Clinical trials: Advanced Malignant Tumor
Advanced Malignant Solid Tumors
A Study to Investigate the Food Effect on the Pharmacokinetics of CM082 Tablet in Chinese Healthy Volunteers
The main objective of this study is to evaluate the Effect of Food on the Pharmacokinetics of CM082 tablet.
- Trial name
- NCT04126668
- Testing
- CM082 with fed or fasting
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AnewPharma
Advanced Malignant Neoplasm, Caregiver
RCT of QPS vs General Information Sheet
This trial studies how well information materials work in helping communication between physicians and participants with cancer that has spread to other places in the body and their caregivers.
- Conditions
- Advanced Malignant Neoplasm, Caregiver, Physician
- Trial name
- NCT03287492
- Testing
- Informational Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Advanced Cancer, Terminal Malignant Tumors
Nurses' Competence and Role in Survival Prediction and Prognostic Communication
[Background] Nurses' roles in survival prediction and prognostic communication have historically been limited due to role delineation, lack of formal training, and cultural norms.
- Conditions
- Advanced Cancer, Terminal Malignant Tumors, Hospices
- Trial name
- NCT06962553
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Advanced Malignant Neoplasm, Locally Advanced Malignant Neoplasm
Caregiver Burden, Quality of Life, and Symptom Distress at Different Palliative Cancer Care Settings
This trial studies caregiver burden, quality of life, and symptom distress of patients and their informal (unpaid) caregivers at different palliative care settings.
- Conditions
- Advanced Malignant Neoplasm, Locally Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm, Recurrent Malignant Neoplasm
- Trial name
- NCT04186884
- Testing
- Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Stage IV Melanoma, Advanced Lung Cancer
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced Cancer
The purpose of this study is to refine and pilot test educational material developed to educate and support patients receiving immunotherapy for advanced cancer.
- Conditions
- Stage IV Melanoma, Advanced Lung Cancer, Stage IV Non-Small Cell Lung Cancer, Unresectable Non-Small Cell Lung Carcinoma
- Trial name
- UPLIFT (NCT04670445)
- Testing
- Educational Video and QPL List, Usual Care
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Neoplams
Pilot Study of Coil Arrays in Patients With Advanced Solid Tumor Malignancies
This is a single center pilot study testing the use of novel coil arrays with MR liver imaging. In part A of the study, up to 30 healthy volunteers will be scanned, with iterative adjustment of coil array geometry and design to…
- Trial name
- NCT02390011
- Testing
- MRI
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Advanced Malignancies
Safety Study of Two Oral Formulations of MGCD265 Administered in Healthy Subjects in the Fasting State
In this study two MGCD265 oral formulations at dose level of 100 mg are administered to healthy male and female subjects under fasting conditions.
- Trial name
- NCT01930006
- Testing
- MGCD265
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mirati Therapeutics Inc.
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Qualitative Techniques to Define Meaningful Within-Patient Change in Symptoms of Advanced Cancer Patients
This study examines qualitative techniques in defining meaningful within patients changes in symptoms in patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the…
- Trial name
- NCT06104657
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing BVD-523FB (Ulixertinib) as Potentially Targeted Treatment in Cancers With Genetic Changes (MATCH - Subprotocol Z1L)
This phase II MATCH treatment trial tests how well BVD-523FB (ulixertinib) works in treating patients with cancer that has certain genetic changes.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Refractory Lymphoma, Refractory Malignant Solid Neoplasm
- Trial name
- NCT06400225
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Cancer, End Stage Cancer
Information Needs Around Parenteral nUTrition in Cancer
This study will explore the information needs of patient's with advanced cancer, and their carers, when making a decision to commence or discontinue parenteral nutrition.
- Conditions
- Cancer, End Stage Cancer, Terminal Cancer, Neoplasms
- Trial name
- INPUT (NCT04495530)
- Testing
- Non-interventional study
- Where
- 4 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Advanced Malignant Solid Neoplasm
Group Meaning-Centered Psychotherapy for the Improvement of Wellbeing in Caregivers of Patients With Serious Illness
This clinical trial assesses the acceptability and feasibility of a virtual group Meaning-Centered Psychotherapy for Cancer Caregivers (MCP-C) and its effect in improving the wellbeing of caregivers of patients with advanced…
- Trial name
- NCT06630351
- Testing
- Behavioral Counseling, Discussion, Health Promotion and Education
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lung Neoplasm Malignant
Aliya™ Pulsed Electric Fields (PEF) for Advanced Cancer
The goal of this clinical trial is to evaluate safety of delivering Aliya PEF in patients with metastatic cancer within the lungs or stage IV non-small cell lung cancer (NSCLC) who are treatment-naïve and indicated for first-line…
- Trial name
- AFFINITY (NCT05890872)
- Testing
- Aliya Pulsed Electric Fields (PEF)
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galvanize Therapeutics, Inc.
Cancer, Neoplasm
Study of SAR444881 Administered Alone and in Combination With Other Therapeutics in Participants With Advanced Solid Tumors
The study enrolled advanced cancer participants with unresectable or metastatic disease who were refractory to or were not candidates for standard approved therapy.
- Trial name
- NCT04717375
- Testing
- SAR444881, Pembrolizumab, Cetuximab
- Where
- 18 sites in United States, Canada and 2 more
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Sanofi
Advanced Solid Tumor
A Drug-drug Interaction Study of SHR6390 on Healthy Chinese Volunteers
The study is a single-center, open, single-dose, self-controlled clinical trial. It is planned to enroll 20 healthy adult subjects.Subjects will take the SHR6390 on Day1 and Day22 , and from Day8 to Day26 take the efavirenz.
- Trial name
- NCT04973020
- Testing
- SHR6390、efavirenz
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Recurrence, Metastasis
Prognostic Value of CTC in HNSCC Patients
We hypothesized that the number of circulating tumor cells (CTCs) and molecular markers on CTCs could be a prognostic factor or predictive factor to patients with head neck cancer.
- Conditions
- Recurrence, Metastasis, Death
- Trial name
- CTCHNSCC01 (NCT01884129)
- Where
- Taiwan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Colon Cancer Stage IIb, Rectum Cancer, Adenocarcinoma
Study of Blood Components as Probable Prognostic and Predictive Markers of Response to Treatment in Advanced Colon and Rectal Cancers
The main reason of cancer-related mortality is the spread of cancer cells to distant sites (micrometastases). However, only a few small groups of tumor cells can metastasize by acquiring mechanism to decrease the immune response.
- Conditions
- Colon Cancer Stage IIb, Rectum Cancer, Adenocarcinoma, Colon Cancer Stage IIIa, Colon Cancer Stage IIIc
- Trial name
- BMACR (NCT02979470)
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AC Camargo Cancer Center
Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm
Impact of Project ECHO on Improving the Quality of Palliative Care in Patients With Advanced Cancer and Their Caregivers in Underserved Areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia
This trial investigates the experience and satisfaction of care in patients with cancer that has spread to other places in the body (advanced) and their caregivers living in underserved areas of Kenya, Nigeria, Ghana, South…
- Trial name
- NCT04984551
- Testing
- Extension of Community Health (ECHO) Telementoring Clinic, In-Country Workshops, Professional Oncology Educations Programs
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Non-Small Cell Lung Cancer
Evaluation of PD1 / PDL1 Expression on Blood Cells & Tumor Tissue, Their Role as a Prognostic Target in NSCLC Patients
Several reports have examined Programmed Death 1 (PD-1) expression on tumor-infiltrating T-cells, and its correlation with prognosis has been discussed.
- Trial name
- NCT02758314
- Testing
- Evaluation of PD-1/PDL-1 expression.
- Where
- Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Advanced Solid Tumor
Safety, Tolerability, Immunogenicity and Pharmacokinetics of ONC-841
The Phase 1 study is a randomized, double-blind, placebo-controlled, single ascending dose, multi-cohort study. The study will evaluate 5 dose levels of the investigational product, in 5 cohorts of 8 healthy volunteers per…
- Trial name
- NCT06219499
- Testing
- ONC-841
- Volunteers
- healthy volunteers welcome
- Sponsor
- OncoC4, Inc.
Advanced Solid Tumor
Effect of Rifampicin on the Pharmacokinetics of HRS-1167 in Healthy Subjects
The primary objective of the study is to evaluate the effect of rifampicin on pharmacokinetics of healthy adult subjects after oral administration of HRS-1167 tablets.
- Trial name
- NCT06198556
- Testing
- HRS-1167 tablets; rifampicin
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.