Clinical trials: Adult Spinal Deformity, active
Friedreich Ataxia, Cardiomyopathies
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ATI-105 in Healthy Adults
The goal of this clinical trial is to learn how ATI-105 administered to healthy participants at works in the body at different doses and with or without food.
- Conditions
- Friedreich Ataxia, Cardiomyopathies, Central Nervous System Diseases, Neuromuscular Diseases
- Trial name
- NCT07869654
- Testing
- ATI-105
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Adjuvia Therapeutics, Inc.
Spinal Deformity, Degenerative Lumbar Spinal Stenosis
Tranexamic Acid in Adult Spinal Deformity Surgery
Posterior spinal surgery for adult deformity is associated with high incidence of blood loss and need for blood transfusion and intraoperative blood salvage, with associated increased cost and risk for perioperative…
- Conditions
- Spinal Deformity, Degenerative Lumbar Spinal Stenosis, Blood Loss, Surgical
- Trial name
- NCT03553186
- Testing
- Tranexamic Acid 100 MG/ML
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hospital for Special Surgery, New York
Degenerative Spine Disease, Spinal Stenosis Lumbar
VR-Cognitive Behavioral Therapy Prehabilitation for Spinal Deformity Surgery
The goal of this clinical trial is to learn whether a virtual reality-based cognitive behavioral therapy (VR-CBT) prehabilitation program can improve recovery and quality of life for adults undergoing elective spine surgery.
- Trial name
- VR-CBT (NCT07777679)
- Testing
- Virtual Reality-Based CBT Prehabilitation (VR-CBT), CBT Prehabilitation without Virtual Reality
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Irvine
Spina Bifida, Self Esteem
Psychosocial Teleassistance Programme for Adults With Spina Bifida
This clinical trial assesses the effect of a telecare psychosocial intervention designed for adults with spina bifida. The intervention consists of 10 weekly 1.5-hour group sessions, followed by two 3-month follow-up sessions.
- Conditions
- Spina Bifida, Self Esteem, Quality of Life (QOL), Self Concept
- Trial name
- NCT07178873
- Testing
- Psychosocial teleassistance intervention
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- University of Deusto
Adult Spinal Deformity
Essential Amino Acid Supplementation in Adult Spinal Deformity Patients
This will be a randomized double-blind placebo controlled clinical trial to determine if supplementing with essential amino acids (EAAs) for two weeks prior to, and 3 months after corrective spinal surgery in adults with spinal…
- Trial name
- NCT07341399
- Testing
- Essential Amino Acid Supplement by Amino Co
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arkansas
Proximal Junctional Kyphosis
Efficacy of Sub-laminar and/or Interspinous Tethers to Prevent Proximal Junctional Kyphosis After Surgical Correction of Adult Spinal Deformity
PJK (proximal junctional kyphosis) at the upper end of spinal fusions after surgical correction of adult spinal deformity is not uncommon.
- Trial name
- TRANSITION (NCT07618897)
- Testing
- Tether strategy, Reference
- Where
- 6 sites in France
- Volunteers
- 128 people
- Sponsor
- Hospices Civils de Lyon
ASD, Scoliosis Idiopathic Adolescent
Quality of Life, Psychosocial Burden, and Structural-functional Status in Adults With Spinal Deformity.
This study examines which factors influence quality of life in adults with a spinal deformity. It looks at imaging findings together with pain, daily functioning, psychosocial factors, and frailty to support more person-centred…
- Conditions
- ASD, Scoliosis Idiopathic Adolescent, Scoliosis Idiopathic Adolescent Treatment
- Trial name
- ASD-QoL (NCT07749534)
- Testing
- first corrective surgery, Reoperation
- Where
- Belgium
- Volunteers
- 320 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Degenerative Disc Disease, Degenerative Scoliosis
Clinical Outcome Measure at Stryker Spine
This is a multicenter, prospective, retrospective, Post Market Clinical Follow-up (PMCF) study in subjects who have undergone or will undergo surgery utilizing one or more Stryker devices according to Stryker cleared Instructions…
- Trial name
- COMPASS (NCT06226272)
- Testing
- Spinal Fusion, Spinal Deformities Correction
- Where
- 7 sites in United States
- Volunteers
- 5,222 people
- Sponsor
- VB Spine, LLC
Adult Spinal Deformity Surgery
SALVAGE Trial (Safety And cLinical Value of AutoloGous rEinfusion)
The investigator hypothesizes intraoperative salvaged red blood cells are a poor substitute for allogenic packed red blood cell transfusions.
- Trial name
- SALVAGE (NCT07712666)
- Testing
- Cell Saver
- Volunteers
- 146 people
- Sponsor
- Mayo Clinic
Adult Spinal Deformity, Sagittal Deformity
A Novel Classification of Sagittal Spinal Alignment to Aid Surgical Planning for Adult Spinal Deformity
Surgical outcomes, including radiographic outcomes, patient-reported outcomes, postoperative complications, and revision surgery rates, were compared in patients with adult spinal deformity who underwent correction surgery with…
- Conditions
- Adult Spinal Deformity, Sagittal Deformity, Sagittal Alignment, Sagittal Imbalance
- Trial name
- CSSAASD (NCT06470152)
- Testing
- Correction strategy in reference to our PI-dependent clustering of sagittal alignment, Correction strategy in reference to the SAAS score
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Spinal Muscular Atrophy, Spinal Muscular Atrophy Type II
Spinraza in Adult Spinal Muscular Atrophy
This is a longitudinal, observational study of adult patients with genetically confirmed chromosome 5q SMA to examine the safety, tolerability, and effectiveness of SPINRAZA® (nusinersen) for up to 30 months.
- Conditions
- Spinal Muscular Atrophy, Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy Type 3
- Trial name
- SAS (NCT03709784)
- Testing
- Observational study to examine safety, tolerability, and effectiveness of SPINRAZA® prescribed as part of standard of care, One time survey
- Where
- 11 sites in United States, Canada
- Volunteers
- 148 people
- Sponsor
- Washington University School of Medicine
Neuromuscular Diseases, Obesity (Disorder)
Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology
The ActiLiège-Adult study is a prospective, longitudinal, observational study designed to collect natural history data on adult patients with neurological or metabolic diseases affecting movement.
- Conditions
- Neuromuscular Diseases, Obesity (Disorder), Myotonic Dystrophy 1, Myasthenic Syndrome
- Trial name
- Acti-Adult (NCT07136844)
- Testing
- Syde, Dynamometric measurements of muscle strength, The 6-minute walk test (6MWT)
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Spinal Deformity
Prospective, Multi-Center Adult Spinal Deformity Outcomes Database Registry
The clinical, radiographic, and HRQL outcomes will be compared in operative and nonoperative adult spinal deformity patients.
- Trial name
- PON (NCT00738439)
- Where
- 9 sites in United States
- Volunteers
- 1,999 people
- Sponsor
- International Spine Study Group Foundation
Recurrent Adult Tethered Cord Syndrome
A Randomized Controlled Trial for Surgical Treatment of Recurrent Adult Tethered Cord Syndrome
This trial compares detethering surgery and spinal column shortening surgery, two treatments for adults with recurrent tethered cord syndrome (TCS), a neurological disorder where the spinal cord becomes abnormally attached to…
- Trial name
- NCT06197399
- Testing
- Detethering Surgery, Spinal Column Shortening Surgery
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Xuanwu Hospital, Beijing
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Adult Spinal Deformity, Wireless Continuous Vital Signs Monitoring
Feasibility of Wireless Continuous Vital Sign Monitoring and Impact on Patients Undergoing Adult Spinal Surgery in a General Ward
The goal of this feasibility study is to explore the use of wireless continuous vital sign monitoring in an orthopaedic setting among orthopaedic nurses and patients undergoing adult spinal deformity surgery.
- Conditions
- Adult Spinal Deformity, Wireless Continuous Vital Signs Monitoring, Wireless Vital Signs Monitoring System, Acceptability
- Trial name
- NCT07105189
- Testing
- Wireless monitoring
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Spinal Deformity, Bone Graft
Prospective i-FactorTM Analysis Fusion Rate and Quality of Life
Adult spinal deformity surgery is a complex procedure that involves many risks and complications. Bone grafts and bone substitutes are essential to achieve fusion and manage stability in spinal surgery.
- Conditions
- Spinal Deformity, Bone Graft, Fusion Rate, Quality of Life
- Trial name
- NCT04610021
- Testing
- i-FactorTM Bone graft
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Complejo Asistencial Universitario de León Urgencias
Spinal Deformity
Intraoperative Alignment in Adult Spinal Deformity Surgery
The purpose of this study is to conduct a prospective study which assesses the utility of the ATEC Intraoperative Alignment (IOA) Imaging Platform tool in intraoperative imaging for patients undergoing adult spinal deformity…
- Trial name
- NCT07416565
- Testing
- ATEC IntraOperative Alignment (IOA) Imaging Platform, Standard 36" cassette imaging, EOS radiographs
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy
High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project
The primary objective is to demonstrate, in a population of chronic neuromuscular disease the non-inferiority of a rehabilitation treatment integrated with robotic and/or technological devices compared to traditional…
- Conditions
- Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy, Charcot-Marie-Tooth Disease
- Trial name
- Fit4MR-ChrMND (NCT06881979)
- Testing
- High-tech rehabilitative treatment, Rehabilitation
- Where
- 7 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Adult Spinal Deformity, Scoliosis
Complex Adult Deformity Surgery (CADS)
Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors…
- Conditions
- Adult Spinal Deformity, Scoliosis, Kyphosis, Sagittal Imbalance
- Trial name
- CADS (NCT04194138)
- Testing
- Index or spine revision surgery for complex adult spinal deformity
- Where
- 18 sites in United States, Canada
- Volunteers
- 1,500 people
- Sponsor
- International Spine Study Group Foundation