Clinical trials: Adverse Event
Music and Anesthesia
The Effects of Instrumental Music on Intraoperative Parameters and Postoperative Pain and Side Effects
The clinical study started after receiving ethical approval from the Clinical Research Ethics Committee of Van Yüzüncü Yıl University and obtaining patient consent.
- Trial name
- NCT05886231
- Testing
- music sound therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Stroke, Stroke, Acute
Impact of COVID-19 Vaccines on Cerebrovascular Health
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may reduce the transmission of and achieve population immunity against the COVID-19 pandemic, which accounted for more than 3.75million…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Dementia
- Trial name
- NCT04992195
- Testing
- Laboratory tests and Montreal Cognitive Assessment
- Where
- Hong Kong
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cognitive Dysfunction
Aprepitant to Mitigate Opioids' Cognitive Side Effects
Morphine and similar substances (called opioids) are often prescribed for moderate to severe pain, such as after a surgery, thus allowing for minimal pain and a better recovery.
- Trial name
- NCT02226601
- Testing
- Aprepitant
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Pain, Vaccination Adverse Event
A Study to Assess the Acceptability and Usability of a New Device for Intradermal Vaccination
The aim of this study was to assess the acceptability and usability of a newly developed intradermal device in healthy adults
- Trial name
- NCT01963338
- Testing
- Intradermal injection in the forearm (0,1cc NaCl 0,9%), Intradermal injection in the upper arm (0,1cc NaCl 0,9%), Intramuscular injection in the upper arm (0,5cc NaCl 0,9%)
- Where
- Belgium
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Pierre Van Damme
Dexmedetomidine, Sedation
Safety Exploration and Evaluation of Dexmedetomidine Hydrochloride Nasal Spray for Pre-anesthesia Sedation in Low-Monitoring Settings
The goal of this clinical trial is to assess the viability of dexmedetomidine hydrochloride nasal spray under minimal or no supervision and to further investigate novel clinical applications for this medication.
- Conditions
- Dexmedetomidine, Sedation, Safety, Preanesthetic Medication
- Trial name
- NCT07298525
- Testing
- Dexmedetomidine hydrochloride nasal spray
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Systemic Lupus Erythematosus
A Prospective Study of Cyclophosphamide in Systemic Lupus Erythematosus Treatment
The purpose of this study is to compare the genotype-based personal prescription of cyclophosphamide with the traditional prescription.
- Trial name
- SLE (NCT01689350)
- Testing
- Genotype Detection
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Side Effects of Acetylsalicylic Acid Use
The Effect of a Probiotic Strain on Aspirin-induced GI Damage.
This trial is a single-site, randomised, double-blind, placebo-controlled, two-armed, parallel-group trial in healthy, adult volunteers.
- Trial name
- PIP-D (NCT03228589)
- Testing
- probiotic strain
- Where
- Ireland
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Iron Deficiency Anemia of Pregnancy
Daily vs Intermittent Iron Therapy in Pregnancy
This is a randomized non inferiority trial to evaluate the response to iron therapy in the standard daily vs. intermittent (three-four times a week on nonconsecutive days) groups by using hematological markers (hemoglobin…
- Trial name
- NCT03706638
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- UConn Health
Dental Carie; Orthodontics
Adverse Event Risk Assessment in the Use of Nitrous Oxide for Pediatric Dental Patients
The objective was to assess adverse event risk in the use of Nitrous Oxide for Pediatric Dental Patients. The investigators performed a multicenter observational study.
- Trial name
- NCT02909816
- Where
- France
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Helicobacter Pylori Infection
Trimebutine on the Development of Adverse Events Related to the Helicobacter Pylori Eradication Medications
Adverse events related to the eradication medication is one of the reason of lower eradication success in the H. pylori treatment.
- Trial name
- NCT04403087
- Testing
- Trimebutine 100 MG
- Where
- South Korea
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Anesthesia, Surgical Procedure, Operative
The Bern Perioperative Biobank
The goal of the research is to define clinically relevant molecular markers for increased risk of peri-/ postoperative organo-dysfunctions, inflammation, adverse events and disease progression.
- Trial name
- BPBB (NCT04767685)
- Where
- Switzerland
- Volunteers
- 547 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Adverse Events
Effectiveness of a Proficiency-based Progression Communication Training Programme
Breakdown in communication between healthcare workers leads to significant patient harm on a daily basis, worldwide. The "safety huddle" is being introduced internationally as a means of overcoming this problem.
- Trial name
- PROTECT (NCT05390125)
- Testing
- A team, proficiency based progression, simulation training programme
- Where
- 2 sites in Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dorothy Breen
Cardiovascular Diseases, Cardiovascular Complication
Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery
Perioperative myocardial injury and major adverse cardiovascular events (MACE) are common causes of morbidity and mortality in patients at increased cardiovascular risk undergoing non-cardiac surgery.
- Conditions
- Cardiovascular Diseases, Cardiovascular Complication, Perioperative Complication, Myocardial Injury
- Trial name
- COLCAT (NCT06279000)
- Testing
- Colchicine
- Where
- Switzerland
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Breast Cancer
Chemotherapy Effect on Brain Structure, Neurophysiology and Psychomotor Behavior in Breast Cancer Patients
Some cancer patients report experiencing mild problems with thinking during or following chemotherapy. Symptoms include problems concentrating, slow thinking, some gaps in memory and difficulty performing complex or multi-tasks.
- Trial name
- NCT02896504
- Testing
- Exposure: Adjuvant chemotherapy treatment, Exposure: Adjuvant hormonal therapy treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Hand-foot Syndrome
Study of Pyridoxine for Hand-Foot Syndrome
Although pyridoxine has been used empirically for the prevention of capecitabine associated hand-foot syndrome (HFS), its efficacy needs to be demonstrated in prospective controlled trials.
- Trial name
- NCT00446147
- Testing
- Pyridoxine
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Submental Fat
Evaluation the Effects of Various Treatments on RZL-012-Induced Adverse Events
This is a Phase 2, open-label, 2-stage, adaptive-design study in which subjects will be randomized into one of 5 treatment groups comprised of RZL-012 with or without additional study treatments:
- Trial name
- NCT05476679
- Testing
- RZL-012, RZL-012+Lidacaine injection prior treatment, RZL-012+Medrol
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Raziel Therapeutics Ltd.
Coronary Disease, Coronary Syndrome
Prognostic Accuracy of the HEART Score in Undifferentiated Chest Pain: A Multicenter Validation Study
Chest pain remains one of the most common, potentially serious presenting complaints for adults emergency department visits with approximately 7.6 million yearly visits in the united states.
- Conditions
- Coronary Disease, Coronary Syndrome, Risk Factor, Cardiovascular, Major Adverse Cardiovascular Events
- Trial name
- NCT04580017
- Where
- 3 sites in Tunisia
- Volunteers
- 4,267 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Drug-Related Side Effects and Adverse Reactions
A Positron Emission Tomography (PET) Imaging Study to Investigate the Biodistribution and Clearance of an Albumin Binding Domain Antibody (AlbudAb) GSK3128349 in Healthy Male Subjects
GSK3128349 is a small protein molecule (biopharmaceutical) that binds to albumin in the body, and by itself, has no pharmacological action.
- Trial name
- NCT02829307
- Testing
- 89Zr-GSK3128349 1 mg
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes Mellitus
Examination of Dermatologic Effects From Subcutaneous Injections of ISIS 113715
10 healthy volunteers will be enrolled to each receive two subcutaneous injections of ISIS 113715 in the abdomen on Study Day 1. Each subject will receive their two injections within a 5-minute period.
- Trial name
- NCT00365781
- Testing
- ISIS 113715
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Quality Health Care
Dural Puncture Epidural Vs Standard Epidural Technique in Parturient Receiving Continuous Labour Epidural Infusion
The goal of this study is to evaluate the quality and safety of labor analgesia by comparing the use of Dural puncture epidural technique to Standard epidural technique while maintaining labor analgesia by means of continuous…
- Trial name
- NCT06653036
- Testing
- Dural puncture epidural, Standard Epidural Technique
- Where
- Pakistan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aga Khan University