Clinical trials: Adverse Effect
Hot Weather; Adverse Effect, Kidney Dysfunction
Renal Considerations in the Heat Stress Recommendations (Aim2)
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is largely unknown, but may be related to kidney dysfunction caused by increases in body…
- Conditions
- Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia
- Trial name
- NCT05458843
- Testing
- Fluid replacement, No fluid replacement
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Indiana University
Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction
Combination of Nitrous Oxide 70% With Fentanyl Intranasal for Procedural Analgosedation in Children
This study analyzes the analgesic efficacy and adverse events of nitrous oxide 70% combined with basic analgetics compared to nitrous oxide 70% with fentanyl intranasal for analgosedation for short and painful procedures in…
- Conditions
- Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction, Pain
- Trial name
- NCT02533908
- Testing
- Fentanyl intranasal, NaCl 0.9% intranasal
- Where
- Switzerland
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Breast Cancer
Chemotherapy Effect on Brain Structure, Neurophysiology and Psychomotor Behavior in Breast Cancer Patients
Some cancer patients report experiencing mild problems with thinking during or following chemotherapy. Symptoms include problems concentrating, slow thinking, some gaps in memory and difficulty performing complex or multi-tasks.
- Trial name
- NCT02896504
- Testing
- Exposure: Adjuvant chemotherapy treatment, Exposure: Adjuvant hormonal therapy treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Hand-foot Syndrome
Study of Pyridoxine for Hand-Foot Syndrome
Although pyridoxine has been used empirically for the prevention of capecitabine associated hand-foot syndrome (HFS), its efficacy needs to be demonstrated in prospective controlled trials.
- Trial name
- NCT00446147
- Testing
- Pyridoxine
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Submental Fat
Evaluation the Effects of Various Treatments on RZL-012-Induced Adverse Events
This is a Phase 2, open-label, 2-stage, adaptive-design study in which subjects will be randomized into one of 5 treatment groups comprised of RZL-012 with or without additional study treatments:
- Trial name
- NCT05476679
- Testing
- RZL-012, RZL-012+Lidacaine injection prior treatment, RZL-012+Medrol
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Raziel Therapeutics Ltd.
Female Sexual Dysfunction, Postmenopausal Symptoms
Sexual Effects of Transdermal or Vaginal Testosterone
The aim of the study is to elucidate the role of testosterone treatment in postmenopausal women's sexual function and their therapeutic safety.
- Conditions
- Female Sexual Dysfunction, Postmenopausal Symptoms, Testosterone Deficiency, Testosterone Adverse Reaction
- Trial name
- NCT06794346
- Testing
- Transdermal testosterone, Vaginal testosterone gel
- Where
- Brazil
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Healing
Evaluation of Preferences of Consumers and Clinicians for the Management of Shave Biopsy Sites With a PolyMem Formulation Dressing or Current Standard of Care.
Shave biopsies are often uncomfortable during the healing process. This is a preliminary study to determine if patients and clinicians prefer using PolyMem formulating dressings on shave biopsy sites compared to the current…
- Trial name
- NCT00727870
- Testing
- Shapes by PolyMem dressing, Shapes by PolyMem Silver Dressing, Shapes by PolyMem on one site and Shapes by PolyMem Silver dressing on second site
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ferris Mfg. Corp.
COVID-19 Vaccine Adverse Reaction, Lower Urinary Tract Symptoms
COVID-19 Vaccines and the Development of New LUTS
This study was conducted to check whether coronavirus disease 2019 (COVID) vaccines have a relationship with LUTS or not in a healthy and mostly medically free population.
- Trial name
- NCT05582525
- Where
- Jordan
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- The Hashemite University
Drug-Related Side Effects and Adverse Reactions
A Positron Emission Tomography (PET) Imaging Study to Investigate the Biodistribution and Clearance of an Albumin Binding Domain Antibody (AlbudAb) GSK3128349 in Healthy Male Subjects
GSK3128349 is a small protein molecule (biopharmaceutical) that binds to albumin in the body, and by itself, has no pharmacological action.
- Trial name
- NCT02829307
- Testing
- 89Zr-GSK3128349 1 mg
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes Mellitus
Examination of Dermatologic Effects From Subcutaneous Injections of ISIS 113715
10 healthy volunteers will be enrolled to each receive two subcutaneous injections of ISIS 113715 in the abdomen on Study Day 1. Each subject will receive their two injections within a 5-minute period.
- Trial name
- NCT00365781
- Testing
- ISIS 113715
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Diagnostic Agent Adverse Reaction, Radiation Exposure
18F-LY3950321-01 Biodistribution and Safety Study
18F-LY3950321 (also known as 18F-MNI-1256) is a radiolabeled positron emission tomography (PET) tracer targeting granzyme B. The overall goal of this protocol is to evaluate the safety, tolerability, and radiation dosimetry of…
- Trial name
- NCT05775601
- Testing
- 18F-LY3950321, PET Scan
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Antibiotic Side Effect, Eyelid; Wound
Topical Antibiotic Prophylaxis for Eyelids
The investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery.
- Conditions
- Antibiotic Side Effect, Eyelid; Wound, Eyelid Diseases, Surgical Wound Infection
- Trial name
- NCT03199911
- Testing
- Topical Antibiotic Product, Topical Non-Antibiotic Ointment
- Where
- United States
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Dependence
Varenicline for Long-term Nicotine Replacement Therapy (NRT) Users
Primary aim: Will varenicline be better than placebo to get long-term users of NRT to stop? Secondary aim: To assess in details some side effects of varenicline i.e. nausea and abnormal dreams.
- Trial name
- NCT00977249
- Testing
- support and visits, varenicline
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Arsenic and/or Arsenic Compound Adverse Reaction
Mitigation Efforts in Arsenic Exposure With Folic Acid Supplementation
The purpose of this study is to evaluate the effects on folic acid supplementation in a population living in an environment with chronic arsenic exposure in Birmingham, Alabama.
- Trial name
- NCT05656664
- Testing
- Folic Acid
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Drug Hypersensitivity
Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase)
The objective of this study was to rule out a greater than 10% incidence of hypersensitivity to Vitrase following a single intradermal injection of 3 USP units Vitrase.
- Trial name
- NCT00198419
- Testing
- Vitrase
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Low-level Laser Acupuncture in Patients With Total Knee Arthroplasty
Low-level Laser Acupuncture Reduces Postoperative Pain and Morphine-related Side Effects in Patients With Total Knee Arthroplasty:
Total knee arthroplasty is a common and effective surgical procedure for patients with end-stage knee osteoarthritis, and wound pain is still a problem for many of the patients.
- Trial name
- NCT03995446
- Testing
- low-level laser
- Where
- Taiwan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Antimicrobial Stewardship, Antibiotics Causing Adverse Effects in Therapeutic Use
A Multimodal Intervention to Optimise Antimicrobial Use in Residential Aged Care Facilities (ENGAGEMENT Study)
The antimicrobial stewardship ENGAGEMENT study aims to deliver a bundle of interventions, including education of GPs and nursing staff, guideline implementation and telehealth support for 18 residential aged care facilities…
- Trial name
- ENGAGEMENT (NCT04705259)
- Testing
- Antimicrobial Stewardship ENGAGEMENT bundle
- Where
- 4 sites in Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Brain Injuries, Pulmonary Embolism
Improving the Stewardship of Diagnostic Imaging Resources in Alberta Emergency Departments
Utilization of diagnostic imaging in the Emergency Department has increased dramatically over the past two decades, driven by an increased availability of advanced imaging, legal pressures to exclude serious diagnoses in low-risk…
- Trial name
- NCT02410941
- Testing
- Clinical decision support
- Where
- 16 sites in Canada
- Volunteers
- 52,058 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Covid19, Vaccine Adverse Reaction
Study of Sputnik V COVID-19 Vaccination in Adults in Kazakhstan
This study will assess the safety, reactogenicity, and immunogenicity of Gam-COVID-Vac (Sputnik V) vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing…
- Trial name
- NCT04871841
- Testing
- Sputnik V
- Where
- Kazakhstan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Karaganda Medical University
Propofol Adverse Reaction, Anesthesia
Impact of Propofol Reduction in Anesthesia Induction
Objective: Determine if, by reducing the dose of propofol and increasing the time elapsed between fentanyl and propofol administration, hemodynamic response is improved.
- Trial name
- NCT04194151
- Testing
- Propofol Injection
- Where
- Spain
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Hospital Central de la Defensa Gómez Ulla