Clinical trials: Advanced Age
Interpandemic Influenza
Safety and Immunogenicity of Surface Antigen, Inactivated, Adjuvanted With MF59C.1 Influenza Vaccine, Formulation 2008-2009
Trial for annual approval of interpandemic influenza vaccines
- Trial name
- NCT00734734
- Testing
- Seasonal Influenza Vaccine
- Where
- 2 sites in Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Malnutrition
The Dietetic Consultation: an Illuminative Evaluation
This study aims to understand the experience of the dietetic consultation from the perspective of nutritionally vulnerable older patients receiving oral nutrition support and dietitians, as well as other key stakeholders involved…
- Trial name
- NCT03509116
- Testing
- Observations, documents, Interviews, key stakeholders, documents
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- King's College London
Age Problem, Abdominal Cancer
Dosage of Epidural Morphine in Elderly Patients
This a clinical trial that evaluates the efficacy and safety of three different doses of morphine, namely 1.5 mg, 3 mg and 4.5 mg, via the epidural route regarding reducing pain in elderly patients after a cancer surgery in the…
- Trial name
- NCT04316871
- Testing
- 1.5 mg of Morphine Sulfate, Normal saline, 3 mg of Morphine Sulfate
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Assiut University
Delirium
Implementation Outcome Assessments of the Emergency Department Delirium Screening and Detection Program
Delirium occurs in up to 20% of older adults presenting to the Emergency Department (ED) and is associated with poor outcomes. Failure to identify patients with ED delirium not only prevents initiation of mitigation strategies…
- Trial name
- ED-DDP (NCT05606328)
- Testing
- Emergency Department Delirium Screening and Detection Program (ED-DDP)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Atrial Fibrillation
Anticoagulation Therapy in the Very Old
This study is designed to evaluate the efficacy and safety of warfarin anticoagulation in the very old and attempt to identify risk factors which may impede safe and effective anticoagulation.
- Trial name
- ATIVO (NCT03103763)
- Testing
- Warfarin
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Robert Stein
Depressive Disorder, Major
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy
The purpose of this study is to assess the efficacy of Seltorexant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in participants with major depressive disorder with insomnia…
- Trial name
- NCT04532749
- Testing
- Seltorexant
- Where
- 80 sites in United States, Argentina and 8 more
- Volunteers
- 212 people
- Sponsor
- Janssen Research & Development, LLC
Healthy Elderly
Generation of Prediction Equations for BIA of the Elderly
The objective of the study is to develop prediction equations for calculating Fat-Free Mass FFM, Total Body Water TBW, Extracellular Water ECW, Visceral Adipose Tissue VAT, total Skeletal Muscle Mass SMM and segmental SMM in a…
- Trial name
- NCT04028648
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Seca GmbH & Co. Kg.
Cognitive Aging
A 14 Week Study of Mindfulness Effects on Attentional Control in Older Adults
Attentional control, or individuals' ability to choose which stimuli in the environment they attend to and which they ignore, declines with older age.
- Trial name
- MACS (NCT02714426)
- Testing
- Mindfulness-inspired treatment, Brain health
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obesity, Weight Loss
Utilizing Protein During Weight Loss to Impact Physical Function and Bone
This study is an ancillary study to the Utilizing Protein During Weight Loss to Impact Physical Function (UPLIFT) trial (NCT03074643) to evaluate the effects of diet composition (i.e., amount of protein and carbohydrate) during a…
- Conditions
- Obesity, Weight Loss, Diet Modification, Aging
- Trial name
- UPLIFT-Bone (NCT03819478)
- Testing
- Weight loss intervention months 0-6, Exercise intervention months 0-6, NutraBio™ CarboMax Supplement
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- Wake Forest University Health Sciences
Hypercholesterolemia, Dyslipidemias
Study of Pitavastatin in Elderly Patients With Primary Hypercholesterolemia or Combined Dyslipidemia
This is an open-label extension study of NK-104-306 (NCT00257686) for elderly patients with hypercholesterolemia or combined dyslipidemia.
- Trial name
- NCT00330876
- Testing
- Pitavastatin
- Where
- 59 sites in Denmark, Germany and 3 more
- Volunteers
- 545 people
- Sponsor
- Kowa Research Europe
Influenza
Safety and Immunogenicity of A/H1N1-SOIV (Swine Flu) Vaccine With and Without Adjuvant in Non-Elderly and Elderly Adults
This study will evaluate the safety and immunogenicity of different combinations of A/H1N1 S-OIV (swine flu) vaccine in non-elderly and elderly adults.
- Trial name
- NCT00973349
- Testing
- MF59-eH1N1_f
- Where
- 21 sites in United States, Mexico
- Volunteers
- 2,719 people, healthy volunteers welcome
- Sponsor
- Novartis
Heart Failure, Diastolic, Obesity
Exercise Intolerance in Elderly Patients With Diastolic Heart Failure
The purpose of this study is to examine the effects of weight loss via hypocaloric diet, aerobic exercise training, combined hypocaloric diet and exercise training, and attention control in patients with heart failure and a…
- Trial name
- SECRET (NCT00959660)
- Testing
- Exercise, Dietary Intervention, Diet and exercise
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University
Care-resistant Behavior, Dementia
Reducing Care-Resistant Behaviors During Oral Hygiene in Persons With Dementia
The main purpose of this study is to test a method of providing mouth care to persons with dementia who live in nursing homes. The method of providing mouth care is designed to reduce fear in persons with dementia, so that these…
- Trial name
- NCT01363258
- Testing
- Care-resistant mouth care (MOUTh), Evidence-based mouth care
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Cognitive Dysfunction
Postoperative Cognitive Dysfunction as Geriatric Syndrome
This study is testing cognitive function before and after the surgery, with patient's informed consent. Patients of interest are 65 year or older, undergoing surgery in general or regional anesthesia.
- Trial name
- NCT05648890
- Where
- Czechia
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Chronic Disease
Preparing Spanish-speaking Older Adults for Advance Care Planning and Medical Decision Making (PREPARE)
In partnership with patients, caregivers, advocacy groups and clinicians, the investigators plan to: Aim 1: Adapt and refine PREPARE in Spanish through cognitive interviews with Spanish-speaking Latinos and stakeholders.
- Trial name
- NCT02072941
- Testing
- PREPARE Intervention
- Where
- United States
- Volunteers
- 445 people
- Sponsor
- University of California, San Francisco
Chronic Lymphocytic Leukemia
Chlorambucil + Lenalidomide and Lenalidomide Maintenance in Untreated Elderly With Chronic Lymphocytic Leukemia (CLL)
This is a phase I multicenter, open label study in previously untreated and elderly patients (> 60 years) with CLL: a non-comparative phase aimed at defining the MTD of lenalidomide given in combination with chlorambucil and the…
- Trial name
- NCT01403246
- Testing
- Lenalidomide; Chlorambucil
- Where
- 10 sites in Italy
- Volunteers
- 9 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Type 2 Diabetes Mellitus
Safety and Efficacy of Sitagliptin Compared With Glimepiride in Elderly Participants With Type 2 Diabetes Mellitus (MK-0431-251)
The primary objectives of this study are to determine if sitagliptin treatment is not inferior to that of glimepiride as measured by the change in baseline hemoglobin A1C (HbA1C) after 30 weeks of treatment, and if sitagliptin…
- Trial name
- NCT01189890
- Testing
- sitagliptin phosphate, Glimepiride
- Volunteers
- 480 people
- Sponsor
- Merck Sharp & Dohme LLC
Cancer Related Fatigue
Body Mind Training Project
Aim 1: Assess the feasibility, safety and efficacy of a Qigong intervention in elderly prostate cancer survivors. Describe participation, retention, and adherence rates and assess reasons for participation, attrition, and…
- Trial name
- NCT01564394
- Testing
- Qigong, Non-aerobic stretching
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
Major Depressive Disorder
Phase 1 Study to Assess the Safety/Tolerability of Brexpiprazole as Adjunctive Therapy in Elderly Subjects With Major Depressive Disorder
The purpose of this study is to assess the safety and tolerability of ascending multiple oral doses of brexpiprazole as adjunctive therapy in the treatment of elderly subjects with MDD.
- Trial name
- NCT01670279
- Testing
- Brexpiprazole
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Stroke
Alteplase in Elderly Acute Ischemic Stroke (AIS) Patients During Hospitalization
The objective of the study is to find out the in-hospital clinical outcomes among Chinese Acute Ischaemic Stroke (AIS) patients, who were treated with intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) within 4.5…
- Trial name
- NCT05395351
- Testing
- rt-PA
- Where
- China
- Volunteers
- 113,035 people
- Sponsor
- Boehringer Ingelheim
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