Clinical trials: Advanced Life Support
Cardiac Arrest
OPALS Cardiac Arrest Database (OCAD)
To provide the infrastructure to answer prehospital research questions posed by scientists at academic health science centers and policy makers at multiple levels of government.
- Trial name
- NCT00300703
- Where
- 11 sites in Canada
- Volunteers
- 1,538 people
- Sponsor
- Ottawa Hospital Research Institute
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Assessment of the Effectiveness, Socio-economic Impact and Implementation of a Digital Solution for Severe Patients
ADLIFE is a EU-funded project developing innovative digital health solutions to support healthcare planning and care delivery for patients with advanced chronic conditions (chronic obstructive pulmonary disease and/or heart…
- Conditions
- Heart Failure NYHA Class III, Heart Failure NYHA Class IV, Chronic Obstructive Pulmonary Disease Severe
- Trial name
- ADLIFE (NCT05575336)
- Testing
- ADLIFE intervention
- Where
- 7 sites in Denmark, Germany and 3 more
- Volunteers
- 185 people
- Sponsor
- Biosistemak Institute for Health Systems Research
Chronic Kidney Disease (Stages 4 and 5), Health Related Quality of Life
Symptom Monitoring With Supported Feedback in Advanced Chronic Kidney Disease
Patient-reported outcome measures (PROMs) are validated tools to reliably measure outcomes highly prioritized by patients, such as health-related quality of life (HRQOL) and symptoms, but the current clinical impact of PROMs is…
- Trial name
- NCT07186218
- Testing
- Electronic patient-reported outcome measure (ePROM) for symptom monitoring
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Cardiac Arrest (CA), Cardiopulmonary Resuscitation (CPR)
The OXY-VENT Study
Effective ventilation during cardiopulmonary resuscitation is essential but can be difficult to achieve consistently. Current practice relies on visible chest rise to guide ventilation volume, although this may not always…
- Trial name
- OXY-VENT (NCT07870551)
- Testing
- Ventilation Feedback Device (Active), Control (Recording-Only)
- Where
- Netherlands
- Volunteers
- 515 people
- Sponsor
- Jeroen van Eijk
Seizure
OPALS Pediatric Study
The OPALS Pediatric Study will examine the incremental impact of introducing a prehospital full advanced life support in pediatric patients.
- Trial name
- NCT00298532
- Testing
- Advanced Life Support
- Where
- 10 sites in Canada
- Volunteers
- 9,000 people
- Sponsor
- Ottawa Hospital Research Institute
Advanced Cancer
Decision Aid to Support Advanced Cancer Patients
To support advanced cancer patients, for whom standard therapy is no longer available, and their oncologists in therapy decisions, the investigators aim to develop a decision-making aid (DA) in a multi-phased bicentric study.
- Trial name
- PETUPAL (NCT04606238)
- Testing
- Decision Aid
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University Hospital Heidelberg
Skill Performance, Knowledge
Standard Two-Day Advanced Life Support (ALS) Versus One Day Recertification Course
this study aims to compare the effectiveness of a one-day versus two-day ALS recertification course in terms of knowledge retention, practical skills performance, participant satisfaction, and confidence.
- Trial name
- NCT07358741
- Where
- Egypt
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Cardiac Arrest, Cardiopulmonary Resuscitation
Cardiac Arrest Extra Corporeal Oxygenation Membrane
French guidelines for Cardio Pulmonary Resuscitation (CPR) consider Extra-Corporeal Life Support (ECLS) as one option in Refractory out-of hospital Cardiac Arrest (ROHCA) patients with a no-flow less than five minutes and absence…
- Conditions
- Cardiac Arrest, Cardiopulmonary Resuscitation, Advanced Cardiac Life Support, Extracorporeal Life Support
- Trial name
- CAREECMO (NCT03352999)
- Testing
- Fast track access to vaECMO
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Advanced Cancer, Psychological Distress
Comprehensive Palliative Care for Cancer Patients in Vietnam
There are exponential increases in cancer incidence and mortality worldwide and in Vietnam. Cancer affects patient's quality of life, which can be improved by palliative care.
- Conditions
- Advanced Cancer, Psychological Distress, Quality of Life
- Trial name
- NCT05103488
- Testing
- Comprehensive palliative care, Standard of care
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Vietnam Palliative Health Care Society
Cardiac Arrest (CA), Cardiopulmonary Arrest
A Randomized Controlled Study of the NEURESCUE Device as an Adjunct to Advanced Cardiac Life Support
The NEURESCUE device is the first intelligent balloon catheter for aortic balloon occlusion (ABO), an emergency technique that supercharges blood flow to the heart and brain within one minute from deployment.
- Trial name
- ARISE RCT (NCT06793033)
- Testing
- Advanced Cardiac Life Support (ACLS), Aortic balloon occlusion (ABO)
- Where
- 2 sites in Germany
- Volunteers
- 84 people
- Sponsor
- neurescue
Intubation, Intratracheal, Advanced Cardiac Life Support
Effect of Using Endotracheal Tube Introducer for Intubation During Mechanical Chest Compressions in a Manikin
The aim of this study was to compare the impact of using ETI with the Macintosh laryngoscope on first pass success rates of the final year students of medical school on a manikin during continuous chest compressions with…
- Trial name
- NCT04116333
- Testing
- Endotracheal tube introducer, Macintosh laryngoscope
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Derince Training and Research Hospital
Out-Of-Hospital Cardiac Arrest, Advanced Cardiac Life Support
Cardiac Arrest and Ventilation Method
Comparison of Manual Ventilation and Automatic Mechanical Ventilation during CPR, Pilot \& Feasibility Study (CAVE-I trial)
- Conditions
- Out-Of-Hospital Cardiac Arrest, Advanced Cardiac Life Support, Ventilation
- Trial name
- NCT05550454
- Testing
- Automatic Mechanical Ventilation, Manual Ventilation
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Cancer, Quality of Life
Financial Distress in Patients With Advanced Cancer
Advanced cancer has an adverse effect in virtually all dimensions of patients' lives (physical, psychosocial, spiritual, familial, role function).
- Trial name
- DIFIC (NCT01868100)
- Testing
- self-completion questionnaire
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Arrest (CA), Pediatric Cardiac Arrest (Simulated)
Augmented Reality-Cardiopulmonary Resuscitation Support for Pediatric Resuscitation
This study evaluates whether an augmented reality cardiopulmonary resuscitation feedback system (AR-CPR) can support health care providers in delivering high-quality chest compressions during pediatric cardiac arrest.
- Conditions
- Cardiac Arrest (CA), Pediatric Cardiac Arrest (Simulated), Cardiopulmonary Resuscitation (CPR)
- Trial name
- AR-CPR (NCT07778823)
- Testing
- AR-CPR
- Where
- 8 sites in United States, Canada
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Heart Failure, Advanced Heart Failure
REACTION-VAD Trial: Remote Exercise Training Via Telemedicine in Patients With Long-Term Ventricular Assist Devices
Current international guidelines recommend that patients with a heart pump (left ventricular assist device, LVAD) participate in supervised exercise cardiac rehabilitation programs.
- Conditions
- Heart Failure, Advanced Heart Failure, Left Ventricular Assist Device, LVAD
- Trial name
- REACTION-VAD (NCT07611188)
- Testing
- Remote Physical Conditioning Program (Telerehabilitation), Usual care. No Remote Monitoring.
- Where
- 10 sites in Spain
- Volunteers
- 78 people
- Sponsor
- Puerta de Hierro University Hospital
Advanced Cardiac Life Support Education
Effects of Two-Tier Test-Based Virtual Reality Instruction on ACLS Outcomes Among Clinical Nurses
This study aims to evaluate the effects of two-tier test-based virtual reality (VR) instruction on Advanced Cardiac Life Support (ACLS) learning outcomes among clinical nurses.
- Trial name
- NCT07862322
- Testing
- Two-Tier Test-Based Virtual Reality Instruction, Traditional Interactive Virtual Reality Instruction
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taoyuan General Hospital
Advanced Cancer
Prognostic Understanding in ESC (ProgESC Study)
This study aims to assess how aware patients with advanced cancer are about their prognosis when they are referred to an Enhanced Supportive Care (ESC) service.
- Trial name
- NCT06067087
- Where
- United Kingdom
- Volunteers
- 91 people
- Sponsor
- University College, London
Head and Neck Squamous Cell Carcinoma, Locally Advanced Rectal Cancer
Galenos 2 Immunonutrition in Head and Neck, Lung, and Rectal Cancer Patients
GALENOS 2 is a single-arm, single-center, phase II interventional study designed to evaluate the effects of a galenic immunonutrition dietary supplement in patients with head and neck squamous cell carcinoma, locally advanced…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Locally Advanced Rectal Cancer, Lung Cancer
- Trial name
- GALENOS 2 (NCT07514754)
- Testing
- Galenic Immunonutrition Formula
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Arrhythmias
Determination and Comparison of Short-term Effectiveness of Three Methods Used for Recognition of Arrhythmias in People With Different Degrees of Medical Training (Advanced Life Support Workshop Participants-ALS): Randomized Controlled Educational Experiment.
Background: Arrhythmia recognition is a fundamental skill for the provider of advanced life support (ALS). Acquire it is difficult, leading to the birth of systematic methods in an attempt to simplify and optimize, however, it…
- Trial name
- NCT02664779
- Testing
- Arrhythmia diagnosis with the 10 steps method, Arrhythmia diagnosis with the 6 steps method, Arrhythmia diagnosis with the 4 steps method
- Where
- Colombia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Head and Neck Squamous Cell Carcinoma, Locally Advanced Rectal Cancer
GALENOS 1 in Head and Neck, Lung, and Rectal Cancer Patients
GALENOS 1 is a prospective observational study designed to explore longitudinal changes in nutritional status and body composition in patients with head and neck squamous cell carcinoma, locally advanced rectal cancer, and lung…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Locally Advanced Rectal Cancer, Lung Cancer
- Trial name
- GALENOS 1 (NCT07511413)
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia