Clinical trials: Advanced Chronic Liver Disease
Advanced Chronic Liver Disease, Healthy Participants
A Study to Investigate the Pharmacokinetics of AZD2389 in Healthy Participants When Administered Alone and in Combination With Quinidine
The purpose of this study is to assess the pharmacokinetics (PK) and safety of AZD2389 when administered alone and in combination with quinidine in healthy participants.
- Trial name
- NCT06974565
- Testing
- AZD2389, Quinidine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Portal Hypertension
Direct Portal Pressure Measurement Via Endoscopic Ultrasound in Advanced Chronic Liver Disease (EVADIPP)
A minimally invasive procedure to directly assess portal pressure gradient under endoscopic ultrasound guidance (EUS-PPG) has become available and initial data have proved the technique to be safe.
- Trial name
- EVADIPP (NCT06266260)
- Testing
- EUS PPG measurement
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chronic HCV Infection
Ledipasvir/Sofosbuvir Fixed-Dose Combination + Ribavirin in Subjects With Chronic HCV With Advanced Liver Disease or Post-Liver Transplant
This study will evaluate ledipasvir/sofosbuvir (LDV/SOF) fixed-dose combination (FDC) plus ribavirin (RBV) in participants with advanced liver disease or posttransplant and chronic genotype 1 or 4 hepatitis C virus (HCV)…
- Trial name
- NCT01938430
- Testing
- LDV/SOF, RBV
- Where
- 30 sites in United States
- Volunteers
- 339 people
- Sponsor
- Gilead Sciences
Non-Alcoholic Fatty Liver Disease, Chronic Liver Disease
Combination Diagnostic Strategies in NAFLD
Serial combination of biological and elastography tests is accurate to diagnosing advanced fibrosis in non-alcoholic fatty liver disease (NAFLD) patients.
- Trial name
- CombinationSSI (NCT04384159)
- Volunteers
- 577 people
- Sponsor
- University Hospital, Montpellier
Hepatitis C, Chronic, Sustained Virological Response
Prediction of Liver-related Outcomes After HCV Cure
Objectives: To develop and validate a predictive model, applicable to daily practice, of liver complications emergence in hepatitis C virus (HCV)-infected patients and advanced fibrosis, who have achieved sustained viral response…
- Conditions
- Hepatitis C, Chronic, Sustained Virological Response, Direct-acting Antivirals, Hepatocellular Carcinoma
- Trial name
- NCT04460157
- Where
- Spain
- Volunteers
- 1,035 people
- Sponsor
- Hospital Universitario de Valme
Compensated Cirrhosis, Gastroesophageal Varices Bleeding
Detachable String Magnetically Controlled Capsule Endoscopy for Detecting High-risk Varices in Compensated Cirrhosis
Gastroesophageal varices is a serious complication of compensated advanced chronic liver disease (cACLD). Primary prophylaxis to reduce the risk of variceal haemorrhage is recommended if high-risk varices (HRV) are detected.
- Trial name
- NCT03749954
- Testing
- Detachable string magnetically controlled capsule endoscopy
- Where
- 13 sites in China, United Kingdom
- Volunteers
- 105 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Compensated Liver Disease, Esophageal Varices
Baveno VIII Criteria for Portal Hypertension in Egyptian Patients
This prospective observational study aims to validate Baveno VIII criteria for detection of clinically significant portal hypertension and to evaluate additional predictors of esophageal varices in Egyptian patients with…
- Conditions
- Compensated Liver Disease, Esophageal Varices, Portal Hypertension, Chronic Liver Disease
- Trial name
- NCT07842666
- Volunteers
- 125 people
- Sponsor
- Assiut University
Compensated Advanced Chronic Liver Disease
Impact of Metabolic Disorders on cACLD Outcomes
This multicenter, prospective, cohort study is designed to investigate how metabolic disorders (such as obesity, diabetes, and high cholesterol) influence the progression of liver disease in patients with compensated advanced…
- Trial name
- NCT07534046
- Testing
- Observational Study
- Volunteers
- 4,307 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Hepatocellular Cancer
HCV-RNA Kinetics During Sorafenib for Hepatocellular Carcinoma (HCC)
This research study is a Phase IV clinical trial. Phase IV trials are used to further test and monitor the safety of a drug approved by the FDA and to see if the drug has any other indications that can be used to treat different…
- Trial name
- NCT01849588
- Testing
- Sorafenib
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Advanced Chronic Liver Disease, Portal Hypertension Related to Cirrhosis
Program to Avoid NSAIDs in Patients With Advanced Chronic Liver Disease
This study aims to implement measures to avoid the use of NSAIDs or metamizole in patients with advanced chronic liver disease (ACLD) scheduled for major surgery, which are contraindicated due to increased risk of renal…
- Trial name
- NCT07249294
- Testing
- Multidisciplinary support program
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Parc de Salut Mar
MAFLD
Liver Stiffness Changes by iLivTouch to Predict Liver-Related Events in MAFLD
This is an observational study (multicenter retrospective real-world cohort study). The purpose of this study is to assess the predictive performance of liver stiffness measurement (LSM, including baseline LSM1, current LSMC and…
- Trial name
- MAFLD (NCT07777198)
- Volunteers
- 2,303 people
- Sponsor
- Beijing Friendship Hospital
Liver Cancer
Improving Response to Immunotherapy in Patients With Advanced Hepatocellular Carcinoma and Chronic Hepatitis C Virus Infection With Direct-Acting Antiviral Therapy
To learn if giving immune checkpoint therapy (such as atezolizumab) and bevacizumab to patients who have HCC and are receiving DAAs may help to control HCC and hepatitis C.
- Trial name
- NCT05717400
- Testing
- Bevacizumab, Atezolizumab, Sofosbuvir
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Carcinoma, Hepatocellular
Atezolizumab Plus Bevacizumab With HCC and HBV Infection
This is a single-arm clinical trial. The main objective is to determine the efficacy of atezolizumab+bevacizumab therapy in patients with advanced hepatocellular carcinoma and with chronic hepatitis B virus infection.
- Trial name
- NCT04180072
- Testing
- Atezolizumab, Bevacizumab
- Where
- 7 sites in Taiwan
- Volunteers
- 51 people
- Sponsor
- National Health Research Institutes, Taiwan
Healthy Participants
A Study to Investigate the Pharmacokinetics of AZD2389 When Administered Alone and in Combination With Itraconazole in Healthy Participants
The purpose of this study is to assess the pharmacokinetics (PK) of AZD2389 when administered alone and in combination with itraconazole in healthy participants.
- Trial name
- NCT06846528
- Testing
- AZD2389, Itraconazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Hepatitis C, Cirrhosis
Interferon/Ribavirin-Free Sofosbuvir Based Treatment (AURIC)
Since the availability of interferon free direct acting antivirals (DAA) the centers authorized to prescribed these drugs in Austria submitted their data to a central data base (AURIC) using treatment regimes without interferon…
- Trial name
- AURIC (NCT02628717)
- Where
- Austria
- Volunteers
- 558 people
- Sponsor
- Medical University of Vienna
Chronic Liver Diseases
Correlation of Liver and Spleen Stiffness by RT-2D-SWE and Severity of Portal Hypertension by HVPG
Portal hypertension (PH) results from the increase of portal flow resistance in fibrotic tissue of the liver in patients with chronic liver diseases, leading to complications such as varices formation and variceal bleeding…
- Trial name
- NCT02653846
- Testing
- RT-2D-SWE measurement, HVPG measurement
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University Hospital Dubrava
Hepatitis C, Chronic Kidney Diseases
Helping Empower Liver and Kidney Patients
The overall purpose of this study is to develop and test a web-based decision aid (DA) to support patients with Hepatitis C and Chronic Kidney Disease during decisions about whether, when, and how to treat each illness.
- Conditions
- Hepatitis C, Chronic Kidney Diseases, Patient Education
- Trial name
- Project HELP (NCT03426787)
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Palliative Care, End Stage Liver DIsease
MELD ESAS Evolution: Assessment of the Symptomatic Burden of Patients With Advanced Chronic Liver Disease
The goal of this observational study is to understand if there is a correlation between the evolution of MELD-Na and symptomatic burden of patients with advanced chronic liver disease.
- Trial name
- MELDESAS (NCT06181474)
- Testing
- ESAS
- Where
- Portugal
- Volunteers
- 44 people
- Sponsor
- Unidade Local de Saúde de Matosinhos, EPE
Liver Diseases, Hepatocellular Carcinoma
Prediction of Decompensation and HCC Development in Advanced Chronic Liver Disease
The aim of this observational study is to predict the short- and long-term development of acute severe disease events, de novo hepatocarcinoma (HCC) and mortality in patients with advanced chronic liver disease using the M10S20…
- Conditions
- Liver Diseases, Hepatocellular Carcinoma, Hepatocarcinoma, Advanced Chronic Liver Disease
- Trial name
- DETECT (NCT06523608)
- Testing
- Standard survillance protocol, Stratified survillance protocol
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- University Hospital Muenster
Liver Diseases
Contrast Enhanced Ultrasound Guidance Biopsy for the Diagnosis of Liver Tumors
The main purpose of this study is to compare contrast-enhanced ultrasound guided liver biopsy (CEUS-LB) with conventional ultrasound guided liver biopsy (US-LB) in the diagnosis of liver tumors developed on a background of…
- Trial name
- ConCLUDe (NCT03811431)
- Testing
- Contrast enhanced ultrasound guided liver biopsy
- Where
- Romania
- Volunteers
- 138 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy