Clinical trials: Adult Periodontitis
Preterm Labor, Periodontitis
Inflammatory Cytokines in GCF and Placental Tissues in Chronic Periodontitis Patients With Preterm Delivery
Investigators have shown the presence of elevated proinflammatory cytokines in amniotic fluid in patients in preterm labor.However, there is limited and mostly negative evidence that the elevation of these mediators in gingival…
- Trial name
- NCT02521688
- Testing
- incisional biopsy from placenta and GCF sample
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chronic Periodontitis, Intrabony Periodontal Defect
Beta-Tricalcium Phosphate and Concentrated Growth Factors in Treatment of Intra-bony Defect Randomized Clinical Trial
This clinical study aimed to evaluate the efficacy of biodegradable gelatin sponge loaded with Beta-tricalcium phosphate socked in concentrated growth factors in the treatment of periodontal intra-bony defects, as compared with…
- Conditions
- Chronic Periodontitis, Intrabony Periodontal Defect, Concentrated Growth Factors
- Trial name
- RCT (NCT04698317)
- Testing
- open flap debridement, use of Biodegradable Gelatin Sponge loaded with Beta-tricalcium Phosphate plus concentrated growth factors, use of Biodegradable Gelatin Sponge loaded with Beta-tricalcium Phosphate alone
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Chronic Periodontitis
Comparison of Alendronate With Atorvastatin in Chronic Periodontitis
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical efficacy of two local drug delivery systems containing 1% ALN gel and 1.2% ATV gel in treatment of…
- Trial name
- NCT02455869
- Testing
- SRP and Atorvastatin, SRP and Alendronate
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontal Diseases, Oral Health Literacy
Oral Health Literacy and Periodontal Status Among Turkish Adults
This observational cross-sectional study aimed to investigate the association between oral health literacy (OHL) and periodontal status among adult individuals attending Biruni University Faculty of Dentistry, Istanbul, Türkiye.
- Conditions
- Periodontal Diseases, Oral Health Literacy, Periodontitis, Health Behaviour
- Trial name
- NCT07341945
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Biruni University
Smoking, Cigarette
Smoking and Peptidoglycan Recognition Protein-1 and Initial Periodontal Therapy
A total of 40 patients with CP (20 smokers (S+CP) and 20 nonsmokers (S-CP)) and 40 periodontally healthy subjects (20 smokers (S+PH) and 20 nonsmokers (S-PH)), comprising 80 subjects, were included in this study.
- Trial name
- NCT03915730
- Testing
- Initial periodontal therapy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Chronic Periodontitis, Periodontal Bone Loss
Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.
The aim of this study is to compare the effectiveness in periodontal regeneration of cross-linked hyaluronic acid at 1.8% (Hyadent BG®) with enamel matrix derivative (Emdogain®) in periodontal bone defects evaluating their…
- Trial name
- NCT04274244
- Testing
- Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML, Enamel Matrix Proteins (Active comparator group)
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- Andres Lopez Roldan
Chronic Periodontitis
Alendronate Compared to Metformin in Chronic Periodontitis
This is a 9 month randomised controlled clinical comparing the clinical efficacy of 1%metformin and 1%alendronate in chronic periodontitis subjects.
- Trial name
- NCT02461667
- Testing
- SRP plus Alendronate gel, SRP plus Metformin gel
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Mild and Moderate Chronic Periodontitis
Effect of Probiotic Lozenge on Gingivitis and Periodontitis
The oral cavity is mostly influenced by general health. The oral microbiota which is as complex as the gastro-intestinal or vaginal microbiota are considered to be difficult therapeutic targets.
- Trial name
- NCT02203812
- Testing
- Probiotic Arm
- Where
- India
- Volunteers
- 32 people
- Sponsor
- CD Pharma India Pvt. Ltd.
Chronic Periodontitis, Periodontal Pocket
Autologous Fibrin Glue Application as an Adjunct to Nonsurgical Periodontal Treatment of Chronic Periodontitis
Chronic periodontitis is an inflammatory and polymicrobic disease characterized by the irreversible loss of alveolar bone and connective tissue attachment of the teeth.
- Conditions
- Chronic Periodontitis, Periodontal Pocket, Periodontal Attachment Loss, Periodontal Diseases
- Trial name
- NCT04082949
- Testing
- autologous fibrin glue application as an adjunct to nonsurgical periodontal treatment of chronic periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Inonu University
Pulpitis, Apical Periodontitis
Validation of PUFA Index in Assessing Untreated Dental Caries Among Malaysian Adult Subpopulation
PUFA Index was introduced to detect the clinical consequences of untreated dental caries. To date, there are no studies on the reliability and accuracy of the PUFA index as a screening tool.
- Trial name
- NCT04126928
- Testing
- Screening using DMFT and PUFA, orthopantomogram is taken and assessed using PAI, comprehensive clinical examination to diagnose pulpal and periapical conditions.
- Where
- Malaysia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Chronic Periodontitis
Role of Herbal Immunomodulators in the Treatment of Chronic Periodontitis
Addition of systemic herbal immunomodulators with scaling \& root planing (SRP) may enhance the therapeutic result of Chronic Periodontitis owing to host modulation \& anti-inflammatory properties.
- Trial name
- Septilin (NCT01997814)
- Testing
- herbal immunomodulator
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Intrabony Defect, Intrabony Defects in Chronic Periodontitis
Treatment of Intrabony Defect in Patient With Periodontitis Stage III by Using I-PRF and Xenograft
Evaluate of the injectable platelet rich fibrin (I-PRF) with xenograft in Intrabony defects of Periodontitis patient stage III versus Xenograft alone.
- Trial name
- NCT07261878
- Testing
- injectable platelet rich fibrin and xenograft, Xenograft alone
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Chronic Periodontitis, Aggressive Periodontitis
Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis
The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses.
- Conditions
- Chronic Periodontitis, Aggressive Periodontitis, Presence / Absence of EBV
- Trial name
- NCT01246596
- Testing
- dental root planing
- Where
- France
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Periodontal Diseases
Effect of Ozone Gel on Treatment of Chronic Periodontitis
To evaluate the efficacy of locally delivered ozone gel as an adjunct to conventional periodontal therapy on selected clinical parameters as well as alveolar bone density (BD) and superoxide dismutase (SOD) activity in patient…
- Trial name
- NCT02066337
- Testing
- scaling and root planing, Ozonated olive oil gel
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- October 6 University
Chronic Periodontitis
Effectiveness of Locally Delivered Morus Alba Gel on Moderate Periodontitis
Background: Periodontitis is a chronic inflammatory disease of tooth and supporting tissues with clinical signs of bone and connective tissue loss and is mediated by a combination of periodontal pathogens and host defense…
- Trial name
- NCT03475394
- Testing
- Chlorhexidine gel, Morus alba gel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- KLE VK Institute of Dental Sciences
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Chronic Generalized Periodontitis
Moxifloxacin in Situ Gel to Treat Periodontal Pocket.
In this Randomized clinical trial locally delivered moxifloxacin in situ gel was evaluated as an adjunct to scaling and root planing for efficacy in the treatment of chronic periodontitis and for short-term effects on the…
- Trial name
- NCT02016157
- Testing
- Moxifloxacin
- Where
- India
- Volunteers
- 5 people
- Sponsor
- Sri Hasanamba Dental College and Hospital
Periodontitis
Release of Cytokines by Stimulated Peripheral Blood Mononuclear Cells (PBMC) From Chronic Periodontitis Subjects
Background and Objective: It has been reported that peripheral blood mononuclear cells (PBMC) from periodontal patients have a different profile of cytokine release when compared to the ones of healthy patients.
- Trial name
- NCT00990041
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Escola Bahiana de Medicina e Saude Publica
Periodontitis, Adult
Locally Delivered Minocycline in Advanced Periodontitis
Local drug delivery provides higher concentrations in the availability of the drug at the specific infected sites with the advantage of sustained release.
- Trial name
- NCT04076098
- Testing
- Minocycline Hydrochloride
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahsa University
Chronic Periodontitis, Diabetes Mellitus, Type 2
Clinical and Microbiological Evaluation of Periodontal Treatment of Diabetic Patients: A Longitudinal Study
The purpose of this study is to determine whether periodontal treatment improves the periodontal clinical parameters in the periodontal patients with diabetes regarding non-diabetics: two years follow-up.
- Trial name
- NCT02643771
- Testing
- Full Mouth Scaling and Root Planing
- Where
- Brazil
- Volunteers
- 144 people
- Sponsor
- Eduardo Aleixo Figueira