Clinical trials: Advanced Malignant Neoplasm
Breast Cancer, Neoplasm, Breast
Neoadjuvant Study of Pyrotinib in Patients With HER2 Positive Breast Cancer
This is a randomized, double-blind multicenter Phase III study for evaluating the efficacy and safety of neoadjuvant pyrotinib and trastuzumab plus docetaxel and Carboplatin versus placebo and trastuzumab plus docetaxel and…
- Conditions
- Breast Cancer, Neoplasm, Breast, Breast Diseases
- Trial name
- NCT03756064
- Testing
- Pyrotinib, Trastuzumab, Docetaxel
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhejiang Cancer Hospital
Advanced Cancer
Online Information and Support for Distance Caregivers
This study seeks to test the effectiveness of two arms of an intervention that use videoconference technology for distance caregivers of patients with advanced cancer.
- Trial name
- NCT02666183
- Testing
- Video-C, Nurse Coaching, Web-Only
- Where
- United States
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Advanced Cancer, Solid Tumors
Spirituality/Religiosity in Patients and Caregivers
Primary Objective: -To examine the association between self-rated spirituality/religiosity and coping strategies (Brief RCOPE, Brief COPE, SBI-15R) among palliative care patients.
- Trial name
- NCT00634257
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cancer, Brain Tumor
A Study of Therapeutic Amplitude-modulated Electromagnetic Fields in Advanced Tumors
In vitro studies suggest that low levels of amplitude-modulated electromagnetic fields may modify cell growth. We have identified specific frequencies that may block cancer cell growth.
- Trial name
- THBC001 (NCT00440570)
- Testing
- Low levels of amplitude-modulated electromagnetic fields, Emitter of low levels of amplitude-modulated electromagnetic fields
- Where
- Switzerland
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Pasche, Boris, M.D.
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing BVD-523FB (Ulixertinib) as Potentially Targeted Treatment in Cancers With Genetic Changes (MATCH - Subprotocol Z1L)
This phase II MATCH treatment trial tests how well BVD-523FB (ulixertinib) works in treating patients with cancer that has certain genetic changes.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Refractory Lymphoma, Refractory Malignant Solid Neoplasm
- Trial name
- NCT06400225
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Gastric Cancer, Lymph Node Metastases
IGG Using in Laparoscopic Gastrectomy for Locally Advanced Gastric Cancer After Neoadjuvant Chemotherapy
Patients with locally advanced gastric adenocarcinoma (cT2-4a N-/+ M0) were selected as study subjects to investigate the safety, efficacy, and feasibility of ICG near-infrared imaging tracing in guiding laparoscopic D2 lymph…
- Trial name
- NCT04611997
- Testing
- Indocyanine Green
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Cachexia; Cancer, Diet Modification
Exercise and Nutritional Rehabilitation in Patients With Cancer
In patients with incurable cancer, general deterioration in their ability to walk, exercise and care for themselves is often regarded as an inevitable consequence of this.
- Conditions
- Cachexia; Cancer, Diet Modification, Physical Activity, Advanced Cancer
- Trial name
- ENeRgy (NCT03316157)
- Testing
- ProSure, Physical Exercise
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Colon Cancer Stage IIb, Rectum Cancer, Adenocarcinoma
Study of Blood Components as Probable Prognostic and Predictive Markers of Response to Treatment in Advanced Colon and Rectal Cancers
The main reason of cancer-related mortality is the spread of cancer cells to distant sites (micrometastases). However, only a few small groups of tumor cells can metastasize by acquiring mechanism to decrease the immune response.
- Conditions
- Colon Cancer Stage IIb, Rectum Cancer, Adenocarcinoma, Colon Cancer Stage IIIa, Colon Cancer Stage IIIc
- Trial name
- BMACR (NCT02979470)
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AC Camargo Cancer Center
Lung Cancer, Gastrointestinal Cancer
NextSteps Intervention for Advanced Cancer Patients and Caregivers
This study seeks to test the efficacy of a psychosocial intervention to empower advanced cancer patients and their caregivers and improve their quality of life (QOL).
- Trial name
- NCT04885439
- Testing
- NextSteps
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Advanced Cancer, Relapsed Cancer
Impact of Human-Animal Interactions on Children With Life-Threatening Conditions and Their Parents
This study will evaluate the effects of human-animal interaction on reducing anxiety, depression, worry, and pain and enhancing quality of life in children ages 6-17 years old with a life threatening cancer and their parent…
- Conditions
- Advanced Cancer, Relapsed Cancer, Refractory Cancer
- Trial name
- NCT04310345
- Testing
- Animal-Assisted Interactions
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Cancer, Neoplasm
Study of SAR444881 Administered Alone and in Combination With Other Therapeutics in Participants With Advanced Solid Tumors
The study enrolled advanced cancer participants with unresectable or metastatic disease who were refractory to or were not candidates for standard approved therapy.
- Trial name
- NCT04717375
- Testing
- SAR444881, Pembrolizumab, Cetuximab
- Where
- 18 sites in United States, Canada and 2 more
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Sanofi
Advanced Cancer
Variation in Cancer Centers' End-of-Life Quality
This is a qualitative study of local organizational and provider practice norms, and how these norms influence patient and family expectations and provider decision-making heuristics for minority patients with advanced cancer at…
- Trial name
- NCT03780816
- Testing
- Observation of provider-patient interactions and interviews
- Where
- United States
- Volunteers
- 473 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cancer, Cancer (Active Cancer, Meaning Not Being Cancer Free), of Any Stage and Involving Any Treatment/Care Regimen; i.e. Curative, Life-extending, or Palliative
Is the 1939 Cancer Act Fit for Purpose in the Modern Technology Era?
The 1939 Cancer Act in the UK (England \& Wales) prohibits advertising of cancer treatments to the public, by anyone but the NHS.
- Conditions
- Cancer, Cancer (Active Cancer, Meaning Not Being Cancer Free), of Any Stage and Involving Any Treatment/Care Regimen; i.e. Curative, Life-extending, or Palliative, Cancer (Solid Tumors), Cancer (With or Without Metastasis)
- Trial name
- NCT07584824
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Royal Cornwall Hospitals Trust
Colonic Cancer
A Follow-up Colonoscopy Examination in Patients Who Had Previously Undergone Screening Colonoscopy
To determine the prevalence of colonic neoplasm in patients who had previously undergone screening colonoscopy To determine the optimal time interval for re-screening in average risk individuals To determine potential baseline…
- Trial name
- NCT00280332
- Testing
- colonoscopy
- Where
- China
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Advanced Cancer
Intervention Study of Communication in Oncologist-Patient Encounters
The overall goal of this study is to improve communication between patients with advanced cancer and their oncologists. A web-based communication intervention will be delivered to patients to help them to express their negative…
- Trial name
- COPE (NCT00994578)
- Testing
- CHESS, COPE, CHESS/COPE
- Where
- 2 sites in United States
- Volunteers
- 659 people, healthy volunteers welcome
- Sponsor
- Duke University
Family Caregivers, Cancer
Pilot Optimization Trial of Decision Partnering Intervention for Advanced Cancer Family Caregivers
Using a highly innovative methodology, the Multiphase Optimization Strategy (MOST), the purpose of this study is to pilot test, for the first time, an optimization trial approach to develop and refine the decision partnering…
- Trial name
- CASCADE (NCT03947606)
- Testing
- CASCADE (CAre Supporters Coached to be Adept DEcision partners)
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Qualitative Techniques to Define Meaningful Within-Patient Change in Symptoms of Advanced Cancer Patients
This study examines qualitative techniques in defining meaningful within patients changes in symptoms in patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the…
- Trial name
- NCT06104657
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cancer Metastatic, Family Members
Lay Coach-Led Early Palliative Care for Underserved Advanced Cancer Caregivers: The Project ENABLE Cornerstone RCT
Multi-Year Funded Merit Award - Years 6-7: For this 2-year merit award funding, we propose to continue enrollment beyond 24-weeks and extend follow-up with participants long-term, through the patient's end of life and for 24…
- Trial name
- NCT04318886
- Testing
- ENABLE Cornerstone
- Where
- United States
- Volunteers
- 387 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Advanced Cancer
Identifying Family Members in Need of Support While Caregiving and After Loss
This screening tool will be used to identify significant relations of patients with advanced medical illness or serious hospitalization and family individuals who lost their loved one and who could use professional support in the…
- Trial name
- NCT02455505
- Testing
- background questionnaire, bereavement risk screening tool
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Advanced Malignant Neoplasm, Locally Advanced Malignant Neoplasm
Caregiver Burden, Quality of Life, and Symptom Distress at Different Palliative Cancer Care Settings
This trial studies caregiver burden, quality of life, and symptom distress of patients and their informal (unpaid) caregivers at different palliative care settings.
- Conditions
- Advanced Malignant Neoplasm, Locally Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm, Recurrent Malignant Neoplasm
- Trial name
- NCT04186884
- Testing
- Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center