Clinical trials: Advanced Maternal Age Pregnancy
the Number of Mature Oocytes
Trigger Time in Advanced Maternal Age Patients With Low AMH
The investigators want to verify if advanced maternal age patients with a low Anti-Müllerian hormone (AMH) level may benefit from an early trigger time (compared to a late trigger).
- Trial name
- NCT03740880
- Testing
- Dual trigger
- Where
- United Arab Emirates
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Female Infertility Due to Advanced Maternal Age
Mitochondrial Energy Production in ART (Assisted Reproductive Technology )
Oocyte maturation requires a lot of energy, which is provided by the mitochondria via the synthesis of ATP. The majority of patients with advanced maternal age (AMA) have poor egg quality.
- Trial name
- Mitenergy (NCT02727400)
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Infertility
Conventional Infertility Treatment vs. Fast Track to IVF
The purpose of this randomized prospective clinical trial is to determine whether an infertility treatment that moves quickly to In Vitro Fertilization (IVF) is more cost effective than the usual treatment strategy which includes…
- Trial name
- FASTT (NCT00260091)
- Testing
- intrauterine insemination, infertility
- Where
- 7 sites in United States
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility Female
NR vs. Vitamin E in Enhancing Fertility
This randomized controlled trial enrolled women of advanced maternal age (≥35 years) undergoing ART, who were allocated to an intervention group (oral nicotinamide riboside, NR) or a control group (oral vitamin E, VitE) for a…
- Trial name
- NRVEERSAAM (NCT06950736)
- Testing
- NR, Vit E
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
In Vitro Fertilization
Preimplantation Genetic Screening in Women Over 35 Year
In view of insufficient evidence to routinely use Preimplantation Genetic Screening (PGS) to improve success rates after IVF, we test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate…
- Trial name
- NCT00593671
- Testing
- Preimplantation genetic screening after embryo biopsy
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Postpartum Hemorrhage
In-vitro Myometrial Contractility After Oxytocin Pre-exposure in Women With Advanced Maternal Age and Morbid Obesity
Women with advanced maternal age and morbid obesity, have a higher incidence of labor induction/ augmentation and cesarean section (CS), and are at a greater risk for postpartum hemorrhage (PPH).
- Trial name
- NCT01865669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Gestational Diabetes Mellitus
Prevention of Gestational Diabetes Mellitus With Lifestyle Intervention Among Women of Advanced Maternal Age.
This is a single-blind randomized controlled trial, aiming to evaluate the preventive effects of mobile-based combining with hospital-based lifestyle interventions on GDM among women with advanced maternal age.
- Trial name
- NCT05421845
- Testing
- mobile-based combining with hospital-based lifestyle interventions
- Where
- China
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- Peking University
Advanced Maternal Age Pregnancy, Premature
Pregnancies Outcomes in Advanced Maternal Age Women
Pregnancies occurring in advanced maternal age (AMA) have become more common over the last few decades for a variety of reasons.
- Conditions
- Advanced Maternal Age Pregnancy, Premature, Labor Complication, Delivery Complication
- Trial name
- POIAMA (NCT06528340)
- Testing
- spontaneous delivery
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centro di Ricerca Clinica Salentino
Infertility
Infertility Therapy for Women Age Thirty-eight and Older
This study will determine the most effective treatment strategy for infertile couples who present when the female partner is 38 years to the 43rd birthday and the couples are determined to have a reasonable chance for success.
- Trial name
- FORT-T (NCT00246506)
- Testing
- intrauterine insemination, in vitro fertilization
- Where
- 4 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility, Female
The Role of Erzhi Tiangui Formula in Expected POR Women Undergoing IVF-ET
This randomized controlled trial aims to determine whether Erzhi Tiangui Formula can optimize the reproductive outcomes of elderly patients with expected poor ovarian response, and to provide a new approach to traditional Chinese…
- Trial name
- NCT05698550
- Testing
- Erzhi Tiangui Granule
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Subfertility
Preimplantation Genetic Testing for Aneuploidy of Polar Bodies
This study intends to randomly group the patients with advanced maternal age and poor ovarian response, and the study group will undergo polar body biopsy, and the next-generation sequencing(NGS) technology will be used to…
- Trial name
- NCT04538560
- Testing
- polar body biopsy
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Infertility, Female
The Role of ICSI in Non-male Factor Infertility in Advanced Maternal Age
The use of Intracytoplasmic sperm injection (ICSI) has increased in the last decades regardless of the cause of infertility. Despite the increased use there is no clear evidence that ICIS is more effective than conventional in…
- Trial name
- ICSI (NCT03370068)
- Testing
- ICSI, Conventional IVF
- Where
- Israel
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Dr. Tal Miller-Elkan
Advanced Maternal Age Pregnancy
Pregnancy Outcomes on Advanced Maternal Age
A prospective observational study of pregnancy outcomes at advanced maternal age among primigravida which include maternal ,fetal, obstetric and perinatal outcomes
- Trial name
- AMA (NCT05182021)
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Diminished Ovarian Reserve, Diminished Ovarian Reserve Due to Advanced Maternal Age
Ovarian Function Following Intraovarian Injection of PRP
Consenting women with evidence of poor ovarian reserve will be randomly assigned to treatment with either Platelet Rich Plasma (PRP) or Platelet Poor Plasma (PPP).
- Trial name
- PRP4POA (NCT04278313)
- Testing
- PRP - Platelet Rich Plasma, PPP - Platelet Poor Plasma
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Chromosomal Abnormalities
Preimplantation Genetic Screening in Women of Advanced Maternal Age
An increased incidence of aneuploid pregnancies has been reported in women of advanced maternal age, with higher miscarriage rates.
- Trial name
- NCT00795795
- Testing
- Preimplantation Genetic Screening, IVF without PGS
- Where
- Spain
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Mitochondrial DNA, Aneuploidy
Aneuploidy Rates in Advanced Maternal Age Patients Supplemented With Coenzyme Q10 (CoQ10) Versus Those That Are Not: a Pilot Study
Pregnancy rates for women over 35 years old are significantly lower when compared to younger women. One of the causes for this decrease is believed to be chromosomal aneuploidy.
- Trial name
- NCT02119117
- Testing
- CoQ10
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Reproductive Endocrinology Associates of Charlotte
Embryo Aneuploidies, Implantation Rates
Preimplantation Genetic Screening (PGS) in Advanced Female Age and Male Severe Factor
Preimplantation Genetic Screening (PGS) is used for the selection of chromosomally normal embryos before the transfer in IVF treatments in many cases.
- Conditions
- Embryo Aneuploidies, Implantation Rates, Infertility
- Trial name
- NCT01571076
- Testing
- PGS, Prolonged culture
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Igenomix
Advanced Maternal Age Pregnancy, High Risk Pregnancy
University Hospital Advanced Age Pregnant Cohort
The University Hospital Advanced Age Pregnant (UNIHOPE) Cohort is the major part of the National Key Research and Development Program on Reproductive Health \& Major Birth Defects Control and Prevention Project, which is funded…
- Conditions
- Advanced Maternal Age Pregnancy, High Risk Pregnancy, Perinatal Death, Maternal Death
- Trial name
- UNIHOPE (NCT03220750)
- Where
- 9 sites in China
- Volunteers
- 22,000 people, healthy volunteers welcome
- Sponsor
- Peking University
Advanced Maternal Age Pregnancy, Early Pregnancy
Very Advanced Maternal Aged Pregnants and Early Adolescent Pregnant Women
Maternal age is an important factor affecting the pregnancy process and its results. Adverse obstetric outcomes such as preterm birth, stillbirth, and infant mortality are more common in women older than 35 years and younger than…
- Trial name
- NCT05484869
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Siirt University
Twin; Complicating Pregnancy, Advanced Maternal Age Pregnancy
Birth Cohort Study of China Medical University
The CMUBCS is a birth cohort study located in Shenyang, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology.
- Conditions
- Twin; Complicating Pregnancy, Advanced Maternal Age Pregnancy, Scarred Uterus, Overweight and Obesity
- Trial name
- NCT03561766
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital