Clinical trials: Adults With Overweight and Obesity
Type 2 Diabetes, Metabolic Health
Effect of Prebiotics in Saudi Adults With Type 2 Diabetes
This study will explore how a natural food ingredient called oligofructose affects blood glucose levels, lipid profiles, inflammation biomarkers, and gut bacteria in Saudi adults with type 2 diabetes.
- Conditions
- Type 2 Diabetes, Metabolic Health, Inflammation, Gut Microbiome
- Trial name
- NCT07464691
- Testing
- oligofructose
- Where
- Saudi Arabia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Princess Nourah Bint Abdulrahman University
Metabolic Syndrome, Pre-diabetes
Effect of Pasteurized Akkermansia Muciniphila on Insulin Resistance in Otherwise Healthy Subjects With Dysglycaemia
The purpose of this study is to demonstrate the efficacy of pasteurized Akkermansia muciniphila (pAKK) in improving insulin sensitivity in hyperglycaemic, but otherwise healthy persons with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Pre-diabetes, Overweight and Obesity
- Trial name
- NCT05114018
- Testing
- Pasteurized A. muciniphila
- Where
- 2 sites in Germany, Ireland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- A-Mansia Biotech S.A.
Obesity, Overweight
A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes
This study will investigate the safety and efficacy of once daily oral treatment with orforglipron compared with placebo on body weight in adult participants with obesity or overweight and type 2 diabetes.
- Conditions
- Obesity, Overweight, Type 2 Diabetes
- Trial name
- ATTAIN-2 (NCT05872620)
- Testing
- Orforglipron
- Where
- 136 sites in United States, Argentina and 9 more
- Volunteers
- 1,613 people
- Sponsor
- Eli Lilly and Company
Obesity & Overweight, Depression Disorders
Physical Activity for Depressive Symptoms in Adults With Obesity: A Randomized Controlled Feasibility Trial
The goal of this clinical trial is to learn whether a supervised physical activity program can be successfully carried out for adults living with obesity and depression, and whether people are willing to take part in this kind of…
- Trial name
- NCT07836582
- Testing
- Supervised Physical Activity Program
- Where
- 3 sites in Canada
- Volunteers
- 26 people
- Sponsor
- Universite du Quebec en Outaouais
Obesity, Overweight
A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes
The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with obesity or overweight and with type 2 diabetes.
- Conditions
- Obesity, Overweight, Diabetes Mellitus, Type 2
- Trial name
- NCT07215559
- Testing
- Macupatide, Eloralintide
- Where
- 42 sites in United States, Argentina and 2 more
- Volunteers
- 200 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes, Obesity
A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk.
- Conditions
- Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight
- Trial name
- ACHIEVE-4 (NCT05803421)
- Testing
- Orforglipron, Insulin Glargine
- Where
- 358 sites in United States, Argentina and 14 more
- Volunteers
- 2,749 people
- Sponsor
- Eli Lilly and Company
Obesity, Overweight
A Study to Evaluate the Change in Weight After 24 Weeks Treatment With LIK066 in Obese or Overweight Adults
This was a dose-finding study that evaluated the change in weight after 24 weeks treatment with 8 different doses of LIK066 compared to placebo in obese or overweight adults, followed by 24 weeks treatment with 2 doses of LIK066…
- Trial name
- NCT03100058
- Testing
- LIK066
- Where
- 83 sites in United States, Austria and 5 more
- Volunteers
- 460 people
- Sponsor
- Novartis Pharmaceuticals
Overweight (BMI > 25), Obesity (Body Mass Index >30 kg/m2)
Real-World Two-Year Weight Loss Outcomes With Breath Biofeedback
The goal of this retrospective observational study is to evaluate the real-world durability of weight loss among adults with overweight or obesity who used the Key to Health breath-biofeedback mHealth program.
- Conditions
- Overweight (BMI > 25), Obesity (Body Mass Index >30 kg/m2), Obesity & Overweight
- Trial name
- NCT07430618
- Testing
- Breath acetone biofeedback device with mHealth program
- Where
- Canada
- Volunteers
- 11,524 people
- Sponsor
- University of British Columbia
Obesity, Overweight
A Study to Evaluate the Effects of Enicepatide in Participants With Obesity or Overweight, With or Without Type 2 Diabetes
The purpose of this study is to assess the efficacy and safety of enicepatide, a dual glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA) being developed for chronic weight…
- Conditions
- Obesity, Overweight, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- NCT07670416
- Testing
- Enicepatide
- Where
- 21 sites in China
- Volunteers
- 300 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus, Type 2, Hypertension
The Effect of Progressive Resistance Exercise Training (PRET) on CVRF in Adults With ID.
Thanks to improved healthcare, the life expectancy of people with ID is increasing and is approaching that of the general population.
- Conditions
- Diabetes Mellitus, Type 2, Hypertension, Hypercholesterolemia, Obesity
- Trial name
- PRET (NCT06579898)
- Testing
- Progressive resistance exercise training
- Where
- 3 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- Erasmus Medical Center
Chronic Weight Management
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC36 Tablets for Oral Use in Adult Participants With Obesity or Overweight
This is a randomized, placebo-controlled, double-blind, single and multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect of ASC36 Tablets for Oral Use in Adult…
- Trial name
- NCT07893106
- Testing
- ASC36 tablets, for oral use
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Ascletis Pharma (China) Co., Limited
Overweight, Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD)
A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease （MAFLD）
This is a multicenter, randomized, open-label Phase 3 clinical study comparing the efficacy and safety of IBI362 9 mg QW versus Semaglutide 2.4 mg QW in overweight or obese (BMI≥27kg/m2) MAFLD subjects.
- Trial name
- NCT06884293
- Testing
- IBI362, semaglutide
- Where
- China
- Volunteers
- 479 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Obesity Prevention, Obesity
External Body Weight Effects on Body Weight in Adults With Grade II and III Obesity
Obesity is a growing problem in industrialized societies. This condition is associated with an increase in metabolic and cardiovascular diseases.
- Trial name
- NCT06619028
- Testing
- Weighted vest
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Escoles Universitaries Gimbernat
Overweight and Obese Adults
Behavioral Weight Loss and Sleep Health Intervention
This is a 6-month single-arm pilot and feasibility study designed to examine if a behavioral weight loss (BWL) intervention with an added sleep health program (BWL+SLEEP) can achieve clinically meaningful weight loss and…
- Trial name
- DREAM (NCT07255287)
- Testing
- BWL+Sleep
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Colorado, Denver
Overweight and Obesity
Texting for Mobility in Overweight/Obese Adults With Peripheral Artery Disease
By doing this study, researchers hope to learn about the feasibility of using a mobile application to help overweight or obese adults with PAD increase their walking distance and lose weight.
- Trial name
- NCT03694652
- Testing
- PACE, Diet, App
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Kansas Medical Center
Overweight and Obesity
The Effect of Supplementation With Species of Lactobacillus on Anthropometric Measurements
The investigators aimed to study the effect of supplementation with species of Lactobacillus on anthropometric measurements, body composition, appetite and serum lipid profile in overweight and obese adults
- Trial name
- NCT02448940
- Testing
- Species of Lactobacillus, lactose
- Where
- Iran
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Urmia University of Medical Sciences
Low Back Pain, Obesity
Resistance Exercise Effects on Fear Avoidance and Physical Function in Obese Older Adults With Low Back Pain
The purpose of this study is to determine if a 4 month resistance exercise program reduces the severity of low back pain, pain-related fear avoidance and improves mobility compared to standard care.
- Trial name
- NCT01250262
- Testing
- normal medical care and follow up, Isolated Lumbar Resistance Exercise Program, Total Body Resistance Exercise Program
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Florida
Obesity
Home-Based Circuit Training in Adults With Obesity
Obesity is associated with impaired vascular function, metabolic dysfunction, and reduced physical fitness, which increase cardiovascular disease risk.
- Trial name
- HBCT (NCT07619612)
- Testing
- Home-Based Circuit Training
- Where
- Thailand
- Volunteers
- 29 people
- Sponsor
- Chulalongkorn University
Breast Cancer
4:3 Intermittent Fasting Intervention in Adults With Breast Cancer and Overweight or Obesity
This is a 3 month single arm pilot and feasibility study designed to examine the impact of an intermittent fasting lifestyle weight loss intervention on pre-specified clinical milestones (change in body weight, adherence to the…
- Trial name
- NCT06399276
- Testing
- Weight Loss
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Obesity
Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity
In this trial, the aim is to assess the clinical benefits and harms, as well as cost-effectiveness of an intensive weight loss (IWL) intervention that includes total dietary replacements, behavioural support and weight-loss…
- Trial name
- LightWAY (NCT06321458)
- Testing
- Intensive weight loss intervention, Usual care
- Where
- 14 sites in Denmark, United Kingdom
- Volunteers
- 605 people
- Sponsor
- Carsten Dirksen