Clinical trials: Advanced Dementia
Alzheimer Disease, Lewy Body Dementia (LBD)
The Role of Advanced Electroencephalographic Data as Marker of Pathology and Prognosis in Primary Dementias
The study aims to use advanced brainwave recordings of electroencephalogram (EEG) to understand early signs of Alzheimer's disease (AD) in people with mild memory problems, known as amnestic Mild Cognitive Impairment (MCI).
- Conditions
- Alzheimer Disease, Lewy Body Dementia (LBD), Mild Alzheimer Disease, Frontotemporal Dementia (FTD)
- Trial name
- NCT06826157
- Testing
- Electroencephalogram, 3 Tesla MRI, Apolipoprotein E genetic test
- Where
- Italy
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Cognitive Impairment, Chronic Kidney Diseases
The Kidney and The Brain Study - Assessment of Cognitive Impairment in Advanced CKD
Patients with failed kidneys need Renal Replacement Therapy (RRT) to remove fluid and toxins from the body. The 3 types of RRT are kidney transplant or removal of waste by dialysis, either via the blood (haemodialysis) or via the…
- Conditions
- Cognitive Impairment, Chronic Kidney Diseases, End Stage Renal Disease, Dementia
- Trial name
- NCT03382444
- Testing
- Cognitive Assessment, Depression and Quality of Life Assessment
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Natalie Garratt
Dementia, Dementia Severe
Effects of FEED@Home Intervention
The main goal of this single-blinded multicenter randomized trial is to learn if the 8-week home-based Feeding EnhancEment in Dementia program (FEED@home) works to improve unplanned hospital utilization of advanced dementia…
- Trial name
- NCT06727461
- Testing
- Home-based Feeding EnhancEment in Dementia (Feed@home)
- Where
- Hong Kong
- Volunteers
- 180 people
- Sponsor
- The University of Hong Kong
Dementia
The Hospice Advanced Dementia Symptom Management and Quality of Life Trial
Alzheimer's Disease and Related Disorders (dementia) are a group of serious life limiting illness that cause significant challenges to our public health system, with significant illness burden for both the person with dementia…
- Trial name
- HAS-QOL (NCT03681119)
- Testing
- Dementia symptom management at home hospice edition, Education and Training
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- NYU Langone Health
Advanced Care Planning, Dementia
Pilot Study of an Advance Care Planning Intervention Among Persons With Dementia
Advance care planning allows people to have their wishes taken into account even in the advanced stages of the persons' condition and at the end of life when the person may be unable to communicate.
- Trial name
- NCT05049291
- Testing
- telehealth advance care planning
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Oregon Health and Science University
DEM, Dementia
Advanced Cognitive Stimulation Therapy (ACST)
This study is a feasibility randomised controlled trial (RCT) for an evidence-based intervention for people with moderate to severe dementia.
- Conditions
- DEM, Dementia, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT04550975
- Testing
- Advanced Cognitive Stimulation Therapy
- Volunteers
- 32 people
- Sponsor
- University College, London
Advanced Dementia
Educational Video to Improve Nursing Home Care in End-stage Dementia
This is a 5-year cluster RCT of a video Advance Care Planning intervention vs. control among 360 nursing home residents with advanced dementia (N=180/arm) in 20 matched nursing homes (10 intervention/10 control).
- Trial name
- EVINCE (NCT01774799)
- Testing
- Advance care planning intervention, Control group
- Where
- United States
- Volunteers
- 804 people
- Sponsor
- Hebrew SeniorLife
Alzheimer Disease
Developing Advanced Blood-Brain Barrier Permeability Imaging for Early AD
Aging is the primary risk factor in aging-related dementia. An important initiating factor for the development and progression of cognitive impairment is disruption of the blood-brain barrier (BBB).
- Trial name
- NCT03389698
- Testing
- GRASP Dynamic Contrast-Enhanced (DCE) MRI, 3T Brain Scan, Gadolinium-based Contrast Agent (GBCA) for MRI
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Dementia, Paratonia
Safety and Effectiveness of Botulinum Toxin in Elderly Patients With Dementia and Muscle Stiffness
Aim of the study is to perform a pilot study to assess the impact of Botulinum toxin on muscle tone, and caregiver burden in individuals who are cognitively impaired and who are fully dependent.
- Trial name
- NCT02212119
- Testing
- Botulinum Toxin, Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Assistive Technology Clinic, Canada