Clinical trials: Adults With Overweight and Obesity
Obesity, Sleep
A Sleep Extension Pilot Study in Adults With Obesity
The pilot study will test the feasibility of a 16-week sleep extension intervention, in adults with obesity, to increase nighttime sleep duration, as well as reduce daytime sleepiness and sleep-related disturbance.
- Conditions
- Obesity, Sleep, Weight, Body, Eating Behavior
- Trial name
- NCT05747105
- Testing
- Sleep Extension
- Where
- United States
- Sponsor
- University of Pennsylvania
Obesity, Overweight
Taldefgrobep Alfa in Adults With Overweight and Obesity
This is a multicenter, randomized, double-blind, placebo-controlled, multiple dose study to evaluate the efficacy, safety, and tolerability of taldefgrobep alfa in adults with overweight and obesity, with an open-label extension.
- Trial name
- NCT07281495
- Testing
- Taldefgrobep Alfa
- Where
- 20 sites in United States
- Volunteers
- 150 people
- Sponsor
- Biohaven Therapeutics Ltd.
Obesity, Overweight and/or Obesity
A Study to Learn About Berobenatide Given Once Weekly in Adults With Knee Osteoarthritis and Overweight or Obesity With or Without Type 2 Diabetes (VESPER-OA 2)
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity with and without type 2 diabetes.
- Conditions
- Obesity, Overweight and/or Obesity, Knee Osteoarthritis, Diabetes Melliuts, Type 2
- Trial name
- NCT07915609
- Testing
- Berobenatide
- Where
- 4 sites in United States
- Volunteers
- 756 people
- Sponsor
- Pfizer
Obesity
Time Restricted Eating for Weight Loss Maintenance
The aim of this pilot feasibility and acceptability, randomized clinical trial will be to examine the effects of two-time restricted eating (TRE) interventions on weight loss maintenance (WLM).
- Trial name
- TWIST (NCT05742165)
- Testing
- Time Restricted Eating (TRE)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- NYU Langone Health
Obesity, NAFLD
Study of NGM395 in Adult Participants
Study of NGM395 in adult participants.
- Trial name
- NCT04187339
- Testing
- NGM395
- Where
- Australia
- Volunteers
- 38 people
- Sponsor
- NGM Biopharmaceuticals, Inc
Atherosclerosis, Cardiovascular Disease
A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event
The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased…
- Conditions
- Atherosclerosis, Cardiovascular Disease, Obesity, Hypertension
- Trial name
- CLARITY-CRP (NCT07783802)
- Testing
- Clazakizumab
- Where
- 46 sites in United States, Argentina and 2 more
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
Diabetes, Obesity
A 12-WEEK TITRATE STUDY TO EVALUATE SAFETY, TOLERABILITY AND PHARMACODYNAMICS OF PF-06882961 IN ADULTS WITH TYPE 2 DIABETES MELLITUS AND IN NON-DIABETIC ADULTS WITH OBESITY
This study will assess tolerability, safety, and pharmacodynamics (PD) of twice daily (BID) administration of PF- 06882961 in adult participants with Type 2 Diabetes Mellitus (T2DM) who are treated with metformin and in…
- Trial name
- NCT04617275
- Testing
- PF-06882961
- Where
- 38 sites in United States
- Volunteers
- 151 people
- Sponsor
- Pfizer
Alcohol Use Disorder (AUD), Overweight or Obese
Tirzepatide Combined With Cognitive-Behavioural Therapy (CBT) for Adults With Alcohol Use Disorder (AUD) and Overweight/Obesity (OOB)
The investigators approach is to conduct a Phase II Double-Blind randomised controlled trial with individuals with co-occurring Alcohol Use Disorder and overweight/obesity (AUD-OOB) to receive either a sub-cutaneous injection of…
- Conditions
- Alcohol Use Disorder (AUD), Overweight or Obese, Comorbidities and Coexisting Conditions
- Trial name
- NCT07292519
- Testing
- Tirzepatide, Take Control CBT Module
- Where
- Australia
- Volunteers
- 46 people
- Sponsor
- South West Sydney Local Health District
Overweight or Obesity Without Diabetes
Efficacy And Safety of Olatorepatide in Adults With Overweight or Obesity Without Diabetes
This study will test olatorepatide (study drug) to determine whether it can help treat overweight or obesity. In this study we will test how safe and how well olatorepatide works compared to placebo in people who are overweight…
- Trial name
- RISE-1 (NCT07896265)
- Testing
- Olatorepatide
- Volunteers
- 3,000 people
- Sponsor
- Regeneron Pharmaceuticals
Overweight and Obesity
Online Dietary Weight Loss Program for Arab Adults: A Randomized Controlled Trial
This study is testing whether a culturally adapted online dietary and lifestyle program can help Arab adults in Saudi Arabia lose weight and improve their overall health.
- Trial name
- NCT07518875
- Testing
- Online Lifestyle and Dietary Program, Usual Dietary Care
- Where
- Saudi Arabia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Asma Yahya
Healthy Subjects;Overweight or Obesity
A Phase 1 Study of GZC8072 Tablets Following a Single Dose in Healthy Study Participants and Multiple Doses in Obese/Overweight Study Participants
This trial is conducted in China. This study plans to include 2 parts, i.e., a single-dose study and a multiple-dose study: The single-dose study will be conducted in healthy adult participants to evaluate the safety…
- Trial name
- NCT07784699
- Testing
- GZC8072 Tablets
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Gan & Lee Pharmaceuticals.
Obesity, Overweight
Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults With Type 2 Diabetes Mellitus
This study will determine whether resting beta cells (cells in the pancreas that produce insulin) for 2 weeks will improve the ability of patients with Type 2 diabetes mellitus (T2DM) to make insulin.
- Conditions
- Obesity, Overweight, Diabetes Mellitus, Type 2
- Trial name
- NCT00445627
- Testing
- Metformin, Insulin, Nutrition counseling
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Overweight and Obesity in Adults Receiving GLP-1RA Treatment
Yeast Protein Supplementation and Muscle Preservation During GLP-1RA-Induced Weight Loss
The goal of this clinical trial is to evaluate whether yeast protein supplementation can help preserve lean body mass and muscle function in adults with overweight or obesity receiving GLP-1 receptor agonist-related treatment for…
- Trial name
- NCT07817823
- Testing
- Yeast Protein, Whey Protein, Yeast Protein/Whey Protein Blend (1:1)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huazhong University of Science and Technology
Schizophrenia, Schizoaffective Disorder
Lifestyle Intervention for Young Adults With Serious Mental Illness
This is a four year project evaluating the effectiveness of a group-based lifestyle intervention (PeerFIT) supported by mobile health (mHealth) technology and social media compared to Basic Education in fitness and nutrition…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT02815813
- Testing
- PeerFIT, BEAT
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Obesity
A Study to Evaluate ALN-2232 in Participants With Obesity
The purpose of this study is to: evaluate the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending doses of ALN-2232 in patients with obesity evaluate the safety, tolerability…
- Trial name
- NCT07463846
- Testing
- ALN-2232, Tirzepatide
- Where
- Canada
- Volunteers
- 156 people
- Sponsor
- Alnylam Pharmaceuticals
Hyperlipidaemia, Hyperlipidemia
Nigella Sativa Supplementation in Hyperlipidemia Treatment
Hyperlipidemia is defined as an elevation of plasma cholesterol, lipid, or lipoprotein levels above normal due to abnormal fat metabolism or function, and individuals with hyperlipidemia are approximately twice as likely to…
- Trial name
- NCT06890546
- Testing
- Nigella Sativa Oil capsule, Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istanbul Bilgi University
Overweight (BMI > 25), Obesity &Amp; Overweight
Effects of Three Dietary Strategies on Body Composition and Metabolic Health in Adults With Overweight or Obesity
This study aims to compare the effects of three dietary interventions-a traditional Mediterranean diet, a Mediterranean low-carbohydrate diet, and a high-protein diet-on body composition, metabolic health markers, and metabolic…
- Conditions
- Overweight (BMI > 25), Obesity &Amp; Overweight, Metabolic Syndrome (MetS), Cardiometabolic Risk Factors
- Trial name
- NCT07314177
- Testing
- Mediterranean Diet, Mediterranean Low-Carbohydrate Diet, High-Protein Diet
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Overweight, Obesity
A Study Collecting Remote Data in People With an Overweight Condition or Obesity on a Weight Management Program
The purpose of this study is to collect health data related from participants living with an overweight condition in a decentralised clinical study set-up.
- Trial name
- NCT06805539
- Testing
- No treatment given
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Novo Nordisk A/S
Time Restricted Feeding, Intermittent Fasting
Effects of Early and Delayed Time-restricted Eating in Adults With Overweight and Obesity
Time-restricted eating (TRE) is a dietary approach that aims to increase fasting time and decrease the eating window. Promising TRE effects on weight loss and some cardiometabolic risk factors have been reported.
- Conditions
- Time Restricted Feeding, Intermittent Fasting, Obesity, Overweight and Obesity
- Trial name
- NCT04647149
- Testing
- Dietary Approach
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Weight Loss
Does Meal Replacement With a Carbohydrates and Protein Supplement Induce Weight Loss in Overweight and/or Obese Adults?
Participants will be randomized into two groups, one group will be the control (no intervention at all) and the other will be CHO-PRO (meal replacement, Generation UCAN supplement, 400ml, 20% solution).
- Trial name
- NCT04458493
- Testing
- satiety, Dietary Supplement: Generation UCAN supplementation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Western University, Canada