Clinical trials: Advanced Heart Failure, open to volunteers
Heart Failure, Heart Diseases
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are…
- Conditions
- Heart Failure, Heart Diseases, Cardiovascular Diseases, Pulmonary Hypertension
- Trial name
- TEAM-HF (NCT06526195)
- Testing
- CardioMEMS HF System, HeartMate 3 Left Ventricular Assist System, Guideline Medical Directed Therapy
- Where
- 70 sites in United States, Austria and 6 more
- Volunteers
- 850 people
- Sponsor
- Abbott Medical Devices
Advanced Heart Failure
Conservative Management of Left Ventricular Assist Device Candidates
Left ventricular assist device (LVAD) candidates will be comprehensively evaluated at our center, including clinical evaluation, echocardiography, right heart catheterization, cardiopulmonary exercise test and laboratory exams.
- Trial name
- NCT05271214
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Palliative Care, Primary Palliative Care
Primary Palliative Care - a Feasibility Cluster Trial
This feasibility cluster-controlled randomized trial (RCT) evaluates a complex intervention for the delivery of primary palliative care in Family Health Units (FHUs).
- Conditions
- Palliative Care, Primary Palliative Care, Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- PrimPal (NCT07737899)
- Testing
- Primary Palliative Care Complex Intervention (PrimPal)
- Where
- 2 sites in Portugal
- Volunteers
- 30 people
- Sponsor
- University of Coimbra
HIV Infection, Advanced End Stage Heart Failure
HIV+ Deceased Donor Heart Transplant Study for HIV+ Recipients
This will be a prospective single-center interventional trial to compare the outcomes of HIV-positive heart transplant recipients by the HIV status of the donor; HIV-positive vs.
- Trial name
- NCT06659952
- Testing
- HIV-positive heart transplant
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Heart Failure
A Pivotal Clinical Trial of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Injection (HiCM-188) for the Treatment of Advanced Heart Failure(NYHA III-IV)
The purpose of this clinical study is to evaluate the efficacy and safety of intramyocardial injection of human induced pluripotent stem cell-derived cardiomyocyte injection (HiCM-188) in patients with advanced heart failure…
- Trial name
- REVIVE-HEART (NCT07496372)
- Testing
- HiCM-188 therapy, CABG surgery
- Where
- China
- Volunteers
- 80 people
- Sponsor
- HELP Therapeutics Co., Ltd.
Advanced Heart Failure, Left Ventricular Assist Devices
Trial of Low-intensity Anticoagulation to Reduce GI or Other Bleeding Complications With Equivalent Therapeutic Efficacy in HeartMate 3 LVAD Patients
The TARGET trial is a prospective, single-center, randomized, open-label, active-controlled inequality clinical trial designed to evaluate the safety and efficacy of low-intensity anticoagulation therapy (target INR 1.5-2.0)…
- Conditions
- Advanced Heart Failure, Left Ventricular Assist Devices, Anticoagulation Treatment, Bleeding Complications
- Trial name
- TARGET (NCT07081035)
- Testing
- Warfarin (low-intensity anticoagulation), Warfarin (standard anticoagulation)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Asan Medical Center
Recurrent Angina After Coronary Artery Bypass Graft, Graft Failure
Prior CABG Patients Evaluated for Saphenous VeIn grAft DysfUnction and Progression of Coronary arTery Disease
This is a multi-center, observational cohort study including patients with prior coronary artery bypass grafting (CABG) and ≥1 saphenous vein grafts (SVG) presenting with recurrent ischemic symptoms.
- Conditions
- Recurrent Angina After Coronary Artery Bypass Graft, Graft Failure, Coronary Artery Disease Progression
- Trial name
- VIADUCT (NCT04772768)
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Amsterdam UMC, location VUmc
Advanced Heart Failure, Heart Transplantation
TORCH-LATAM-002: Regional Pathway for Adult Heart Transplant Evaluation and Candidacy
TORCH-LATAM-002 is a pragmatic stepped-wedge cluster randomized trial evaluating an integrated regional pathway for adults with advanced heart failure who require specialized heart transplant evaluation and a documented candidacy…
- Conditions
- Advanced Heart Failure, Heart Transplantation, Acquired Heart Disease
- Trial name
- TORCH-002 (NCT07836803)
- Testing
- TORCH Adult Heart Transplant Evaluation and Candidacy Pathway
- Volunteers
- 360 people
- Sponsor
- CardioVision International Tech, S.A.S. de C.V.
Cardiovascular Disease Acute, Emergency Department Patient
Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers
The aim of this study is to assess emergency medicine physician and advanced practice provider (APP) knowledge and technical skill in performance of a point-of-care ultrasound simulation and just-in-time training pathway to…
- Conditions
- Cardiovascular Disease Acute, Emergency Department Patient, Heart Failure Acute, Pulmonary Embolism (Diagnosis)
- Trial name
- NCT07159269
- Testing
- Cardiac point-of-care ultrasound (POCUS) training and clinical pathway
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Duke University
Advanced Heart Failure, Advanced Non-Colorectal Gastrointestinal Cancer
Tier Palliative Care For Patients With Advanced Heart Failure or Cancer
TIER-PC is an adaptive model of delivering palliative care that provides the right level of care to the right patients at the right time.
- Conditions
- Advanced Heart Failure, Advanced Non-Colorectal Gastrointestinal Cancer, Advanced Lung Cancer, Advanced Triple Negative Breast Cancer
- Trial name
- TIER-PC (NCT07391956)
- Testing
- Tier-Palliative Care, Community Health Worker
- Where
- 5 sites in United States
- Volunteers
- 400 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Heart Failure, Cardiovascular Diseases
AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices
The goal of this observational, multicenter study is to evaluate whether AI-driven remote monitoring using a mini-invasive wearable device can improve clinical outcomes in adult patients (≥18 years) with chronic heart failure…
- Conditions
- Chronic Heart Failure, Cardiovascular Diseases, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- SMART-CARE (NCT06909682)
- Testing
- Intervention Group (Device Group - AI-Based Remote Monitoring), Standard Clinical Follow-Up
- Where
- Italy
- Volunteers
- 205 people
- Sponsor
- University of Salerno
Advanced Heart Failure
A Prospective, Multicenter,Single-arm Study of DuoCor 2 Ventricular Assist System for the Treatment of Advanced Biventricular Heart Failure
The objective of this clinical investigation is to evaluate the safety and efficacy of the DuoCor 2 Ventricular Assist System (DuoCor 2 VAS) in subjects with advanced biventricular heart failure requiring circulatory support.
- Trial name
- NCT07757451
- Testing
- DuoCor 2 Ventricular Assist System (DuoCor 2 VAS)
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shenzhen Core Medical Technology CO.,LTD.
Advanced Heart Failure
Wearables and Artificial Intelligence in Advanced Heart Failure Care
The goal of this observational study is to evaluate whether AI-based analyses of wearable sensor data can identify early signs of deterioration leading to hospitalization in patients with advanced heart failure.
- Trial name
- WAI-HF (NCT07051356)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Implementation Science, Heart Transplant
Seeking Objectivity in Allocation of Advanced Heart Failure (SOCIAL HF) Therapies Trial
The primary goal of this study is to assess real-world effectiveness and implementation of an evidence-based multi-component strategy to reduce disparities in the allocation rate of advanced heart failure therapies, heart…
- Conditions
- Implementation Science, Heart Transplant, Decision Making
- Trial name
- SOCIAL HF (NCT05390411)
- Testing
- SOCIAL HF
- Where
- United States
- Volunteers
- 1,463 people, healthy volunteers welcome
- Sponsor
- Indiana University
ESRD, CKD Stage 4, CKD Stage 5
Canagliflozin in Advanced Renal Disease With MRI Endpoints
This is a phase II, proof of concept, placebo-controlled, randomized clinical trial, assessing the effect of canagliflozin on cardiac structure and function in patients with advanced renal disease, including those on maintenance…
- Trial name
- CARe-MRI (NCT06182839)
- Testing
- Canagliflozin 300Mg Tab
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Heart Failure, Cardiogenic Shock
Cardiac Power Output in Cardiogenic Shock Patients
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
- Trial name
- NCT05700617
- Testing
- 1:1 Randomization to receive milrinone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Chicago
Heart Failure
Evaluating Adherence to Guideline-Directed Medical Therapy in Patients With Advanced Heart Failure
A Prospective Observational, Multi-Center, Real-World Pharmacological Study Evaluating Adherence to Guideline-Directed Medical Therapy Using the Four-Pillar Strategy in Patients with Advanced Heart Failure
- Trial name
- ad-HUB (NCT07560982)
- Testing
- GDMT, Quality of life questionnaire
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Università Vita-Salute San Raffaele
Ventricular Assist Device, Advanced Heart Failure
Multi-Site Feasibility Testing of the Ventricular Assist Device Anticipatory Guidance Tool
There are a variety of educational documents available to help in a participant's decision for VAD implant, however there is little information available to potential participants to help understand areas of satisfaction and…
- Conditions
- Ventricular Assist Device, Advanced Heart Failure, Anticipatory Guidance
- Trial name
- NCT06823583
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Bryan Heart
End-stage Heart Failure
LVAD Versus GDMT in Ambulatory Advanced Heart Failure Patients
Heart failure is a severe disease affecting approximately 1-2% of the adult population in developed countries and around 26 million people worldwide.
- Trial name
- AMBU-VAD (NCT04768322)
- Testing
- HeartMate 3 TM Left Ventricular Assist System, Guideline Directed Medical Therapy
- Where
- 8 sites in France
- Volunteers
- 92 people
- Sponsor
- Hospices Civils de Lyon
Insuficiência Cardíaca, Transplante Cardíaco
Effects of Physical Training in Patients With Advanced Heart Failure
Heart failure is a condition where the heart cannot pump blood effectively. This can happen due to changes in the heart's structure or function, leading to symptoms like shortness of breath, fatigue, and reduced ability to…
- Conditions
- Insuficiência Cardíaca, Transplante Cardíaco, Exercício Físico
- Trial name
- NCT07501143
- Testing
- physical training
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- University of Nove de Julho