Clinical trials: Adverse Reaction
Drug Hypersensitivity
Cephalosporin Hypersensitivity
Background : Although the hypersensitivity reactions to cephalosporins have been recently a more focused subject, studies on the cephalosporin as an allergen are significantly less frequent that those regarding penicillins.
- Trial name
- CephALL (NCT04421638)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Effects of Chemotherapy, Cognitive Impairment
Cognitive Changes in Adult Cancer Survivors
This study will document the cognitive (mental) and functional abilities of newly diagnosed cancer patients. The study will also examine the changes in cognitive and functional abilities during and after chemotherapy (your cancer…
- Trial name
- CFCC (NCT01569932)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Head and Neck Cancer Survivors, Cancer of the Head and Neck Surviors
Head and Neck Cancer Survivorship Ototoxicity Screening (SOS)
To evaluate the effectiveness, feasibility, acceptability, and appropriateness of an ototoxicity screening protocol among head and neck (H\&N) cancer patients followed in survivorship clinic that received cisplatin-based…
- Trial name
- NCT05789316
- Testing
- Ototoxicity Screening Protocol
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Washington University School of Medicine
Drug/Agent Toxicity by Tissue/Organ, Head and Neck Cancer
Chemotherapy Plus Radiation Therapy With or Without Amifostine in Treating Patients With Locally Advanced Cancer of the Nasopharynx
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Head and Neck Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00025298
- Testing
- amifostine trihydrate, carboplatin, cisplatin
- Where
- 13 sites in Belgium, France and 4 more
- Volunteers
- 5 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
HIV Infections, Clinical Outcomes
Dolutegravir and Clinical Outcomes Among ART-recipients in Brazil
Access to antiretroviral therapy (ART) in low-income and middle-income countries has been scaled-up effectively over recent years.
- Conditions
- HIV Infections, Clinical Outcomes, Adverse Drug Event, Effect of Drugs
- Trial name
- CODE (NCT04326504)
- Testing
- No intervention
- Where
- 3 sites in Brazil
- Volunteers
- 5,000 people
- Sponsor
- Fundação Bahiana de Infectologia
Ototoxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Assessing Ear Damage in Young Cancer Patients Treated With Cisplatin
RATIONALE: New ways to find out about hearing loss after treatment with chemotherapy may improve the ability to plan cancer treatment and may help patients live more comfortably.
- Trial name
- NCT00458887
- Testing
- management of therapy complications
- Where
- 81 sites in United States, Australia and 1 more
- Volunteers
- 301 people
- Sponsor
- Children's Oncology Group
Adverse Effect
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia.
The purpose of this study is to investigate the suitable infusion dose of norepinephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.
- Trial name
- NCT04556370
- Testing
- Normal saline, Norepinephrine
- Where
- China
- Volunteers
- 180 people
- Sponsor
- General Hospital of Ningxia Medical University
Ototoxicity, Drug-Induced
Diagnostic of Various Ototoxicity Induced by Cancer Treatment
Visit the clinic once every 2 weeks for checkups and tests The goal of this clinical trial is to learn if systematic hearing tests (eg fonctional assesment, electrophysiology and seric biomarkers) can diagnose hidden hearing loss…
- Trial name
- BIO-OTOTOX (NCT06490029)
- Testing
- Auditory, vestibular and electrophysiological investigations, Biologic investigations; seric proteins
- Where
- France
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Anesthesia, Bupivacaine Adverse Reaction
Bupivacaine Levels After ESPB
Erector Spinae Plane Block (ESPB) is a regional anesthesia technique that is used for as a part of multimodal analgesia. Bupivacaine is one of the local anesthetic drugs and it is applied for ESPB.
- Trial name
- NCT04239053
- Testing
- Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Maltepe University
Medication Adherence, Medication Nonadherence
Feasibility of Using a Telemedicine Medication Delivery Unit for Older Adults
Care transition interventions have been successful in reducing medication-related problems and associated rehospitalization primarily by focusing on medication reconciliation conducted by trained healthcare professionals.
- Conditions
- Medication Adherence, Medication Nonadherence, Adverse Reaction to Drug
- Trial name
- EMMA (NCT01430702)
- Testing
- Computerized medication delivery unit (Electronic Medication Management Assistant (EMMA)
- Where
- United States
- Sponsor
- University of Pittsburgh
Lung Cancer, Carboplatin Adverse Reaction
Personalized Therapy in Non-small Cell Lung Cancer
Excision repair cross complementing 1 (ERCC1) ribonucleotide reductase M1 (RRM1) and thymidylate synthase(TS) are molecular determinants that predict sensitivity or resistance to platinum agents 、 gemcitabine and pemetrexed…
- Trial name
- PTINCLC (NCT01781988)
- Testing
- carboplatin, gemcitabine , pametrexed
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Guangzhou Medical University
Tetanus, Diphtheria
An Immunogenicity and Safety Study of Tetanus, Diphtheria and Acellular Pertussis Vaccine Booster
Open-label, randomized, multi-centre study in which 400 subjects, divided into two groups, will receive Td5ap or Td1aP as a single injection.
- Conditions
- Tetanus, Diphtheria, Pertussis
- Trial name
- Tdap Booster (NCT00870350)
- Testing
- Td5ap, Td1aP
- Where
- Sweden
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Swedish Institute for Infectious Disease Control
Liver Injury, Liver Injury, Drug-Induced
A Retrospective Study in Patients With Liver Injury After the Use of Novel Antineoplastic Agents
This is an open-enrollment, retrospective, observational study without interventions. Its primary objective is to understand 1) incidence of liver injury among all the hospitalized patient from participating centers after the…
- Trial name
- NCT06670391
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Drug Induced Liver Disease Study Group
Local Anesthetic Drug Adverse Reaction, Local Infiltration
: Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
Anesthetics with vasoconstrictors decrease pulpal blood flow but the impact of intranasal local anesthetics on blood flow is unknown.
- Conditions
- Local Anesthetic Drug Adverse Reaction, Local Infiltration, Pulp Disease, Dental
- Trial name
- NCT03368391
- Testing
- tetracaine HCl and oxymetazoline HCL, 2% Lidocaine with 1:100,000 epinephrine, 3% Mepivacaine with 1:100,000 epinephrine
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Drug-induced Liver Injury,Chronic
Efficacy and Safety of Glucocorticosteroid Treatment in the Patients With Chronic Recurrent DILI
This study is to observe the efficacy and safety of glucocorticosteroid treatment in the patients with chronic recurrent drug-induced liver injury (DILI).
- Trial name
- NCT02651350
- Testing
- Methylprednisolone, Standard Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing 302 Hospital
Statin Adverse Reaction, Skeletal Myopathy
NIRS to Diagnose SAMS
This proposal seeks to determine whether near infrared spectroscopy (NIRS) can differentiate between patients with confirmed SAMS and those with non-specific muscle complaints.
- Trial name
- NCT03653663
- Testing
- Simvastatin 20 mg
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Complications; Arthroplasty, Complications; Arthroplasty, Mechanical
Using MRI To Detect Soft Tissue Reactions And Implant Integration As Related To Implant Modularity
Patients with a total hip replacement may require early revision surgery due to an adverse local tissue reaction or bone resorption that occurs due to wear debris released from the implant.
- Trial name
- NCT02255331
- Where
- United States
- Volunteers
- 587 people
- Sponsor
- Hospital for Special Surgery, New York
Polypharmacy, Adverse Drug Reaction
Educational Intervention to Reduce Drug-related Hospitalizations in Elderly Primary Health Care Patients
The purpose of this study is to determine whether an educational intervention given towards health care providers working in primary health care centers can reduce inappropriate prescribing in the elderly patient and thus reduce…
- Trial name
- NCT01732302
- Testing
- Educational intervention
- Where
- Sweden
- Volunteers
- 69 people
- Sponsor
- Karolinska Institutet
Diarrhea, Drug/Agent Toxicity by Tissue/Organ
N2003-01: Irinotecan, Temozolomide, and Cefixime in Treating Young Patients With Recurrent or Resistant Neuroblastoma
RATIONALE: Drugs used in chemotherapy, such as irinotecan and temozolomide, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Diarrhea, Drug/Agent Toxicity by Tissue/Organ, Neuroblastoma
- Trial name
- NCT00093353
- Testing
- cefixime, irinotecan hydrochloride, temozolomide
- Where
- 13 sites in United States
- Volunteers
- 30 people
- Sponsor
- New Approaches to Neuroblastoma Therapy Consortium
Drug Allergy, Penicillin Allergy
Provocation After Nurse-Directed Assessment (PANDA) Study
The study aims to evaluate the effectiveness and safety of a collaborative nurse-allergist approach in penicillin allergy delabeling services.
- Trial name
- PANDAS (NCT07127835)
- Testing
- Nurse-led penicillin allergy delabelling service, Allergist-led penicillin allergy delabelling service
- Where
- 4 sites in Hong Kong
- Volunteers
- 440 people
- Sponsor
- The University of Hong Kong
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