Clinical trials: Adverse Reaction
Allergic Hypersensitivity Drug Reaction Versus Non-allergic Hypersensitivity Drug Reaction Cross Reaction
Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo)
The creation of a database containing the medical data of patients followed in allergology at the University Hospital of Grenoble will permit to study allergic versus non-allergic hypersensitivity drug reaction as well as the…
- Trial name
- BdDAllergo (NCT03369509)
- Where
- France
- Volunteers
- 456 people
- Sponsor
- University Hospital, Grenoble
Breast Cancer, Palmar-plantar Erythrodysesthesia
F511 Cream in Preventing Palmar-Plantar Erythrodysesthesia in Patients Receiving Doxorubicin Hydrochloride Liposome for Metastatic Breast Cancer
RATIONALE: F511 cream may prevent or reduce palmar-plantar erythrodysesthesia in women receiving doxorubicin hydrochloride liposome for metastatic breast cancer.
- Trial name
- NCT00992706
- Testing
- antiperspirant cream F511, pegylated liposomal doxorubicin hydrochloride
- Where
- 15 sites in Switzerland
- Volunteers
- 91 people
- Sponsor
- Swiss Cancer Institute
Effects, Drug Side
An Investigational Study to Evaluate Experimental Medication SYHX1901 Tablets With Moderate to Severe Plaque Psoriasis
The purpose of this study is to evaluate the efficacy and safety of different doses of SYHX1901 tablets in the treatment of moderate to severe plaque psoriasis in order to select doses for further clinical trials.
- Trial name
- NCT05858047
- Testing
- SYHX1901
- Where
- China
- Volunteers
- 93 people
- Sponsor
- CSPC Ouyi Pharmaceutical Co., Ltd.
ER+ Breast Cancer, HER2-negative Breast Cancer
Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Patients With Early Breast Cancer
This study is a pragmatic international, multicenter, randomized, open label 3- arm trial of standard care vs. two pharmacological interventions: duloxetine or furosemide in patients with stage I-III ER+/HER2- early breast cancer…
- Conditions
- ER+ Breast Cancer, HER2-negative Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II
- Trial name
- NCT06407401
- Testing
- Duloxetine 60 MG, Furosemide 40 mg, Booklet for healthy behaviors
- Volunteers
- 399 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
HIV, Tuberculosis
Preliminary Evaluation of a Point-Of-Care Liver Function Test
The proposed preliminary field evaluation will compare a point-of-care (POC) transaminase test with the standard of care test used in an HIV clinic at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam.
- Conditions
- HIV, Tuberculosis, Drug-Induced Liver Injury
- Trial name
- DFA (NCT01705041)
- Testing
- Diagnostics for All liver function test (LFT)
- Where
- Vietnam
- Volunteers
- 700 people
- Sponsor
- PATH
SCAR
An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate
The reason for this study is to understand if people with certain genes are predisposed to develop severe skin reactions after they are administered Eslicarbazepine Acetate.
- Trial name
- NCT02520557
- Testing
- Blood or Saliva
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Sumitomo Pharma America, Inc.
HIV Infections
Implementation and Assessment of a Medication Therapy Management Program in HIV Patients at High Risk of Adverse Drug Events at Khartoum, Sudan
This clinical trial aims to evaluate the effectiveness and cost-effectiveness of two levels of a pharmacist-led Medication Therapy Management (MTM) program, Basic MTM and Enhanced MTM, compared with usual care for HIV patients at…
- Trial name
- HIV-MTM-SUDAN- (NCT07750834)
- Testing
- Basic MTM, Enhanced MTM
- Where
- Sudan
- Volunteers
- 1,149 people
- Sponsor
- Universiti Sains Malaysia
Fetal and Neonatal Alloimmune Thrombocytopenia, Long Term Adverse Effects
Neurodevelopmental Outcome After Fetal Neonatal AlloImmune Thrombocytopenia
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease caused by allo-immunisation during pregnancy. If left untreated, FNAIT can lead to severe fetal intracranial haemorrhage.
- Conditions
- Fetal and Neonatal Alloimmune Thrombocytopenia, Long Term Adverse Effects, Neurodevelopmental Abnormality, Intravenous Immunoglobulin Adverse Reaction
- Trial name
- NOFNAIT (NCT04529382)
- Testing
- Cognitive testing (Bayley III, WPPSI III and WISC V)
- Where
- Netherlands
- Volunteers
- 78 people
- Sponsor
- Leiden University Medical Center
Autism Spectrum Disorder
Dietetic Pattern in Children With Autism Spectrum Disorders
To date, it is well documented that the gut microbiota (GM) influences numerous physiological processes in the healthy "host". The alteration of the composition and function of the intestinal microbiota, commonly referred to as…
- Trial name
- NCT04719923
- Testing
- Children with autism spectrum disorders
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Vasopressin Causing Adverse Effects in Therapeutic Use, Shock
Registry of Patients in Shock Treated With Vasopressin
Arginine-vasopressin (AVP) is a non-catecholaminergic hormone produced in the hypothalamus and released into the circulation via the neurohypophysis.
- Conditions
- Vasopressin Causing Adverse Effects in Therapeutic Use, Shock, Vasopressor Adverse Reaction, Vasopressin Deficiency
- Trial name
- NCT06422975
- Testing
- Vasopressin
- Where
- 24 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitario 12 de Octubre
Vaccine Reaction, Vaccine Adverse Reaction
Immunogenicity and Safety Following In-House Recombinant Hepatitis B Vaccine in Indonesian Population (Phase III)
This is a phase 3, experimental, randomized, observer-blind, lot to lot consistency study. The primary objective of this study is to assess the protectivity of In-House Recombinant Hepatitis B vaccine 28 days after 3 doses…
- Trial name
- NCT05482295
- Testing
- In-House Recombinant Hepatitis B (Bio Farma) vaccine, Registered Hepatitis B vaccine recombinant (Engerix-B)
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
Anesthesia; Adverse Effect
Perfusion Index Changes in Cardiovascular Autonom Neuropathia Type-2 Dm Whit Spinal Anesthesia
Cardiovascular autonomic neuropathy in diabetic patients, hypertension, sympathovagal imbalance, orthostatic hypotension, painless myocardial infarction, ischemia, left ventricular dysfunction, cardiac sympathetic and…
- Trial name
- PI (NCT03869775)
- Testing
- perfusion index monitor, ewing test
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Erzincan University
Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter
Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products
The overarching goal of this project is to develop a panel of cardiovascular risk biomarkers that can detect differences in the cardiovascular safety of various tobacco products, whether conventional, new or emerging, in order to…
- Trial name
- NCT01964807
- Testing
- Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cardiotoxicity, Pulmonary Toxicity
Study on Proton Radiotherapy of Thymic Malignancies
This is a multicentre non-randomized phase II study of proton beam radiotherapy in patients with thymic epithelial tumours (i.e.
- Conditions
- Cardiotoxicity, Pulmonary Toxicity, Thymus Neoplasms
- Trial name
- PROTHYM (NCT04822077)
- Testing
- Proton radiation
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Ass. Prof. Jan Nyman
Head and Neck Cancer, Radiotherapy; Adverse Effect
Monitoring Skeletal Muscle Mass Using CBCT in Patients With H&N Cancer Undergoing Chemoradiotherapy
Chemoradiotherapy is the standard treatment for unresectable locally advanced head and neck cancer (HNC). However, malnutrition is present in 44-88% HNC patients during chemoradiotherapy, which leads to loss of skeletal muscle…
- Trial name
- MELINOE (NCT05126095)
- Testing
- Radical radiotherapy
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Guangdong Provincial People's Hospital
Diffuse Large B Cell Lymphoma
Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma
To explore the clinical features and efficacy evaluation of large b-cell lymphoma in old age.
- Trial name
- NCT03513601
- Testing
- (R)-CHOP regimen, (R)-CVP regimen
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Mingzhi Zhang
Neoplasm, Colorectal, Cognitive Impairment
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute.
- Conditions
- Neoplasm, Colorectal, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change
- Trial name
- Chemo Brain (NCT05014399)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joseph McCollom
Acute Pain, Opioid Analgesic Adverse Reaction
the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery
The goal of this clinical trial is to learn if Oliceridine fumarate injection works to treat acute pain after abdominal surgery. It will also learn about the safety of Oliceridine fumarate injection.
- Trial name
- NCT06530563
- Testing
- Oliceridine Injection [Olinvyk], Sufentanil Citrate
- Where
- China
- Volunteers
- 606 people
- Sponsor
- Xiangya Hospital of Central South University
Adverse Reaction to Spinal Anesthetic, Maternal Care for Cervical Incompetence
Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)
This study aims to determine whether or not spinal anesthesia with the local anesthetic drug, chloroprocaine, wears off faster than the local anesthetic drug, bupivacaine, and results in faster discharge from the post-anesthesia…
- Trial name
- NCT02862912
- Testing
- Chloroprocaine, Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Columbia University
Medication Adverse Effects, Older Adults (65 Years and Older)
Population Health Approach to Optimizing Medications in Older Adults
This randomized controlled pragmatic pilot study examines the feasibility and acceptability of a population health-based deprescribing intervention that leverages a polypharmacy risk prediction model.
- Conditions
- Medication Adverse Effects, Older Adults (65 Years and Older), Polypharmacy, Polypharmacy Patients
- Trial name
- POP-MED (NCT06110156)
- Testing
- Patient-tailored deprescribing assessment and intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
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