Clinical trials: Adult Spinal Deformity
Spinocerebellar Ataxias, Spinocerebellar Ataxia Genotype Type 1
Trial in Adult Participants With Spinocerebellar Ataxia (SCA)
The primary purpose of this study was to compare the efficacy of BHV-4157 (Troriluzole) 140 milligrams (mg) once daily versus placebo after 8 weeks of treatment in participants with spinocerebellar ataxia (SCA).
- Conditions
- Spinocerebellar Ataxias, Spinocerebellar Ataxia Genotype Type 1, Spinocerebellar Ataxia Genotype Type 2, Spinocerebellar Ataxia Genotype Type 3
- Trial name
- NCT02960893
- Testing
- Troriluzole
- Where
- 18 sites in United States
- Volunteers
- 141 people
- Sponsor
- Biohaven Pharmaceuticals, Inc.
Cerebral Palsy, Brain Injuries
The LETS Study: A Longitudinal Evaluation of Transition Services
This project will describe and evaluate the impact of a unique partnership model designed to coordinate transfer of care by formally linking pediatric and adult heath care services.
- Conditions
- Cerebral Palsy, Brain Injuries, Spinal Dysraphism
- Trial name
- LETS (NCT00975338)
- Testing
- LIFEspan, Non-LIFEspan
- Where
- 2 sites in Canada
- Volunteers
- 149 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Friedreich Ataxia
Study to Evaluate Multiple Ascending Dose and Multi-Dose of DT-216 in Adult Patients With Friedreich Ataxia
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic, and pharmacodynamic effects of multiple doses of intravenous DT-216 in adult patients with Friedrich Ataxia.
- Trial name
- NCT05573698
- Testing
- DT-216
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Design Therapeutics, Inc.
Spine Deformity, Adult Scoliosis
The Effect of Peloidotherapy in Young Adults Undergoing Physical Therapy Scoliosis Specific Exercises (PSSE)
Scoliosis is a musculoskeletal disorder defined by a three-dimensional spinal deformity that can result in substantial clinical and functional limitations, particularly during adolescence and young adulthood.
- Conditions
- Spine Deformity, Adult Scoliosis, Peloidotherapy
- Trial name
- NCT07459400
- Testing
- Adult Scoliosis Study Form, Scoliosis graphy, Visuel Aanalog Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Perioperative Anemia, Surgery
The Effects of Ferric Derisomaltose on Postoperative Anemia in Spinal Deformity Surgery
The prognosis of patients undergoing spinal deformity surgery is often compromised by perioperative anemia due to iron deficiency.
- Conditions
- Perioperative Anemia, Surgery, Spinal Deformity, Adult
- Trial name
- NCT05714007
- Testing
- Ferric derisomaltose, Ferrous succinate
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Pedicle Screw, Surgical Navigation Systems
Performance Measurement and Safety Evaluation of the PYTHEAS® ODYSSEE Angular Assistance System for Intra-pedicular Screw Placement in Adult Spine Surgery
Pedicle screw malposition is a common problem for spine surgeons. A poorly placed screw can lead to potentially serious complications (hemorrhage, paralysis) in the short- or medium-term.
- Trial name
- ODYSSEE (NCT05565131)
- Testing
- Guided placement with PYTHEAS® ODYSSEE
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Spinocerebellar Ataxia
Coordination Training With Complete Body Video Games in Children and Adults With Degenerative Ataxias
Exergame training might offer a novel treatment approach even in largely nonambulatory subjects with multisystemic degenerative spinocerebellar ataxia.
- Trial name
- Move'n Fun (NCT02874911)
- Testing
- General training
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
Spinal Deformity
Research of Factors Determining the Improvement of Quality of Life at One Year of Adult Patients Treated for Spinal Deformity (COFTASD)
The objective of this study is to find the predictive factors of improvement of the quality of life of operated patients from spinal deformity.
- Trial name
- COFTASD (NCT05108948)
- Testing
- Quality of life questionnaires, Radiography
- Where
- France
- Volunteers
- 866 people
- Sponsor
- Elsan
Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1
Troriluzole in Adult Participants With Spinocerebellar Ataxia
The purpose of this study is to compare the efficacy of Troriluzole (200 mg once daily) versus placebo after 48 weeks of treatment in subjects with spinocerebellar ataxia (SCA).
- Conditions
- Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3
- Trial name
- NCT03701399
- Testing
- troriluzole
- Where
- 23 sites in United States, China
- Volunteers
- 299 people
- Sponsor
- Biohaven Pharmaceuticals, Inc.
Idiopathic Scoliosis, Spinal Curvatures
UNiD Rods Register
Retro-prospective study allowing inclusion of patients with spinal deformities treated by patient-specific rods (UNiD). This study aims to assess performance, clinical outcomes and safety
- Conditions
- Idiopathic Scoliosis, Spinal Curvatures, Spondylolisthesis, Degenerative Scoliosis
- Trial name
- NCT02926404
- Testing
- UNiD Rods
- Where
- 13 sites in Belgium, France and 1 more
- Volunteers
- 743 people
- Sponsor
- Medicrea International
ASD, Scoliosis Idiopathic Adolescent
Quality of Life, Psychosocial Burden, and Structural-functional Status in Adults With Spinal Deformity.
This study examines which factors influence quality of life in adults with a spinal deformity. It looks at imaging findings together with pain, daily functioning, psychosocial factors, and frailty to support more person-centred…
- Conditions
- ASD, Scoliosis Idiopathic Adolescent, Scoliosis Idiopathic Adolescent Treatment
- Trial name
- ASD-QoL (NCT07749534)
- Testing
- first corrective surgery, Reoperation
- Where
- Belgium
- Volunteers
- 320 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Neurofibromatosis 2, Vestibular Schwannoma
Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors
The purpose of this study is to determine if Lapatinib has any effect on tumors found in patients with Neurofibromatosis Type 2 (NF2). NF2 is a condition that mainly affects the skin and nervous system.
- Trial name
- NCT00973739
- Testing
- Lapatinib
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Spinal Deformity
Cost Effectiveness of Nonoperative Management for Adult Spinal Deformity
Quantify the efficacy and cost of nonoperative treatment modalities used for adult spinal deformity.
- Trial name
- HEO (NCT01880164)
- Where
- 10 sites in United States
- Volunteers
- 21 people
- Sponsor
- Shay Bess
Kyphoscoliosis
Indication and Treatment of Adult Kyphoscoliosis
Degeneration, iatrogenic-/idiopathic causes and fractures can lead to kypho- scoliotic deformities potentially resulting in pain and loss of function.
- Trial name
- INTRAKS (NCT04536909)
- Testing
- Non-surgical, Surgical
- Where
- 5 sites in Japan, Norway and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Spinal and Bulbar Muscular Atrophy, Kennedy's Disease
A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Of AJ201 In Patients
This is a phase 1/2a randomized, double-blind study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of study drug AJ201 in subjects with Spinal and Bulbar Muscular Atrophy (SBMA).
- Trial name
- NCT05517603
- Testing
- AJ201
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- AnnJi Pharmaceutical Co., Ltd.
Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy
High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project
The primary objective is to demonstrate, in a population of chronic neuromuscular disease the non-inferiority of a rehabilitation treatment integrated with robotic and/or technological devices compared to traditional…
- Conditions
- Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy, Charcot-Marie-Tooth Disease
- Trial name
- Fit4MR-ChrMND (NCT06881979)
- Testing
- High-tech rehabilitative treatment, Rehabilitation
- Where
- 7 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Spina Bifida
Telemedicine in Spina Bifida Transition: A Pilot Study
The purpose of this study is to explore the feasibility and efficacy of using telemedicine to improve transition from pediatric to adult care in patients with spina bifida.
- Trial name
- NCT03466996
- Testing
- Intervention group, Standard of care group
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
Scoliosis, Unspecified
Single Versus Dual Spine Attending Surgeons in Complex Adult Deformity Surgery:
Two recent studies showed that having two attending spine surgeons performing complex adult spine deformity surgery instead of one, decreased complications, unplanned surgeries within 30-days [Ames], 90-day readmissions, wound…
- Trial name
- NCT02703831
- Testing
- Dual attending, Single Attending
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Norton Leatherman Spine Center
Scoliosis, Quality of Life
Assessing the Quality of Life in Adults With Spinal Deformity
Spinal deformities, such as scoliosis, can have a significant impact on the physical and psychological health of patients. Over time, specific tools for this condition have been developed to investigate the extent of this impact…
- Trial name
- NCT05333757
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Scientifico Italiano Colonna Vertebrale
Spine Deformity
A Prospective Randomized Study on the Clinical Benefits of OrthoPAT Drains
The examination of the ability of the OrthoPAT® blood collection device to decrease the transfusion rate and volume of adults undergoing posterior spine surgery for deformity correction of 6 levels or more.
- Trial name
- NCT02286102
- Testing
- OrthoPAT, Constavac
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York