Clinical trials: Advanced Age
Healthy
MOS Prebiotic Potential in Older Adults
Mannooligosaccharides (MOS) derived from baker's yeast may have prebiotic properties such as improving gastrointestinal function.
- Trial name
- NCT05939336
- Testing
- Mannooligosaccharides yeast extract
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aging, Age Related Hearing Loss
Cognitive Training to Improve Mobility in Middle-aged and Older Adults
The proposed study is designed to evaluate the effect of at-home executive function training on cognition and mobility in older adults with age-related hearing loss (ARHL), older adults with normal hearing, and middle-aged adults.
- Trial name
- HnW (NCT05418998)
- Testing
- Executive function (EF) training
- Where
- Canada
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal
Influenza
Immunogenicity, Safety and Tolerability of Two Doses of FLUAD-H5N1 Influenza Vaccine in Adult and Elderly Subjects
This study is designed to evaluate the immunogenicity, safety and tolerability of 2 doses of FLUAD-H5N1 vaccine compared to 2 doses of trivalent, interpandemic FLUAD, each administered 3 weeks apart.
- Trial name
- NCT00434733
- Testing
- Pandemic influenza vaccine
- Where
- Poland
- Volunteers
- 4,400 people, healthy volunteers welcome
- Sponsor
- Novartis
Pressure Ulcer, Pressure Injury
Pressure Ulcer Incidence Cat. II+ on a Static Air Mattress: a Multicenter Cohort Study in Nursing Home Residents at Risk
Pressure Ulcers are a serious and common problem for residents admitted to long-term care facilities and community care patients.
- Conditions
- Pressure Ulcer, Pressure Injury, Pressure Sore, Bed Sore
- Trial name
- NCT03725787
- Testing
- CuroCell S.A.M. ® pro mattress
- Where
- 8 sites in Belgium
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University Ghent
Ageing, Blood Flow Restriction
Comparing Vascular Responses to Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults
Aging leads to declines in functional capacity and effort tolerance. Muscle strength remains stable from ages 25 to 50 but declines significantly after age 60, affecting activities like stair climbing and walking, reducing…
- Trial name
- HOLD TIGHT (NCT06596304)
- Testing
- Low intensity-resistance training with lower limb blood flow restriction, High Intensity Resistance Training
- Where
- 2 sites in Portugal
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Cognition, Anxiety
Biopsychosocial Effects of Gardening Activities
Due to the increasing number of elderly population worldwide, elderly care is becoming increasingly important and the number of elderly in institutional care is increasing.
- Conditions
- Cognition, Anxiety, Depression, Life Satisfaction
- Trial name
- NCT06844084
- Testing
- Gardening Activity
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ordu University
Sarcopenia
Investigating Loss of Neuromuscular Junction Transmission Fidelity in Older Adults
Sarcopenia is a condition characterised by age-related loss of muscle mass and function. Factors affecting the strength of muscle contraction independent of mass, such as neuromuscular junction (NMJ) transmission, are…
- Trial name
- STAMINA (NCT04904926)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- NMD Pharma A/S
Japanese Encephalitis
This is a Study to Assess the Safety and Immunogenicity of Ixiaro® (IC51) in an Elderly Population
This is an open-label, uncontrolled phase 4 study to assess the safety and immunogenicity of the Japanese encephalitis (JE) vaccine Ixiaro® (IC51) in an elderly population.
- Trial name
- NCT01158599
- Testing
- IXIARO®
- Where
- 5 sites in Austria, Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Healthy Elderly Subjects
Safety and Pharmacokinetics/ Pharmacodynamics of Methoxyethyl Etomidate Hydrochloride in Healthy Elderly Subjects
16 subjects were divided into two groups: One group consisted of healthy non-elderly subjects aged 18-64 years (including boundary value).
- Trial name
- NCT06764147
- Testing
- ET-26HCl
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Physical Function, Cognitive Decline
Face-to-face vs Online Physical Exercise in Seniors Living in Nursing Homes (ExerMOT-NH)
The benefits of multicomponent physical exercise (MPE) in the mental and physical health of older adults are widely accepted. However, during Covid19 pandemic, some face-to-face programs for physical exercise were canceled.
- Conditions
- Physical Function, Cognitive Decline, Psychological Well-Being
- Trial name
- ExerMOT-NH (NCT06352749)
- Testing
- Advice to increase physical activity and reduce sedentary behavior, Online Physical Exercise, Face-to-Face Exercise
- Where
- 4 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Functional Disability, Obesity
Effects of a Weight Reduction and Lifestyle Program in Older Adults
This research study will assess the effects of two different programs on weight, body composition, mobility and improved health. Measures of health will include functional abilities, and physical performance.
- Conditions
- Functional Disability, Obesity, Physical Inactivity
- Trial name
- NCT00714506
- Testing
- Diet and physical activity, Physical activity control
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy
A Study to Investigate Safety, Tolerability and Pharmacokinetics of REM0045392 Compared With Placebo in Healthy Participants.
This study is testing if the medicine REM0045392 is safe and well-tolerated. It also looks at whether food affects how the medicine works.
- Trial name
- NCT07016464
- Testing
- REM0045392
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- reMYND
Aging, Functional Status
Remote Physical and Cognitive Training Effects in Older Adults at Increased Risk of Clinical-functional Vulnerability
This study is a randomized, single-blind, parallel, controlled, superiority trial. The main objective is to verify the chronic effects of a remote 12-week low-intensity physical training program alone or in combination with…
- Trial name
- NCT05309278
- Testing
- Physical training, Cognitive training
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Sleep Quality
PBM or Dry Float Therapy on Sleep Quality in Middle-aged and Elderly
The main objective of this study is to assess the impact of implementing photobiomodulation (PBM) therapy, either localized or whole body, or dry float on sleep quality in middle-aged and elderly individuals experiencing sleep…
- Trial name
- NCT05963555
- Testing
- NovoThor, VieLight, ZeroBody
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- West Virginia University
tDCS, Physical Activity + tDCS
Influence of Physical Exercise on Neuroplasticity and Sensorimotor Networks in Older Adults
The purpose of this study is to investigate the influence of a single session of moderate aerobic exercise on motor cortex neuroplasticity in older adults, both alone and in combination with transcranial direct current…
- Conditions
- tDCS, Physical Activity + tDCS, Physical Inactivity + tDCS
- Trial name
- EXOPLASTIC (NCT07438808)
- Testing
- Aerobic Exercise, Physical Inactivity, Transcranial Magnetic Stimulation
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Dementia Risk Factors, Prevention
The REMINDER4Care Program for Older Adults Supported by Residential and Daycare Facilities
Dementia incidence is rising, posing a public health challenge, but 45% of cases can be prevented by addressing modifiable risk factors.
- Conditions
- Dementia Risk Factors, Prevention, Cognitive Health
- Trial name
- REMINDER4Care (NCT06922071)
- Testing
- REMINDER4Care
- Where
- Portugal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Muscle Loss
Galactooligosaccharide and Aging
Sarcopenia is a progressive muscle disease, most commonly affecting older individuals, that is categorised by 1) low muscle strength, 2) low muscle quantity or quality, and 3) low physical performance.
- Trial name
- NCT06411964
- Testing
- Prebiotic
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Healthy
A Study To Look At Safety And Blood Concentrations After Multiple Doses Of PF-03382792 In Healthy Elderly Individuals
This study is designed to look at the safety and blood concentrations of PF-03382792 in healthy elderly subjects after taking multiple doses for 14 days.
- Trial name
- NCT01089738
- Testing
- PF-03382792 0.5mg, PF-03382792 1.5 mg, PF-03382792 5 mg
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Caregiver Burnout, Stress
mHealth Mindfulness for Dementia Caregivers
The investigators will recruit 60 family caregivers of older adults with cognitive impairment or dementia to participate in a pilot feasibility and acceptability trial of Mindfulness Coach, an mHealth mobile application that…
- Conditions
- Caregiver Burnout, Stress, Anxiety
- Trial name
- NCT04150055
- Testing
- Mindfulness Coach
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Polypharmacy, Deprescriptions
Deprescribing: a Portrait and Out-comes of the Reduction of Polypharmacy in Portugal
This study protocol comprises three phases. The first two phases will be nationwide and aim to evaluate the prevalence and patterns of polypharmacy and assess the barriers and facilitators of deprescribing perceived by older…
- Trial name
- DePil17-20 (NCT03283735)
- Testing
- Elderly Enablement
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Beira Interior
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.