Clinical trials: Adults With Overweight and Obesity
Obesity, Diabetes Mellitus, Type 2
Behavior Intervention for Weight Loss for Type 2 Diabetes Mellitus Adults With Obesity Problem (BMI of ≥23kg/m2)
This quasi-experimental study aims to determine the effectiveness of a health intervention (Chance2Act) on behaviour change to act for weight loss among overweight/obese type 2 diabetes adults.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Behavior
- Trial name
- BMI (NCT05736536)
- Testing
- Chance2Act
- Where
- 2 sites in Malaysia
- Volunteers
- 104 people
- Sponsor
- Universiti Teknologi Mara
Obesity, Multiple Chronic Conditions
Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults
This study seeks to answer the fundamental questions of which initial, first-line weight loss intervention should be offered to older adults with obesity and multiple chronic conditions and how to address the high non-response…
- Trial name
- NCT06044571
- Testing
- Prescriptive, Behavioral
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of North Carolina, Chapel Hill
Metabolic Syndrome, Overweight and Obesity
Effects of Early and Late Time-restricted Eating on Overweight Adults With Metabolic Syndrome
Investigators aim to compare the effects of early and late time-restricted feeding on overweight adults with metabolic syndrome
- Conditions
- Metabolic Syndrome, Overweight and Obesity, Time Restricted Eating
- Trial name
- NCT06018415
- Testing
- Early time-restricted eating (eTRE), Late time-restricted eating (lTRE)
- Where
- China
- Volunteers
- 103 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Time Restricted Feeding, Intermittent Fasting
Effects of Early and Delayed Time-restricted Eating in Adults With Overweight and Obesity
Time-restricted eating (TRE) is a dietary approach that aims to increase fasting time and decrease the eating window. Promising TRE effects on weight loss and some cardiometabolic risk factors have been reported.
- Conditions
- Time Restricted Feeding, Intermittent Fasting, Obesity, Overweight and Obesity
- Trial name
- NCT04647149
- Testing
- Dietary Approach
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Obesity, Weight Loss
Obesity Treatment With a Very Low Energy Diet in Mexican Adults
Clinical practice guidelines recommend behavioral change protocols for obesity treatment, such as the Diabetes Prevention Program, which involves a low-energy diet, physical activity recommendations, behavioral therapy, and…
- Trial name
- NCT05631535
- Testing
- Intensive lifestyle change program with a very-low-energy diet, Intensive lifestyle change program with a low-energy diet
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Universidad de Sonora
Overweight and Obesity
Evaluation of the Plant-based Approaches to Stop Obesity Diet for the Treatment of Overweight and Obesity
The accumulation of excess of body weight is one of the most important problems worldwide, thus effective and accessible treatments are required.
- Trial name
- PASO diet (NCT03608176)
- Testing
- PASO diet group, Low-fat diet group, Waiting list group
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Universidad de Sonora
Obesity & Overweight, Foot and Ankle Disorders
Effects of Whole-Body Vibration With Foot Core Exercises: A Randomized Controlled Trial
This randomized, single-blind clinical trial investigates whether adding whole-body vibration (WBV) to a supervised foot core exercise program improves ankle muscle strength, balance, and proprioception in overweight and obese…
- Trial name
- FoCo-WBV (NCT07556198)
- Testing
- Supervised Foot Core Exercise Training (No Vibration), Whole-Body Vibration via DKN Technology Xg-10 Pro
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Istinye University
Diabetes Mellitus, Type 2 Diabetes
Improving Glycemic Control Using a Virtual Weight Control Program and Continuous Glucose Monitoring
This study is a randomized clinical trial with the primary aim examining the efficacy of a novel integrated solution of a digitally delivered behavioral weight management program tailored for diabetes utilizing a continuous…
- Conditions
- Diabetes Mellitus, Type 2 Diabetes, Obesity
- Trial name
- VITAL-CGM (NCT05935514)
- Testing
- WW Intervention, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 152 people
- Sponsor
- Pennington Biomedical Research Center
Insulin Resistance, Impaired Glucose Tolerance
Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL)
The purpose of this study is to investigate the effects of a fibre mixture added to a high-protein diet on metabolic, gut and brain health.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, PreDiabetes, Overweight and Obesity
- Trial name
- DISTAL (NCT05354245)
- Testing
- Fibre supplement (potato-pectin), High-protein diet
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Overweight (BMI > 25), Obesity &Amp; Overweight
Effects of Three Dietary Strategies on Body Composition and Metabolic Health in Adults With Overweight or Obesity
This study aims to compare the effects of three dietary interventions-a traditional Mediterranean diet, a Mediterranean low-carbohydrate diet, and a high-protein diet-on body composition, metabolic health markers, and metabolic…
- Conditions
- Overweight (BMI > 25), Obesity &Amp; Overweight, Metabolic Syndrome (MetS), Cardiometabolic Risk Factors
- Trial name
- NCT07314177
- Testing
- Mediterranean Diet, Mediterranean Low-Carbohydrate Diet, High-Protein Diet
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Obesity, Food Addiction
Probiotic Intervention Study
The current standard of care for obesity is the optimal management of comorbid conditions such as diabetes and hyperlipidemia, and counseling on diet, weight loss, or increased physical activity programs.
- Trial name
- NCT06030362
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity, Adolescent
Young Adults With Early-onset Obesity Treated With Semaglutide
Introduction: The increasing prevalence of obesity is particularly pronounced among adolescents. Currently available treatment options consist of structured lifestyle interventions.
- Trial name
- RESETTLE (NCT05574439)
- Testing
- TCOC treatment, Semaglutide 3 mg/ml
- Where
- 2 sites in Denmark
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Signe Torekov
Obesity, Physical Inactivity
Exercise Snacks Enabled by an mHealth Intervention Delivered in General Practice to Promote a Sustainable Active Lifestyle in Adults With Obesity
Adults with obesity gain as much from regular physical activity as anyone else, but structured exercise programmes are hard to sustain once the programme ends.
- Conditions
- Obesity, Physical Inactivity, Sedentary Behavior
- Trial name
- SnackFIT (NCT07867665)
- Testing
- Exercise snacks programme, Conversational agent, Wrist-worn activity tracker
- Where
- 3 sites in Czechia
- Volunteers
- 306 people
- Sponsor
- Charles University, Czech Republic
Overweight , Obesity, Obesity (Disorder)
Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity
Tirzepatide is one of the new medications for the treatment of obesity. In clinical research people treated with Tirzepatide have weight loss up to 21%.
- Trial name
- TIRZ-DOSE-NL (NCT07504172)
- Testing
- Tirzepatide
- Where
- 10 sites in Netherlands
- Volunteers
- 915 people
- Sponsor
- Radboud University Medical Center
Gout, Obesity (BMI>30)
Mazdutide for Weight Management and Gout in Adults With Obesity
This is a single-arm, open-label, pre-post controlled study to evaluate the effect of Mazdutide on the annualized flare rate (AFR) in adults with obesity and gout.
- Conditions
- Gout, Obesity (BMI>30), Hyperuricemia, Metabolic Syndrome
- Trial name
- NCT07824895
- Testing
- Mazdutide
- Volunteers
- 30 people
- Sponsor
- Hongwei Jiang
Obesity & Overweight, Adult Congenital Heart Disease
Effect of Tirzepatide on Cardiovascular and Metabolic Parameters in Obese Adult Patients With Congenital Heart Disease
Several drugs have been shown effective in the treatment of obesity, with concomitant favourable cardiovascular effects. Today, there are no studies on novel anti-obesity drugs in patients with adult congenital heart disease…
- Trial name
- TEACH (NCT07354880)
- Testing
- Treatment with tirzapatide
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Central Obesity
Effectiveness of High-intensity Interval Training (HIIT) Versus Moderate-intensity Continuous Training (MICT) in Reducing Visceral Fat in Adults With Central Obesity
Obesity is a major risk factor for cardiovascular disease and diabetes as well as all-cause mortality. The prevalence of obesity has continuously increased in most countries and has doubled in over 70 countries since 1980.
- Trial name
- NCT04545320
- Testing
- Usual care control group, HIIT group, MICT group
- Where
- Hong Kong
- Sponsor
- The University of Hong Kong
Overweight or Obesity
Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes
This study will test an experimental drug called olatorepatide ("study drug") to determine how safe and effective this drug is compared to placebo and how easily the body can accept this drug at different doses and dosing…
- Trial name
- NCT07685808
- Testing
- Olatorepatide
- Where
- 21 sites in United States
- Volunteers
- 360 people
- Sponsor
- Regeneron Pharmaceuticals
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Obesity, Stigma, Social
Brief mHealth Self-Compassion Intervention on Internalized Weight Bias
The proposed investigation is an experimental trial among 80 adults with obesity and internalized weight bias to determine preliminary effects of a smartphone-delivered brief self-compassion mindfulness intervention on…
- Trial name
- ruby (NCT04678973)
- Testing
- Self-compassion mindfulness practice
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University