED CLINICAL TRIAL.
Human periodontitis is a group of highly prevalent oral inflammatory diseases and infections with relatively easy treatment and preventive features.
- Trial name
- NCT01906450
- Testing
- Scaling and root planing plus Azithromycin
- Where
- Colombia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad del Valle, Colombia
Chronic Periodontitis
Clinical Efficacy of 0.75% Boric Acid Gel in Chronic Periodontitis
The purpose of the present study was to evaluate the effects of subgingival delivery of boric acid gel as an adjunct to scaling and root planing in chronic periodontitis (CP) patients.
- Trial name
- NCT02903108
- Testing
- SRP plus boric acid gel
- Where
- India
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Evaluation Efficacy of Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis
This study was conducted to assess the benefit of locally delivered melatonin gel as adjunctive to scaling and root planning (SRP) in the treatment of chronic periodontitis.
- Trial name
- NCT05759416
- Testing
- Melatonin2%gel
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Chronic Periodontitis, Intrabony Periodontal Defect
Clinical and Radiological Effect Of Platelet Rich Fibrin on the Healing of Periodontal Intrabony Periodontal Defects
The aim of this split mouth, single-center, controlled study is to compare the healing of intrabony defects treated with a combination of Anorganic Bovine Bone Mineral (ABBM)/Platelet Rich Fibrin (PRF) or Anorganic Bovine Bone…
- Trial name
- NCT02836314
- Testing
- Anorganic Bovine Bone Mineral (ABBM), Anorganic Bovine Bone Mineral and Platelet Rich Fibrin (PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Baskent University
Chronic Periodontitis
Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets
This study will determine whether the supplemental use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD)…
- Trial name
- NCT02316652
- Testing
- Scaling and root planing, Scaling and root planing with solution
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Chronic Periodontitis
Comparison Between Two Non-surgical Periodontal Treatment Procedures With and Without Interdental Hygiene Devices in Periodontitis Patients: a Longitudinal Prospective Controlled Clinical Trial
Periodontitis is treated by regularly clearance of the disease-causing biofilm through domestic care and dental measures (Petersilka et al., 2002, Herrera et al., 2008).
- Trial name
- NCT04339309
- Testing
- Non-surgical periodontal treatment with interdental hygiene devices, Non-surgical periodontal treatment without interdental hygiene devices
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Adult
Clinical Efficacy of NST With Adjunctive Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis.
The aim of this clinical trial is to evaluate the effectiveness of local delivery ozonated olive gel versus curcumin gel as adjunct to scaling and root planing in the treatment of stage II grade B periodontitis in on both males…
- Trial name
- NCT07184268
- Testing
- full mouth non-surgical scaling
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis
Hyaluronic Acid With Scaling & Root Planing In Chronic Periodontitis Patients With Diabetes Mellitus Type 2
The present study aimed to assess the adjunctive use of Hyaluronic acid with scaling \& root planing (SRP) in patients with chronic periodontitis \& diabetes mellitus type 2.
- Trial name
- NCT03807596
- Testing
- Periodontal treatment with Hyaluronic acid associated with SRP, Scaling & root planning alone
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Periodontitis, Adult
Full Mouth Ultrasonic Debridement Carried Out With Either Piezoelectric or Magnetostrictive Device
The treatment of periodontitis requires the removal of dental biofilm through both professional mechanical plaque removal and at-home oral hygiene practices.
- Trial name
- NCT06934291
- Testing
- Full-mouth ultrasonic debridement with piezoelectric device (EMS, mini piezon), Full-mouth ultrasonic debridement with magnetostrictive device (Cavitron Select, Dentsply)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- University of Siena
Chronic Periodontitis
Evaluation of Indian Gooseberry/ Amla in the Management of Chronic Periodontitis
This study aimed to evaluate the influence of amla (Emblica officinalis) on patients with chronic generalized periodontitis, using a single-blind, randomized controlled study design. 1.
- Trial name
- NCT07531823
- Testing
- Scaling and root planing + Amla, Scaling and root planing
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Mahatma Gandhi Postgraduate Institute of Dental Sciences
Periodontal Regeneration
Amnion Chorion Membrane Combined With Allograft Bone Putty for the Management of Intrabony Defects
The ultimate goal for periodontal management is to obtain true periodontal regeneration. Periodontal regeneration implies that CAL gain is achieved through the formation of new cementum and new inserted periodontal ligaments…
- Trial name
- NCT05922527
- Testing
- Combined regenerative technique, Open flap debridement
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Combat and Operational Stress Reaction
Role of Stress Reduction Protocol on Outcome of Periodontal Therapy
Psychological conditions, particularly psychosocial stress, have been implicated as risk indicators for periodontal disease. Minimal evidence in literature exists to assess the effect of stress reduction therapy (SRT) in the…
- Trial name
- NCT02487862
- Testing
- Stress Reduction Protocol
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Chronic Periodontitis
Relationship Between Chronic Periodontitis and Vitamin D and Calcium in Men
Objective: The objective was to evaluate whether serum vitamin D and calcium concentrations are associated with chronic periodontitis in Syrian men Methods: This study designed as "Matched Case-Control Study".200 males will be…
- Trial name
- NCT02127346
- Where
- Syria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Damascus University
Chronic Periodontitis
Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis
Periodontal disease is an immune-inflammatory disease which consists of connective tissue breakdown, loss of attachment, and alveolar bone loss.In normal physiology, there is an equilibrium maintained between reactive oxygen…
- Trial name
- NCT03533972
- Testing
- Ashwagandha
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Periodontal Diseases
Asprosın And Tumor Necrosıs Factor-α Levels In Type 2 Dıabetıc Chronıc Periodontitis
Periodontal disease is a chronic, multifactorial inflammatory disease in which biochemical and cellular events trigger each other, leading to the destruction of the tissues supporting the teeth .
- Trial name
- NCT06993818
- Testing
- Gingival Crevicular Fluid, Serum Asprosin
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Eda Cetin Ozdemir
Chronic Periodontitis
Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis
The investigators evaluated the effect of initial periodontal treatment on clinical findings and receptor activator of Nuclear Factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) of patients…
- Trial name
- NCT02808988
- Testing
- periodontal phase 1 therapy, gingival crevicular fluid collection, zoledronic acid
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Chronic Periodontitis
Effect of a Locally Delivered Probiotic in Periodontitis
Saccharomyces boulardii is commonly employed as a live non-pathogenic probiotic microbial feed or food supplement. S. boulardii reduces the secretion of key pro inflammatory cytokines and promotes the production of…
- Trial name
- NCT02645669
- Testing
- Study site, Control site
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences