Clinical trials: Advanced Dementia
Alzheimer Disease, Late Onset, Cognitive Impairment
Effects of Personalized Music Listening in Advanced Alzheimer's
Recent functional imaging studies have facilitated a better understanding of the neuroplasticity mechanisms underlying the strong and multifaceted effects of music on brain development.
- Trial name
- NCT06765434
- Testing
- Music ( Dmitri Shostakovich's Jazz Waltz Suite), Music( Personalized music)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Okan University
Asthma in Children, Allergy
Study of Indoor Air Pollutants and Their Impact in Childhood Health and Wellbeing
The number and types of indoor air pollutants in schools is rising, however little is known about the impact of their potentially synergistic interactions, upon schoolchildren health.
- Trial name
- SynAIR-G (NCT05997784)
- Testing
- Performing lung function tests (spirometry and fraction of exhaled nitric oxide (FeNO)), Filling of standardized questionnaires, Using an App on a device
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Urinary Tract Infections (UTIs), Urinary Tract Infection, Recurrent
Effects of Pomegranate Seed Oil Supplementation in Patients With Advanced Dementia
The goal of this clinical study is to learn if Pomegranate Seed Oil supplementation works to combat urinary tract infections, recurrenturinary tract infections, or pneumonia and contributes to the tapering or discontinuation of…
- Conditions
- Urinary Tract Infections (UTIs), Urinary Tract Infection, Recurrent, Antipsychotics Discontinuation, Antipsychotics Tapering
- Trial name
- NCT07432763
- Testing
- Pomegranate Seed Oil Supplementation in Palliative Care Patients with Advanced Dementia, Care-as-usual
- Where
- Greece
- Volunteers
- 18 people
- Sponsor
- Panhellenic Federation of Alzheimer's Disease and Related Disorders
Coronary Atherosclerosis, Coronary Artery Disease
Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angiography in Comparison With Invasive Multimodality Imaging
In a prospective international multicenter observational study, 1080 stable chest pain patients (REALITY Advanced registry of CCTA patients) with the suspected chronic coronary syndrome will be enrolled.
- Conditions
- Coronary Atherosclerosis, Coronary Artery Disease, Contrast-induced Nephropathy, Cerebrovascular Disease
- Trial name
- REALITY (NCT02440646)
- Testing
- Coronary computed tomography angiography, Quantitative coronary angiography, intravascular imaging with percutaneous intervention
- Where
- 4 sites in Estonia, Netherlands and 1 more
- Volunteers
- 1,080 people
- Sponsor
- Central Clinical Hospital of the Russian Academy of Sciences
Dementia
A Pilot Study of an RCT to Improve Infection Management in Advanced Dementia
To conduct a pilot study of cluster randomized clinical trial of an practice intervention to improve the quality of care for suspected lower respiratory and and urinary tract infections among 60 nursing home residents with…
- Trial name
- NCT01966523
- Testing
- Intervention, Control
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Hebrew SeniorLife
Alzheimer Disease
Study of Azeliragon in Patients With Mild Alzheimer's Disease and Impaired Glucose Tolerance
This is a study to evaluate the efficacy and safety of azeliragon in patients with mild Alzheimer's disease and impaired glucose tolerance.
- Trial name
- Elevage (NCT03980730)
- Testing
- Azeliragon
- Where
- 33 sites in United States, Canada
- Volunteers
- 43 people
- Sponsor
- vTv Therapeutics
Advanced Cancer, Delirium
Delirium Recall in Advanced Cancer Patients
Primary Objectives: 1. To determine the proportion of patients who experience partial or complete recollection of symptoms of delirium and the level of distress associated with this recall. 2.
- Trial name
- NCT00493714
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Symptomatic, Aggressive, Sporadic, Unresectable, Locally, Advanced/Metastatic Medullary Thyroid Cancer (MTC)
Observational Study to Evaluate Vandetanib in RET -/+ Patients With Metastatic Medullary Thyroid Cancer
This is a European multinational, multicenter, non-interventional (observational) and prospective study. It is carried on to confirm in real life conditions the benefit/risk of vandetanib (CAPRELSA™) 300 mg, both in RET negative…
- Trial name
- Caprelsa104 (NCT01945762)
- Testing
- Vandetanib 300 mg
- Where
- 8 sites in Belgium, France and 6 more
- Volunteers
- 31 people
- Sponsor
- Genzyme, a Sanofi Company
Healthy Individuals (Controls), Parkinson Disease
Motor Learning in Health and Movement Disorders: Role of Physical Activity and Advanced Devices
The goal of this clinical trial is to investigate motor responses in healthy subjects and patients with movement disorders, brain and spinal cord injury, neuromuscular diseases, or cardiovascular diseases.
- Conditions
- Healthy Individuals (Controls), Parkinson Disease, Multiple Sclerosis, Alzheimer Disease
- Trial name
- Allena-mente (NCT07066137)
- Testing
- CAREN, Control group
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Alzheimer Disease
Improving Access to Care for Veterans With Memory Loss
This study evaluates a care delivery protocol to improve access to care for Veterans with Alzheimer's Disease and Related Disorders (ADRD).
- Trial name
- NCT07117162
- Testing
- ADRD Care Delivery Protocol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Pittsburgh Healthcare System
Dementia
The Effect of Shared Listening to Personalized Music on Symptoms of Behavioral Disorders in the Elderly With Advanced Dementia
This study is of great importance because it uses a method that has not been tested in the past. To date, various interventions have been examined that use music for patients with dementia.
- Trial name
- NCT04293263
- Testing
- 2gether app used by trained personal
- Volunteers
- 42 people
- Sponsor
- 2gether
Dementia Frontal, Dementia Alzheimers
Optimization and Harmonization of Advanced MRI Sequences
Development of a shared multimodal MRI protocol for the definition and quantification of imaging biomarkers in AD, DLB, FDT dementias, especially white matter alterations.
- Conditions
- Dementia Frontal, Dementia Alzheimers, Lewy Body Variant of Alzheimer Disease, Neuro-Degenerative Disease
- Trial name
- NCT06217237
- Testing
- AD FDT DBL GROUP
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Dementia
Palliative and End-of-life Care in Advanced Dementia: Evaluation of a Program of Organization of Care in Long-term Care
Rationale: In Canada, as in most industrialized countries, Alzheimer's disease and other related dementia are increasingly prevalent in older people.
- Trial name
- NCT01441726
- Where
- Canada
- Volunteers
- 175 people
- Sponsor
- Laval University
Dementia Caregivers, End of Life Decision Making
A Culturally Adapted Decision Aid Intervention to Support Chinese American Dementia Caregivers in Feeding-Related Decisions
Family caregivers of people with dementia have to decide between tube feeding and hand feeding when persistent eating problems arise.
- Conditions
- Dementia Caregivers, End of Life Decision Making, Advanced Dementia
- Trial name
- NCT07370311
- Testing
- Chinese version of Making Choices Feeding Options for Patients with Dementia Decision Aid
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yaolin Pei
Dementia
Tracking Technologies for the Analysis of Mobility in Alzheimer's Disease
The research is aimed at exploring the application of novel tracking technique for the study of spatial activity among dementia patients and its implication on their families.
- Trial name
- SenTra (NCT00743418)
- Testing
- GPS modem and RFID
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Advanced Care Planning
A Portal-based Advance Care Planning Intervention Among Community-Dwelling Persons Living With Cognitive Impairment
The purpose of this research is to examine the feasibility of using a patient portal based advance care planning (ACP) tool to improve ACP discussions and documentation in persons living with cognitive impairment in outpatient…
- Trial name
- Portal-Voice (NCT06509373)
- Testing
- Advance Care Planning Tool - ACPVoice, Standard of Care for Advance Care Planning
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences
Advanced Dementia
Panel Study Investigating Status of Cognitively Impaired Elderly in Singapore
Dementia affects 10% of the elderly population in Singapore. However, there is a lack of systematic information regarding end of life (EOL) care received by patients dying with severe dementia (PDSD), PDSD's EOL direct and…
- Trial name
- PISCES (NCT03382223)
- Where
- 9 sites in Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Dementia, Dementia, Vascular
Enhancing Care Coordination: Hospital to Home for Cognitively Impaired Older Adults and Their Caregivers
Aim 1. To compare across three hospital sites the effects on health and cost outcomes observed by the following three interventions, each designed to enhance adaptation and improve outcomes of hospitalized cognitively impaired…
- Conditions
- Dementia, Dementia, Vascular, Alzheimer Disease, Delirium, Dementia, Amnestic, Cognitive Disorders
- Trial name
- NCT00294307
- Testing
- Augmented Standard Care (ASC), Resource Nurse Care (RNC), Advanced Practice Nurse Care (APNC)
- Where
- 3 sites in United States
- Volunteers
- 814 people
- Sponsor
- University of Pennsylvania
Pain, Dementia
Systematic Pain Assessment in Nursing Home Residents With Advanced Dementia
It is estimated that 45-80 % of nursing home residents have substantial pain at any given time. Residents with impaired cognition have been found to report chronic pain more often, more frequent and more severe, compared to…
- Conditions
- Pain, Dementia, Quality of Life
- Trial name
- NCT02945865
- Testing
- Pain assessment
- Where
- Norway
- Volunteers
- 112 people
- Sponsor
- Oslo Metropolitan University
Alzheimer Disease
ADvanced ALzheimer Disease and Effects of Protologic and LAnguage Rehabilitation Tools in Nursing Home (ADALPA)
Background: During Alzheimer's disease when cognitive disorders become too severe, language and communication are no longer present and/or mobilizable, and as a consequence there is a frequent discontinuation of Care and morever…
- Trial name
- ADALPA (NCT06993285)
- Testing
- Protologic and LAnguage adaptation rehabilitation
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Central Hospital, Nancy, France