Clinical trials: Adverse Reaction
Breast Cancer, Cognitive Decline
Cognitive Stimulation and Chemobrain. An Innovative Intervention for Cancer Survivors
The present study aims to establish a non-pharmacological alternative in alleviating cognitive deterioration derived from undergoing chemotherapy treatment.
- Trial name
- NCT05409248
- Testing
- Personalized cognitive stimulation
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad Antonio de Nebrija
Carcinoid Syndrome
Study of Panitumumab in the Treatment of Carcinoid Syndrome
The primary hypothesis of this study is that panitumumab, an inhibitor of the epidermal growth factor receptor (EGFR), is an effective treatment for carcinoid syndrome in people who fail or do not adequately respond to octreotide…
- Trial name
- NCT01172717
- Testing
- Panitumumab
- Where
- 2 sites in United States
- Sponsor
- Boston Medical Center
Cis-Platinum Nephropathy, Mannitol Adverse Reaction
The Effect of Intravenous Mannitol Plus Saline on the Prevention of Cisplatin-induced Nephrotoxicity: A Randomized, Double-blind, Placebo Controlled Trial
This study include cancer patients who had received chemotherapy that include cisplatin. Patients were randomly assigned to either a mannitol 20 g intravenous single dose after cisplatin or a placebo (saline).
- Trial name
- MACIN (NCT04251689)
- Testing
- Mannitol
- Where
- Thailand
- Volunteers
- 48 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Mercaptopurine Adverse Reaction, Leukemia, Lymphoblastic
Hematotoxicity in Maintenance Therapy of Children With Acute Lymphoblastic Leukemia
Subjects who are recruited in this study are LLA patient, who are treated for routine control to Cipto Mangunkusumo Hospital, who meet the inclusion criteria and do not meet the exclusion criteria.
- Trial name
- NCT03255668
- Where
- Indonesia
- Volunteers
- 106 people
- Sponsor
- Universitas Indonesia
Anesthesia; Adverse Effect, Spinal and Epidural
Comparative Study Between Continuous Epidural Anesthesia And Continuous Spinal Anesthesia Using Wiley™ Spinal Catheter
Geriatric patients have a significantly higher incidence of morbidity and morality during surgery compared with younger age group.
- Trial name
- NCT01845389
- Testing
- Epidural (B. Braun), Spinal (Wiley Spinal Catheter)
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Theodor Bilharz Research Institute
Anemia, Drug/Agent Toxicity by Tissue/Organ
Docetaxel and Cisplatin With or Without Dimesna in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel and cisplatin, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Anemia, Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Neutropenia
- Trial name
- NCT00077311
- Testing
- darbepoetin alfa, pegfilgrastim, cisplatin
- Where
- 64 sites in United States
- Volunteers
- 160 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Blood, Injection, Injury Type Phobia, Gastrointestinal Ulcer Haemorrhage
Comparative Study of Autologous Blood Injection Versus Diluted Epinephrine in Treating Actively Bleeding Gastroduodenal Ulcers
Endoscopic injection of autologous blood can control bleeding from gastroduodenal ulcers.
- Conditions
- Blood, Injection, Injury Type Phobia, Gastrointestinal Ulcer Haemorrhage, Adverse Reaction to Epinephrine
- Trial name
- NCT01560702
- Testing
- Epinephrine, Blood
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Zagazig University
Leishmaniasis; American, Cutaneous, Drug Side Effect
Phase 2 Trial to Evaluate 18-Methoxycoronaridine Efficacy, Safety and Tolerability in Cutaneous Leishmaniasis Patients
It is a randomized phase II clinical study, unicentre aimed to evaluate the tolerability, safety and efficacy of 18-Methoxyoronaridine as a candidate of tegumentary leishmaniasis treatment.
- Trial name
- NCT03084952
- Testing
- 18-Methoxycoronaridine, Glucantime
- Volunteers
- 52 people
- Sponsor
- Infan Industria Quimica Farmaceutica Nacional
Adverse Drug Event, Drug Drug Interaction
Implementation of a Pharmacist-led Pharmacogenomic Clinical Service
Tabula Rasa HealthCare (TRHC), doing business as CareKinesis, is the first national pharmacy that provides science-based medication risk identification and mitigation technologies and services.
- Conditions
- Adverse Drug Event, Drug Drug Interaction, Pharmacogenomics, Elderly
- Trial name
- NCT04984538
- Testing
- Pharmacogenomic Testing
- Where
- United States
- Sponsor
- Tabula Rasa HealthCare
Positron-Emission Tomography
Early Diagnosis of Therapy-associated Cardiotoxicity Basing on PET/CT in Lymphoma
To explore the value of 18F-fluorodeoxyglucose (FDG) PET/CT imaging in early diagnosis of treatment-related cardiotoxicity (TACT) of lymphoma using visual method and semi-quantitative method.
- Trial name
- NCT05411250
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
DRESS Syndrome
Interest of a Targeted Therapy for the Treatment of a Severe Form of Hypersensitivity to Drug (DRESS Syndrome)
Drug Reaction with eosinophilia and Systemic Symptoms (DRESS) is a rare and severe multiorgan drug reaction whose pathophysiological mechanisms underlying remain unclear, but may involve the role of several immune cells like…
- Trial name
- BENRADRESS (NCT06734884)
- Testing
- Benralizumab 30 MG/ML [Fasenra]
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Lille
Efficacy, Team, Adverse Reaction to Drug
Efficacy and Safety of Sertraline in the Treatment of Maintenance Hemodialysis Patients With Depression
Depression is a common mental disorder in patients undergoing maintenance hemodialysis (MHD), which increases the risk of cardiovascular events, hospitalization rates, and mortality, but has not received enough attention from…
- Trial name
- NCT06124417
- Testing
- Sertraline
- Where
- China
- Volunteers
- 125 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Myocarditis, Cardiac Complication
Evaluation of Reporting of Immune Checkpoint Inhibitor Associated Cardio-vascular Adverse Reactions
Immune checkpoint inhibitors (ICIs) might have high grade immune-related adverse events (irAEs) on the cardio-vascular system. This study investigates reports of cardio-vascular toxicity with treatment including anti-PD1…
- Trial name
- RAFALE (NCT03387540)
- Testing
- ICI
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Lurasidone Cardiotoxicity, Schizophrenia Patients
Effects of Lurasidone on Left Ventricle Systolic Functions
The goal of our study to learn if lurasidone molecule which is used on patients with schizophrenia or bipolar disorder has any cardiotoxic effect.
- Conditions
- Lurasidone Cardiotoxicity, Schizophrenia Patients, Bipolar Disorders
- Trial name
- Lurasidone (NCT06695676)
- Testing
- Global Longitudinal Strain
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Adverse Reaction to Drugs Affecting the Gastrointestinal System
ELIGIBLE (Efficacy of Left atrIal Appendage Closure After GastroIntestinal BLEeding)
Patients with atrial fibrillation requiring anticoagulation treatment are at high risk of gastrointestinal bleeding. The investigators propose the percutaneous stop the oral anticoagulation and closure of the left atrial…
- Trial name
- ELIGIBLE (NCT01628068)
- Testing
- Left atrial appendage occlusion
- Where
- 6 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Clinic of Barcelona
Drug/Agent Toxicity by Tissue/Organ, Lung Cancer
Amifostine, Chemotherapy, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Radiation Toxicity
- Trial name
- NCT00004176
- Testing
- amifostine trihydrate, cisplatin, etoposide
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- Washington University School of Medicine
Drug Allergy
Teicoplanin Allergy Testing Using Autologous Serum (TATAS)
Allergy testing for Teicoplanin is much more unreliable than for other similar drugs. This means that we run the risk of missing serious Teicoplanin allergy, and these patients will be given another dose in future, not knowing…
- Trial name
- TATAS (NCT06803758)
- Testing
- Teicoplanin Allergy Testing using autologous serum
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Adverse Effect of Other General Anesthetics
Folic Acid Intervention During Recovery
Research purposes：Comparison of preoperative folic acid and placebo intervention on postoperative recovery of sputum in children undergoing general anesthesia for head and neck and maxillofacial surgery Test type：Randomized…
- Trial name
- NCT04135885
- Testing
- Folic Acid
- Volunteers
- 300 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Bradycardia, Neostigmine Adverse Reaction
0.6 vs. 1.2 mg Atropine Together With Neostigmine 2.5 mg on Heart Rate in Patient Receiving Muscle Relaxant
Balanced general anesthesia with neuromuscular blocking agents has been widely used for surgery.. At the end of surgery, neostigmine has been given for the reversal of neuromuscular blocking agents with several adverse effects…
- Conditions
- Bradycardia, Neostigmine Adverse Reaction, Adverse Reaction to Belladonna or Atropine
- Trial name
- NCT02186132
- Testing
- Atropine 0.6 mg, Atropine 1.2 mg
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Adverse Effect
Coload Optimization Guided by Inferior Vena Cava Collapsibility Index
The purpose of this study is to investigate the optimal coload guided by inferior vena cava collapsibility index in parturients with prophylactic norepinephrine infusion undergoing cesarean section.
- Trial name
- NCT04272632
- Testing
- 4 ml/kg group, 8 ml/kg group, 12 ml/kg group
- Where
- China
- Volunteers
- 168 people
- Sponsor
- General Hospital of Ningxia Medical University
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