Clinical trials: Adults With Overweight and Obesity
Overweight , Obesity, Adults
Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss
A study of ALV-100 to assess efficacy, safety and tolerability among participants with overweight or obesity who have previously achieved a body weight reduction of ≥10% while treated with incretin-based therapies.
- Trial name
- PRESERVE (NCT07837973)
- Testing
- ALV-100
- Where
- 20 sites in United States
- Volunteers
- 220 people
- Sponsor
- Alveus Therapeutics, Inc.
Obesity, Overweight
A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
This study will investigate the efficacy and safety of once daily oral orforglipron in adult participants with obesity or overweight with weight-related comorbidities.
- Conditions
- Obesity, Overweight, Overweight or Obesity
- Trial name
- ATTAIN-1 (NCT05869903)
- Testing
- Orforglipron
- Where
- 138 sites in United States, Brazil and 8 more
- Volunteers
- 3,127 people
- Sponsor
- Eli Lilly and Company
Obesity
Impact of Whey and Soy Protein Ingestion in Conjunction With Energy Restriction in Overweight/Obese Individuals
It is known that dieting (restricted energy intake) without resistance training leads to a reduced metabolic rate, and the loss of both fat and muscle mass.
- Trial name
- NCT01530646
- Testing
- Weight loss, Soy, Whey
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity & Overweight, Foot and Ankle Disorders
Effects of Whole-Body Vibration With Foot Core Exercises: A Randomized Controlled Trial
This randomized, single-blind clinical trial investigates whether adding whole-body vibration (WBV) to a supervised foot core exercise program improves ankle muscle strength, balance, and proprioception in overweight and obese…
- Trial name
- FoCo-WBV (NCT07556198)
- Testing
- Supervised Foot Core Exercise Training (No Vibration), Whole-Body Vibration via DKN Technology Xg-10 Pro
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Istinye University
Chronic Weight Management
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Two Formulations of ASC36 Injection in Participants With Obesity or Overweight
This randomized, double-blind, placebo-controlled single ascending dose (SAD)/ multiple ascending dose (MAD) study is designed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of Two Formulations of…
- Trial name
- NCT07893093
- Testing
- ASC36 Injection A, for subcutaneous use, ASC36 Injection B, for subcutaneous use
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- Ascletis Pharma (China) Co., Limited
Obesity & Overweight
Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults
This is a phase 2 randomized, double-blind, placebo-controlled, multi-center study evaluating the efficacy and safety of LUM-201 plus Semaglutide versus Semaglutide plus placebo in obese adults with body mass index between 30 and…
- Trial name
- NCT07754045
- Testing
- LUM-201, Semagludtide
- Volunteers
- 202 people
- Sponsor
- Lumos Pharma
Obesity, Adolescent
Young Adults With Early-onset Obesity Treated With Semaglutide
Introduction: The increasing prevalence of obesity is particularly pronounced among adolescents. Currently available treatment options consist of structured lifestyle interventions.
- Trial name
- RESETTLE (NCT05574439)
- Testing
- TCOC treatment, Semaglutide 3 mg/ml
- Where
- 2 sites in Denmark
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Signe Torekov
Type 2 Diabetes, Hypertension
NUTRITION MATTERS: A Food is Medicine Intervention for African-American Adults With Multiple Chronic Conditions
African Americans have higher rates of diabetes, obesity, heart disease, and high blood pressure. In addition, middle-aged non-Hispanic Black adults develop multiple chronic conditions (MCCs) at an earlier age, which share most…
- Conditions
- Type 2 Diabetes, Hypertension, Obesity and Obesity-related Medical Conditions, Heart Disease
- Trial name
- NCT06933940
- Testing
- Nutrition Matters
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Winston Salem State University
Knee Osteoarthritis, Stochastic Resonance Therapy-Whole Body Vibration
Comparing Whole-Body Vibration vs. Balance Board Exercise for Pain, Function, and Quality of Life in Obese Adults With Knee Osteoarthritis
Background: Osteoarthritis (OA) is a joint disease commonly found in the knee. Therapeutic exercise has been known as the most common therapy to treat OA, however, therapy only focuses on reducing symptoms, not on treatment of…
- Conditions
- Knee Osteoarthritis, Stochastic Resonance Therapy-Whole Body Vibration, Obesity, Balance Board
- Trial name
- NCT07568691
- Testing
- Stochastic Resonance Therapy-Whole Body Vibration, Balance Board
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Universitas Indonesia
Aging, Adults With Overweight and Obesity
Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in Adults With a Metabolically Challenging Profile
Early-onset metabolic disturbances (such as mild hyperglycemia, subclinical dyslipidemia, excess body fat, and reduced functional capacity) represent one of the major public health challenges among middle-aged and older adults.
- Conditions
- Aging, Adults With Overweight and Obesity, Supplementation, Exercise
- Trial name
- NCT07504068
- Testing
- Group 1: Exercise + thermogenic supplement (EX-TS)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- University of Valencia
Chronic Weight Management
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC35 Injection in Participants With Obesity or Overweight
This randomized, double-blind, placebo-controlled single ascending dose (SAD)/ multiple ascending dose (MAD) study is designed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ASC35 injection
- Trial name
- NCT07842640
- Testing
- ASC35 Injection B, for subcutaneous use, Tirzepatide
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharma (China) Co., Limited
Obesity, Weight Management
A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH)
The aim of the study is to compare the efficacy and safety of XW003 injection versus semaglutide injection in Chinese adults with obesity
- Trial name
- NCT07073417
- Testing
- XW003 injection, semaglutide injection
- Where
- China
- Volunteers
- 163 people
- Sponsor
- Hangzhou Sciwind Biosciences Co., Ltd.
Metabolic Disturbance
Exercise, Gut Microbiota in Sedentary Adults With Overweight
This project offers the opportunity to obtain detailed measurements on the health of body composition, metabolic health, and intestinal microbial diversity in overweight adults; moreover to provide information about the effects…
- Trial name
- NCT03515642
- Testing
- HIIT group
- Where
- Colombia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Dietary Supplement
To Evaluate the Post-Prandial Metabolic Effects of Oligomalt in Adults With T2D and in HAO
The goal of this mechanistic, exploratory study is to compare the effectiveness of Oligomalt to Glucidex 40 after eating in adults with Type 2 Diabetes (T2D) and in otherwise healthy adults with overweight or obesity (HAO).
- Trial name
- LORIS-02 (NCT05963594)
- Testing
- Oligomalt, maltodextrin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Professional Role, Physical Activity
Are Women With Higher Professional Status More Sedentary Compared to Men?
It is aimed to understand the gender differences on factors affecting the resting metabolic rate of people in different professional status.
- Conditions
- Professional Role, Physical Activity, Obesity, Education
- Trial name
- NCT03587233
- Testing
- Physical assessment, Analyses of body composition, physical activity level assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istinye University
Obesity & Overweight
BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or Obesity
The goal of this clinical trial is to evaluate the efficacy and safety of Bofanglutide (GZR18) compared with Semaglutide in Latin American adults with overweight or obesity.
- Trial name
- NCT07622810
- Testing
- Bofanglutida, Semaglutide
- Where
- 6 sites in Mexico
- Volunteers
- 352 people
- Sponsor
- Carnot Laboratories
Body Weight
Health Effects of Substituting Sugary Beverages With Artificially-sweetened Beverages or Water
Sugar-sweetened beverages (SSBs) contribute an alarming ~7% of calories in the US diet among adults, making SSBs the single largest source of added sugar.
- Trial name
- SUB-POP (NCT04567108)
- Testing
- Maintain usual SSBs, Substitute to non-SSBs, Study app
- Where
- United States
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Overweight and Obesity
Effectiveness and Safety of Semaglutide Combined With Dietary Fiber (Soloways) in Adults With Overweight or Obesity
This clinical trial investigated the combined effects of Semaglutide and a fiber supplement (glucomannan, inulin, psyllium) on weight loss in adults with overweight or obesity.
- Trial name
- ESSENCE (NCT06215196)
- Testing
- Fiber Supplement Group
- Where
- Russia
- Volunteers
- 81 people
- Sponsor
- S.LAB (SOLOWAYS)
Overweight , Obesity, Obesity (Disorder)
Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity
Tirzepatide is one of the new medications for the treatment of obesity. In clinical research people treated with Tirzepatide have weight loss up to 21%.
- Trial name
- TIRZ-DOSE-NL (NCT07504172)
- Testing
- Tirzepatide
- Where
- 10 sites in Netherlands
- Volunteers
- 915 people
- Sponsor
- Radboud University Medical Center
Prader-Willi Syndrome, Hypothalamic Obesity
Tirzepatide in PWS, HO and GNSO
This research study is comparing the effectiveness of a weight loss medication called Tirzepatide in young adults with Prader-Willi Syndrome and/or hypothalamic obesity, as compared to young adults with obesity that is unrelated…
- Conditions
- Prader-Willi Syndrome, Hypothalamic Obesity, Obesity/Therapy
- Trial name
- NCT06901245
- Testing
- Tirzepatide
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Grace Kim