Clinical trials: Adverse Effect
Breast Neoplasms
Breast Cancer Long-term Outcome of Cardiac Dysfunction
The purpose of this study is to assess the prevalence of cardiac dysfunction and (undiagnosed) heart failure in women registered in general practice with a history of breast cancer who received chemotherapy and / or radiotherapy…
- Trial name
- BLOC (NCT01904331)
- Where
- Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Positron-Emission Tomography
Early Diagnosis of Therapy-associated Cardiotoxicity Basing on PET/CT in Lymphoma
To explore the value of 18F-fluorodeoxyglucose (FDG) PET/CT imaging in early diagnosis of treatment-related cardiotoxicity (TACT) of lymphoma using visual method and semi-quantitative method.
- Trial name
- NCT05411250
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Drug-Induced Liver Injury
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Pill.
This is a prospective registry study to surveil early liver injuries caused by Xianlin Gubao Pill (XLGB Pill) through a non-intervention observational way.
- Trial name
- NCT03091556
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Oral Manifestations, Covid19
Oral Side Effects of COVID-19 Vaccine
This study is a multicenter cross-sectional survey-based study conducted in four European countries (Czech Republic, Germany, Slovak Republic, and Turkey).
- Conditions
- Oral Manifestations, Covid19, Vaccine Adverse Reaction
- Trial name
- NCT04706156
- Testing
- COVID-19 Vaccine
- Where
- 4 sites in Czechia, Germany and 1 more
- Volunteers
- 1,540 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Brain Injuries, Pulmonary Embolism
Improving the Stewardship of Diagnostic Imaging Resources in Alberta Emergency Departments
Utilization of diagnostic imaging in the Emergency Department has increased dramatically over the past two decades, driven by an increased availability of advanced imaging, legal pressures to exclude serious diagnoses in low-risk…
- Trial name
- NCT02410941
- Testing
- Clinical decision support
- Where
- 16 sites in Canada
- Volunteers
- 52,058 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Pain, Side Effect
Analgosedation for Elective Colonoscopy
Aim: The aim of the study was to to compare the analgesic effects of ketamine over fentanyl combined with propofol in analgesia-based elective colonoscopy with purpose of patient safety and satisfaction.
- Trial name
- NCT05421962
- Testing
- Ketamine
- Where
- Bosnia and Herzegovina
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital Zenica
Acute Lymphoblastic Leukemia
Vitamin D and Methotrexate Adverse Effects
Since methotrexate toxicity represents a major problem in patients treating with cancer and there are few studies about the role of vitamin D in the pathogenesis of this toxicity, so the aim of the present study is investigation…
- Trial name
- NCT04488237
- Testing
- Vitamin D
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Human Microbiome
Effects of H.Pylori Eradication on Microbiome
The aim of this Project is, within the scope of industrial research, to evaluate the long term effects of H.pylori eradication on microbiome (gut microbiome, upper respiratory tract microbiome) and lasting adverse events.
- Trial name
- NCT03231332
- Testing
- Microbiome Diversity detection
- Where
- Latvia
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Esophageal Neoplasms, Adverse Drug Event
Effect of NST Whole-course Nutritional Management on Nutritional Status and Adverse Reactions in Esophageal Cancer
This study is a randomized, open, parallel controlled clinical trial. The main purpose of this study was to compare the changes in body weight/body mass index (BMI) before and after treatment between the two groups of patients…
- Trial name
- NCT05800054
- Testing
- Nutritional Support Team, Docetaxel, cisplatin
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Bioequivalence, Adhesion
Bioequivalence and Adhesion of a Rotigotine Patch in Healthy Subjects
This study was intended to demonstrate bioequivalence of the Amarin's Rotigotine patch respect to Neupro, (RLD), as well as non-inferiority in adhesion, when tested at a dose of 2 mg/24h in healthy subjects of both sexes.
- Conditions
- Bioequivalence, Adhesion, Adverse Effects
- Trial name
- No acronyms (NCT07769359)
- Testing
- Rotigotine Transdermal Delivery System (TDS)
- Where
- India
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Amarin Technologies S.A.U.
Tetanus, Diphtheria
An Immunogenicity and Safety Study of Tetanus, Diphtheria and Acellular Pertussis Vaccine Booster
Open-label, randomized, multi-centre study in which 400 subjects, divided into two groups, will receive Td5ap or Td1aP as a single injection.
- Conditions
- Tetanus, Diphtheria, Pertussis
- Trial name
- Tdap Booster (NCT00870350)
- Testing
- Td5ap, Td1aP
- Where
- Sweden
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Swedish Institute for Infectious Disease Control
Latent Tuberculosis, Human Immunodeficiency Virus
Doravirine, Rifapentine and Isoniazid Interaction
Drug therapy for persons living with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) co-infected with latent tuberculosis infection (LTBI) is complex.
- Conditions
- Latent Tuberculosis, Human Immunodeficiency Virus, Rifamycins Causing Adverse Effects in Therapeutic Use, Drug Interaction Potentiation
- Trial name
- DORIIS (NCT03886701)
- Testing
- Doravirine (DOR), Rifapentine (RPT), Isoniazid (INH)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Walter K. Kraft
Drug Metabolism, Poor, CYP2D6-RELATED
Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine
Pharmacokinetic of Metoclopramide (MCP) in correlation to polymorphisms of CYP2D6 and Dopamine-D2-Receptor. Pharmacokinetic of Diphenhydramine (DPH) in correlation to polymorphisms of CYP2D6
- Trial name
- MalD (NCT01289938)
- Testing
- Diphenhydramine, Metoclopramide
- Where
- Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Matthias Schwab
Schizophrenia, Alzheimer's Disease
Side Effects of Newer Antipsychotics in Older Adults
This study will compare four atypical antipsychotic medications in terms of the risk of specific side effects each of them presents in middle-aged and elderly individuals.
- Conditions
- Schizophrenia, Alzheimer's Disease, Dementia
- Trial name
- NCT00245206
- Testing
- Aripiprazole, Olanzapine, Risperidone
- Where
- United States
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Veterans Medical Research Foundation
Neoplasm, Breast, Heart Failure
Breast Cancer Long-term Outcomes on Cardiac Functioning: a Longitudinal Study
Rationale: In addition to surgery, effective breast cancer (BC) treatment typically requires chemotherapy, radiotherapy, or both.
- Conditions
- Neoplasm, Breast, Heart Failure, Cardiotoxicity, Ventricular Dysfunction
- Trial name
- BLOC-II (NCT05851053)
- Testing
- Echocardiography
- Where
- Netherlands
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Immunoglobulin E-Mediated Food Allergy, Immunoglobulin G4-Related Disease
Immunoglobulin G4 and Immunoglobulin E Antibodies in a Population With Adverse Reactions to Foodstuffs-related Symptoms
The aim of this study is to analyze a population with symptoms associated with adverse reactions to foodstuffs (ARFS). To determine the levels of food-specific immunoglobulin G4 (IgG4) and immunoglobulin E (IgE) antibody…
- Conditions
- Immunoglobulin E-Mediated Food Allergy, Immunoglobulin G4-Related Disease, Symptoms and Signs, Adverse Reaction to Food
- Trial name
- NCT05681975
- Testing
- Food-specific Immunoglobulin G4 and/or Immunoglobulin E antibody reactions
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Paresis
Bupivacaine Versus Ropivacaine on Diaphragmatic Motility and Ventilatory Function
Background: Outpatient continuous interscalene brachial plexus blocks are used to control pain after shoulder surgery, with infusions of 0.125% bupivacaine or 0.2% ropivacaine.
- Trial name
- NCT02059070
- Testing
- Ropivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Anesthesiology WSU/DMC-NorthStar
Adverse Effects
Method of Fish Oil Administration on Patient Compliance
Many patients complain of fishy breath, upset stomach, or heartburn when taking the recommended amount of fish oil. A common recommendation made by pharmacists is to freeze the fish oil capsules to help decrease adverse…
- Trial name
- NCT01471366
- Testing
- Frozen capsule, Capsule with food, Capsule without food
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Mississippi, Oxford
Anthracycline Related Cardiotoxicity in Childhood Cancers, Chemotherapeutic Toxicity
Evaluation of Cardiac and Endothelial Function in Children and Adolescents Treated With Anthracycline
In recent decades, the survival rate of children with cancer has increased significantly thanks to personalized treatments and the adoption of international therapeutic protocols.
- Conditions
- Anthracycline Related Cardiotoxicity in Childhood Cancers, Chemotherapeutic Toxicity, Childhood Cancer Survivors
- Trial name
- CARDIO-PED (NCT07253077)
- Testing
- Biomarker detection
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Antibiotic Side Effect, Eyelid; Wound
Topical Antibiotic Prophylaxis for Eyelids
The investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery.
- Conditions
- Antibiotic Side Effect, Eyelid; Wound, Eyelid Diseases, Surgical Wound Infection
- Trial name
- NCT03199911
- Testing
- Topical Antibiotic Product, Topical Non-Antibiotic Ointment
- Where
- United States
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco