Clinical trials: Adverse Reaction
Antibiotic Allergy
Support Tool for Antibiotic Allergy deLabeling
Antibiotic allergy labels (AAL) are reported in 7% of inpatient's charts, especially for beta-lactams (86% of AAL, i.e., prevalence of 6%).
- Trial name
- STAAL (NCT06771440)
- Testing
- EPR search
- Where
- Belgium
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adenosquamous Cell Lung Cancer, Drug/Agent Toxicity by Tissue/Organ
Radiation Therapy, Bevacizumab, Paclitaxel, and Carboplatin in Treating Patients With Unresectable Stage IIIB or Stage IV Non-Small Cell Lung Cancer at High Risk for Hemoptysis Caused by Bevacizumab
This phase II trial is studying the side effects and how well giving radiation therapy together with bevacizumab, paclitaxel, and carboplatin works in treating patients with unresectable stage IIIB or stage IV non-small cell lung…
- Conditions
- Adenosquamous Cell Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, Hemoptysis, Squamous Cell Lung Cancer
- Trial name
- NCT00387374
- Testing
- bevacizumab, paclitaxel, carboplatin
- Volunteers
- 72 people
- Sponsor
- National Cancer Institute (NCI)
Drug-Induced Liver Injury, Anti-Tuberculous Drug Reaction
Assessing Antibiotic Induced Liver Injury for Stratification of Tuberculosis Patients
A panel of highly sensitive circulating biomarkers for acute liver injury have been identified and demonstrated to identify liver injury on first presentation to hospital before standard tests are elevated in patients with…
- Conditions
- Drug-Induced Liver Injury, Anti-Tuberculous Drug Reaction, Tuberculosis
- Trial name
- ALISTER (NCT03211208)
- Where
- United Kingdom
- Volunteers
- 194 people
- Sponsor
- University of Edinburgh
Complications; Cesarean Section
Use of Intrathecal Fentanyl and Development of Hyperalgesia in Patients Undergoing Elective Cesarean
Opioid analgesic drugs are the main treatment of patients during anesthesia. Although highly effective, their use is not without problems. One is the increasing requirement of these address the same nociceptive stimulus.
- Trial name
- NCT02387060
- Testing
- H-Bupivacaine, Fentanyl
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Cardiac Toxicity, Leukemia
Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Cardiac Toxicity, Leukemia, Lymphoma
- Trial name
- T-Cell #4 (NCT01230983)
- Testing
- asparaginase, cytarabine, dexrazoxane hydrochloride
- Volunteers
- 573 people
- Sponsor
- Children's Oncology Group
Anesthesia, Adverse Effect of Handovers of Anesthesia Care
Impact of Handover of Anesthesia Care on Adverse Postoperative Outcomes
Our goal is to conduct a prospective, national, randomized-controlled, multicenter trial to investigate the effect of handover of anesthesia care on the occurrence of adverse outcomes in the perioperative period.
- Trial name
- HandiCAP (NCT04016454)
- Testing
- Intervention
- Where
- 11 sites in Germany
- Volunteers
- 1,817 people
- Sponsor
- University Hospital Muenster
Vitamin D, Chemotherapy
Effect of Vitamin D Supplementation on Chemotherapy Side Effects After Adjuvant Chemotherapy for Breast Cancer
This randomized controlled Phase III trial was designed to evaluate the effect of vitamin D supplementation (VD) on chemotherapy side effects following adjuvant chemotherapy in breast cancer
- Conditions
- Vitamin D, Chemotherapy, Breast Cancer, Adverse Reaction
- Trial name
- NCT06642441
- Testing
- Chemotherapy + vitamin D2, Chemotherapy
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Jiuda Zhao
Covid19, SARS-CoV Infection
Reactogenicity, Safety and Immunogenicity of QazCoVac-P COVID-19 Vaccine
Randomized, Blind, Placebo-controlled Phase- I Study and Randomized, Open Phase Phase-II Study of QazCoVac-P - COVID-19 Subunit Vaccine in Healthy Adult Volunteers From 18 Years Old and Elder
- Conditions
- Covid19, SARS-CoV Infection, Vaccine Adverse Reaction
- Trial name
- NCT04930003
- Testing
- QazCoVac-P -COVID-19 Subunit Vaccine
- Where
- Kazakhstan
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Research Institute for Biological Safety Problems
Cervical Cancer, Endometrial Cancer
MH-ART vs CF-IMRT in Postoperative Cervical/Endometrial Cancer
This is an investigator-initiated, prospective, national multi-center, phase III, randomized, open-label, non-inferiority clinical study.
- Trial name
- ARTISAN (NCT07584161)
- Testing
- Moderately fractionated radiotherapy using online adaptive radiotherapy technology, Conventionally fractionated radiotherapy using image-guided intensity-modulated radiotherapy technology.
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Xiaorong Hou
Genetics of Drug Metabolism
Pharmacogenomic Testing Of the Elderly To Reduce Morbidity
The goal of the POETRY Registry is to determine whether data from Pharmacogenomic (PGx) Testing for elderly and disabled patients can help physicians manage patient medication regimens and assess if the testing has an effect on…
- Trial name
- POETRY (NCT02095769)
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 280,000 people
- Sponsor
- General Genetics Corporation
Drug Toxicity, Lung Cancer
13-Cis Retinoic Acid With or Without Vitamin E for Prevention of Lung Cancer
RATIONALE: 13 Cis retinoic acid may prevent the development of cancer cells. PURPOSE: Randomized double-blinded phase II trial to study the effectiveness of 13-cis retinoic acid with or without vitamin E for chemoprevention or…
- Trial name
- 13-Cis (NCT00002586)
- Testing
- 13-cis retinoic acid, Tocopherol
- Where
- 4 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Colorado, Denver
Terbinafine Adverse Reaction
Clinical Effect of Caffeine Consumption in Patients Taking Oral Terbinafine
The investigators hypothesize that there would be significant changes in blood pressure or heart rate in patients consuming caffeine while taking terbinafine.
- Trial name
- NCT05667246
- Testing
- Caffeinated Coffee, Decaffeinated Coffee
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Adverse Drug Reaction, Therapy Failure
Pharmacogenetic Testing of Patients With Unwanted Adverse Drug Reactions or Therapy Failure
Genetic makeup of a patient influences the efficacy and safety profile of a drug. This study is to summarize individual cases, where Pharmacogenetics (PGx) has been applied during pharmaceutical care.
- Trial name
- NCT04154553
- Testing
- Buccal swab, EDTA Blood sample (4.9mL), Serum sample (7.5mL)
- Where
- Switzerland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Carcinoid Syndrome
An Open-label Study to Evaluate the Absorption, Metabolism, and Excretion of [14C]-Telotristat Etiprate in Males
To evaluate the metabolism and routes and extent of elimination of telotristat etiprate and its primary metabolite LX1033.
- Trial name
- LX1606-104 (NCT01932528)
- Testing
- 500 mg [14C]-LX1606
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Lexicon Pharmaceuticals
Adverse Drug Event, Potential Adverse Drug Event, and Quality Measures
Emergency Pharmacist Safety Study
The Emergency Department (ED) is a unique environment in medicine, and many safety mechanisms used in other hospital settings cannot be applied in the ED.
- Trial name
- NCT00382434
- Testing
- presence of an emergency pharmacist in the ED
- Where
- United States
- Volunteers
- 10,224 people
- Sponsor
- University of Rochester
Cancer
Prevention of Capecitabine Induced Hand and Foot Syndrome
Capecitabine is a common anti cancer drug. One of the most common side effects is a syndrome called hand and foot syndrome which comprises of hands and feet redness, swelling, dryness and painful sores.
- Trial name
- NCT01291628
- Testing
- socks containing copper-oxide fibers
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Relapsing-Remitting Multiple Sclerosis (RRMS)
Brimonidine Tartrate for the Treatment of Injection Related Erythema
The primary objective of this study is to evaluate the Injection Related Erythema (IRE) mitigation effect of a single administration of brimonidine tartrate in comparison with a vehicle gel (placebo).
- Trial name
- BRITE (NCT02568111)
- Testing
- peginterferon beta-1a, brimonidine tartrate, Vehicle Gel
- Sponsor
- Biogen
Immune Checkpoint Inhibitor-Related Pneumonitis, Drug-Related Side Effects and Adverse Reactions
Nutritional + Usual Corticosteroids Randomized Trial for Immune-Related pneumoniA - Therapeutic Utilization Evaluation
This is a prospective, single-center, open-label, randomized controlled clinical trial evaluating whether the addition of a nutritional therapy regimen (Spirulina-Bifidobacterium capsules, fish oil-grape seed-blueberry soft…
- Conditions
- Immune Checkpoint Inhibitor-Related Pneumonitis, Drug-Related Side Effects and Adverse Reactions, Neoplasms
- Trial name
- NCT07554885
- Testing
- Spirulina-Bifidobacterium capsule, Fish oil-grape seed-blueberry soft capsule, Ganoderma spore oil
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Multiple Sclerosis
Evaluating the Use of Prednisone to Decrease Pegylated Interferon Beta-1a Side Effects
Some of the most common side effects of the multiple sclerosis drug Plegridy (pegylated interferon beta-1a) include flu-like symptoms and injection site reactions.
- Trial name
- NCT03424733
- Testing
- Plegridy, Prednisone, Tylenol Pill
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Holy Name Medical Center, Inc.
Cardiotoxicity, Chemotherapeutic Toxicity
Prevention of Chemotherapy-induced Cardiotoxicity in High-risk Patients
In cancer patients, the increase of troponin I soon after chemotherapy is a strong predictor of left ventricular dysfunction and poor cardiologic outcome.
- Trial name
- NCT00292526
- Testing
- Enalapril
- Where
- Italy
- Volunteers
- 114 people
- Sponsor
- European Institute of Oncology